Peripheral Artery Disease Clinical Trials

23 studies are recruiting for peripheral artery disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. Community-based Exercise Following Revascularization for PAD

   The primary goal of this clinical trial is to evaluate whether a community-based structured exercise therapy (CB-SET) intervention, which could be accessible and easily disseminated, adds benefit to peripheral artery disease (PAD) patients undergoing revascularization (REVASC) to improve their func…

   Stage

   Not phased

   Ages

   40 to 90

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT04252950 on ClinicalTrials.gov

2. Leg Heat Therapy in Peripheral Artery Disease

   The goal of this randomized, double-blind, sham-controlled clinical trial is to evaluate the benefits of home-based, leg heat therapy (HT) on lower-extremity functioning and quality of life in patients who suffer from lower-extremity peripheral artery disease (PAD). We will randomize 106 patients t…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Indiana University Health Methodist Hospital, Indianapolis, Indiana

   Run by

   Indiana University

   See if you can join NCT05465070 on ClinicalTrials.gov

3. Response to Exercise and Nitric Oxide in PAD

   RESIST PAD is a randomized trial of 200 PAD patients to establish: 1) whether a 12-week exercise intervention significantly increases Δ nitrite at 12-week follow-up, compared to control; 2) whether exercise "responders" have greater Δ nitrite increases compared to "non-responders"; 3) among non-res…

   Stage

   Phase 2

   Ages

   50 and older

   Site

   Northwestern University Feinberg School of Medicine, Chicago, Illinois

   Locations

   2 in total

   Run by

   Northwestern University

   See if you can join NCT06657976 on ClinicalTrials.gov

4. Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease

   Peripheral artery disease (PAD) is associated with elevated oxidative stress, and oxidative stress has been implicated as the cause of reduced endothelial reactivity in individuals with PAD. Endothelial function is important because the endothelium contributes to the dilation of arteries during exe…

   Stage

   EARLY_Phase 1

   Ages

   50 to 75

   Site

   University of Nebraska - Omaha, Omaha, Nebraska

   Run by

   University of Nebraska

   See if you can join NCT06319339 on ClinicalTrials.gov

5. Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy

   This single-center, 400-patient, randomized controlled trial assesses the impact of a patient- and provider-facing EPIC Best Practice Advisory (BPA; alert-based computerized decision support tool) to increase guideline-directed utilization of statin and statin-alternative oral LDL-C lowering therap…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06300450 on ClinicalTrials.gov

6. The THOR IDE Study

   The goal of this clinical trial is to test the Thor system in adult (≥ 18 year old) patients with de novo (new, never treated) calcified lesions in infrainguinal (leg) arteries (peripheral artery disease or PAD). The main question[s] it aims to answer are: * Is the Thor system safe in treating thes…

   Stage

   Not phased

   Ages

   18 and older

   Site

   St. Helena Hospital, St. Helena, California

   Locations

   29 in total

   Run by

   Philips Clinical & Medical Affairs Global

   See if you can join NCT05916950 on ClinicalTrials.gov

7. The Effects of a Novel, Non-ischemic and Pain-free Exercise Intervention in Peripheral Artery Disease

   This study is a 3-month, prospective, randomized controlled clinical trial designed to address the efficacy of the Non-Ischemic Exercise (NICE) program to improve exercise and vascular outcome measures in patients with peripheral artery disease (PAD).

   Stage

   Not phased

   Ages

   40 and older

   Site

   O'Donoghue Research Building, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

   Run by

   University of Oklahoma

   See if you can join NCT05712395 on ClinicalTrials.gov

8. The COCOA-PAD II Trial

   Among people with peripheral artery disease (PAD) age 55 and older, the investigators will test the hypothesis that PAD participants randomized to cocoa flavanols will have greater improvement or less decline in six-minute walk distance at six-month follow-up, compared to those randomized to placeb…

   Stage

   Phase 3

   Ages

   55 and older

   Site

   Northwestern University, Chicago, Illinois

   Locations

   3 in total

   Run by

   Northwestern University

   See if you can join NCT04794530 on ClinicalTrials.gov

9. Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss

   The PROVE Trial is a randomized clinical trial that will determine whether a weight loss intervention combined with walking exercise achieves greater improvement or less decline in six-minute walk distance at 12 month follow-up than walking exercise alone in people with PAD and BMI>25 kg/m2. The in…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Northwestern University, Chicago, Illinois

   Locations

   7 in total

   Run by

   Northwestern University

   See if you can join NCT04228978 on ClinicalTrials.gov

10. Telehealth Delivered Home-based Walking for Vets With Peripheral Artery Disease

    Walking is beneficial for adults with peripheral arterial disease. Benefits include the ability to walk for longer periods and general well being (quality of life). This study will look at two types of delivery methods for a home-based walking program. The walking program includes step count goals,…

    Stage

    Not phased

    Ages

    21 and older

    Site

    VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California

    Locations

    3 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06033924 on ClinicalTrials.gov

11. Red Light Treatment in Peripheral Artery Disease

    Subjects with a known diagnosis of peripheral artery disease as measured by an abnormal ankle brachial index (<.9 or >1.1) will undergo a single 5 min exposure of 670 nm light, 1 cm above the gastrocnemius muscle. Blood flow will be measured by infusion of ultrasound contrast and subsequent acquisi…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    University of Alabama at Birmingham

