Retinitis Pigmentosa Clinical Trials

17 studies are recruiting for retinitis pigmentosa in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Bethesda, Maryland 3

Studies now recruiting

  1. A Phase 1/2 Study in Healthy Volunteers and Participants With Autosomal Dominant Retinitis Pigmentosa (RHO-adRP)

    This integrated Ph1/2 clinical study is to assess the safety, tolerability and pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of OCT-980 in healthy volunteers and participants with RHO-adRP.

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Retina Foundation of the Southwest, Dallas, Texas
    Run by
    Octant, Inc.

    See if you can join NCT07408232 on ClinicalTrials.gov

  2. Cell Collection to Study Eye Diseases

    Background: - Best Vitelliform Dystrophy (Best disease), Late-Onset Retinal Degeneration (L-ORD), and Age-Related Macular Degeneration (AMD) all affect the retina, the light sensing area at the back of the eye. Doctors cannot safely obtain retinal cells to study these diseases. However, cells colle…

    Stage
    Not phased
    Ages
    0 to 120
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Eye Institute (NEI)

    See if you can join NCT01432847 on ClinicalTrials.gov

  3. The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

    Oral disulfiram (Antabuse®) has been shown to improve image-forming vision in animal models with retinal degeneration due to its ability to decrease Retinoic Acid synthesis and consequently reduce hyperactivity in the inner retina. The investigator will aim to evaluate the impact of oral disulfiram…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York
    Run by
    University of Rochester

    See if you can join NCT06319872 on ClinicalTrials.gov

  4. Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

    This is an international, multicenter study with two components: Registry * A standardized genetic screening and a prospective, standardized, cross-sectional clinical data collection * Enrollment is open to all genes on the RD Rare Gene List Natural History Study * A prospective, standardized, long…

    Stage
    Not phased
    Ages
    4 and older
    Site
    University of Arkansas, Jones Eye Institute, Little Rock, Arkansas
    Locations
    36 in total
    Run by
    Jaeb Center for Health Research

    See if you can join NCT05589714 on ClinicalTrials.gov

  5. Rod and Cone Mediated Function in Retinal Disease

    Background: Retinal diseases cause the loss of rod and cone photoreceptors. Symptoms include vision loss and night blindness. Researchers want to learn about rod and cone function in healthy people and people with retinal disease. They want to know if how well a person sees in the dark can test the…

    Stage
    Not phased
    Ages
    5 to 100
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Eye Institute (NEI)

    See if you can join NCT02617966 on ClinicalTrials.gov

  6. Stem Cell Ophthalmology Treatment Study II

    This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.

    Stage
    Not phased
    Ages
    18 and older
    Site
    MD Stem Cells, Westport, Connecticut
    Locations
    4 in total
    Run by
    MD Stem Cells

    See if you can join NCT03011541 on ClinicalTrials.gov

  7. Retinal Imaging in Patients With Inherited Retinal Degenerations

    The purpose of this study is to determine whether the structure and function of the human retina can be studied with high resolution in patients with inherited retinal degenerations using the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO).

    Stage
    Not phased
    Ages
    13 and older
    Site
    Department of Ophthalmology Retinal Degenerations Clinic, UCSF, San Francisco, California
    Run by
    University of California, San Francisco

    See if you can join NCT00254605 on ClinicalTrials.gov

  8. Inherited Retinal Degenerative Disease Registry

    The My Retina Tracker® Registry is sponsored by the Foundation Fighting Blindness and is for people affected by one of the rare inherited retinal degenerative diseases studied by the Foundation. It is a patient-initiated registry accessible via a secure on-line portal at www.MyRetinaTracker.org. Af…

    Stage
    Not phased
    Ages
    Any age
    Site
    Foundation Fighting Blindness, Columbia, Maryland
    Run by
    Foundation Fighting Blindness

    See if you can join NCT02435940 on ClinicalTrials.gov

  9. Adaptive Optics Imaging of Outer Retinal Diseases

    The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement membrane or choroidal pathologies) to develop new diagnostic methods, biomar…

