Preeclampsia Clinical Trials

27 studies are recruiting for preeclampsia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound

   This study explores a novel approach to improving care for postpartum patients with preeclampsia, a pregnancy-related condition characterized by high blood pressure, protein in the urine, and organ dysfunction. Preeclampsia affects up to 9% of pregnancies and can progress to include complications o…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of California Irvine Medical Center, Orange, California

   Run by

   University of California, Irvine

   See if you can join NCT07167862 on ClinicalTrials.gov

2. Antidepressant Therapy for Improved Blood Vessel Health After Preeclampsia

   Preeclampsia is a condition in pregnancy where a woman develops high blood pressure and other complications. Women who develop preeclampsia are 4 times more likely to have heart disease later in life. They are also more likely to have depression after pregnancy. Why they are more likely to develop …

   Stage

   EARLY_Phase 1

   Ages

   18 to 45

   Site

   University of Iowa, Iowa City, Iowa

   Run by

   Anna Stanhewicz, PhD

   See if you can join NCT07715669 on ClinicalTrials.gov

3. Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure

   High blood pressure during or after pregnancy (such as preeclampsia, gestational hypertension, eclampsia, or Hemolysis, Elevated Liver enzymes, and Low Platelet (HELLP) syndrome) raises a mother's risk of heart disease later in life. Many patients do not return for follow-up care after delivery, mi…

   Stage

   Not phased

   Ages

   16 to 56

   Site

   University of Alabama at Birmingham (UAB Women and Infants Center), Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT07778966 on ClinicalTrials.gov

4. Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

   The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertensive disorders of pregnancy (HDP), and that there are multiple factors associated with adherence wit…

   Stage

   Phase 4

   Ages

   14 to 35

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   20 in total

   Run by

   Ohio State University

   See if you can join NCT06468202 on ClinicalTrials.gov

5. AtorvaStatin Postpartum and Reduction of Cardiovascular risK

   The objective is to conduct a double-blinded randomized controlled trial of atorvastatin vs. placebo among postpartum individuals with hypertensive disorders of pregnancy, to improve cardiovascular risk score postpartum. For this, 76 individuals with hypertensive disorders of pregnancy (HDP) will b…

   Stage

   Phase 4

   Ages

   20 to 50

   Site

   The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT06632379 on ClinicalTrials.gov

6. Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders

   The researchers are testing a medication named ravulizumab for the treatment of severe preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelets (HELLP) syndrome.

   Stage

   Phase 2

   Ages

   18 to 50

   Site

   Mayo Clinic Minnesota, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06333652 on ClinicalTrials.gov

7. MitoQ to Improve Vascular Funciton in Preeclampsia

   Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality. There is a lack of effective therapeutics for prevention or treatment. Our previous ex vivo work demonstrated that mitochondrial-antioxidants can reverse placental microvascular damage. Therefore, this study will eval…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   Froedtert & the Medical College of Wisconsin, Milwaukee, Wisconsin

   Run by

   Medical College of Wisconsin

   See if you can join NCT07229261 on ClinicalTrials.gov

8. Advancing Stillbirth Prevention Through Innovative Risk Evaluation (ASPIRE) Clinical Study

   ASPIRE will be a multi-site, prospective, two-part longitudinal, noninterventional observational cohort study of nulliparous singleton pregnant women to evaluate biomarkers from blood and ocular imaging for prediction of pregnancy complications [i.e., preeclampsia (PE), fetal growth restriction (FG…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Woman's Hospital, Baton Rouge, Louisiana

   Locations

   2 in total

   Run by

   Medicines360

   See if you can join NCT07669935 on ClinicalTrials.gov

9. Mindfulness and Wearable Biosensors to Prevent Hypertensive Disorders of Pregnancy

   The MINDBP study will enroll 90 pregnant women at risk for HDP across two sites (MCW and Brown) and randomize them to: (1) mindfulness training (MT) plus wearable biosensors, (2) MT alone, or (3) routine prenatal care. MT participants will receive 8 weekly phone-based MT sessions plus two booster s…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brown University, Providence, Rhode Island

   Locations

   2 in total

   Run by

   Medical College of Wisconsin

   See if you can join NCT07218237 on ClinicalTrials.gov

10. Progesterone Preeclampsia

    This randomized controlled trial evaluates whether nightly vaginal micronized progesterone (400 mg) initiated before 12 weeks' gestation reduces the incidence of preeclampsia in low-risk pregnant individuals. Participants will be randomly assigned (1:1) to receive either vaginal progesterone throug…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07448597 on ClinicalTrials.gov

11. Cardiovascular Protection After Preeclampsia With Enalapril

    The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Women and Infants Hospital, Providence, Rhode Island

    Run by

    Women and Infants Hospital of Rhode Island

    See if you can join NCT07222852 on ClinicalTrials.gov

12. Mobile Health Program for Post-Preeclampsia Hypertension

    Strategies targeted to optimize hypertension (HTN) control for midlife women after hypertensive disorders of pregnancy (HDP) have not been studied, despite evidence of a critical need. This proposal targets the 10-20 years postpartum as a key time when women have subclinical cardiovascular (CV) seq…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UPMC Magee Womens Hospital, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07599579 on ClinicalTrials.gov

