Stress Disorders, Post-Traumatic Clinical Trials

18 studies are recruiting for stress disorders, post-traumatic in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. MOCHA: Embedded Inpatient Mental Health Care for High-Risk Perinatal Patients

   Pregnant and postpartum patients hospitalized for medical complications experience high rates of depression, anxiety, and trauma-related symptoms, yet access to timely psychiatric care during obstetric hospitalization is limited. Project MOCHA integrates early mental health screening, trauma-inform…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana

   Run by

   Indiana University

   See if you can join NCT07540585 on ClinicalTrials.gov

2. Massed Prolonged Exposure for PTSD in Substance Use Treatment

   The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder in intensive outpatient substance use treatment. T…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA San Diego Healthcare System, San Diego, California

   Locations

   6 in total

   Run by

   Veterans Medical Research Foundation

   See if you can join NCT06296186 on ClinicalTrials.gov

3. Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure

   The goal of this clinical trial is to learn if receiving Trauma-Informed Guilt Reduction (TrIGR) Therapy is as effective as receiving Prolonged Exposure Therapy among veterans with PTSD and trauma related guilt. The main questions it aims to answer are: Will TrIGR be comparable to PE in terms of PT…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Little Rock Veterans Health Care System (LRVHCS), Little Rock, Arkansas

   Locations

   4 in total

   Run by

   Veterans Medical Research Foundation

   See if you can join NCT06296589 on ClinicalTrials.gov

4. SMART Therapist Training: A Hybrid Factorial-SMART Design

   Cognitive Processing Therapy (CPT) is highly effective in randomized controlled trials, but its effectiveness drops substantially in standard clinical practice, largely due to therapist "drift" from fidelity to the protocol. What remains unknown is which components of CPT training yield high therap…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California

   Locations

   4 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT07010770 on ClinicalTrials.gov

5. Enhancing Memory in Cognitive Processing Therapy for PTSD

   Several psychotherapies for posttraumatic stress disorder (PTSD) have a strong evidence base for their efficacy, but nonresponse rates are high, particularly among older Veterans. Accumulating evidence indicates that memory deficits and poor learning of therapy contents adversely affect psychothera…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia, Pennsylvania

   Run by

   VA Office of Research and Development

   See if you can join NCT06000475 on ClinicalTrials.gov

6. Computational Assessment of GABA Receptor Modulation in PTSD

   A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications. Progress in developing more effective medications is hampered by the substantial variability within Veterans with PTSD, meaning the most effective medication likel…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   VA San Diego Healthcare System, San Diego, CA, San Diego, California

   Run by

   VA Office of Research and Development

   See if you can join NCT06852469 on ClinicalTrials.gov

7. Manage Emotions to Reduce Aggression (MERA)

   PTSD is one of the most prevalent mental health conditions affecting Veterans who have served since 9/11. Veterans with posttraumatic stress disorder (PTSD) report difficulty controlling impulsive aggression (IA). An inability to manage one's emotions (emotion dysregulation) is an underlying mechan…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   James A. Haley Veterans' Hospital, Tampa, FL, Tampa, Florida

   Locations

   2 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT04793776 on ClinicalTrials.gov

8. Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV

   The purpose of this study is to find out why patients with post-traumatic stress disorder (PTSD) have an increased risk for heart disease and high blood pressure later in life. A second purpose is to find out what causes PTSD patients to have high adrenaline levels during stress. This study will al…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Atlanta VA Medical Center, Decatur, Georgia

   Run by

   Emory University

   See if you can join NCT02560805 on ClinicalTrials.gov

9. Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery

   The proposed R21 project will attempt to further develop a novel intervention for posttraumatic stress symptoms inspired by the science of memory reconsolidation. Work in normal humans has shown that when a stable, consolidated memory is reactivated (i.e., retrieved) under appropriate conditions, i…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Massachusetts General Hospital Home Base Program, Charlestown, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT05853627 on ClinicalTrials.gov

10. Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication

    The purpose of this clinical trial is to learn whether existing treatments for posttraumatic stress disorder (PTSD) can be improved. Two treatments for PTSD, cognitive processing therapy (CPT) and prolonged exposure (PE) will be studied. CPT and PE are effective treatments that are widely available…

