Skin Cancer Clinical Trials

23 studies are recruiting for skin cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Cryoablation+Ipilimumab+Nivolumab in Melanoma

   The aim of this study is to find out whether the combination of two approved drugs, ipilimumab and nivolumab, in combination with cryoablation are safe and effective for participants who have an unresectable melanoma that is resistant, or is growing, after receiving immunotherapy with a PD-1 inhibi…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Massachusetts General Hospital Cancer Center, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT05779423 on ClinicalTrials.gov

2. High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial

   The purpose of this study is to determine whether high-intensity exercise and high-fiber diet are feasible and improve various health outcomes among participants with advanced melanoma receiving immunotherapy. The names of the groups in this research study are: * High-Intensity Exercise (EX) * High…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington

   Locations

   2 in total

   Run by

   Fred Hutchinson Cancer Center

   See if you can join NCT06298734 on ClinicalTrials.gov

3. Cosibelimab for CSCC in Patients With Kidney Transplant or Hematologic Malignancy

   This is study is to evaluate the safety and efficacy of cosibelimab in special populations with advanced cutaneous squamous cell carcinoma (CSCC). The name of the drug involved in this research study is: -cosibelimab (a type of an anti-PD-L1 antibody)

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT07426484 on ClinicalTrials.gov

4. Rural Adult and Youth Sun Protection Study

   The purpose of this study is to help prevent skin cancer by improving the use of sun protective behaviors among youths living in rural communities in Utah and West Virginia.

   Stage

   Not phased

   Ages

   3 to 7

   Site

   University of Utah, Salt Lake City, Utah

   Locations

   2 in total

   Run by

   University of Utah

   See if you can join NCT06439979 on ClinicalTrials.gov

5. The Florida ASCENT Study

   The goal of this clinical trial is to adapt, implement, and evaluate MyCarePulse and ASCENT patient navigator to overcome barriers to care among patients with cancer. The main hypotheses it aims to test are: * At the patient level, the intervention will result in higher levels of food security, sel…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT07042243 on ClinicalTrials.gov

6. DNA Repair Activity in the Skin of Day and Night Shift Workers

   The purpose of this study is to test how the skin of night shift workers responds to artificial sunlight (ultraviolet B radiation; UVB) at two different times of the day in comparison to normal day shift workers. After the skin biopsies are obtained, they will be brought to the laboratory to be exp…

   Stage

   Not phased

   Ages

   18 to 40

   Site

   Wright State Physicians, Fairborn, Ohio

   Run by

   Wright State University

   See if you can join NCT04122456 on ClinicalTrials.gov

7. Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous SCC for Immunocompromised Patients

   This is a multi-center clinical study enrolling up to 28 participants. The primary objectives are to determine the objective response rate (ORR) established by the confirmed best overall response (BOR) following intratumoral administration of DaRT - Diffusing Alpha-Emitters Radiation Therapy. Secon…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Banner Health, Gilbert, Arizona

   Locations

   11 in total

   Run by

   Alpha Tau Medical LTD.

   See if you can join NCT06615635 on ClinicalTrials.gov

8. Integrated Cancer Repository for Cancer Research

   The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct char…

   Stage

   Not phased

   Ages

   19 to 110

   Site

   Advent Health, Greenwood Village, Colorado

   Locations

   42 in total

   Run by

   University of Nebraska

   See if you can join NCT02012699 on ClinicalTrials.gov

9. Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

   This study will collect tumor specimens with correlated clinical and demographic data from patients who are undergoing a biopsy or similar procedure to obtain tumor tissue as a normal course of their medical management or diagnostic work-up for suspected or confirmed cancer.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mercy Hospital - FTS, Fort Smith, Arkansas

   Locations

   8 in total

   Run by

   Elephas

   See if you can join NCT07327489 on ClinicalTrials.gov

10. A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients

    A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Organ Transplant Recipients This study is designed to evaluate whether a topical 5% niacinamide cream can help prevent skin cancer in organ transplant recipients. Individuals who have received an organ transplant …

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    UPMC Falk Dermatology, Pittsburgh, Pennsylvania

    Locations

    2 in total

    Run by

    Marissa Lobl

    See if you can join NCT07286318 on ClinicalTrials.gov

11. Mechanisms for Laser-Induced Rejuvenation

    It has shown that laser wounding of geriatric skin protects it against skin cancer. The purpose of this study is to determine the origin of cells called fibroblasts which are present after treatment with Fractionated Laser Resurfacing (FLR). These cells restore a youth-like ultraviolet B (UVB) resp…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Pharmacology Translational Unit, Fairborn, Ohio

    Run by

    Wright State University

    See if you can join NCT06489301 on ClinicalTrials.gov

12. Brodalumab in the Treatment of Immune-Related Adverse Events

    The purpose of this study is to test the safety and effectiveness of using brodalumab in patients who develop side effects from cancer immune therapy. Immune-related side effects are due to activation of the immune system in patients who previously received immunotherapy and the goal of this study …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Brian Henick, MD