    Stage
    Not phased
    Ages
    21 and older
    Site
    NIH Clinical Center, Bethesda, Maryland
    Locations
    2 in total
    Run by
    Food and Drug Administration (FDA)

    See if you can join NCT05355415 on ClinicalTrials.gov

  10. High Resolution Retinal Imaging

    Studying the morphology and function of the normal and diseased retina in vivo is needed for advancing the detection, diagnosis, and treatment of retinal disease. This protocol uses an adaptive optics scanning laser ophthalmoscope (AOSLO) to image the normal and diseased retina with individual cell…

    Stage
    Not phased
    Ages
    7 and older
    Site
    University of Pennsylvania, Philadelphia, Pennsylvania
    Run by
    University of Pennsylvania

    See if you can join NCT01866371 on ClinicalTrials.gov

  11. A Study to Investigate the Safety of DSP-3077 After a Unilateral Eye Injection in Male and Female Participants 18 Years of Age or Older With Retinitis Pigmentosa

    The Goal of this study is to evaluate the safety, tolerability, and clinical responses following single dose of DSP-3077. Study enrolls both male and female patients in 3 cohorts with each cohort defined by visual acuity (VA) criteria and dose level of DSP-3077. Each cohort will include 4 participa…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Massachusetts Eye and Ear, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Sumitomo Pharma America, Inc.

    See if you can join NCT06891885 on ClinicalTrials.gov

  12. Development and Evaluation of Functional Visual Field and Navigation Endpoints in Moderate to Profound Inherited Retinal Disease (DEFINE-IRD)

    The Vision Research and Assessment Institute (VRAI) was established with the purpose of serving as a testing facility for efficacy endpoints for patients with Low Vision. The mission of the VRAI is to enable the highest quality, standardized efficacy testing of patients with visual impairment. The …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Vision Research and Assessment Institute, Irvine, California
    Run by
    Ray Therapeutics, Inc.

    See if you can join NCT07502664 on ClinicalTrials.gov

  13. BS01 in Patients With Retinitis Pigmentosa

    A Phase 1/2, Safety and Efficacy Trial of BS01, a Recombinant Adeno-Associated Virus Vector Expressing ChronosFP (AAV2-CAG-ChronosFP) in Patients with Retinitis Pigmentosa

    Stage
    Phase 1
    Ages
    18 and older
    Site
    New Jersey Retina, Teaneck, New Jersey
    Run by
    Bionic Sight LLC

    See if you can join NCT04278131 on ClinicalTrials.gov

  14. Study of BEST1 Vitelliform Macular Dystrophy

    The purpose of this study is to establish the natural history of of participants with BESTROPHIN 1 Vitelliform Macular Dystrophy. The blinding disorder Best Vitelliform Macular Dystrophy (VMD) is caused by any one of more than 250 different mutations in the BEST1 gene. As new treatments are develop…

    Stage
    Not phased
    Ages
    Any age
    Site
    Columbia University Irving Medical Center, New York, New York
    Locations
    3 in total
    Run by
    Columbia University

    See if you can join NCT05809635 on ClinicalTrials.gov

  15. Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

    CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help …

    Stage
    Not phased
    Ages
    Any age
    Site
    Sanford Health, Sioux Falls, South Dakota
    Locations
    2 in total
    Run by
    Sanford Health

    See if you can join NCT01793168 on ClinicalTrials.gov

  16. Observational Study to Assess Endpoint Operational Feasibility & Measurement Properties in Patients with Retinal Degeneration

    The Vision Research and Assessment Institute (VRAI) was established with the purpose of serving as a testing facility for efficacy endpoints for patients with Low Vision. The mission of the VRAI is to enable the highest quality, standardized efficacy testing of patients with visual impairment. The …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Vision Research and Assessment Institute, Irvine, California
    Run by
    Ray Therapeutics, Inc.

    See if you can join NCT06375239 on ClinicalTrials.gov

  17. Experimental and Clinical Studies of Retinal Stimulation

    The study will evaluate new methods of retinal stimulation and training with the goal of improving the visual ability of retinal prosthesis participants.

    Stage
    Not phased
    Ages
    25 to 89
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT03635645 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.