Smoking Clinical Trials

27 studies are recruiting for smoking in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos

   The purpose of this randomized controlled trial is to assess the efficacy of Actívatexto (Aim 1) and the mediators of the presumed treatment effect (Aim 2) among Latino adults who smoke. Actívatexto is a mobile intervention that integrates four components: 1) a text messaging program that promotes …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Rochester Medical Center, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT06926608 on ClinicalTrials.gov

2. A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home

   The purpose of this study is to evaluate how using an indoor air quality monitor can promote a smoke-free home for cancer patients who are enrolled in MSK's Tobacco Treatment Program.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Basking Ridge (Consent only), Basking Ridge, New Jersey

   Locations

   8 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT06693700 on ClinicalTrials.gov

3. A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

   This study evaluates the efficacy and safety of brenipatide when compared to placebo for reducing the risk of relapse to cigarette smoking in adults who have recently quit. Study participation will last approximately 34 weeks with up to 17 study visits, which includes a 2-week screening period, 24-…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Woodland Research Northwest, Rogers, Arkansas

   Locations

   29 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07223840 on ClinicalTrials.gov

4. Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network

   The goal of this clinical trial is to compare the reach and effectiveness of the Refer2Quit intervention for increasing tobacco use treatment and quit rates among household members who smoke versus a treatment as usual group. This clinical trial also aims to study household member and pediatric pat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT06582693 on ClinicalTrials.gov

5. Personalized Tobacco Treatment in Primary Care (MOTIVATE)

   This study examines the application of precision treatment intervention for smoking cessation from both the clinician perspective and patient perspective, and compares it to usual care on tobacco treatment in the primary care setting. The precision treatment intervention includes personalized tobac…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT05846841 on ClinicalTrials.gov

6. Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients

   This study evaluates the feasibility and preliminary effects of precision tobacco treatment, compared to usual care, on promoting tobacco treatment in oncology patients and providers in the oncology care setting. The precision treatment intervention includes personalized tobacco treatment recommend…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   John Cochran Veteran's Affairs Medical Center, St Louis, Missouri

   Locations

   2 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT07166120 on ClinicalTrials.gov

7. Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment

   Tobacco use is a chronic relapsing condition. That is, even with state-of-the-art treatment, >70% of smoking cessation attempts end in a return to regular smoking. Research demonstrates that everyday environments associated with smoking trigger craving for cigarettes, provoke smoking, and lead to r…

   Stage

   Phase 4

   Ages

   21 and older

   Site

   Duke University Medical Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT07089901 on ClinicalTrials.gov

8. Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE

   The goal of this clinical research study is to learn more about whether individual differences in brain responses to emotional triggers impact rTMS (repetitive transcranial magnetic stimulation) responses in people who smoke.

   Stage

   Not phased

   Ages

   21 to 60

   Site

   The University of Texas M. D. Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT06991062 on ClinicalTrials.gov

9. A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers

   The goal of this study is to evaluate the rate of end of study complete cigarette reduction in health adult consumers of cigarettes when given access to a heated tobacco product (HTP). The primary study objective is to evaluate the impact of access to HTP Device 1 or HTP Device 2 and a single stick…

   Stage

   Not phased

   Ages

   21 to 65

   Site

   Opinions Brandon, Brandon, Florida

   Locations

   9 in total

   Run by

   RAI Services Company

   See if you can join NCT07710820 on ClinicalTrials.gov

10. Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

    The investigators aim to address the following specific aims: * Determine the efficacy of Prog in preventing postpartum smoking relapse and reducing smoking relapse risk factors. * Examine the effects of this maternal smoking intervention on infant health. * Examine racial and ethnic differences in…

    Stage

    Phase 4

    Ages

    18 to 45

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT04783857 on ClinicalTrials.gov

11. Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers

    Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that affects only a fraction of those who smoke tobacco. The origin of this variability in susceptibility to develop COPD is unclear, but understanding its underlying biology has important implications for our ability to design…

    Stage

    Not phased

    Ages

    40 to 75

    Site

    San Francisco VA Medical Center, San Francisco, California

    Locations

    3 in total

    Run by

    University of California, San Francisco

    See if you can join NCT04722835 on ClinicalTrials.gov

12. A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

    The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine delivery system (ENDS) power unit (2) and varying levels of access to tobac…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    Sago Orlando, Maitland, Florida

