Overweight or Obesity Clinical Trials

19 studies are recruiting for overweight or obesity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

   The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with active PsA and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months.

   Stage

   Phase 4

   Ages

   18 and older

   Site

   AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale, Avondale, Arizona

   Locations

   55 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06864026 on ClinicalTrials.gov

2. Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

   The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last ab…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   AMR Clinical, Mobile, Alabama

   Locations

   152 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07353931 on ClinicalTrials.gov

3. A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

   The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe plaque PsO and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months.

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Medical Dermatology Specialists, Phoenix, Arizona

   Locations

   39 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06857942 on ClinicalTrials.gov

4. Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

   The researchers will conduct 'Taxi ROADmAP (Realizing Optimization Around Diet And Physical activity)', which also utilizes MOST, and the same 4 obesity intervention components as in SANOS, but targets the overweight/obesity crisis in another at-risk, low socioeconomic status (SES) population, taxi…

   Stage

   Phase 2

   Ages

   21 and older

   Site

   Mexican Consulate's Ventanilla de Salud (VDS), New York, New York

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT05770570 on ClinicalTrials.gov

5. Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes

   This study will test an experimental drug called olatorepatide ("study drug") to determine how safe and effective this drug is compared to placebo and how easily the body can accept this drug at different doses and dosing schedules without causing side effects, as well as how the drug is processed …

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Diablo Clinical Research - Flourish Research, Walnut Creek, California

   Locations

   5 in total

   Run by

   Regeneron Pharmaceuticals

   See if you can join NCT07685808 on ClinicalTrials.gov

6. Testing Just-in-Time Adaptive Interventions (JITAIs) to Prevent Goal Disengagement in Response to Weight Regain

   This trial will test the effectiveness of a weight loss maintenance intervention designed to help participants respond more adaptively to weight regain. Participants will be randomly assigned to one of two conditions. In one condition, participants will receive brief exercises (e.g., written reflec…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Oregon Research Institute Community and Evaluation Services, Springfield, Oregon

   Run by

   ORI Community and Evaluation Services

   See if you can join NCT07708064 on ClinicalTrials.gov

7. Better Lifestyle Counseling for African American Women During Pregnancy

   The purpose of this randomized controlled trial is to establish the effectiveness of a culturally targeted and individually tailored behavioral intervention to promote maternal glucose metabolism in African American women.

   Stage

   Not phased

   Ages

   18 to 40

   Site

   University of Illinois at Chicago, Chicago, Illinois

   Locations

   2 in total

   Run by

   University of Illinois at Chicago

   See if you can join NCT05234125 on ClinicalTrials.gov

8. Safety and Drug Concentrations of REGN20934 in Adults With Overweight or Obesity

   This study will test a study drug called REGN20934 to see how safe and well tolerated this drug is, as well as how the drug is processed in the body for participants with overweight or obesity. The study is looking at: * What side effects REGN20934 might cause * How much REGN20934 is in the blood a…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   California Clinical Trials Medical Group, Glendale, California

   Run by

   Regeneron Pharmaceuticals

   See if you can join NCT07594093 on ClinicalTrials.gov

9. Effect of the Thrive AI Health App on Lifestyle Behaviors and Quality of Life

   The goals of this randomized trial is to learn: 1. If the Thrive AI Health app will help adults improve their everyday habits (diet, exercise, and sleep). 2. How often participants will use the Thrive AI Health app to which they will have free access The Thrive AI Health app uses artificial intelli…

   Stage

   Not phased

   Ages

   40 and older

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT07376655 on ClinicalTrials.gov

10. Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss

    The PROVE Trial is a randomized clinical trial that will determine whether a weight loss intervention combined with walking exercise achieves greater improvement or less decline in six-minute walk distance at 12 month follow-up than walking exercise alone in people with PAD and BMI>25 kg/m2. The in…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northwestern University, Chicago, Illinois

