Preeclampsia Clinical Trials

25 studies are recruiting for preeclampsia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Iowa City, Iowa 4 Birmingham, Alabama 3 Columbus, Ohio 3 Milwaukee, Wisconsin 3 Pittsburgh, Pennsylvania 3 Providence, Rhode Island 3

Studies now recruiting

  1. Mindfulness and Wearable Biosensors to Prevent Hypertensive Disorders of Pregnancy

    The MINDBP study will enroll 90 pregnant women at risk for HDP across two sites (MCW and Brown) and randomize them to: (1) mindfulness training (MT) plus wearable biosensors, (2) MT alone, or (3) routine prenatal care. MT participants will receive 8 weekly phone-based MT sessions plus two booster s…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brown University, Providence, Rhode Island
    Locations
    2 in total
    Run by
    Medical College of Wisconsin

    See if you can join NCT07218237 on ClinicalTrials.gov

  2. Progesterone Preeclampsia

    This randomized controlled trial evaluates whether nightly vaginal micronized progesterone (400 mg) initiated before 12 weeks' gestation reduces the incidence of preeclampsia in low-risk pregnant individuals. Participants will be randomly assigned (1:1) to receive either vaginal progesterone throug…

    Stage
    Phase 4
    Ages
    18 and older
    Site
    Medical University of South Carolina, Charleston, South Carolina
    Run by
    Medical University of South Carolina

    See if you can join NCT07448597 on ClinicalTrials.gov

  3. Cardiovascular Protection After Preeclampsia With Enalapril

    The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Women and Infants Hospital, Providence, Rhode Island
    Run by
    Women and Infants Hospital of Rhode Island

    See if you can join NCT07222852 on ClinicalTrials.gov

  4. Mobile Health Program for Post-Preeclampsia Hypertension

    Strategies targeted to optimize hypertension (HTN) control for midlife women after hypertensive disorders of pregnancy (HDP) have not been studied, despite evidence of a critical need. This proposal targets the 10-20 years postpartum as a key time when women have subclinical cardiovascular (CV) seq…

    Stage
    Not phased
    Ages
    18 and older
    Site
    UPMC Magee Womens Hospital, Pittsburgh, Pennsylvania
    Run by
    University of Pittsburgh

    See if you can join NCT07599579 on ClinicalTrials.gov

  5. Antidepressant Therapy for Improved Blood Vessel Health After Preeclampsia

    Preeclampsia is a condition in pregnancy where a woman develops high blood pressure and other complications. Women who develop preeclampsia are 4 times more likely to have heart disease later in life. They are also more likely to have depression after pregnancy. Why they are more likely to develop …

    Stage
    EARLY_Phase 1
    Ages
    18 to 45
    Site
    University of Iowa, Iowa City, Iowa
    Run by
    Anna Stanhewicz, PhD

    See if you can join NCT07715669 on ClinicalTrials.gov

  6. Exosome Cargo From Preeclampsia Patients

    Although extensively studied, the cause of preeclampsia remains uncertain other than it is thought that the placenta plays a critical role in the development of preeclampsia. Recent data revealed that exosomes released from the placenta could cause preeclampsia by transporting specific cargo respon…

    Stage
    Not phased
    Ages
    18 to 45
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Run by
    University of Alabama at Birmingham

    See if you can join NCT04154332 on ClinicalTrials.gov

  7. Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy

    Cardiovascular disease is the leading cause of death among women in the United States, and women with hypertensive disorders of pregnancy have a 2-fold higher risk for cardiovascular disease later in life compared to women with uncomplicated pregnancies. This research investigates a patient-centere…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Utah Hospital, Salt Lake City, Utah
    Run by
    University of Utah

    See if you can join NCT05826925 on ClinicalTrials.gov

  8. Placental Imaging Techniques

    The goal of this proof-of-concept, case-control, clinical trial is to evaluate the efficacy of using two newer ultrasound technologies, quantitative ultrasound (QUS) and ultrafast power Doppler imaging (uPDI), to evaluate the health of the placenta, visualize blood flow through the placental vascul…