    Locations

    7 in total

    Run by

    RAI Services Company

    See if you can join NCT07598136 on ClinicalTrials.gov

13. The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study

    Mobile health (mHealth) will be used for early detection of oral cancer and pre-cancer lesions, and to improve awareness of oral cancer among the population and knowledge of oral cancer diagnosis among frontline health providers. This program is inclusive of long term surveillance to downstage oral…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center (All protocol activites), New York, New York

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT06535867 on ClinicalTrials.gov

14. Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior

    Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt). Thus, characterizing why lapses occur is essential to understanding and preventing smoking relapse. Functional magnetic r…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    The Pennsylvania State University, University Park, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT05572671 on ClinicalTrials.gov

15. Integrating Financial Coaching and Smoking Cessation Coaching

    This study conduct a two-arm, parallel-group randomized controlled trial. The study will recruit and randomize 900 smokers (n=450 per arm) to either: (1) Control: Standard Smoking Cessation Counseling or (2) Intervention: Integrated Financial-Smoking Cessation Counseling.

    Stage

    Phase 3

    Ages

    18 to 100

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT05154669 on ClinicalTrials.gov

16. Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia

    The goal of this clinical trial is to evaluate the effectiveness and implementation of a pharmacist-delivered MTM (medication therapy management) approach, called QuitAid, to quitting cigarette smoking in rural Appalachia. The main questions it aims to answer are: * Is QuitAid, alone or combined wi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT05660525 on ClinicalTrials.gov

17. Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

    The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products. Participants will be randomized to receive either e-cigarettes or nicotine pouches for a duration of 4 weeks and to 1 of 4 possible reg…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06077240 on ClinicalTrials.gov

18. The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

    This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tob…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06264154 on ClinicalTrials.gov

19. Take A Break - Rural

    The study team proposes a multi-level trial to test 1) novel implementation programs in rural counties designed to increase access to 2) recent advances in tobacco control services for people who are not-yet-ready-to-quit smoking. In this field, most trials have focused only on those already ready-…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Wake Forest University Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT05790486 on ClinicalTrials.gov

20. The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence

    This study will evaluate the compliance with a daily kava regimen among active smokers who have an intention to quit smoking. This study will also investigate whether kava use can facilitate tobacco cessation, reduce stress, and improve sleep.

    Stage

    Phase 2

    Ages

    21 to 75

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT05814055 on ClinicalTrials.gov

21. Abuse Liability for Five Modern Oral Nicotine Products

    This is a two-site, open-label, randomized, 4-way (2 arm) cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]) and plasma nicotine uptake (pharmacokinetics [PK]) during and following ad libitum use of …

    Stage

    Not phased

    Ages

    21 to 60

    Site

    Dr. Vince Clinical Research, Overland Park, Kansas

    Run by

    RAI Services Company

    See if you can join NCT07132814 on ClinicalTrials.gov

22. Inspire HER: Inspiring the Heart and Emotions for Radical Health

    Poor heart health puts Black women at risk for a shorter life with more illness than people of any other non-indigenous racial group. We will refine and conduct a randomized, wait-list controlled trial of Inspire HER (a heart health lifestyle intervention for Black women that provides health educat…

    Stage

    Not phased

    Ages

    30 to 79

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06966258 on ClinicalTrials.gov

23. Enhancing Motivation to Quit Smoking Via Self-Help Intervention Targeted to Cancer Type

    The purpose of this research study is assess feasibility and acceptability of a recently developed brief self-help intervention targeted by cancer type to increase motivation to quit smoking.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Huntsman Cancer Institute, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT06484179 on ClinicalTrials.gov

24. Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

    The purpose of this study is to obtain biologic materials from the blood, airways and/or urine of normal individuals and individuals with lung disease. The normal are used to establish a set of normal ranges for various parameters. These provide control information when compared to individuals with…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Weill Cornell Medical College and Weill Cornell Medical Center, Department of Genetic Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT01776398 on ClinicalTrials.gov

25. Technology Assisted Motivational Interviewing

    Building on our successful pilot work to develop a Motivational Interviewing (MI)-capable chatbot and cessation coach, the investigators propose to address the problems of intrinsic motivation and social barriers to smoking cessation by evaluating a highly scalable and easily accessible digital-coa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    San Francisco General Hospital, San Francisco, California

    Locations

    2 in total

    Run by

    University of California, San Francisco

    See if you can join NCT06713603 on ClinicalTrials.gov