    Locations

    7 in total

    Run by

    Northwestern University

    See if you can join NCT04228978 on ClinicalTrials.gov

11. NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks

    The goal of this clinical trial is to test an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) that is tailored to young women in childbearing years. The investigators will recruit 360 women aged 18-39 years with overweight/obesity who are not currently pregnant, but like…

    Stage

    Not phased

    Ages

    18 to 39

    Site

    Wake Forest University Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT05674799 on ClinicalTrials.gov

12. Craving Network Neurofeedback

    This project tests whether individuals with overweight or obesity and high craving can learn to change their brain response to food cues using neurofeedback, to impact their craving and eating behavior.

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Yale MRRC Anlyan Center, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06426693 on ClinicalTrials.gov

13. Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

    The goal of the study is to learn how a weight loss medication called semaglutide, which is used to treat obesity, in addition to standard AF treatment might affect AF, atrial fibrillation severity, and whether it changes the risk of atrial fibrillation recurring after standard AF treatments.

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    University of Chicago, Chicago, Illinois

    Locations

    2 in total

    Run by

    University of Chicago

    See if you can join NCT06499857 on ClinicalTrials.gov

14. Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BGM1812 Injection Following Single and Multiple Subcutaneous Administration in Normal to Overweight or Obese But Otherwise Healthy Men and Women

    This is a Phase 1, single-center, double-blind, placebo-controlled, dose-escalation study. The study will evaluate the pharmacokinetics (PK), pharmacodynamic (PD), preliminary efficacy, safety and tolerability of BGM1812 following single and multiple SC administrations in normal to overweight or ob…

    Stage

    Phase 1

    Ages

    18 to 55

    Site

    Pharmaron CPC, Inc, Baltimore, Maryland

    Run by

    BrightGene Bio-Medical Technology Co., Ltd.

    See if you can join NCT07224399 on ClinicalTrials.gov

15. eMOTION: Examining Implicit Attitudes in Physical Activity Engagement

    This early-phase trial will test intervention strategies to influence implicit attitudes towards physical activity and determine whether changes in those mechanisms result in change in physical activity behavior among inactive adults who are overweight or obese.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Univeristy of Southern California, Los Angeles, California

    Run by

    University of Southern California

    See if you can join NCT07044570 on ClinicalTrials.gov

16. Community Park-Based Programs for Health Promotion: The Fit2Lead Prospective Cohort Study

    The Fit2Lead prospective cohort study examines the effects of a park-based youth mental health and resilience afterschool program on youth participant mental health, resilience, physical fitness, and violence prevention outcomes. Duke will perform a secondary analysis of the data collected as part …

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Miami-Dade County Parks, Recreation and Open Spaces Department, Miami, Florida

    Run by

    Duke University

    See if you can join NCT06596265 on ClinicalTrials.gov

17. Healthy Living BEYOND Weight Study

    The Healthy Living BEYOND Weight Study is an observational research study of participants living with overweight and obesity. The principal objectives for this project will be to answer fundamental unanswered questions regarding patient experiences and outcomes related to overweight and obesity, an…

    Stage

    Not phased

    Ages

    18 and older

    Site

    American Heart Association, Dallas, Texas

    Run by

    American Heart Association

    See if you can join NCT07075341 on ClinicalTrials.gov

18. eMOTION: Examining Affective Mechanisms in Physical Activity Engagement

    This early-phase trial will test intervention strategies to influence affective mechanisms underlying physical activity and determine whether changes in those mechanisms result in change in physical activity behavior among inactive adults who are overweight or obese.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Southern California, Los Angeles, California

    Run by

    University of Southern California

    See if you can join NCT06570642 on ClinicalTrials.gov

19. The Acute T-Rex (Timing of Resistance Exercise) Study

    The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laborator…

    Stage

    Not phased

    Ages

    50 to 74

    Site

    University of Utah HPER E Buildling, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT06366399 on ClinicalTrials.gov