    Stage
    Not phased
    Ages
    18 to 45
    Site
    Carilion Clinic Maternal Fetal Medicine, Roanoke, Virginia
    Run by
    Carilion Clinic

    See if you can join NCT06861309 on ClinicalTrials.gov

  9. Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

    The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertensive disorders of pregnancy (HDP), and that there are multiple factors associated with adherence wit…

    Stage
    Phase 4
    Ages
    14 to 35
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Locations
    16 in total
    Run by
    Ohio State University

    See if you can join NCT06468202 on ClinicalTrials.gov

  10. Cardiometabolic Disease and Substrate Metabolism

    This study's primary purpose is to determine the potential relationship between cardiometabolic disease, specifically insulin resistance (HOMA-IR), and maternal lipid oxidation.

    Stage
    Not phased
    Ages
    18 to 45
    Site
    University of Tennessee Graduate School of Medicine, Knoxville, Tennessee
    Run by
    University of Tennessee Graduate School of Medicine

    See if you can join NCT07565727 on ClinicalTrials.gov

  11. MitoQ to Improve Vascular Funciton in Preeclampsia

    Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality. There is a lack of effective therapeutics for prevention or treatment. Our previous ex vivo work demonstrated that mitochondrial-antioxidants can reverse placental microvascular damage. Therefore, this study will eval…

    Stage
    Not phased
    Ages
    18 to 50
    Site
    Froedtert & the Medical College of Wisconsin, Milwaukee, Wisconsin
    Run by
    Medical College of Wisconsin

    See if you can join NCT07229261 on ClinicalTrials.gov

  12. Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders

    The researchers are testing a medication named ravulizumab for the treatment of severe preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelets (HELLP) syndrome.

    Stage
    Phase 2
    Ages
    18 to 50
    Site
    Mayo Clinic Minnesota, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT06333652 on ClinicalTrials.gov

  13. Exercise Testing After Preeclampsia

    Though cardiovascular disease (CVD) is the leading cause of mortality in women, traditional epidemiology in this area has focused on later life, when cardiometabolic risk has already exacted a cumulative toll on the vascular system. Recent data from the investigators and others has highlighted preg…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Vanderbilt University Medical Center, Nashville, Tennessee
    Run by
    Vanderbilt University Medical Center

    See if you can join NCT06741436 on ClinicalTrials.gov

  14. Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

    The hypertensive disorders of pregnancy (preeclampsia and gestational hypertension) are associated with increased long-term maternal risk of developing cardiovascular disease. Recent evidence suggests that activation of the mineralocorticoid receptor promotes ongoing susceptibility to hypertension …

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    3 in total
    Run by
    Massachusetts General Hospital

    See if you can join NCT07041281 on ClinicalTrials.gov

  15. Effects of High Altitude on AMPK Activation

    Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue…

    Stage
    Not phased
    Ages
    18 to 45
    Site
    University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT02391519 on ClinicalTrials.gov

  16. Vascular Effects of High-Salt After Preeclampsia

    Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy. Importantly, women who had preeclampsia have an exaggerated vascular responsiveness to hypertensive stimuli, such as high-salt intake, comp…

    Stage
    EARLY_Phase 1
    Ages
    18 to 45
    Site
    University of Iowa, Iowa City, Iowa
    Run by
    Anna Stanhewicz, PhD

    See if you can join NCT06749418 on ClinicalTrials.gov

  17. EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE)

    The goal of this prospective observational cohort study of pregnant people at-risk of preeclampsia receiving aspirin as part of clinical care or a planned randomized controlled trial of 81mg vs. 162mg of aspirin is to generate proteomic data to show a distinct maternal and fetal Extracellular Vesic…

    Stage
    Not phased
    Ages
    18 and older
    Site
    The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio
    Run by
    Ohio State University

