Stage IV Lung Cancer AJCC v8 Clinical Trials in Irvine, California

7 studies are recruiting for stage iv lung cancer ajcc v8 in Irvine, California right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

   This phase I/II trial tests the safety, side effects, and best dose of iadademstat when given together with atezolizumab or durvalumab, and studies the effect of the combination in treating patients with small cell lung cancer that has spread outside of the lung in which it began or to other parts …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   City of Hope at Irvine Lennar, Irvine, California

   Locations

   43 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT06287775 on ClinicalTrials.gov

2. Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

   This phase II Lung-MAP treatment trial test the combination of targeted drugs (capmatinib, osimertinib, and/or ramucirumab) in treating patients with non-small cell lung cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) an…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Kaiser Permanente-Irvine, Irvine, California

   Locations

   454 in total

   Run by

   SWOG Cancer Research Network

   See if you can join NCT05642572 on ClinicalTrials.gov

3. Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

   This phase II Expanded Lung-MAP treatment trial tests tepotinib with or without ramucirumab for the treatment of patients with advanced non-small cell lung cancer that has spread from where it first started (primary site) to other places in the body (stage IV) or that has come back after a period o…

   Stage

   Phase 2

   Ages

   Any age

   Site

   Kaiser Permanente-Irvine, Irvine, California

   Locations

   266 in total

   Run by

   SWOG Cancer Research Network

   See if you can join NCT06031688 on ClinicalTrials.gov

4. Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

   This phase II/III Expanded Lung-MAP treatment trial compares the effect of adding cemiplimab to docetaxel and ramucirumab versus docetaxel and ramucirumab alone in treating patients with non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Cem…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   City of Hope at Irvine Lennar, Irvine, California

   Locations

   386 in total

   Run by

   SWOG Cancer Research Network

   See if you can join NCT06616584 on ClinicalTrials.gov

5. Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

   This phase II trial tests the impact of biomarkers in predicting initial treatment (first-line) PD1 or PD-L1 (PD[L]-1)-based immunotherapy response and in selecting second-line treatment in patients with stage IIIB-IV non-small cell lung cancer (NSCLC). Response and survival rates in advanced stage…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   City of Hope at Irvine Lennar, Irvine, California

   Locations

   13 in total

   Run by

   City of Hope Medical Center

   See if you can join NCT07288034 on ClinicalTrials.gov

6. Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

   This phase I trial tests the safety, side effects, and best dose of carfilzomib in combination with sotorasib in treating patients with KRAS G12C-mutated non-small cell lung cancer (NSCLC) that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   City of Hope at Irvine Lennar, Irvine, California

   Locations

   2 in total

   Run by

   City of Hope Medical Center

   See if you can join NCT06249282 on ClinicalTrials.gov

7. Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

   This phase II trial tests how well craniospinal irradiation (CSI) using photon volumetric modulated arc radiotherapy (VMAT) works in treating patients with breast cancer or non-small cell lung cancer (NSCLC) that has spread from the original (primary) tumor to the cerebrospinal fluid and meninges (…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   City of Hope at Irvine Lennar, Irvine, California

   Locations

   2 in total

   Run by

   City of Hope Medical Center

   See if you can join NCT06910761 on ClinicalTrials.gov