Pre Diabetes Clinical Trials

18 studies are recruiting for pre diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

Studies now recruiting

1. Inflammation, Diabetes, Ethnicity and Obesity Cohort

   Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities including diabetes, hypertension, dyslipidemia, ost…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   University of California San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT03022682 on ClinicalTrials.gov

2. Mechanisms of Fatigability With Diabetes

   Pre-diabetes (Pre-D) is a precursor to type 2 diabetes (T2D) and characterized by increased exercise fatigability of lower limb muscles, that can impede exercise performance. The cause for the increased fatigability in people with Pre-D is not known. Given the profound vascular disease present in p…

   Stage

   Not phased

   Ages

   30 to 85

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT04442451 on ClinicalTrials.gov

3. The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

   The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further improved by combination therapy with tadalafil. The investigator will …

   Stage

   Phase 4

   Ages

   35 to 65

   Site

   University of Kentucky, Lexington, Kentucky

   Run by

   Philip Kern

   See if you can join NCT05051436 on ClinicalTrials.gov

4. MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors

   Inflammation and stressors can interfere with the function of the lining of blood vessels and insulin activity, therefore, investigators are aiming to see how the Grape seed Extract (GSE) called MegaNatural BP can help with limiting the effects of these factors. This research will study the effects…

   Stage

   Not phased

   Ages

   40 to 60

   Site

   Clinical Nutrition Research Center, Chicago, Illinois

   Run by

   Clinical Nutrition Research Center, Illinois Institute of Technology

   See if you can join NCT06555952 on ClinicalTrials.gov

5. The GRoceries Aimed at Increasing Nutrition Study

   Only 2% of Americans meet the recommended levels of whole grain consumption, despite its association with reduced risk of type 2 diabetes. This study aims to assess if consumers with prediabetes or type 2 diabetes can be encouraged to switch from buying refined grain products to whole grain product…

   Stage

   Not phased

   Ages

   45 to 70

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT07167004 on ClinicalTrials.gov

6. Sisters for Heart Health: A Community Health Worker Initiative for Improving Heart Health in Farmworker Women

   The goal of this hybrid Type 1 effectiveness-implementation trial is to test the extent to which a peer support and community resource navigation intervention improves psychological well-being, addresses non-biologic drivers of health (access to healthcare, supportive services, nutrition, housing s…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   Southern GA - Colquitt County, Ellenton, Georgia

   Run by

   Emory University

   See if you can join NCT07111026 on ClinicalTrials.gov

7. Milk for Diabetes Prevention

   Individuals with lactase non-persistence (LNP; determined by a functional variant in the LCT gene [rs4988235, GG genotype]) are susceptible to lactose intolerance in adulthood due to deficiency of lactase, the enzyme which digests milk lactose sugars. However, many LNP individuals still drink ≥1 cu…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   HCHS/SOL Bronx Field Center, The Bronx, New York

   Run by

   Albert Einstein College of Medicine

   See if you can join NCT06513026 on ClinicalTrials.gov

8. Stand up for Your Health With a Sit-stand Desk

   More than 84 million - or 1 out of every 3 U.S. adults - have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years. Average medical expenditures among diabetics are about 2.3 times higher than expenditures for people without diabetes. Physical inactivity and…

   Stage

   Not phased

   Ages

   18 to 79

   Site

   Medical College of Wisconsin, Milwaukee, Wisconsin

   Run by

   Medical College of Wisconsin

   See if you can join NCT05585190 on ClinicalTrials.gov

9. Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide

   This study is to investigate how adipocyte (fat cell) function and fat distribution differ between individuals with normal-weight type 2 diabetes (NWD), those with overweight type 2 diabetes (OWD), and normal-weight controls without diabetes (NWC). The study will assess whether adipocyte-directed t…

