Post Traumatic Stress Disorder (PTSD) Clinical Trials

18 studies are recruiting for post traumatic stress disorder (ptsd) in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Grappling With Trauma: Brazilian Jiu-Jitsu for First Responders

   This study explores whether participating in an 8-week Brazilian Jiu-Jitsu (BJJ) program is linked to changes in trauma-related symptoms among first responders. Many first responders experience ongoing stress or exposure to traumatic events, and some prefer physical, movement-based activities rathe…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Research Site, Conroe, Texas

   Run by

   Sam Houston State University

   See if you can join NCT07783516 on ClinicalTrials.gov

2. Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans

   The VA wants to understand what type of integrative and whole health approaches are helpful for Veterans. The study is comparing two primary care based mental health treatments, a mindfulness class that teaches mindfulness meditation and a problem-solving class that teaches problem-solving skills a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Phoenix VA Health Care System, Phoenix, AZ, Phoenix, Arizona

   Locations

   4 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06162741 on ClinicalTrials.gov

3. Shared Decision Making in PTSD Treatment

   The purpose of this research study is to learn about how Shared Decision Making, when used to decide treatment, impacts treatment engagement, retention, and outcomes for active duty military personnel seeking treatment for posttraumatic stress disorder (PTSD). Shared Decision Making between the ser…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Carl R. Darnall Army Medical Center (CRDAMC), Fort Hood, Texas

   Locations

   2 in total

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT06953687 on ClinicalTrials.gov

4. Targeted Accelerated TMS for Post-Traumatic Stress Disorder

   Post-traumatic stress disorder (PTSD) is a highly prevalent and debilitating condition among veterans and active-duty military personnel, with rates as high as 30% in certain combat-exposed populations. Conventional treatments such as prolonged exposure therapy and pharmacotherapy have limited effi…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT07245641 on ClinicalTrials.gov

5. Evaluating Treatments for Suicidal Veterans With PTSD

   Posttraumatic Stress Disorder (PTSD) is a significant driver of suicide risk among Veterans, but there is a critical knowledge gap about how to treat PTSD among people at elevated risk for suicide. Although evidence-based treatments for PTSD reduce suicide risk, Veterans at high risk for suicidal b…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota

   Locations

   4 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT05974631 on ClinicalTrials.gov

6. Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery

   Using a hybrid type 1 effectiveness-implementation approach, this study aims to evaluate the impact of a novel stepped care model ("PCT+2HOPE") versus treatment as usual (TAU) on increasing retention in community-based medication for opioid use disorder (MOUD) treatment among women who have experie…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Liberation Programs, Bridgeport, Connecticut

   Locations

   3 in total

   Run by

   Yale University

   See if you can join NCT07115030 on ClinicalTrials.gov

7. TMS for PTSD in Youth

   The purpose of this study is to test whether transcranial magnetic stimulation, or TMS, is an acceptable and helpful treatment for ongoing symptoms of posttraumatic stress syndrome disorder (PTSD) in 12-20 year olds. Ongoing PTSD refers to symptoms that continue after completing trauma-focused psyc…

   Stage

   Not phased

   Ages

   12 to 20

   Site

   UT Health Department of Psychiatry, San Antonio, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT07401225 on ClinicalTrials.gov

8. The Effects of Stellate Ganglion Block Sleep in U.S. Active Duty Service Members and Veterans Receiving Prolonged Exposure Therapy for PTSD

   Participants in this study will have already been enrolled in another research study: Combining Stellate Ganglion Block with Prolonged Exposure for PTSD, NCT05889741. The investigators are using a Sleep Profiler, EEG headband to monitor a participants brainwaves while they sleep to see what effects…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Carl R. Darnall Army Medical Center at Fort Hood, Killeen, Texas

   Locations

   2 in total

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT07667309 on ClinicalTrials.gov

9. Suvorexant for Treatment of AUD and PTSD

   This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD). All participants will have a 7-day placebo run-in period, followed by a random a…

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   University of California - Los Angeles, Los Angeles, California

