Pain, Chronic Clinical Trials

23 studies are recruiting for pain, chronic in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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By city

Boston, Massachusetts 5 Chicago, Illinois 3 New York, New York 3

Studies now recruiting

  1. Evaluate the Impact of Targeted Physical Activity on Clinically Debilitated Dialysis Patients.

    This research is being done to better understand the impact of the use of a specific physical activity training program (GH Method) in dialysis/kidney disease patients.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Illinois at Chicago, Chicago, Illinois
    Run by
    University of Illinois at Chicago

    See if you can join NCT06374537 on ClinicalTrials.gov

  2. Pain Reprocessing Therapy in Post-Operative Knee Pain

    The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain. The main questio…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Hospital for Special Surgery, New York, New York
    Locations
    2 in total
    Run by
    Weill Medical College of Cornell University

    See if you can join NCT06800209 on ClinicalTrials.gov

  3. Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks

    This study examines the relationship between central nervous system (CNS) mechanisms of pain inhibition and the pain relief that occurs following a lumbar medial branch block (MBB).

    Stage
    Not phased
    Ages
    18 and older
    Site
    UPMC St. Margaret, Pittsburgh, Pennsylvania
    Run by
    University of Pittsburgh

    See if you can join NCT05961800 on ClinicalTrials.gov

  4. Screening Trial for Pain Relief in Schwannomatosis (STARFISH)

    This is a placebo-controlled, multi-arm phase II platform screening trial designed to test the safety, pain responses, and pharmacodynamic activity of multiple experimental therapies simultaneously in participants with moderate-to-severe pain due to schwannomatosis (SWN). This Master Study is being…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Massachusetts General Hospital Cancer Center, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT05684692 on ClinicalTrials.gov

  5. Using Technology to Track Pain and Pain-related Outcomes

    Persistent pain is a public health epidemic. The current protocol seeks to develop technology to aid patients' tracking of patients' pain, medications and pain-related variables. The investigators seek to talk with patients in co-investigator's clinic to solicit feedback, as well as pilot test the …

    Stage
    Not phased
    Ages
    21 and older
    Site
    Behavioral Medicine Research Lab, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT04267588 on ClinicalTrials.gov

  6. Pain and Weight Treatment: Development and Trial of PAW

    Pediatric weight management efficacy is impacted by failure to complete treatment protocols and, for those that do complete treatment, a return to unhealthy behaviors. This project tests whether treating pain, a common comorbid condition to pediatric obesity, will enhance treatment. This study will…

    Stage
    Not phased
    Ages
    12 to 18
    Site
    Connecticut Children's Medical Center, Hartford, Connecticut
    Run by
    Connecticut Children's Medical Center

    See if you can join NCT04046562 on ClinicalTrials.gov

  7. The PROACTIVE Study for Black Elders

    Chronic musculoskeletal pain (CMP), while a leading cause of physical disablement, is a neglected national health disparity issue in Black communities. The purpose of this study is to test a novel culturally congruent pain self-management intervention. A total of 120 persons aged 50-92, self-identi…

    Stage
    Not phased
    Ages
    50 to 92
    Site
    University of Florida, Gainesville, Florida
    Run by
    University of Florida

    See if you can join NCT06512727 on ClinicalTrials.gov

  8. MIVetsCan: Cannabidiol (CBD)-Care Trial

    This research is studying the effects of cannabidiol (CBD), an active component from cannabis (a.k.a. marijuana), on Veterans' chronic pain. The purpose of this study is to better understand if CBD can improve pain symptoms in Veterans with chronic pain. Eligible participants will be randomly assig…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    Kevin Boehnke

    See if you can join NCT06213233 on ClinicalTrials.gov

  9. Comparative Effectiveness of Online 8-session CBT vs. 1-Session Empowered Relief for Chronic Pain - The PROGRESS Study

    The purpose of this study is to conduct a pragmatic clinical trial comparing the effectiveness of: (1) 8-week cognitive behavioral therapy for chronic pain (pain-CBT; sixteen hours total treatment time); and (2) a 1-session pain relief skills intervention for chronic pain (Empowered Relief; two hou…

    Stage
    Not phased
    Ages
    18 and older
    Site
    SCAN Health Plan, Long Beach, California
    Locations
    5 in total
    Run by
    Stanford University

    See if you can join NCT05612750 on ClinicalTrials.gov

  10. Interoceptive Awareness and Function in Adolescents With Chronic Pain

    The main objectives of this study are to compare the levels of interoceptive awareness and self-reported function pre and post completion of an occupational therapy treatment plan. The target population are adolescents aged 11-21 years that are diagnosed with chronic pain and are seen through the P…

    Stage
    Not phased
    Ages
    11 to 21
    Site
    Connecticut Children's Medical Center, Hartford, Connecticut
    Run by
    Connecticut Children's Medical Center

    See if you can join NCT07325110 on ClinicalTrials.gov

  11. Home-based Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for IBS Pain

    The goal of this clinical trial is to learn the feasibility and safety of using home-based taVNS in young adults with IBS to manage their IBS-related pain and symptoms. It will also learn about participants' experience in using the home-based taVNS intervention. The main questions it aims to answer…

    Stage
    Not phased
    Ages
    18 to 29
    Site
    Yale University, New Haven, Connecticut
    Run by
    Yale University

