Pain Management Clinical Trials

17 studies are recruiting for pain management in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults

   The purpose of this research is to see if ketamine is effective and safe in treating children and young adults with sickle cell disease experiencing sickle cell related pain. In this study, we will compare the outcomes (such as pain scores) in persons who receive standard of care pain medicine (an …

   Stage

   Phase 2

   Ages

   5 to 20

   Site

   Harbor UCLA Medical Center, Torrance, California

   Run by

   Mohsen Saidinejad

   See if you can join NCT07369024 on ClinicalTrials.gov

2. Assessment of Morbidity and Mortality Following Serratus Anterior Plane Block (SAPB) for Unilateral Rib Fractures

   The goal of this observational study is to learn about the long-term effects of the serratus anterior plane block (SAPB) in adult patients who suffered multiple unilateral anterolateral rib fractures within 24 hours of patient presentation to the emergency department. The main question it aims to a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Jacobi Medical Center, The Bronx, New York

   Run by

   Albert Einstein College of Medicine

   See if you can join NCT07032766 on ClinicalTrials.gov

3. Psilocybin in Cancer Pain Study

   The overall objective of this study is to assess the feasibility, safety and preliminary efficacy of psilocybin-assisted therapy to alleviate opioid-refractory pain in patients with advanced-cancer. The name of the study intervention used in this research study is: Psilocybin (a tryptamine derivati…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Dana-Farber Cancer Institute, Boston, Massachusetts

   Run by

   Yvan Beaussant, MD, MSci

   See if you can join NCT06001749 on ClinicalTrials.gov

4. Suzetrigine in Total Hip Arthroplasty

   Total hip and knee joint replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery. Despite widespread use of multimodal regimens, many patients still rely on opioids, which can cause se…

   Stage

   Phase 3

   Ages

   18 to 80

   Site

   Hospital for Special Surgery, New York, New York

   Run by

   Hospital for Special Surgery, New York

   See if you can join NCT07226700 on ClinicalTrials.gov

5. The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair

   The goal of this clinical trial is to understand which group of pain control medications work best in adults after rotator cuff surgery.

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Montefiore Hutchinson Campus, The Bronx, New York

   Run by

   Montefiore Medical Center

   See if you can join NCT07076069 on ClinicalTrials.gov

6. R.E.C.K vs Exparel in Robotic Nephrectomy

   The purpose of the study is to evaluate the efficacy of R.E.C.K (ropivacaine epinephrine clonidine ketorolac) vs Exparel during robotic partial and radical nephrectomy in a single institution, prospective, randomized trial. The study will evaluate post operative Numerical Rating Score (NRS) pain sc…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Levine Cancer, Charlotte, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT07092566 on ClinicalTrials.gov

7. Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain

   This project is a single-site, three-arm, randomized controlled trial investigating whether different length audio-recorded mindfulness practices differentially decrease pain among patients in a waiting room awaiting orthopedic care.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tallahassee Orthopedic Clinic, Tallahassee, Florida

   Run by

   Florida State University

   See if you can join NCT07562412 on ClinicalTrials.gov

8. Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement

   The purpose of this study is to improve pain management for participantswho need osmotic dilators for cervical preparation the day before their second trimester abortion procedure.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Rush University Medical Center, Chicago, Illinois

   Run by

   Rush University Medical Center

   See if you can join NCT07487246 on ClinicalTrials.gov

9. The Impact of Enhanced Music & Natural Visuals on Emotional Health

   The investigators are conducting research on factors related to the self-regulation of mood and arousal states across a range of everyday activities as well as different levels of stress. Behavioral interventions-such as meditation, listening to music, or visualizing art or nature-offer important a…

   Stage

   Not phased

   Ages

   13 and older

   Site

   Colorado State University, Fort Collins, Colorado

   Locations

   3 in total

   Run by

   soundBrilliance LLC

   See if you can join NCT07676110 on ClinicalTrials.gov

10. Imagined Acupuncture for Postoperative Pain After Spinal Surgery

    The goal of this clinical trial is to evaluate whether imagined acupuncture can reduce postoperative acute pain in adult patients undergoing spinal surgery. The main questions it aims to answer are: Does video-guided imagined acupuncture improve postoperative pain control? Does the intervention red…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Jingping Wang, MD, Ph.D.

    See if you can join NCT07197710 on ClinicalTrials.gov

11. Virtual Reality as a Method for Pain and Anxiety Control During First Trimester Procedural Abortion

    The goal of this clinical trial is to learn whether use of a virtual reality (VR) headset showing a meditative nature video will help reduce pain and anxiety during a first trimester procedural abortion. Investigators will enroll 72 patients undergoing a first trimester procedural abortion with usu…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Center for Family Planning Research, Magee-Womens Hospital, Pittsburgh, Pennsylvania

    Locations

    2 in total

    Run by

    Study Investigator

    See if you can join NCT07288047 on ClinicalTrials.gov

12. Opioid-Sparing Joint Replacement

    The goal of this clinical trial is to evaluate whether an opioid-sparing postoperative pain regimen can reduce opioid consumption and maintain effective pain control in adults undergoing anterior total hip arthroplasty for osteoarthritis. The main questions it aims to answer are: * Does an opioid-l…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Emory University Orthopedics and Spine Hospital, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07348627 on ClinicalTrials.gov

13. Pain in Aging Former Athletes, Master's Athletes, and Nonathletes

    The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus aerobic) compared with both current master's athletes and nonathletes. The main questions this study aims to address are: 1. How do former …

    Stage

    Not phased

    Ages

    35 to 65

    Site

    Marquette University, Milwaukee, Wisconsin

    Run by

    Marquette University

    See if you can join NCT07502742 on ClinicalTrials.gov

14. Local Anesthesia for Facial Fractures

    The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics. Patients with operative facial fractures are randomized to receive either bupivacaine or saline injections prior to the anesthesia emergence.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Washington University, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06429501 on ClinicalTrials.gov

15. Sensory Spinal Cord Stimulation

    The purpose of this research study is to identify sensations that can be evoked with spinal cord stimulation (SCS) and to understand how these sensations change when stimulation parameters are modified.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Ambulatory Care Center, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT07095036 on ClinicalTrials.gov

16. Efficacy of Methylprednisolone for Pain Control After ACL Repair

    Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL rep…

    Stage

    Phase 4

    Ages

    13 to 50

    Site

    Saint Louis University, St Louis, Missouri

    Run by

    St. Louis University

    See if you can join NCT07158476 on ClinicalTrials.gov

17. E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app

    The goal of this clinical trial is to test whether a web-based application called the Pain Control Enhancement App (PACE-app) can support family caregivers in managing pain for their care recipients with dementia. The main questions it aims to answer are: Is it feasible and acceptable for family ca…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    College of Nursing, Iowa City, Iowa

    Run by

    University of Iowa

    See if you can join NCT07032350 on ClinicalTrials.gov