Post Operative Pain Clinical Trials

26 studies are recruiting for post operative pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Charleston, South Carolina 3 Cleveland, Ohio 3 New York, New York 3

Studies now recruiting

  1. Dextenza in the Post-op Management of Vitreoretinal Surgeries

    This study will assess the control of inflammation at days 1, 7, 14, and 21 days following the vitreoretinal surgical procedure analyzing two randomized study arms: Intracanalicular dexamethasone insert group or topical steroid drop group. Patients must be 18 years of age and older, of any race and…

    Stage
    Phase 4
    Ages
    18 and older
    Site
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio
    Run by
    The Cleveland Clinic

    See if you can join NCT04371445 on ClinicalTrials.gov

  2. QL vs LAI for Palatoplasty

    This study will consist of patients ages 6-18 who are undergoing a surgery on the hard or soft palate of the mouth (palatoplasty), with removal of bone from the front of the hip (anterior iliac bone graft harvesting). The patients will be randomized to receive either a unilateral QL block by an ane…

    Stage
    Not phased
    Ages
    6 to 18
    Site
    Medical University of South Carolina, Charleston, South Carolina
    Run by
    Medical University of South Carolina

    See if you can join NCT06420336 on ClinicalTrials.gov

  3. Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy

    The purpose of this study is to evaluate the use of an injectable combination of bupivacaine and meloxicam (Zynrelef) vs injectable liposomal bupivacaine (Exparel), two extended local anesthesia strategies currently approved by FDA and on the market for post-surgical pain control. The investigators…

    Stage
    EARLY_Phase 1
    Ages
    18 to 65
    Site
    Texas Tech University Health Sciences Center, Lubbock, Texas
    Run by
    Texas Tech University Health Sciences Center

    See if you can join NCT06349772 on ClinicalTrials.gov

  4. A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves

    This is a retrospective and prospective, multicenter, observational patient registry to record outcomes from patients undergoing cryoablation of the intercostal nerves (cryoanalgesia) for post-operative pain management.

    Stage
    Not phased
    Ages
    12 and older
    Site
    Baptist MD Anderson Cancer Center, Jacksonville, Florida
    Locations
    11 in total
    Run by
    AtriCure, Inc.

    See if you can join NCT05110989 on ClinicalTrials.gov

  5. Opioid Use After Laparoscopic Salpingectomy

    The purpose of this study is to evaluate patient-reported post-operative pain scores following minimally invasive tubal sterilization procedures to determine if a multimodal, non-opioid pain control regimen is non-inferior to a pain control regimen including opioids. The study team hypothesizes tha…

    Stage
    Phase 4
    Ages
    18 and older
    Site
    Johns Hopkins Bayview Medical Center, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT06434233 on ClinicalTrials.gov

  6. Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease

    Objective: To improve quality-of-life and health care delivery to patients receiving ureteral stents. Specific Aims: Evaluate the feasibility, practicality, and qualitative outcomes of utilizing intra-nasal ketorolac in patients with indwelling ureteral stents (Phase I), followed by a randomized tr…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    UT Southwestern Medical Center, Dallas, Texas
    Run by
    University of Texas Southwestern Medical Center

    See if you can join NCT06158620 on ClinicalTrials.gov

  7. Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery

    This is prospective, randomized study. The purpose of this study is to evaluate whether the addition of Suzetrigine to well established multimodal pain regimen for participants undergoing bariatric patients undergoing weight-loss surgery and cardiac patients undergoing sternotomy will reduce post-o…

    Stage
    Phase 3
    Ages
    18 to 85
    Site
    Mount Sinai Morningside, New York, New York
    Run by
    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07539623 on ClinicalTrials.gov

  8. Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN

    This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will effect pain control. 1. Does Suzetrigine given pre-operatively decrea…

    Stage
    Phase 3
    Ages
    18 to 85
    Site
    Mount Sinai West, New York, New York
    Run by
    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07548385 on ClinicalTrials.gov

  9. The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty

    The purpose of this study is to evaluate the efficacy of cryoablation use on patient-reported outcomes (PROMs) and opioid consumption following total knee arthroplasty. This is a randomized study that will involve a 1:1 randomization to total knee arthroplasty +/- cryoablation.

    Stage
    Not phased
    Ages
    18 and older
    Site
    NYU Langone Health, New York, New York
    Run by
    NYU Langone Health

    See if you can join NCT06991231 on ClinicalTrials.gov

  10. Dextromethorphan for Treatment of Postoperative Pain

    A Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Perioperative Dextromethorphan compared to Placebo for the Treatment of Postoperative Pain

    Stage
    Not phased
    Ages
    18 and older
    Site
    Keck School of Medicine of USC, Los Angeles, California
    Run by
    Nathanael Heckmann

    See if you can join NCT05278494 on ClinicalTrials.gov

  11. Force Sensor Study

    This research is to understand more about the forces that are involved on the tongue and other oropharyngeal structures during laryngeal surgery. This information will be used to determine if these forces can affect outcomes (pain, numbness, taste, etc) and whether factors such as procedure type, s…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of California San Francisco, San Francisco, California
    Run by
    University of California, San Francisco

    See if you can join NCT07434583 on ClinicalTrials.gov

  12. Preoperative Acetazolamide

    The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain. Researchers will compare acetazolamide to a placebo or inactive drug, to see if acetazolamide helps the…

    Stage
    Phase 4
    Ages
    21 to 65
    Site
    Prisma Health, Greenville, South Carolina
    Run by
    Prisma Health-Upstate

