Seizures Clinical Trials

16 studies are recruiting for seizures in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy

   Approximately a fourth of children with seizures do not respond adequately to available therapy. Ketogenic therapy has a long history as treatment for intractable epilepsy, but there is no agreement concerning how it works and what is the best way to administer it. This natural history study will c…

   Stage

   Not phased

   Ages

   Up to 50

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT02216500 on ClinicalTrials.gov

2. Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

   This is a randomized trial for patients with brain metastases in the primary motor cortex who have not had seizures to receive either the prophylactic anti-seizure medication levetiracetam (also known by its trade name Keppra) or proceed with standard of care management, which does not currently in…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Ayal A. Aizer, MD

   See if you can join NCT07130786 on ClinicalTrials.gov

3. buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

   RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Zuckerberg San Francisco General Hospital, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT05851391 on ClinicalTrials.gov

4. PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest

   Brain injury is the main cause of death and disability for patients surviving cardiac arrest resuscitation and seizures are diagnosed in up to a third of these patients. The investigators are proposing a pilot randomized placebo-controlled clinical trial to evaluate the safety and feasibility of pe…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Zuckerberg San Francisco General Hospital, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06401707 on ClinicalTrials.gov

5. Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children

   Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management. When identified, electrographic seizures are generally treated with anti-seizure medications, but there are very limited da…

   Stage

   Not phased

   Ages

   0 to 18

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT03419260 on ClinicalTrials.gov

6. De-identified UNMH EEG Corpus Database Creation With Fully De-identified Clinical Information

   This proposal outlines the steps required for the creation of a pilot database of EEG recordings and de-identified medical records from patients internally referred within the UNMH Comprehensive Epilepsy Center. The UNMH EEG Corpus would be the first database of its kind. Other public databases con…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of New Mexico Health Science, Albuquerque, New Mexico

   Run by

   University of New Mexico

   See if you can join NCT05140265 on ClinicalTrials.gov

7. Investigating Epilepsy: Screening and Evaluation

   Background: Epilepsy affects about 1 percent of the U.S. population. Most people with epilepsy respond well to medicine, but some do not. Researchers want people who have diagnosed or suspected epilepsy to participate in ongoing studies. They want to learn more about clinical care for epilepsy. The…

   Stage

   Not phased

   Ages

   8 to 110

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT03478852 on ClinicalTrials.gov

8. Modulating Movement Intention Via Cortical Stimulation

   The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies. These results could provide preliminary data for subsequent studies evaluating local and global efficacy of pl…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   New York University School of Medicine, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT03233399 on ClinicalTrials.gov

9. Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients

   In this study, the investigators propose Pulsed Low-Intensity Focused Ultrasound (PLIFU) stimulation of brain regions that modulate (thalamus) or generate focal motor seizures (primary motor cortex), with the goal of ameliorating seizure activity in subjects in non-convulsive or focal motor status …

   Stage

   Not phased

   Ages

   19 to 85

   Site

   Yale New Haven Hospital, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT05784805 on ClinicalTrials.gov

10. Ear-Seizure Detection (EarSD) Study

    The proposed study is an investigator-initiated study that aims to measure the accuracy of a wearable seizure detection and prediction device (Ear-Seizure Detection Device (EarSD)) by simultaneous recording with conventional video-EEG (Electroencephalogram) on patients with epileptic seizures in th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ummmc-Memorial Campus, Worcester, Massachusetts

    Locations

    2 in total

    Run by

    Felicia Chu

    See if you can join NCT06598189 on ClinicalTrials.gov

11. Longitudinal Study of Neurogenetic Disorders

    The purpose of this study is to analyze patterns in individuals with hnRNP (and other) genetic variants, including their neurological comorbidities, other medical problems and any treatment. The investigators will maintain an ongoing database of medical data that is otherwise being collected for ro…

    Stage

    Not phased

    Ages

    Any age

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT03492060 on ClinicalTrials.gov

12. Oxygen Toxicity: Mechanisms in Humans

    The goal of this clinical trial is to learn about the mechanisms of oxygen toxicity in scuba divers. The main questions it aims to answer are: * How does the training of respiratory muscles affect oxygen toxicity? * How do environmental factors, such as sleep deprivation, the ingestion of commonly …

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Duke University Health Sustem, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT05761756 on ClinicalTrials.gov

13. Pharmacological Modulation of Brain Oscillations in Memory Processing

    The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure…

    Stage

    EARLY_Phase 1

    Ages

    18 to 55

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05594017 on ClinicalTrials.gov

14. Pediatric Dose Optimization for Seizures in Emergency Medical Services

    The Pediatric Dose Optimization for Seizures in Emergency Medical Services (PediDOSE) study is designed to improve how paramedics treat seizures in children on ambulances. Seizures are one of the most common reasons why people call an ambulance for a child, and paramedics typically administer midaz…

    Stage

    Phase 3

    Ages

    0 to 13

    Site

    University of Arizona, Tucson, Arizona

    Locations

    20 in total

    Run by

    Stanford University

    See if you can join NCT05121324 on ClinicalTrials.gov

15. Genetic Markers of Cardiovascular Disease in Epilepsy

    Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age. The exact mechanisms and causes are not understood but can be due to un…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT02824822 on ClinicalTrials.gov

16. Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults

    The primary objective is to evaluate the efficacy of carisbamate (YKP509) as adjunctive treatment in reducing the number of drop seizures (tonic, atonic, and tonic-clonic) compared with placebo in pediatric and adult subjects (age 4-55 years) diagnosed with Lennox Gastaut Syndrome (LGS).

    Stage

    Phase 3

    Ages

    4 to 55

    Site

    Stanford University Hospital, Palo Alto, California

    Locations

    71 in total

    Run by

    SK Life Science, Inc.

    See if you can join NCT05219617 on ClinicalTrials.gov