Psychosis Clinical Trials

18 studies are recruiting for psychosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Cerebellar Modulation of Cognition in Psychosis

   The goal of this clinical trial is to learn about cognition in psychotic disorders (schizophrenia, bipolar disorder, and schizoaffective disorder). The main question it aims to answer is: Can we use magnetic stimulation to change processing speed (how quickly people can solve challenging tasks). Pa…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   McLean Hospital, Belmont, Massachusetts

   Locations

   2 in total

   Run by

   Mclean Hospital

   See if you can join NCT06107764 on ClinicalTrials.gov

2. Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

   This is a randomized, controlled clinical trial to assess the effects of the ketogenic diet in combination with treatment as usual on brain energy metabolism and psychiatric symptoms in individuals with first episode bipolar disorder and schizoaffective disorder.

   Stage

   Not phased

   Ages

   18 to 45

   Site

   McLean Hospital, Belmont, Massachusetts

   Run by

   Mclean Hospital

   See if you can join NCT06221852 on ClinicalTrials.gov

3. Determining the Role of Social Reward Learning in Social Anhedonia

   This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be…

   Stage

   Not phased

   Ages

   18 to 35

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   2 in total

   Run by

   University of Alabama at Birmingham

   See if you can join NCT05617898 on ClinicalTrials.gov

4. Cognitive Strategies in Early Psychosis 2

   The goal of this clinical trial is to learn more about decision making in psychosis spectrum disorders, like schizophrenia. Participants will be people who have had symptoms of a psychosis spectrum disorder start within the last five years. The investigators will study how two study agents change d…

   Stage

   Phase 3

   Ages

   18 to 35

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT07263022 on ClinicalTrials.gov

5. Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

   The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   Massachusetts General Hospital, Charlestown, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT04940663 on ClinicalTrials.gov

6. A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)

   The purpose of this study is to evaluate KarXT + KarX-EC as a treatment for psychosis associated with Alzheimer's disease.

   Stage

   Phase 3

   Ages

   55 to 90

   Site

   Gilbert Neurology Partners/CCT Research, Gilbert, Arizona

   Locations

   22 in total

   Run by

   Bristol-Myers Squibb

   See if you can join NCT06947941 on ClinicalTrials.gov

7. Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia

   The central hypothesis is this: Brain circuits most relevant to cannabis use in schizophrenia are distinct from pathways identified in healthy controls who use cannabis. This study seeks to provide evidence that targeted stimulation of the DMN leads to both altered network activity and a concomitan…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Vanderbilt Psychiatric Hospital, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT07196462 on ClinicalTrials.gov

8. Examining the Effects of Estradiol on Neural and Molecular Response to Reward

   This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR).

   Stage

   Phase 4

   Ages

   45 to 55

   Site

   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT05282277 on ClinicalTrials.gov

9. Enhanced Coordinated Specialty Care for Early Psychosis

   The goal of this clinical trial is to compare engagement in treatment in coordinated specialty care (CSC) to five extra care elements (CSC 2.0) in first-episode psychosis. The main question it aims to answer is: • Does the addition of certain elements of care increase the number of visits in treatm…

   Stage

   Not phased

   Ages

   Any age

   Site

   McLean Hospital OnTrack Clinic, Belmont, Massachusetts

   Locations

   5 in total

   Run by

   Mclean Hospital

   See if you can join NCT06071858 on ClinicalTrials.gov

10. Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis

    Single-blind, randomized controlled trial of normobaric oxygen therapy among individuals with first-episode psychosis: Effects on symptomatology and cognition.

    Stage

    Not phased

    Ages

    15 to 35

    Site

    Harding Hospital, Columbus, Ohio

    Run by

    Nicholas Breitborde

    See if you can join NCT04368039 on ClinicalTrials.gov

11. Neural Basis of Social Cognition Deficits

    Difficulties in reciprocal social interaction are hallmark features of several neuropsychiatric disorders, most notably autism spectrum disorder (ASD) and schizophrenia spectrum disorder (SSD). While recent studies have demonstrated substantial overlap in genetic etiology between ASD and SSD, littl…

    Stage

    Not phased

    Ages

    12 to 18

    Site

    Loma Linda U, Loma Linda, California

    Run by

    Loma Linda University

    See if you can join NCT05185128 on ClinicalTrials.gov

12. Enhancing Rehabilitation for Veterans With Serious Mental Illness

    This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI suffer from cognitive impairments, leading to chro…

    Stage

    Not phased

    Ages

    18 to 83

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Run by

    VA Office of Research and Development

    See if you can join NCT06586164 on ClinicalTrials.gov

13. Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk

    This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability factor for psychosis. This remotely-delivered intervention combining targ…

    Stage

    Not phased

    Ages

    14 to 20

    Site

    Northwell Health- The Zucker Hillside Hospital, Glen Oaks, New York

    Run by

    Northwell Health

    See if you can join NCT05131035 on ClinicalTrials.gov

14. Targeting Emotion Dysregulation to Reduce Suicide in People With Psychosis

    People with psychotic disorders are excluded from most suicide-focused clinical trials despite incredibly high rates of completed suicide, and interventions that have been tested for this population have shown limited impact on suicide. Emotion dysregulation is a significant suicidogenic factor tha…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Maryland, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05440214 on ClinicalTrials.gov

15. The Effectiveness of Individualized Imagery Scripts on Sleep, Psychosis, and Suicidality Among Inpatients With Psychosis

    The purpose of this study is to see how feasible is the use of compact EEG and paired audio technology to administer sleep interventions for inpatients with psychosis, to see if individuals that receive individualized technology-based sleep interventions experience improvements in sleep quality and…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT06194344 on ClinicalTrials.gov

16. Toward a Computationally-Informed, Personalized Treatment for Hallucinations

    Auditory hallucinations are among the most distressing aspects of psychotic illness, and between 10 and 30% of people with hallucinations do not respond to antipsychotic medications. The authors have used computational modeling of behavior to link brain activity to development of auditory hallucina…

    Stage

    EARLY_Phase 1

    Ages

    18 to 65

    Site

    Connecticut Mental Health Center, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT04366518 on ClinicalTrials.gov

17. A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults

    Researchers aim to test a brief culturally-responsive young adult orientation program for community mental health services. They will conduct a 24-month randomized trial with 80 young adults from racial and ethnic minority groups in a community-based mental health clinic.

    Stage

    Not phased

    Ages

    18 to 34

    Site

    The Jewish Board, The Bronx, New York

    Run by

    New York University

    See if you can join NCT06508450 on ClinicalTrials.gov

18. Multiomic Diagnostics in Youth With Psychosis

    Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic symptoms or schizophrenia. Cutting-edge genome and protein sequencing …

    Stage

    Not phased

    Ages

    7 to 17

    Site

    Rady Children's Hospital San Diego, San Diego, California

    Run by

    Rady Pediatric Genomics & Systems Medicine Institute

    See if you can join NCT05457140 on ClinicalTrials.gov