Rectal Adenocarcinoma Clinical Trials

15 studies are recruiting for rectal adenocarcinoma in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer

   This study measures the levels of circulating tumor DNA (ctDNA) in patients with stage II-III rectal cancer before, during, and after treatment to find out if the presence or absence of ctDNA in patient's blood using the Signatera test can be used to gauge how different treatments may affect rectal…

   Stage

   Not phased

   Ages

   18 and older

   Site

   OHSU Knight Cancer Institute, Portland, Oregon

   Locations

   2 in total

   Run by

   OHSU Knight Cancer Institute

   See if you can join NCT05081024 on ClinicalTrials.gov

2. Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

   The purpose of this study is to find out whether the study drug, TSR-042, followed by standard chemoradiotherapy (the chemotherapy drug capecitabine + radiation therapy) and standard surgery is an effective treatment for advanced dMMR solid tumors. The study will also look at the safety of the stud…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Hartford Healthcare (Data Collection), Hartford, Connecticut

   Locations

   10 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT04165772 on ClinicalTrials.gov

3. ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

   The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctDNA test results are linked to clinical outcomes in order to demonstrate clinical validity for rec…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   57 in total

   Run by

   Guardant Health, Inc.

   See if you can join NCT05059444 on ClinicalTrials.gov

4. Evaluating Novel Therapies in ctDNA Positive GI Cancers

   This study is a non-randomized, open-label, multi-cohort, multi-site, pilot feasibility therapeutic trial. The study will enroll 20 patients across 4 cohorts (CRC, gastric, PDAC, and HCC/intra-hepatic-/extra-hepatic-, gall bladder adenocarcinomas) diagnosed with histologically confirmed GI cancers.…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Georgetown Lombardi Comprehensive Cancer Center, Washington D.C., District of Columbia

   Locations

   3 in total

   Run by

   Georgetown University

   See if you can join NCT05482516 on ClinicalTrials.gov

5. A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

   Researchers are looking for other ways to treat locally advanced or metastatic colorectal cancer (mCRC) that is unresectable and has a gene mutation called KRAS G12C. Standard (or usual) treatments for this type of colorectal cancer may include mFOLFOX6 with or without bevacizumab. Researchers want…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Mayo Clinic - Arizona ( Site 0090), Phoenix, Arizona

   Locations

   236 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT06997497 on ClinicalTrials.gov

6. Family Communications After Genetic Testing

   This clinical trial compares patient (proband)-mediated communication to provider-mediated communication for improving genetic testing in first-degree relatives of patients with newly diagnosed colorectal cancer. It is estimated that 30% of cases of colorectal cancer have a genetic basis and about …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Anchorage Associates in Radiation Medicine, Anchorage, Alaska

   Locations

   319 in total

   Run by

   Alliance for Clinical Trials in Oncology

   See if you can join NCT07143487 on ClinicalTrials.gov

7. Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

   Rectal cancer patients who do not achieve a complete response to standard of care chemotherapy and radiation often require surgical resection as part of curative intent therapy. This study will evaluate whether additional "focal" radiation delivered internally (rectal brachytherapy) can provide com…

   Stage

   Phase 2

   Ages

   18 to 100

   Site

   University of Colorado Cancer Center, Aurora, Colorado

   Locations

   3 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT07292298 on ClinicalTrials.gov

8. Evaluation of Quality of Life and Utilities Following Surgical Treatment of Stage I-IV Rectal Cancer

   This study evaluates quality of life and utilities following surgical treatment of stage I-IV rectal cancer. This study may help researches learn more about quality of life in patients who have or have had rectal cancer.

   Stage

   Not phased

   Ages

   18 and older

   Site

   M D Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT02107105 on ClinicalTrials.gov

9. FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

   This phase II trial tests how well fluorouracil, oxaliplatin and leucovorin calcium (folinic acid) (FOLFOX) with botensilimab and balstilimab given before surgery (neoadjuvant) works in treating patients with rectal adenocarcinoma that has not spread to other parts of the body (localized). Currentl…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   City of Hope Medical Center, Duarte, California

   Run by

   City of Hope Medical Center

   See if you can join NCT06780787 on ClinicalTrials.gov

10. Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer

    This pilot trial studies how well active surveillance and chemotherapy before surgery work in treating participants with stage II-III rectal cancer. Active surveillance involves monitoring participants for additional tumor growth after receiving cancer treatment. Drugs used in chemotherapy work in …

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    M D Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT03594630 on ClinicalTrials.gov

11. A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

    The study researchers believe that a combination of the drugs trastuzumab and tucatinib, given with standard chemotherapy (capecitabine and oxaliplatin/FOLFOX), may help participants with rectal cancer.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT05672524 on ClinicalTrials.gov

12. Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy

    To learn if adding metronidazole to standard therapy can decrease populations of Fusobacterium nucleatum (F. nucleatum) and other anaerobes (small organisms that cause infections) in participants with rectal cancer receiving neoadjuvant therapy, compared to neoadjuvant therapy alone.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    MD Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT06569368 on ClinicalTrials.gov

13. Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer

    This phase I trial investigates how well short-course radiation therapy followed by combination chemotherapy works in treating patients with stage II-III rectal cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Chemotherapy drugs, such as leucovorin, fluoroura…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California

    Run by

    Jonsson Comprehensive Cancer Center

    See if you can join NCT04703101 on ClinicalTrials.gov

14. MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer

    This study is a prospective, open-label, phase I design.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Froedtert & the Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT04808323 on ClinicalTrials.gov

15. Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems

    feasibility of using a diffusion sequence of a MRgRT system as an early marker of treatment response during nRCT of rectal adenocarcinoma.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Institut Paoli Calmettes, Marseille, Bouches Du Rhone

    Locations

    2 in total

    Run by

    Institut Paoli-Calmettes

    See if you can join NCT03961776 on ClinicalTrials.gov