    See if you can join NCT07101250 on ClinicalTrials.gov

  13. Sensory Outcomes in Active Substance Users

    The incidence and severity of postoperative pain after spine surgery are notably high, often requiring intensive management and potentially affecting the patient's recovery, satisfaction, and long-term outcomes. Post-operative pain is particularly difficult to manage in patients with substance use …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Boston Medical Center/Boston University Medical Campus, Boston, Massachusetts
    Run by
    Boston Medical Center

    See if you can join NCT06639438 on ClinicalTrials.gov

  14. Post-operative Cesarean Trial of Pain Control

    This study plans to learn more about postoperative pain management after cesarean deliveries (C-sections). As a part of standard of care, the Children's Hospital Colorado's Colorado Fetal Care Center (CFCC) follows the standard Enhanced Recovery After Cesarean (ERAC) guidelines to manage pain follo…

    Stage
    Not phased
    Ages
    18 to 50
    Site
    Children's Hospital Colorado, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT05131178 on ClinicalTrials.gov

  15. Methadone in THA for Post-op Pain and Opioid Reduction

    This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. T…

    Stage
    Phase 3
    Ages
    18 to 75
    Site
    Medical University of South Carolina, Charleston, South Carolina
    Run by
    Medical University of South Carolina

    See if you can join NCT07227064 on ClinicalTrials.gov

  16. Methadone in TKA for Post-op Pain and Opioid Reduction

    This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.

    Stage
    Phase 3
    Ages
    18 to 75
    Site
    Medical University of South Carolina, Charleston, South Carolina
    Run by
    Medical University of South Carolina

    See if you can join NCT07226076 on ClinicalTrials.gov

  17. A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi

    The purpose of this research is to evaluate if corticosteroid (prednisone) after ureteroscopy and placement of the stent will help alleviate postoperative pain control in addition to other normal postoperative pain medications

    Stage
    Phase 4
    Ages
    18 and older
    Site
    Mayo Clinic in Arizona, Scottsdale, Arizona
    Run by
    Mayo Clinic

    See if you can join NCT07223580 on ClinicalTrials.gov

  18. Post Operative Infusion Pump Pain Study

    This study will be a pragmatic, prospective cluster randomized trial, where clusters will formed based on sequential 2 week time increments across the study recruitment period.. Patients 18 years or older undergoing ACL reconstruction, open shoulder labrum or rotator cuff surgery, arthroscopic rota…

    Stage
    Phase 4
    Ages
    18 and older
    Site
    University Center for Ambulatory Surgery, Somerset, New Jersey
    Run by
    Rutgers, The State University of New Jersey

    See if you can join NCT07349810 on ClinicalTrials.gov

  19. Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

    The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surge…

    Stage
    Phase 4
    Ages
    18 to 72
    Site
    Cleveland Clinic, Cleveland, Ohio
    Run by
    The Cleveland Clinic

    See if you can join NCT07222072 on ClinicalTrials.gov

  20. Effects of Assisted Robotic vs Laparoscopic Sleeve Gastrectomy

    This will be a prospective, obesity-registry based, single-blind randomized controlled trial with a 1:1 allocation ratio. Specific inclusion criteria are all patients eligible to undergo a Laparoscopic sleeve gastrectomy (LSG) based on the current National Institute of Health (NIH) patient selectio…

    Stage
    Not phased
    Ages
    18 to 70
    Site
    Cleveland Clinic, Cleveland, Ohio
    Run by
    Ricard Corcelles

    See if you can join NCT06425016 on ClinicalTrials.gov

  21. Temperature Rise Caused by Short or Long-wavelengths

    Red light has been shown to be less harmful than blue light in vitro and in vivo. Although red light has been already introduced in the market and is currently being used in patients for several reasons, no data exist on the use of red light applied to restorative procedures. This study aims to spe…

    Stage
    Not phased
    Ages
    21 to 35
    Site
    University of Florida College of Dentistry Dental Clinical Research Unit, Gainesville, Florida
    Run by
    University of Florida

    See if you can join NCT06418958 on ClinicalTrials.gov

  22. Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties

    Comparison of post-operative pain after total shoulder surgery. The Principle Investigator will be comparing Exparel single shot block to Interscalene catheter

    Stage
    Phase 4
    Ages
    18 to 90
    Site
    University of Iowa Hospital and Clinics, Iowa City, Iowa
    Run by
    Melinda Seering

    See if you can join NCT05868330 on ClinicalTrials.gov

  23. Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine

    A randomized controlled trial (RCT) investigating whether the local anesthetic injection of liposomal bupivacaine during posterior spinal fusion (PSF) for AIS is more effective in reducing acute postoperative opioid consumption compared to an equal volume injection of 0.25% bupivacaine with epineph…

    Stage
    Not phased
    Ages
    10 to 17
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT06471348 on ClinicalTrials.gov

  24. Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

    This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary goal of the study is to use fluctuations in daily self-reported symptoms…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brown University, Providence, Rhode Island
    Run by
    Brown University

    See if you can join NCT05754190 on ClinicalTrials.gov

  25. Liposomal Bupivacaine and Transoral Robotic Surgery

    This study is for patients with oropharyngeal squamous cell carcinoma. We want to learn more about how we can optimize pain control in patients who undergo transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma. Our goal is to determine if a local anesthetic called EXPAREL® (Lip…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Geisinger Medical Center, Danville, Pennsylvania
    Run by
    Geisinger Clinic

    See if you can join NCT05862792 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.