13. Exosome Cargo From Preeclampsia Patients

    Although extensively studied, the cause of preeclampsia remains uncertain other than it is thought that the placenta plays a critical role in the development of preeclampsia. Recent data revealed that exosomes released from the placenta could cause preeclampsia by transporting specific cargo respon…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04154332 on ClinicalTrials.gov

14. Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy

    Cardiovascular disease is the leading cause of death among women in the United States, and women with hypertensive disorders of pregnancy have a 2-fold higher risk for cardiovascular disease later in life compared to women with uncomplicated pregnancies. This research investigates a patient-centere…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Utah Hospital, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT05826925 on ClinicalTrials.gov

15. Placental Imaging Techniques

    The goal of this proof-of-concept, case-control, clinical trial is to evaluate the efficacy of using two newer ultrasound technologies, quantitative ultrasound (QUS) and ultrafast power Doppler imaging (uPDI), to evaluate the health of the placenta, visualize blood flow through the placental vascul…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Carilion Clinic Maternal Fetal Medicine, Roanoke, Virginia

    Run by

    Carilion Clinic

    See if you can join NCT06861309 on ClinicalTrials.gov

16. Cardiometabolic Disease and Substrate Metabolism

    This study's primary purpose is to determine the potential relationship between cardiometabolic disease, specifically insulin resistance (HOMA-IR), and maternal lipid oxidation.

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Tennessee Graduate School of Medicine, Knoxville, Tennessee

    Run by

    University of Tennessee Graduate School of Medicine

    See if you can join NCT07565727 on ClinicalTrials.gov

17. Exercise Testing After Preeclampsia

    Though cardiovascular disease (CVD) is the leading cause of mortality in women, traditional epidemiology in this area has focused on later life, when cardiometabolic risk has already exacted a cumulative toll on the vascular system. Recent data from the investigators and others has highlighted preg…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT06741436 on ClinicalTrials.gov

18. Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

    The hypertensive disorders of pregnancy (preeclampsia and gestational hypertension) are associated with increased long-term maternal risk of developing cardiovascular disease. Recent evidence suggests that activation of the mineralocorticoid receptor promotes ongoing susceptibility to hypertension …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT07041281 on ClinicalTrials.gov

19. Effects of High Altitude on AMPK Activation

    Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT02391519 on ClinicalTrials.gov

20. Vascular Effects of High-Salt After Preeclampsia

    Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy. Importantly, women who had preeclampsia have an exaggerated vascular responsiveness to hypertensive stimuli, such as high-salt intake, comp…

    Stage

    EARLY_Phase 1

    Ages

    18 to 45

    Site

    University of Iowa, Iowa City, Iowa

    Run by

    Anna Stanhewicz, PhD

    See if you can join NCT06749418 on ClinicalTrials.gov

21. EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE)

    The goal of this prospective observational cohort study of pregnant people at-risk of preeclampsia receiving aspirin as part of clinical care or a planned randomized controlled trial of 81mg vs. 162mg of aspirin is to generate proteomic data to show a distinct maternal and fetal Extracellular Vesic…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06249178 on ClinicalTrials.gov

22. The ACHIEVE Trial: Achieving Longer Gestation in Preeclampsia Via Antihypertensive Therapy.

    The Achieve Trial is a randomized clinical trial to test whether lowering blood pressure to less than 140/90 mmHg in women with hypertensive disorders of pregnancy will prolong pregnancy.

    Stage

    Not phased

    Ages

    14 to 49

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    2 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05676476 on ClinicalTrials.gov

23. Predictors of Aspirin Failure in Preeclampsia Prevention

    Hypertensive disorders of pregnancy (including preeclampsia) are among the leading causes of pregnancy complications and maternal deaths worldwide. They also increase the risks to the babies. Numerous interventions have been suggested in order to reduce the rate of preeclampsia. Low-dose aspirin is…

    Stage

    EARLY_Phase 1

    Ages

    18 to 45

    Site

    Rockefeller University, New York, New York

    Run by

    Rockefeller University

    See if you can join NCT05709483 on ClinicalTrials.gov

24. Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia

    This study's primary purpose is to determine the relationship between aspirin metabolism and markers of metabolic dysfunction among patients at risk for preeclampsia.

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Tennessee Medical Center, Knoxville, Tennessee

    Run by

    University of Tennessee Graduate School of Medicine

    See if you can join NCT06802861 on ClinicalTrials.gov

25. Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)

    Aspirin is recommended in high risk patients to reduce the risk of preeclampsia and preterm birth, which are leading causes of both maternal and neonatal morbidity and mortality, but up to 20% will have these adverse outcomes despite therapy. Gaps in knowledge regarding pregnancy specific aspirin p…

    Stage

    Phase 1

    Ages

    16 to 55

    Site

    Thomas Jefferson University, Philadelphia, Pennsylvania

    Run by

    Thomas Jefferson University

    See if you can join NCT06826859 on ClinicalTrials.gov