Preterm Birth Clinical Trials

16 studies are recruiting for preterm birth in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants

   This study aims to evaluate the feasibility and effects of nicotinamide riboside (NR) supplementation in lactating mothers of infants expected to be hospitalized in the neonatal intensive care unit (NICU) for at least four weeks.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of California, Davis, Sacramento, California

   Run by

   University of California, Davis

   See if you can join NCT04614714 on ClinicalTrials.gov

2. Prenatal Education on Environmental Exposures During Pregnancy Study (PEEPS)

   The purpose of this project is to reduce maternal environmental exposures to toxicants through a patient education program designed to help pregnant women learn about exposure through consumption of contaminated seafood and to be able to use the lessons they learn to have a better understanding of …

   Stage

   Not phased

   Ages

   18 and older

   Site

   St Vincent's Hope Clinics, Galveston, Texas

   Locations

   2 in total

   Run by

   The University of Texas Medical Branch, Galveston

   See if you can join NCT07758114 on ClinicalTrials.gov

3. DE-RESTRICT: Deimplementing Activity Restriction for Preterm Birth Prevention

   DE-RESTRICT is a pilot study testing whether a strategy to reduce the use of activity restriction and bedrest in pregnancy is acceptable, appropriate, and feasible for prenatal care providers, and whether it changes how often activity restriction is recommended. Activity restriction and bedrest are…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

   Locations

   2 in total

   Run by

   University of Pennsylvania

   See if you can join NCT07698483 on ClinicalTrials.gov

4. Prospective Evaluation of Pathways for Preterm Birth

   This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preterm birth, patient's with a short cervix and patient's symptomatic for preterm birth will be included. A control cohort of nulliparous patient…

   Stage

   Not phased

   Ages

   18 to 45

   Site

   University of Kentucky, Lexington, Kentucky

   Run by

   John O'Brien, MD

   See if you can join NCT05246579 on ClinicalTrials.gov

5. The Effect of Sulfasalazine on CRH Levels in Pregnant Women

   The goal of this randomized clinical trial is to assess sulfasalazine as a potential treatment to prevent recurrent preterm birth. The main questions it aims to answer are: * Does sulfasalazine down regulate corticotropin releasing hormone (CRH) levels in pregnant persons with a prior history of pr…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT05703425 on ClinicalTrials.gov

6. Stress Phenotypes and Preterm Birth

   Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational imp…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT05229666 on ClinicalTrials.gov

7. Optimal Timing of Routine Cervical Length Measurements During Anatomy Survey

   The goal of this clinical trial is to determine the optimal timing for measuring cervical length (CL) during fetal anatomy surveys in pregnant individuals. This study focuses on improving the accuracy of cervical length assessments, which are critical for identifying individuals at risk for preterm…

   Stage

   Not phased

   Ages

   Any age

   Site

   Henry Ford Health New Center One, Detroit, Michigan

   Run by

   Henry Ford Health System

   See if you can join NCT06822647 on ClinicalTrials.gov

8. Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)

   To conduct an unblinded pragmatic randomized controlled trial (pRCT) "Improvement of PPROM Management with Prophylactic Antimicrobial Therapy (iPROMPT)" of a seven-day course of ceftriaxone, clarithromycin, and metronidazole versus the current standard of care of a seven-day course of ampicillin/am…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio

   Locations

   2 in total

   Run by

   Ohio State University

   See if you can join NCT06396078 on ClinicalTrials.gov

9. Effect of Support for Low-Income Mothers of Preterm Infants

   Preterm birth is a leading cause of childhood mortality and developmental disabilities. Socioeconomic disparities in the incidence of preterm birth and morbidities, mortality, and quality of care for preterm infants persist. An important predictor of the long-term consequences of preterm birth is m…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Children's Healthcare of Atlanta and Emory University, Atlanta, Georgia

   Locations

   4 in total

   Run by

   University of Massachusetts, Worcester

   See if you can join NCT06362798 on ClinicalTrials.gov

10. Mitochondrial DNA Signatures of Poor Aerobic Exercise Trainability in Young Adults Born Preterm

    Young adults born very preterm (32 weeks gestation or earlier) do not respond well to aerobic exercise training, meeting the recommendations set by the Physical Activity Guidelines for Americans, where they do not increase their fitness level (or cardiorespiratory fitness). Thus, they do not receiv…

    Stage

    Not phased

    Ages

    18 to 35

    Site

    Texas Tech University | Kinesiology and Sport Management Building, Lubbock, Texas

    Run by

    Texas Tech University

    See if you can join NCT06334107 on ClinicalTrials.gov

11. Transition From Donor Milk: a Feasibility Study

    Preterm and very low birth weight (VLBW, < 1,500g) infants who receive donor human milk (DHM) often experience slow postnatal growth and no clinical data is available to guide the duration of DHM for preterm infants. The investigators hypothesize that transitioning from DHM to preterm infant formul…

    Stage

    Not phased

    Ages

    0 and older

    Site

    Wellstar-MCG, Augusta, Georgia

    Run by

    Augusta University

    See if you can join NCT06514014 on ClinicalTrials.gov

12. Reducing Pregnancy Risks: The Mastery Lifestyle Intervention

    This randomized controlled trial will test an intervention called the Mastery Lifestyle Intervention (the MLI) that was developed from data of 1000+pregnant Hispanic women related to risks of preterm birth. The investigators will deliver a psychoeducational intervention that is manualized over 6 gr…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Women's Specialist of PLLC, Webster, Texas

    Run by

    Microgen LLC

    See if you can join NCT05012072 on ClinicalTrials.gov

13. Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)

    Aspirin is recommended in high risk patients to reduce the risk of preeclampsia and preterm birth, which are leading causes of both maternal and neonatal morbidity and mortality, but up to 20% will have these adverse outcomes despite therapy. Gaps in knowledge regarding pregnancy specific aspirin p…

    Stage

    Phase 1

    Ages

    16 to 55

    Site

    Thomas Jefferson University, Philadelphia, Pennsylvania

    Run by

    Thomas Jefferson University

    See if you can join NCT06826859 on ClinicalTrials.gov

14. Sodium Awareness in Lactation Trial

    SALT is a multi-centre, non-blinded, non-randomized prospective interventional pilot study teaching lactating parents of hospitalized preterm infants how to test their breastmilk sodium (Na) using point-of-care (POC) meters. A drop in Na is a sign of secretory activation in the breast that is assoc…

    Stage

    Not phased

    Ages

    Any age

    Site

    Seattle Children's Hospital, Seattle, Washington

    Locations

    2 in total

    Run by

    The Hospital for Sick Children

    See if you can join NCT06563726 on ClinicalTrials.gov

15. Blood Warming in Preterm Infants to Decrease Hypothermia

    Background/significance: Over 100,000 early preterm infants are born annually in the United States and suffer morbidity and mortality during hospitalization in a neonatal intensive care unit. One such condition is hypothermia. Hypothermia has been defined as a contributor of neonatal morbidity by T…

    Stage

    Not phased

    Ages

    0 to 0

    Site

    Kayla Everhart, Columbia, South Carolina

    Run by

    University of South Carolina

    See if you can join NCT05170633 on ClinicalTrials.gov

16. Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA

    This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after a patient's water bag has ruptured prematurely. If a patient has been …

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Woman's Hospital, Baton Rouge, Louisiana

    Run by

    Woman's

    See if you can join NCT04047849 on ClinicalTrials.gov