Sleep Deprivation Clinical Trials

15 studies are recruiting for sleep deprivation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Neurobehavioral Changes Following Spaceflight Stressors

   This study aims to investigate the impairing effects of known central nervous system (CNS) stressors in a controlled environment in order to predict and mitigate analogous risks in spaceflight. Up to 56 healthy individuals aged 25-60 will spend approx. 110 hours in a laboratory, where they will be …

   Stage

   Not phased

   Ages

   21 to 60

   Site

   University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT07293494 on ClinicalTrials.gov

2. Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

   The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (interve…

   Stage

   Not phased

   Ages

   18 to 45

   Site

   College of Health Research Complex--University of Utah, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT06180837 on ClinicalTrials.gov

3. Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.

   Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks. Ketogenic supplementation is speculated to alleviate some sleep deprivation issues via action of ketones…

   Stage

   Not phased

   Ages

   18 to 40

   Site

   The Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT06075914 on ClinicalTrials.gov

4. Mind After Midnight

   This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts. Adults with a history of suicidal ideation in the past six months will complete laboratory and home-based assessments under…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   University of Arizona - Center for Sleep, Circadian, and Neuroscience Research, Tucson, Arizona

   Run by

   University of Arizona

   See if you can join NCT07438912 on ClinicalTrials.gov

5. Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle

   More than 5 million patients are admitted to the intensive care unit every year in the United States; most of these patients experience profound sleep and circadian disruption. Promotion of circadian alignment (i.e., alignment of the body's clocks) would make it possible to strategically schedule b…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Yale New Haven Hospital Medical Intensive Care Unit (YNHH MICU) at St Raphael's Campus, New Haven, Connecticut

   Locations

   2 in total

   Run by

   Yale University

   See if you can join NCT05551325 on ClinicalTrials.gov

6. The Effect of Sleep Loss on Emotion Regulation

   The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control. The investigators will address and attempt to answer two questions. (i) How do three nights …

   Stage

   Not phased

   Ages

   18 to 40

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Run by

   Beth Israel Deaconess Medical Center

   See if you can join NCT05393830 on ClinicalTrials.gov

7. Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period

   Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely understood. Habitual short sleepers are constantly eating, the proposed stud…

   Stage

   Not phased

   Ages

   18 to 45

   Site

   Recruiting core Pennington, Baton Rouge, Louisiana

   Run by

   Pennington Biomedical Research Center

   See if you can join NCT06070194 on ClinicalTrials.gov

8. Nighttime Synchrony of Your Nutrition and Circadian Health

   Sleep is an important factor for overall health. This study will see how different light exposure patterns and food intake impact a person's metabolism (how the body breaks down food) when sleeping is reduced. Participants will attend 6 to 8 in-person visits to the study clinic, including three ove…

   Stage

   Not phased

   Ages

   18 to 35

   Site

   College of Health Research Complex - University of Utah, Salt Lake City 84112, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT07329283 on ClinicalTrials.gov

9. Immune Status After Being on Call for 24 Hrs

   Sleep deprivation is a prevalent problem in modern societies. Sleep deprivation can cause hormonal changes, such as an increase in cortisol, as well as inflammation. Animal studies have shown an increase in inflammatory cytokine production following sleep deprivation. Additionally, humans experienc…

   Stage

   Not phased

   Ages

   18 and older

   Site

   The University of Chicago, Chicago, Illinois

   Run by

   University of Chicago

   See if you can join NCT06636318 on ClinicalTrials.gov

10. Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)

    This clinical trial will be a comparison between personalized recommended caffeine dosing regimen versus the standard recommended caffeine dosing regimen for sustaining performance during sleep deprivation and minimizing side effects and subsequent sleep disruption. The questions this study aims to…

    Stage

    Not phased

    Ages

    18 to 39

    Site

    University of Arizona, Tucson, Arizona

    Locations

    2 in total

    Run by

    University of Arizona

    See if you can join NCT05588934 on ClinicalTrials.gov

11. Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency During NREM Sleep

    The purpose of this study is to determine if the enhancement of electroencephalographic (EEG) slow-wave activity using transcranial electrical stimulation (TES) at Slow Oscillation (SO) frequency, during a restricted period of nocturnal sleep, enhances the restorative properties of that period of s…

    Stage

    Not phased

    Ages

    18 to 39

    Site

    Naval Medcical Research Center (NMRC) Clincal Trials Center, Bethesda, Maryland

    Run by

    U.S. Army Medical Research and Development Command

    See if you can join NCT02945501 on ClinicalTrials.gov

12. The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers

    Insufficient and disrupted sleep are rarely addressed in expectant and new mothers, despite evidence that disturbed sleep is a modifiable risk factor for negative health outcomes for mothers and their children. In this study the investigators will adapt, refine, and pilot test the implementation of…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Rhode Island Hospital, Providence, Rhode Island

    Run by

    Rhode Island Hospital

    See if you can join NCT06737055 on ClinicalTrials.gov

13. The Function of Biphasic Sleep in Infants

    This study is designed to investigate developmental changes in naps and nap function on memory from 9 to 15 months of age. Memory is measured by a task in which the experimenter interacts with a toy and the measure of memory is whether the child imitates that action when given the toy. Sleep is ass…

    Stage

    Not phased

    Ages

    0 to 1

    Site

    University of Massachusetts, Amherst, Amherst, Massachusetts

    Run by

    University of Massachusetts, Amherst

    See if you can join NCT06399939 on ClinicalTrials.gov

14. Acoustic Stimulation During Restricted Sleep After Sleep Deprivation

    The purpose of this study is to determine if brief sounds or tones presented within a restricted period of recovery sleep after a period of sleep deprivation will enhance restorative properties and improve performance during a subsequent period of wakefulness.

    Stage

    Not phased

    Ages

    18 to 39

    Site

    Walter Reed Army Institute of Research, Silver Spring, Maryland

    Run by

    Walter Reed Army Institute of Research (WRAIR)

    See if you can join NCT05309473 on ClinicalTrials.gov

15. Sleep and Metabolism

    The goal of this study is to uncover sleep and circadian mechanisms contributing to adverse metabolic health. The protocol is a 21 day (7 outpatient days, 14 inpatient days) mechanistic randomized-crossover study designed to identify the impact of chronic sleep restriction and circadian timing, ind…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT05775627 on ClinicalTrials.gov