    Stage

    Not phased

    Ages

    18 and older

    Site

    National Center for PTSD at VA Boston Healthcare System, Boston, Massachusetts

    Run by

    Boston University

    See if you can join NCT06088303 on ClinicalTrials.gov

11. A Study of a Novel EEG Neurofeedback System for PTSD Treatment

    The goal of this clinical trial is to learn if training with the Prism system can reduce PTSD symptoms in US military Veterans and civilians with PTSD. Prism is a form of neurofeedback training that uses EEG signals to promote self-regulation of brain function. The main question this study aims to …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Birmingham VA Medical Center, Birmingham, Alabama

    Locations

    6 in total

    Run by

    Foundation for Atlanta Veterans Education and Research, Inc.

    See if you can join NCT06770998 on ClinicalTrials.gov

12. MDMA for Co-occurring PTSD and OUD After Childbirth

    This is an open-label study of the use of MDMA Assisted Therapy for postpartum people with co-occurring Post Traumatic Stress Disorder (PTSD) and Opioid Use Disorder (OUD). The study protocol has been adapted from the Phase 3 studies sponsored by the Multidisciplinary Association for Psychedelic St…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of New Mexico Health Sciences, Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT05219175 on ClinicalTrials.gov

13. Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder

    This study effects the effects of transcutaneous cervical vagal nerve stimulation (tcVNS) or a sham control on brain, physiology, and PTSD symptoms in Veterans with posttraumatic stress disorder (PTSD). Veterans undergo brain imaging and physiological measures in conjunction with traumatic scripts …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia

    Run by

    VA Office of Research and Development

    See if you can join NCT05517304 on ClinicalTrials.gov

14. Healthy Recovery After Trauma Study

    Mental contamination-an internal experience of dirtiness evoked in the absence of physical contact with an external source-has been linked to the development and maintenance of posttraumatic stress disorder (PTSD) following exposure to sexual abuse or assault (Adams et al., 2014; Badour et al., 201…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kentucky Clinic for Emotional Health (CEH), Lexington, Kentucky

    Run by

    Christal L Badour

    See if you can join NCT04585685 on ClinicalTrials.gov

15. Postpartum Care in the NICU (PeliCaN) Transitions

    This is a randomized controlled trial of a dyad-centered, doula support and healthcare coordination model of care in a large urban neonatal intensive care unit (NICU), which serves a high-risk, low-income, majority Black population. In addition to doula support and coordination of care in the NICU,…

    Stage

    Not phased

    Ages

    16 and older

    Site

    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06521398 on ClinicalTrials.gov

16. Combining Stellate Ganglion Block With Prolonged Exposure for PTSD

    The goal of this clinical trial is to compare the combination of Massed Prolonged Exposure (PE); a behavioral therapy for PTSD) and a stellate ganglion block (SGB; an injection of a local anesthetic into the front of the neck) with Massed Prolonged Exposure and a sham injection in a sample of milit…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Carl R. Darnall Army Medical Center, Fort Hood, Texas

    Locations

    2 in total

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT05889741 on ClinicalTrials.gov

17. Computer Monitor vs Augmented Reality 3MDR for PTSD PTSD: A Randomized Controlled Trial

    This is a prospective randomized controlled trial comparing two ways of delivering Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR) therapy for posttraumatic stress disorder (PTSD). The study seeks 60 volunteers who have PTSD and are eligible for care in the Departme…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Uniformed Services University, Bethesda, Maryland

    Run by

    Uniformed Services University of the Health Sciences

    See if you can join NCT05244564 on ClinicalTrials.gov

18. An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample

    Given the high prevalence of post-traumatic stress disorder (PTSD) in veterans and active duty military, the focus of this research study is to test the reliability of two new PTSD assessments, the Clinician Administered PTSD Scale for DSM-5 (CAPS-5) and the PTSD Symptom Scale Interview for DSM-5 (…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tripler Army Medical Center, Honolulu, Hawaii

    Locations

    3 in total

    Run by

    U.S. Army Medical Research and Development Command

    See if you can join NCT04180930 on ClinicalTrials.gov