    See if you can join NCT06673329 on ClinicalTrials.gov

13. Raman Spectroscopy and Skin Cancer

    The goal of this observational study is to find out if Raman Spectroscopy, a type of imaging, can be used to determine the size of skin cancer tumors. The main question it aims to answer is: -Can Raman Spectroscopy help figure out how far a tumor spreads? This study will take measurements using las…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stony Brook Hospital, Stony Brook, New York

    Run by

    Tiezhi Zhang

    See if you can join NCT06384924 on ClinicalTrials.gov

14. A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

    This study is an open-label Phase Ib (Part A) dose escalation followed by a blinded, randomized, multi cohort Phase 2a (Part B) comparison of combination vs. reference regimens. Currently study will only be enrolling the Phase 1b and the Phase 2a protocol requirements will be added to the study nea…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Colorado Cancer Center, Aurora, Colorado

    Locations

    5 in total

    Run by

    7 Hills Pharma, LLC

    See if you can join NCT06362369 on ClinicalTrials.gov

15. Pilot Trial of Supplemental Vitamin A and Nicotinamide

    The goal of this clinical trial is to assess the feasibility and safety of oral nicotinamide (NAM; a derivative of vitamin B3 [niacin]) and vitamin A in a high-risk population of kidney transplant recipients with a history of skin cancer to generate preliminary data for future cancer prevention cli…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Rhode Island Hospital, Providence, Rhode Island

    Run by

    Rhode Island Hospital

    See if you can join NCT05702398 on ClinicalTrials.gov

16. Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

    Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escala…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT04354064 on ClinicalTrials.gov

17. TIL Therapy in cSCC and MCC

    The purpose of this research study is to test the safety and effectiveness of a tumor-infiltrating lymphocyte (TIL) cellular therapy, also called LN-145 or lifileucel, and chemotherapy in combination with Interleukin-2 (IL-2) to find out what effects, if any, the combination has on participants wit…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Dana-Farber Cancer Institute, Boston, Massachusetts

    Run by

    Karam Khaddour, MD, MS

    See if you can join NCT07288073 on ClinicalTrials.gov

18. Hybrid Effectiveness-Implementation Trial to Integrate Precision Skin Cancer Risk Feedback in FQHCs

    The purpose of this study is to examine how different messages about risk of skin cancer can impact the uptake of skin cancer prevention activities.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Moffitt Cancer Center, Tampa, Florida

    Locations

    2 in total

    Run by

    H. Lee Moffitt Cancer Center and Research Institute

    See if you can join NCT07222995 on ClinicalTrials.gov

19. A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

    A phase 1, multicenter, open label, non-randomized dose escalation and dose expansion study to examine the maximum tolerated dose, (MTD), minimum effective dose (MED) and/or recommended dose for expansion (RDE) of intratumoral ONM-501 as monotherapy and in combination with a PD-1 checkpoint inhibit…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    St Vincent's Hospital, Darlinghurst, New South Wales

    Locations

    16 in total

    Run by

    OncoNano Medicine, Inc.

    See if you can join NCT06022029 on ClinicalTrials.gov

20. Meloxicam in Mohs Micrographic Surgery

    The goal of this clinical trial is to explore alternative methods of postoperative pain control in Mohs micrographic surgery. The main aims are: * To provide more information to the Mohs surgery community regarding postoperative pain control. * Reducing pain improves the overall comfort and well-be…

    Stage

    Phase 4

    Ages

    18 to 110

    Site

    University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT07200544 on ClinicalTrials.gov

21. A Phase 0 Window of Opportunity Trial of Intratumoral Seasonal Influenza Immunization in Cutaneous Squamous Cell Carcinoma (CSCC) Patients Awaiting Curative Excision

    This study is investigating the effects on immune cells of injecting the influenza vaccine (also known as "flu shot") into cutaneous squamous cell carcinoma (CSCC) tumors prior to having standard-of-care Mohs excision surgery. The study will help understand if the addition of the influenza vaccine …

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT06664151 on ClinicalTrials.gov

22. Treating Basal and Squamous Cell Carcinomas With Fractional Laser and Tirbanibulin Ointment

    The investigators seek to evaluate the effectiveness of fractional laser therapy and tirbanibulin ointment to treat squamous and basal cell carcinomas. This will be executed by using both thulium and erbium lasers on previously biopsy-confirmed SCCs and BCCs and applying bulk heating methods. Then,…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Bruce Robinson, MD, New York, New York

    Run by

    Bruce Robinson, MD

    See if you can join NCT07010692 on ClinicalTrials.gov

23. A Beta-only IL-2 ImmunoTherapY Study

    This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a checkpoint inhibitor in patients with advanced solid tumors.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Sharp Memorial Hospital, San Diego, California

    Locations

    27 in total

    Run by

    Medicenna Therapeutics, Inc.

    See if you can join NCT05086692 on ClinicalTrials.gov