Schizoaffective Disorder Clinical Trials

21 studies are recruiting for schizoaffective disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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San Diego, California 5 Belmont, Massachusetts 4 Boston, Massachusetts 4 Dallas, Texas 4 New York, New York 3

Studies now recruiting

  1. A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

    This study will evaluate the efficacy of valbenazine on clinician- and patient-reported outcomes in participants with TD while receiving or after stopping a VMAT2 inhibitor.

    Stage
    Phase 4
    Ages
    18 and older
    Site
    Neurocrine Clinical Site, Bryant, Arkansas
    Locations
    19 in total
    Run by
    Neurocrine Biosciences

    See if you can join NCT07105111 on ClinicalTrials.gov

  2. Cerebellar Modulation of Cognition in Psychosis

    The goal of this clinical trial is to learn about cognition in psychotic disorders (schizophrenia, bipolar disorder, and schizoaffective disorder). The main question it aims to answer is: Can we use magnetic stimulation to change processing speed (how quickly people can solve challenging tasks). Pa…

    Stage
    Not phased
    Ages
    18 to 55
    Site
    McLean Hospital, Belmont, Massachusetts
    Locations
    2 in total
    Run by
    Mclean Hospital

    See if you can join NCT06107764 on ClinicalTrials.gov

  3. Enhancing Veteran-Clinical Collaboration in VA PRRCs

    Over 60% of Veterans with serious mental illness have a service-connected disability that impairs their ability to work, go to school, and/or have successful personal lives. Although traditional treatments tend to focus on symptom remission, Veterans prioritize a range of treatment goals, including…

    Stage
    Not phased
    Ages
    18 and older
    Site
    New Mexico VA Health Care System, Albuquerque, NM, Albuquerque, New Mexico
    Locations
    3 in total
    Run by
    VA Office of Research and Development

    See if you can join NCT06898879 on ClinicalTrials.gov

  4. Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

    This is a randomized, controlled clinical trial to assess the effects of the ketogenic diet in combination with treatment as usual on brain energy metabolism and psychiatric symptoms in individuals with first episode bipolar disorder and schizoaffective disorder.

    Stage
    Not phased
    Ages
    18 to 45
    Site
    McLean Hospital, Belmont, Massachusetts
    Run by
    Mclean Hospital

    See if you can join NCT06221852 on ClinicalTrials.gov

  5. Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode

    The participants in the study will receive psychiatric treatment at the UCLA Aftercare Research Program. All participants in this 12-month RCT will receive cognitive training. Half of the patients will also be randomly assigned to the aerobic exercise and strength training condition, and the other …

    Stage
    Not phased
    Ages
    18 to 45
    Site
    UCLA Aftercare Research Program, Los Angeles, California
    Run by
    University of California, Los Angeles

    See if you can join NCT05890183 on ClinicalTrials.gov

  6. Cognitive Strategies in Early Psychosis 2

    The goal of this clinical trial is to learn more about decision making in psychosis spectrum disorders, like schizophrenia. Participants will be people who have had symptoms of a psychosis spectrum disorder start within the last five years. The investigators will study how two study agents change d…

    Stage
    Phase 3
    Ages
    18 to 35
    Site
    University of Minnesota, Minneapolis, Minnesota
    Run by
    University of Minnesota

    See if you can join NCT07263022 on ClinicalTrials.gov

  7. MicroRNAs as Biomarkers in First Episode Schizophrenia

    This study investigates whether tiny molecules called microRNAs (miRNAs), found in special brain-derived "packages" (neural-derived extracellular vesicles, or NDEs) that travel from the brain into the blood, can serve as helpful indicators (biomarkers) for schizophrenia. Currently, doctors diagnose…

    Stage
    Not phased
    Ages
    15 to 40
    Site
    Zucker Hillside Hospital, Glen Oaks, New York
    Run by
    Northwell Health

    See if you can join NCT07703670 on ClinicalTrials.gov

  8. Exercise and Olanzapine-samidorphan

    This is a single site trial in 30 patients with schizophrenia, schizoaffective, or bipolar I/II/NOS disorder in which all participants will receive eight weeks of olanzapine and samidorphan (Olz/Sam) plus four weeks of aerobic exercise.

    Stage
    Phase 4
    Ages
    18 to 65
    Site
    New York State Psychiatric Institute, New York, New York
    Run by
    New York State Psychiatric Institute

    See if you can join NCT06740890 on ClinicalTrials.gov

  9. Anticholinergic Deprescription in Schizophrenia

    In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with schizophrenia. Individuals identified by clinical services who have unnee…

    Stage
    Phase 4
    Ages
    40 to 70
    Site
    UPMC Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh, Pennsylvania
    Run by
    Deepak K. Sarpal, M.D.