   Stage

   Phase 4

   Ages

   30 to 70

   Site

   Stanford University, Palo Alto, California

   Locations

   2 in total

   Run by

   Stanford University

   See if you can join NCT06657209 on ClinicalTrials.gov

10. Glycemic Metrics and Patterns in People With and Without Prediabetes

    The FreeStyle Libre 3 Continuous Glucose Monitoring (FSL3) System is used to characterize the glycemic profiles of people with and without a prediabetes diagnosis.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Diabetes and Obesity Care, Bend, Oregon

    Run by

    Abbott Diabetes Care

    See if you can join NCT06921902 on ClinicalTrials.gov

11. Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health

    In a randomized controlled trial, the investigators intend to measure the health impact of time restricted eating (TRE) in patients with metabolic syndrome (with elevated blood pressure and at least 2 of the following: increased waist circumference, abnormal cholesterol levels, elevated triglycerid…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Altman Clinical and Translational Research Institute, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT07189234 on ClinicalTrials.gov

12. Lifestyle Patterns and Glycemic Control

    The goal of the proposed study is to evaluate the feasibility and initial efficacy of stabilizing lifestyle behaviors to improve glucose control and body composition in patients with pre-diabetes. The investigator proposes that following stable lifestyle behaviors will improve patients' glucose con…

    Stage

    Not phased

    Ages

    25 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT05224986 on ClinicalTrials.gov

13. Prevention of Progression of Prediabetes, Obesity and CV Risk

    The investigators are studying how to help people with prediabetes (Pre-DM) and obesity. The goal is to use new and affordable treatments to bring blood sugar levels back to normal and help participants to lose weight. The investigators also want to reduce participants risk of heart problems. The s…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Texas Health Science Center at San Antonio, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06446531 on ClinicalTrials.gov

14. Breaking up Sedentary Time to Improve Glucose Control in a Population at Risk for Developing Type 2 Diabetes

    Newly released guidelines recommend increased physical activity (PA) and reduced sedentary behaviors (SB) to improve glycemia and prevent the onset and progression of type 2 diabetes (T2D). Typically, 30-60 min bouts of PA are advocated per day. Although this approach increases PA, it does not decr…

    Stage

    EARLY_Phase 1

    Ages

    18 to 64

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT05041491 on ClinicalTrials.gov

15. Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)

    Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an acce…

    Stage

    Not phased

    Ages

    8 to 14

    Site

    Children's Hospital Colorado, Aurora, Colorado

    Locations

    2 in total

    Run by

    Petter Bjornstad

    See if you can join NCT05008276 on ClinicalTrials.gov

16. The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults

    The goal of this study is to determine the impact of pre-diabetes and type 2 diabetes on muscle atrophy during a period of bed rest and recovery of muscle mass, strength, and physical function following bed rest.

    Stage

    Not phased

    Ages

    60 to 80

    Site

    Translational Research Institute for Metabolism and Diabetes, Orlando, Florida

    Run by

    AdventHealth Translational Research Institute

    See if you can join NCT03761446 on ClinicalTrials.gov

17. Treatment to Regress to Normoglycemia in Women with a Recent History of GDM

    The purpose of the study is to determine the efficacy of semaglutide 1mg (Ozempic®) to aid recently postpartum women with dysglycemia and a history of GDM to regress to normoglycemia; thereby filling a gap in efficacious pharmacologic intervention options for clinicians to support postpartum diabet…

    Stage

    Phase 4

    Ages

    18 to 45

    Site

    Woman's Hospital, Baton Rouge, Louisiana

    Run by

    Woman's

    See if you can join NCT04873050 on ClinicalTrials.gov

18. Efficacy of Viome's Precision Nutrition Program Towards Reducing HbA1c

    This is a randomized, placebo-controlled trial that will test the efficacy of VPNP in reducing HbA1c. Participant recruitment will occur through direct-to-participant enrollment. No additional clinical sites will be used for recruitment.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Viome Life Sciences, Bothell, Washington

    Run by

    Viome

    See if you can join NCT05465616 on ClinicalTrials.gov