    See if you can join NCT06847360 on ClinicalTrials.gov

  12. Adolescent Outcomes of Post-operative Opioid EXposure

    The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical patients. The main question aims to identify factors (moderators, mediators, and covariates) associ…

    Stage
    Not phased
    Ages
    12 to 17
    Site
    Boston Childrens Hopsital - Division of Addiction Medicine, Boston, Massachusetts
    Locations
    5 in total
    Run by
    Sharon Levy

    See if you can join NCT06350409 on ClinicalTrials.gov

  13. Evaluating the Efficacy of the Pain Identification and Communication Toolkit

    This study will evaluate the Pain Identification and Communication Toolkit (PICT), a multicomponent intervention for caregivers of people with Alzheimer's disease and related dementias (ADRD). PICT provides training in observational pain assessment and coaching in effective pain communication techn…

    Stage
    Not phased
    Ages
    21 and older
    Site
    Weill Cornell Medicine, New York, New York
    Run by
    Weill Medical College of Cornell University

    See if you can join NCT06168604 on ClinicalTrials.gov

  14. Diabetic Neuropathy in Spinal Cord Stimulator Patients

    The objective of this study is to assess the effect Spinal Cord Stimulators have toward improving vascular changes of diabetes mellitus in patients eligible for SCS placement based on their condition of painful diabetic neuropathy; we will evaluate improving their disability and quality of life, im…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Chicago Medical Center, Chicago, Illinois
    Run by
    University of Chicago

    See if you can join NCT04687215 on ClinicalTrials.gov

  15. Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain

    The purpose of this study is to determine whether exposure to prescription opioids is associated with brain structural changes on magnetic resonance imaging (MRI), with the primary outcome of white matter integrity as measured by fractional anisotropy of the corpus callosum.

    Stage
    Phase 2
    Ages
    65 and older
    Site
    Mayo Clinic in Rochester, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT06837857 on ClinicalTrials.gov

  16. fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

    Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).

    Stage
    Not phased
    Ages
    8 to 35
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT04439552 on ClinicalTrials.gov

  17. Evaluation of the PACE/PACENET BHL Clinical Program

    The SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program is a telephone-based clinical service designed to help identify and manage behavioral health issues among PACE/PACENET enrollees. The purpose of the current project is to a) explore moderators of treatment response among …

    Stage
    Not phased
    Ages
    65 and older
    Site
    Department of Psychiatry (Center for Psychotherapy Research), University of Pennsylvania, Philadelphia, Pennsylvania
    Run by
    University of Pennsylvania

    See if you can join NCT02463266 on ClinicalTrials.gov

  18. Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients

    During breast surgery, sensory nerves are cut which may lead to reduced sensation and pain. Surgical reinnervation techniques have been developed with the aim of improving postoperative sensation by preserving the nerves and connecting them to the nipple and areola. The investigators aim to compare…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Weill Medical College of Cornell University

    See if you can join NCT06094257 on ClinicalTrials.gov

  19. Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee

    In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee. Veterans with as history of chronic shoulder, hip or knee pain and mild/moderate joint degenerative changes will be potential s…

    Stage
    Not phased
    Ages
    25 to 80
    Site
    VA Palo Alto Healthcare System, Palo Alto, California
    Run by
    Palo Alto Veterans Institute for Research

    See if you can join NCT05700682 on ClinicalTrials.gov

  20. iCanCope With Post-Operative Pain (iCanCope PostOp)

    There are few applications available in the community to help teenagers manage pain after surgery. The focus of this study is to better understand the pain experience of children after having surgery and to design a Smartphone app called "iCanCope with Post-Operative Pain" (iCanCope PostOp), to hel…

    Stage
    Not phased
    Ages
    12 to 18
    Site
    Hospital for Sick Children, Toronto, Ontario
    Locations
    2 in total
    Run by
    The Hospital for Sick Children

    See if you can join NCT05382962 on ClinicalTrials.gov

  21. Assessment of Methadone Dose Taken

    Proof of concept: Pilot Study A Pilot, proof of concept, observational study with a long-term goal to develop a minimally invasive wearable Remote Medication Monitor (RMM) that provides continuous, real-time data on methadone levels in interstitial fluid (ISF). An RMM could be used as a medication …

    Stage
    Not phased
    Ages
    18 to 70
    Site
    Synergy, Lemon Grove, California
    Run by
    Cari Health Inc.

    See if you can join NCT05981573 on ClinicalTrials.gov

  22. Embo Registry; National Registry for Artery Embolization

    Embo Registry is a retrospective and prospective observational study to evaluate real world effectiveness and the use of Artery Embolization as a treatment for chronic pain with patients that have osteoarthritis and localized pain to provide symptomatic relief. This study is to determine the effica…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Vascular Solutions of North Carolina, Cary, North Carolina
    Locations
    2 in total
    Run by
    Vascular Solutions of North Carolina

    See if you can join NCT06477965 on ClinicalTrials.gov

  23. VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain

    This study will examine the impact of virtual reality used in conjunction with sedation compared to sedation alone in patients undergoing watervcooled genicular nerve ablations for chronic knee pain. The goals of the study is to determine the relative efficacy of virtual reality as a distraction mo…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Northwestern Medicine Pain Center, Chicago, Illinois
    Run by
    Northwestern University

    See if you can join NCT06336447 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.