    See if you can join NCT06562608 on ClinicalTrials.gov

  10. CLOZAPINE Response in Biotype-1

    The CLOZAPINE study is designed as a multisite study across 5 sites and is a clinical trial, involving human participants who are prospectively assigned to an intervention. The study will utilize a stringent randomized, double-blinded, parallel group clinical trial design. B2 group will serve as ps…

    Stage
    Phase 4
    Ages
    18 to 60
    Site
    Hartford Healthcare, Hartford, Connecticut
    Locations
    5 in total
    Run by
    University of Texas Southwestern Medical Center

    See if you can join NCT04580134 on ClinicalTrials.gov

  11. Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

    Two-hundred and eighty individuals with schizophrenia who have a recent history of violent acts will be randomized in this 2-arm, parallel-group, 24-week, open-label, 7-site clinical trial to examine the effects of treatment with clozapine vs antipsychotic treatment as usual (TAU) for reducing the …

    Stage
    Phase 4
    Ages
    18 to 65
    Site
    University of California, Los Angeles, Los Angeles, California
    Locations
    7 in total
    Run by
    New York State Psychiatric Institute

    See if you can join NCT05208190 on ClinicalTrials.gov

  12. Database Registry for Neural Network Biomarkers in Psychosis

    Several observations have been made with magnetic resonance imaging (MRI) that characterize brain connections and brain function in individuals with schizophrenia and other mental disorders. For example, research investigating schizophrenia focuses on the dysfunction of connections within and betwe…

    Stage
    Not phased
    Ages
    18 to 60
    Site
    University of Texas Southwestern Medical Center, Dallas, Texas
    Run by
    University of Texas Southwestern Medical Center

    See if you can join NCT01409109 on ClinicalTrials.gov

  13. Synbiotic Compound to Reduce Symptoms of Schizophrenia

    The purpose of this study is to determine if taking a synbiotic supplement versus a placebo will reduce symptoms of schizophrenia when used in addition to standard antipsychotic medications.

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    Sheppard Pratt Health System, Batlimore, Maryland
    Run by
    Sheppard Pratt Health System

    See if you can join NCT04226898 on ClinicalTrials.gov

  14. Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study

    The goal of this clinical trial is to learn if attention and ways of thinking impact decision-making and brain processes related to decision-making in people with schizophrenia or schizoaffective disorder relative to people without either condition. It will also learn how brain functioning during d…

    Stage
    Not phased
    Ages
    18 to 50
    Site
    Center for Advanced Human Brain Imaging Research, Piscataway, New Jersey
    Run by
    Rutgers, The State University of New Jersey

    See if you can join NCT06745479 on ClinicalTrials.gov

  15. Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

    The Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS) study aims to understand the early stages of psychotic disorders like Schizophrenia, Schizoaffective Disorder, and Bipolar I Disorder. It involves gathering mental health information, brain scans (MRI), eye movement …

    Stage
    Not phased
    Ages
    18 to 40
    Site
    Hartford Hospital, Hartford, Connecticut
    Locations
    6 in total
    Run by
    Beth Israel Deaconess Medical Center

    See if you can join NCT06740383 on ClinicalTrials.gov

  16. Enhanced Coordinated Specialty Care for Early Psychosis

    The goal of this clinical trial is to compare engagement in treatment in coordinated specialty care (CSC) to five extra care elements (CSC 2.0) in first-episode psychosis. The main question it aims to answer is: • Does the addition of certain elements of care increase the number of visits in treatm…

    Stage
    Not phased
    Ages
    Any age
    Site
    McLean Hospital OnTrack Clinic, Belmont, Massachusetts
    Locations
    5 in total
    Run by
    Mclean Hospital

    See if you can join NCT06071858 on ClinicalTrials.gov

  17. Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness (R33)

    This randomized clinical trial will test a new technology-supported blended intervention, mobile Social Interaction Therapy by Exposure (mSITE), that targets social engagement in consumers with serious mental illness.

    Stage
    Not phased
    Ages
    18 to 65
    Site
    University of California - San Diego, San Diego, California
    Run by
    University of California, San Diego

    See if you can join NCT06865937 on ClinicalTrials.gov

  18. Enhancing Rehabilitation for Veterans With Serious Mental Illness

    This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI suffer from cognitive impairments, leading to chro…

    Stage
    Not phased
    Ages
    18 to 83
    Site
    VA San Diego Healthcare System, San Diego, CA, San Diego, California
    Run by
    VA Office of Research and Development

    See if you can join NCT06586164 on ClinicalTrials.gov

  19. Randomized Clinical Trial of iTEST: A Blended Intervention Targeting Introspective Accuracy

    The purpose of this study is to evaluate the effectiveness of a psychosocial intervention called iTEST for people with psychotic disorders that targets introspective accuracy, or the ability to accurately gauge ones abilities. iTEST combines daily cognitive training on a mobile device with coaching…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    UC San Diego, San Diego, California
    Locations
    3 in total
    Run by
    University of California, San Diego

    See if you can join NCT07098169 on ClinicalTrials.gov

  20. Effectiveness of Motivation Skills Training (MST)

    This study will take place at four outpatient clinics serving adults with serious mental illness. Informed consent will be obtained from N=80 individuals with a Diagnostic and Statistical Manual of Mental Illnesses (DSM)-5 diagnosis of schizophrenia or schizoaffective disorder meeting inclusion/exc…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    The Bridge, Inc., New York, New York
    Locations
    2 in total
    Run by
    Columbia University

    See if you can join NCT05805397 on ClinicalTrials.gov

  21. Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates

    To test the feasibility of studying effects of smoking cessation with varenicline on antipsychotic drug-induced neurological side effects, we propose a 12 week pilot study of smoking cessation treatment with varenicline in 10 schizophrenia or schizoaffective disorder patients who are actively smoki…

    Stage
    Phase 4
    Ages
    18 to 75
    Site
    Corporal Michael J Crescenz VA Medical Center, Philadelphia, Pennsylvania
    Run by
    Corporal Michael J. Crescenz VA Medical Center

    See if you can join NCT03495024 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.