    See if you can join NCT06249178 on ClinicalTrials.gov

  18. Daily Aspirin Treatment After Preeclampsia

    Women who develop preeclampsia during pregnancy are four times more likely to develop cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs may be related to lasting blood vessel damage after the pregnancy but there are currently no specific treatment …

    Stage
    EARLY_Phase 1
    Ages
    18 to 50
    Site
    University of Iowa, Iowa City, Iowa
    Run by
    Anna Stanhewicz, PhD

    See if you can join NCT06168461 on ClinicalTrials.gov

  19. The ACHIEVE Trial: Achieving Longer Gestation in Preeclampsia Via Antihypertensive Therapy.

    The Achieve Trial is a randomized clinical trial to test whether lowering blood pressure to less than 140/90 mmHg in women with hypertensive disorders of pregnancy will prolong pregnancy.

    Stage
    Not phased
    Ages
    14 to 49
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Locations
    2 in total
    Run by
    University of Alabama at Birmingham

    See if you can join NCT05676476 on ClinicalTrials.gov

  20. Predictors of Aspirin Failure in Preeclampsia Prevention

    Hypertensive disorders of pregnancy (including preeclampsia) are among the leading causes of pregnancy complications and maternal deaths worldwide. They also increase the risks to the babies. Numerous interventions have been suggested in order to reduce the rate of preeclampsia. Low-dose aspirin is…

    Stage
    EARLY_Phase 1
    Ages
    18 to 45
    Site
    Rockefeller University, New York, New York
    Run by
    Rockefeller University

    See if you can join NCT05709483 on ClinicalTrials.gov

  21. AtorvaStatin Postpartum and Reduction of Cardiovascular risK

    The objective is to conduct a double-blinded randomized controlled trial of atorvastatin vs. placebo among postpartum individuals with hypertensive disorders of pregnancy, to improve cardiovascular risk score postpartum. For this, 76 individuals with hypertensive disorders of pregnancy (HDP) will b…

    Stage
    Phase 4
    Ages
    20 to 50
    Site
    The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio
    Run by
    Ohio State University

    See if you can join NCT06632379 on ClinicalTrials.gov

  22. Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia

    This study's primary purpose is to determine the relationship between aspirin metabolism and markers of metabolic dysfunction among patients at risk for preeclampsia.

    Stage
    Not phased
    Ages
    18 to 45
    Site
    University of Tennessee Medical Center, Knoxville, Tennessee
    Run by
    University of Tennessee Graduate School of Medicine

    See if you can join NCT06802861 on ClinicalTrials.gov

  23. Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)

    Aspirin is recommended in high risk patients to reduce the risk of preeclampsia and preterm birth, which are leading causes of both maternal and neonatal morbidity and mortality, but up to 20% will have these adverse outcomes despite therapy. Gaps in knowledge regarding pregnancy specific aspirin p…

    Stage
    Phase 1
    Ages
    16 to 55
    Site
    Thomas Jefferson University, Philadelphia, Pennsylvania
    Run by
    Thomas Jefferson University

    See if you can join NCT06826859 on ClinicalTrials.gov

  24. Prenatal Aspirin and Postpartum Vascular Function

    Preeclampsia is a pregnancy disorder affecting ~5-10% of pregnancies in the United States. Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs is unclear but may be…

    Stage
    EARLY_Phase 1
    Ages
    18 to 50
    Site
    University of Iowa, Iowa City, Iowa
    Run by
    Anna Stanhewicz, PhD

    See if you can join NCT05653973 on ClinicalTrials.gov

  25. The Preeclampsia Registry

    The purpose of The Preeclampsia Registry is to collect and store medical and other information from women who have been medically diagnosed with preeclampsia or a related hypertensive (high blood pressure) disorder of pregnancy such as eclampsia or HELLP syndrome, their family members, and women wh…

    Stage
    Not phased
    Ages
    13 and older
    Site
    Preeclampsia Foundation, Melbourne, Florida
    Run by
    Preeclampsia Foundation

    See if you can join NCT06377878 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.