    See if you can join NCT03203239 on ClinicalTrials.gov

12. Exercise Therapy for PAD Using Mobile Health

    Peripheral artery disease (PAD) is a highly prevalent condition affecting up to 10% of Veterans that leads to loss of walking ability and increased risk of amputation. Veterans have limited access to supervised exercise therapy, a facility-based program proven to improve walking ability in PAD, whi…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia

    Run by

    VA Office of Research and Development

    See if you can join NCT04889105 on ClinicalTrials.gov

13. The Effects of Diet and Exercise Interventions in Peripheral Artery Disease

    This study is a 3-month, prospective, randomized controlled clinical trial designed to address the efficacy of the DASH dietary program combined with a home-based exercise program, quantified by a step activity monitor, to improve exercise and vascular outcome measures in patients with PAD.

    Stage

    Not phased

    Ages

    40 and older

    Site

    O'Donoghue Research Building, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT03845036 on ClinicalTrials.gov

14. BEETroot Juice to Reverse Functional Impairment in PAD

    The BEET PAD Trial is a multi-centered double-blind randomized clinical trial designed to determine whether beetroot juice, compared to placebo, improves six-minute walk distance at four month follow-up in people with lower extremity peripheral artery disease (PAD). Investigators hypothesize that b…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Northwestern University Feinberg School of Medicine, Chicago, Illinois

    Locations

    4 in total

    Run by

    Northwestern University

    See if you can join NCT05624125 on ClinicalTrials.gov

15. ENhancing Exercise With LIGHT to Improve Functioning in PAD

    The ENLIGHTEN PAD Trial will collect preliminary data to test whether daily 660 nm light treatment of the lower extremities immediately before home-based walking exercise sessions improves six-minute walk distance at 4-month follow-up, compared to sham light, in people with lower extremity peripher…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT06399900 on ClinicalTrials.gov

16. Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation

    The population of older Veterans with non-traumatic lower limb amputation is growing. Following lower limb amputation, asymmetrical movements persist during walking and likely contribute to disabling sequelae including secondary pain conditions, poor gait efficiency, impaired physical function, and…

    Stage

    Not phased

    Ages

    40 to 89

    Site

    Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT03995238 on ClinicalTrials.gov

17. Oxygen-guided Supervised Exercise Therapy

    Peripheral artery disease (PAD) is a cardiovascular disease manifesting from systemic atherosclerosis, which blocks the leg arteries and results in insufficient blood flow to the lower extremities. Limb ischemia from PAD is the most common disorder treated within the vascular surgery service at the…

    Stage

    Not phased

    Ages

    Any age

    Site

    Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE, Omaha, Nebraska

    Run by

    VA Office of Research and Development

    See if you can join NCT06003855 on ClinicalTrials.gov

18. Vascular Lab Resource (VLR) Biorepository

    This is a study of biomarkers obtained from prospectively collected subject samples and their correlation with cardiovascular and metabolic diseases. The purpose of this initiative is to develop an enduring tool to allow for collaborative research between clinicians at Cleveland Clinic Main Campus …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT05628948 on ClinicalTrials.gov

19. Improving Mobility After Revascularization in Peripheral Artery Disease

    Lower extremity revascularization combined with supervised exercise significantly improves walking performance compared to revascularization alone in people who have PAD without limb threatening ischemia. However, supervised exercise is inaccessible or burdensome for most PAD patients. Investigator…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Rancho Research Institute, Downey, California

    Locations

    7 in total

    Run by

    Northwestern University

    See if you can join NCT06686121 on ClinicalTrials.gov

20. Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee

    A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Temsirolimus Perivascular Injection 0.1 mg/mL on the incidence of ischemia-driven major amputation, clinically driven target lesion revascularization, and clinically relevant target lesion occlusion after re…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Cardiovascular Institute of the South, Houma, Louisiana

    Locations

    2 in total

    Run by

    Mercator MedSystems, Inc.

    See if you can join NCT04433572 on ClinicalTrials.gov

21. Passive Calf Stretching Therapy in Peripheral Artery Disease

    The goal of this clinical trial is to assess the effects of passive calf muscle stretching in patients diagnosed with peripheral artery disease (PAD). The main question it aims to answer are: 1. To determine if daily calf muscle stretching at home improves calf muscle and vascular health. 2. To det…

    Stage

    Not phased

    Ages

    40 to 85

    Site

    Penn State University, University Park, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT06041880 on ClinicalTrials.gov

22. Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease

    The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical outcomes in patients with peripheral artery disease (PAD) who are undergoing …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Nationwide Children's Hospital, Columbus, Ohio

    Run by

    Nationwide Children's Hospital

    See if you can join NCT03622359 on ClinicalTrials.gov

23. PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG

    To evaluate the proportion of diabetic mellitus patients with CV events as measured by HEMOTAG.

    Stage

    Not phased

    Ages

    40 and older

    Site

    Metabolic Research Institute, Inc, West Palm Beach, Florida

    Run by

    Aventusoft, LLC.

    See if you can join NCT06567795 on ClinicalTrials.gov