Stage IV Pancreatic Cancer AJCC v8 Clinical Trials

19 studies are recruiting for stage iv pancreatic cancer ajcc v8 in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Chicago, Illinois 6 Portland, Oregon 6 Atlanta, Georgia 4 Cincinnati, Ohio 4 Green Bay, Wisconsin 4 Houston, Texas 4 Lexington, Kentucky 4 Sacramento, California 4 St Louis, Missouri 4 Wilmington, Delaware 4 Baltimore, Maryland 3 Bloomington, Illinois 3 Buffalo, New York 3 Canton, Illinois 3 Carthage, Illinois 3 Centralia, Illinois 3 Columbus, Ohio 3 Danville, Illinois 3 Dayton, Ohio 3 Decatur, Illinois 3 Denver, Colorado 3 Des Moines, Iowa 3 Effingham, Illinois 3 Eureka, Illinois 3 Fargo, North Dakota 3 Franklin, Ohio 3 Gainesville, Florida 3 Galesburg, Illinois 3 Grand Rapids, Michigan 3 Greenville, Ohio 3 Honolulu, Hawaii 3 Jacksonville, Florida 3 Kalamazoo, Michigan 3 Kewanee, Illinois 3 Macomb, Illinois 3 Memphis, Tennessee 3 Milwaukee, Wisconsin 3 New Haven, Connecticut 3 New Orleans, Louisiana 3 New York, New York 3 Newark, Delaware 3 O'Fallon, Illinois 3 Omaha, Nebraska 3 Ottawa, Illinois 3 Pekin, Illinois 3 Peoria, Illinois 3 Peru, Illinois 3 Phoenix, Arizona 3 Pittsburgh, Pennsylvania 3 Princeton, Illinois 3 Reno, Nevada 3 Rochester, Minnesota 3 San Francisco, California 3 Seattle, Washington 3 Sheboygan, Wisconsin 3 Springfield, Illinois 3 Troy, Ohio 3 Urbana, Illinois 3 Washington, Illinois 3 Washington D.C., District of Columbia 3

Studies now recruiting

  1. Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis

    This phase II trial studies the effects of hyperthermic intraperitoneal chemotherapy (HIPEC) in treating patients with pancreatic cancer that has spread to the internal abdominal area (peritoneal metastasis). Chemotherapy drugs, such as nab-paclitaxel and cisplatin, work in different ways to stop t…

    Stage
    Phase 2
    Ages
    18 to 80
    Site
    Mayo Clinic in Rochester, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT04858009 on ClinicalTrials.gov

  2. iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation

    This phase I trial studies the best dose and side effects of mesenchymal stromal cells-derived exosomes with KrasG12D siRNA (iExosomes) in treating participants with pancreatic cancer with KrasG12D mutation that has spread to other places in the body. iExosomes may work better at treating pancreati…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    M D Anderson Cancer Center, Houston, Texas
    Run by
    M.D. Anderson Cancer Center

    See if you can join NCT03608631 on ClinicalTrials.gov

  3. Targeted Pathway Inhibition in Patients With Pancreatic Cancer

    This early phase I trial aims to determine how cobimetinib, olaparib, onvansertib, azenosertib, AZD5305 or tremelimumab works in patients with pancreatic cancer. Validation of cobimetinib, olaparib, onvansertib azenosertib, AZD5305 and tremelimumab molecular targets will be explored by comparing pr…

    Stage
    EARLY_Phase 1
    Ages
    18 and older
    Site
    OHSU Knight Cancer Institute, Portland, Oregon
    Run by
    OHSU Knight Cancer Institute

    See if you can join NCT04005690 on ClinicalTrials.gov

  4. Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

    This phase I trial tests the safety, side effects, and best dose of neratinib in combination with trastuzumab deruxtecan in treating patients with solid tumors that have spread from where it first started (primary site) to other places in the body (metastatic) or that cannot be removed by surgery (…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    City of Hope Comprehensive Cancer Center, Duarte, California
    Locations
    18 in total
    Run by
    National Cancer Institute (NCI)

    See if you can join NCT05372614 on ClinicalTrials.gov

  5. Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

    This phase III trial compares the effect of dose-escalated radiation therapy to usual care in patients with locally advanced unresectable pancreatic ductal adenocarcinoma who have received an initial 4-8 months of chemotherapy. Usual care options include additional chemotherapy, observation, or sta…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Banner MD Anderson Cancer Center, Gilbert, Arizona
    Locations
    333 in total
    Run by
    NRG Oncology

    See if you can join NCT06958328 on ClinicalTrials.gov

  6. BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion

    This phase Ib/II trial tests the safety and side effects of BMS-986504 in combination with pemetrexed and how well the combination works in treating patients with solid tumors with MTAP deletion and that has spread from where it first started (primary site) to other places in the body (metastatic).…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Northwestern University, Chicago, Illinois
    Run by
    Northwestern University

    See if you can join NCT07594626 on ClinicalTrials.gov

  7. AB801 in Combination With Chemotherapy and Immunotherapy for the Treatment of Patients With Borderline Resectable, Locally Advanced or Metastatic Cholangiocarcinoma or Pancreatic Cancer

    This phase I trial tests the safety, side effects, best dose and effectiveness of AB801 in combination with chemotherapy and immunotherapy in treating patients with cholangiocarcinoma or pancreatic adenocarcinoma that may be removed by surgery (borderline resectable), that has spread to nearby tiss…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
    Run by
    Jonsson Comprehensive Cancer Center