   Locations

   2 in total

   Run by

   Pharmacotherapies for Alcohol and Substance Use Disorders Alliance

   See if you can join NCT06679062 on ClinicalTrials.gov

10. Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD

    People living with HIV (PLWH) have a higher rate of post-traumatic stress disorder (PTSD) diagnosis than the general population. Comorbid PTSD is also associated with negative HIV-related health outcomes. Unfortunately, little outcome research has examined the usefulness of PTSD treatments for PTSD…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Albert Einstein College of Medicine, The Bronx, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT05929911 on ClinicalTrials.gov

11. Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974

    Imaging PDE4B in people with psychiatric disorders with PET and the radiotracer [18F]PF974

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT07488819 on ClinicalTrials.gov

12. Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD

    Leveraging veterans' intimate relationships during treatment for posttraumatic stress disorder (PTSD) has the potential to concurrently improve PTSD symptoms and relationship quality. Brief Cognitive-Behavioral Conjoint Therapy (bCBCT) is a manualized treatment designed to simultaneously improve PT…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Run by

    VA Office of Research and Development

    See if you can join NCT06194851 on ClinicalTrials.gov

13. Nurse-Led PTSD Treatment in Primary Care

    Purpose of the Study Post-traumatic stress disorder (PTSD) is a common and serious condition, but many people cannot get the help they need because there are not enough mental health specialists (like psychologists or psychiatrists) available. This study is testing a new program called NurseNET. Th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rush University Medical Center, Chicago, Illinois

    Locations

    2 in total

    Run by

    Rush University Medical Center

    See if you can join NCT07430657 on ClinicalTrials.gov

14. Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)

    The goal of this clinical trial is to evaluate the safety and effectiveness of the gammaCore non-invasive vagus nerve stimulation (nVNS) device as an additional treatment for symptoms of post-traumatic stress disorder (PTSD) in adults. The vagus nerve connects the brain with many organs and systems…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Acacia Research Center, Sunnyvale, California

    Run by

    Acacia Clinics

    See if you can join NCT07523685 on ClinicalTrials.gov

15. Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD

    The purpose of this study is to examine comparative effectiveness of two home-based telemedicine delivered interventions: transcranial Direct Current Stimulation (tDCS) combined with Massed Prolonged Exposure (Massed-PE) vs. Sham tDCS combined with Massed PE, focusing on pain and PTSD outcomes, to …

    Stage

    Not phased

    Ages

    21 and older

    Site

    Charleston VA Healthcare System, Charleston, South Carolina

    Locations

    2 in total

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT07116109 on ClinicalTrials.gov

16. Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

    The goal of this clinical trial is to learn if ketamine, given during surgery, can help improve recovery for adults with serious orthopedic trauma. The study will test whether ketamine reduces pain, lowers the need for opioids, and improves mental health outcomes like depression and post-traumatic …

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Texas Tech University Health Sciences Center Lubbock, Lubbock, Texas

    Locations

    2 in total

    Run by

    Texas Tech University Health Sciences Center

    See if you can join NCT06903819 on ClinicalTrials.gov

17. Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study

    The overall objective of the proposed study is to determine if Dexmedetomidine HCl (BXCL501) is safe for treatment of alcohol use disorder (AUD) with comorbid posttraumatic stress disorder (PTSD) in an outpatient setting and also shows potential signals of efficacy thereby supporting the conduct of…

    Stage

    Phase 1

    Ages

    21 to 65

    Site

    VA Connecticut Healthcare System, West Haven, Connecticut

    Run by

    Pharmacotherapies for Alcohol and Substance Use Disorders Alliance

    See if you can join NCT06335407 on ClinicalTrials.gov

18. NightWare and Cardiovascular Health in Veterans With PTSD

    The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans with nightmares related to posttraumatic stress disorder (PTSD). The investigators also want to learn whether it improves cardiovascular he…

    Stage

    Not phased

    Ages

    22 to 88

    Site

    Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado

    Run by

    VA Office of Research and Development

    See if you can join NCT06419959 on ClinicalTrials.gov