    See if you can join NCT07619313 on ClinicalTrials.gov

  8. Understanding New Cachexia Subtypes Through Observational Epidemiological Research

    The UNCOVER study is a longitudinal observational cohort focused on patients at high risk for cancer cachexia. At Kaiser Permanente Northern California, up to 800 individuals with advanced or unresectable non-small cell lung cancer, pancreatic adenocarcinoma, or colorectal cancer will be enrolled, …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Kaiser Permanente Northern California, Pleasanton, California
    Run by
    Kaiser Permanente

    See if you can join NCT07776353 on ClinicalTrials.gov

  9. Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma

    This phase I/II trial tests the effect of pegcetacoplan in combination with oxaliplatin, irinotecan, leucovorin, and fluorouracil (mFOLFIRINOX) in treating patients with pancreatic ductal adenocarcinoma (PDAC) that has spread from where it first started (primary site) to other places in the body (m…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Roswell Park Cancer Institute, Buffalo, New York
    Run by
    Roswell Park Cancer Institute

    See if you can join NCT07214298 on ClinicalTrials.gov

  10. TR-002 for the Treatment of Advanced Unresectable Metastatic Solid Tumors Unresectable or Metastatic, Refractory Pancreatic Adenocarcinoma

    This phase I trial tests the safety, side effects and best dose of TR-002 for the treatment of solid tumors that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced), that cannot be removed by surgery (unresectable), that has spread from…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    University of California Davis Comprehensive Cancer Center, Sacramento, California
    Run by
    University of California, Davis

    See if you can join NCT07189195 on ClinicalTrials.gov

  11. Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors

    This phase I/II trial tests the safety, side effects, and best dose of entinostat and ZEN003694 in treating patients with solid tumors that have spread to other places in the body (advanced) or does not respond to treatment (refractory). Entinostat is in a class of drugs called histone deacetylase …

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Yale University, New Haven, Connecticut
    Locations
    3 in total
    Run by
    National Cancer Institute (NCI)

    See if you can join NCT05053971 on ClinicalTrials.gov

  12. BMS-986340 in Combination With Nivolumab, Gemcitabine and Nab-paclitaxel for the Treatment of Metastatic and Recurrent Pancreatic Adenocarcinoma

    This phase II trial tests the safety, side effects and best dose of BMS-986340 in combination with nivolumab, gemcitabine, and nab-paclitaxel and how well it works in treating patients with pancreatic adenocarcinoma that has spread from where it first started (primary site) to other places in the b…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Mayo Clinic in Arizona, Scottsdale, Arizona
    Locations
    3 in total
    Run by
    Mayo Clinic

    See if you can join NCT07226856 on ClinicalTrials.gov

  13. Intravital Microscopy in Human Solid Tumors

    This study will investigate the tumor-associated vasculature of patients with solid tumors. The investigators will use a technology known as intravital microscopy (IVM) in order to visualize in real-time the vessels associated with solid tumors. The IVM observations may determine if an individual p…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic Florida, Jacksonville, Florida
    Run by
    Mayo Clinic

    See if you can join NCT03823144 on ClinicalTrials.gov

  14. Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations

    This phase III trial compares the effect of adding panitumumab to standard chemotherapy (with nanoliposomal Irinotecan, leucovorin, and 5-fluorouracil [5-FU] or irinotecan, leucovorin, and 5-FU or nab-paclitaxel and gemcitabine) versus standard chemotherapy alone in treating patients with KRAS wild…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Anchorage Associates in Radiation Medicine, Anchorage, Alaska
    Locations
    274 in total
    Run by
    SWOG Cancer Research Network

    See if you can join NCT06998940 on ClinicalTrials.gov

  15. Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer

    This phase Ib trial tests the safety, side effects, and best dose of leflunomide in combination with gemcitabine in treating patients with pancreatic cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and cannot be removed …

    Stage
    Phase 1
    Ages
    18 and older
    Site
    City of Hope Medical Center, Duarte, California
    Run by
    City of Hope Medical Center

    See if you can join NCT06454383 on ClinicalTrials.gov

  16. OMO-103 for the Treatment of Locally Advanced or Metastatic Pancreatic Ductal Adenocarcinoma

    This early phase I trial studies the biological activity of OMO-103 in patients with pancreatic ductal adenocarcinoma that has spread to nearby tissue or lymph nodes (locally advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic). OMO-103 ma…

    Stage
    EARLY_Phase 1
    Ages
    18 and older
    Site
    OHSU Knight Cancer Institute, Portland, Oregon
    Run by
    OHSU Knight Cancer Institute

    See if you can join NCT07089940 on ClinicalTrials.gov

  17. A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

    This phase II study evaluates how well pemigatinib works for the treatment of adult patients with pancreatic cancer that has spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or has spread from where it first started to other places in the bod…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Ohio State University-Telemedicine, Birmingham, Alabama
    Locations
    109 in total
    Run by
    Sameek Roychowdhury

    See if you can join NCT06906562 on ClinicalTrials.gov

  18. LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

    This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery (unresectable) or is stage IV. Patients with these cancer types are at risk for d…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mercy Hospital Fort Smith, Fort Smith, Arkansas
    Locations
    225 in total
    Run by
    University of Rochester

    See if you can join NCT06073431 on ClinicalTrials.gov

  19. CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors

    This phase II trial tests how well CPI-613 (devimistat) in combination with hydroxychloroquine (HCQ) and 5-fluorouracil (5-FU) or gemcitabine works in patients with solid tumors that may have spread from where they first started to nearby tissue, lymph nodes, or distant parts of the body (advanced)…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Northwestern University, Chicago, Illinois
    Run by
    Northwestern University

    See if you can join NCT05733000 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.