Osteoarthritis Clinical Trials

26 studies are recruiting for osteoarthritis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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By city

Chicago, Illinois 3 Gainesville, Florida 3 Grove City, Pennsylvania 3 Tampa, Florida 3

Studies now recruiting

  1. ARVIS TKA vs Conventional TKA

    This study is a pilot analysis of a novel augmented reality guidance platform, the augmented reality visualization and information system (ARVIS, Insight Medical), with aims to demonstrate accuracy of bone resection and implant alignment during kinematic alignment total knee arthroplasty.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Florida Orthopaedic Institute, Tampa, Florida
    Run by
    Foundation for Orthopaedic Research and Education

    See if you can join NCT06663384 on ClinicalTrials.gov

  2. A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

    The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Arizona Research Center, Phoenix, Arizona
    Locations
    88 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT07153471 on ClinicalTrials.gov

  3. Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

    The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last ab…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    AMR Clinical, Mobile, Alabama
    Locations
    152 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT07353931 on ClinicalTrials.gov

  4. Clinical Orthopaedic Data Bank (Acute and Chronic)

    Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF) and Shands Orthopaedics and Sports Medicine Institute.

    Stage
    Not phased
    Ages
    Any age
    Site
    UF&Shands Orthopaedics and Sports Medicine Institute, Gainesville, Florida
    Run by
    University of Florida

    See if you can join NCT00411060 on ClinicalTrials.gov

  5. Ketorolac in Upper Extremity Tendinopathy and Arthropathy

    Osteoarthritis (OA) and inflammatory conditions of the tendons and joints of the shoulder, elbow, hand, and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes co…

    Stage
    Phase 4
    Ages
    18 and older
    Site
    Emory Saint Joseph's Hospital, Atlanta, Georgia
    Locations
    4 in total
    Run by
    Emory University

    See if you can join NCT05292339 on ClinicalTrials.gov

  6. Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy

    This single-site, single-arm study evaluates the feasibility, safety, tolerability, and efficacy of trans-arterial embolization (TAE) using Embozene microparticles for treating facetogenic pain due to facet arthropathy (osteoarthritis of the facet joints) in the lumbar spine.

    Stage
    Not phased
    Ages
    18 to 85
    Site
    North Shore University Hospital, Manhasset, New York
    Run by
    Northwell Health

    See if you can join NCT06965452 on ClinicalTrials.gov

  7. EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

    The purpose of this research is to gather clinical and radiographic (X-ray) information about EMPHASYS™ acetabular shell (also called a hip 'cup') placement in total hip replacement surgery using a non-invasive surgical navigation system called VELYS™ hip navigation system with CUPTIMIZE™ Advanced …

    Stage
    Not phased
    Ages
    21 and older
    Site
    Florida Orthopaedic Institute, Gainesville, Florida
    Locations
    2 in total
    Run by
    DePuy Orthopaedics

    See if you can join NCT06631638 on ClinicalTrials.gov

  8. A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System

    The goal of this study is to demonstrate the safety and performance of the Incompass™ Total Ankle System after surgery over the standard follow-up period. The study will measure improvements in patient-reported information related to quality of life and pain following surgery. In order to do this, …

    Stage
    Not phased
    Ages
    21 and older
    Site
    Illinois Bone and Joint Institute, Morton Grove, Illinois
    Locations
    5 in total
    Run by
    Stryker Trauma and Extremities

    See if you can join NCT07118501 on ClinicalTrials.gov

  9. Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department

    The purpose of this clinical trial is to compare the analgesic effects (relief of pain) of glucocorticoids (steroids) and pain medication versus pain medication alone in adult patients presenting to the emergency department with joint pain due to osteoarthritis. Steroids are drugs that can reduce i…

    Stage
    Phase 4
    Ages
    18 and older
    Site
    WellSpan York Hospital, York, Pennsylvania
    Run by
    WellSpan Health

    See if you can join NCT06603662 on ClinicalTrials.gov

  10. Genicular Artery Embolization for Knee Osteoarthritis

    Patients will be asked to take part in this research study because they have mild-to-moderate knee osteoarthritis (OA) and were referred clinically for a procedure called Genicular Artery Embolization (GAE). Osteoarthritis is the most common form of arthritis. It occurs when the protective cartilag…

    Stage
    Not phased
    Ages
    40 to 80
    Site
    Northwestern University, Chicago, Illinois
    Run by
    Northwestern University

    See if you can join NCT07537153 on ClinicalTrials.gov

  11. The PROACTIVE Study for Black Elders

    Chronic musculoskeletal pain (CMP), while a leading cause of physical disablement, is a neglected national health disparity issue in Black communities. The purpose of this study is to test a novel culturally congruent pain self-management intervention. A total of 120 persons aged 50-92, self-identi…

    Stage
    Not phased
    Ages
    50 to 92
    Site
    University of Florida, Gainesville, Florida
    Run by
    University of Florida

    See if you can join NCT06512727 on ClinicalTrials.gov

  12. A Prospective Total Joint Surgery Registry to Monitor Short- and Long-Term Clinical Outcomes

    The investigators propose a prospective longitudinal registry study to collect and compare preoperative and postoperative information from patients who undergo total joint arthroplasty (TJA). Outcomes will be assessed with common, routinely available patient-reported outcomes measures (PROM's) such…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Spokane Joint Replacement Center, Spokane, Washington
    Run by
    Spokane Joint Replacement Center

    See if you can join NCT06687109 on ClinicalTrials.gov

  13. Dose Response of Exercise for Arthritis Management

    The purpose of the study is to see examine the effects of 3 different levels of physical activity (45 minutes/week, 90 minutes/week, or 150 minutes/week) on arthritis symptoms.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of South Carolina, Columbia, South Carolina
    Run by
    University of South Carolina

    See if you can join NCT06880653 on ClinicalTrials.gov

  14. Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

    Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health. Towards this goal, extensive efforts are ongoing to develop quantitativ…

    Stage
    Not phased
    Ages
    18 to 50
    Site
    Cleveland Clinic Foundation, Cleveland, Ohio
    Run by
    Xiaojuan Li

    See if you can join NCT04536103 on ClinicalTrials.gov

  15. A Mobile Intervention to Reduce Pain and Improve Health-III

    The experience of chronic pain powerfully and negatively affects quality of life and functional independence in aging. Unfortunately, while as many as three in four older adults experience chronic pain, few have access to effective non-pharmacological pain management strategies. Participating in re…

    Stage
    Phase 2
    Ages
    65 and older
    Site
    Wake Forest University, Winston-Salem, North Carolina
    Run by
    Wake Forest University

    See if you can join NCT06623669 on ClinicalTrials.gov

  16. Activating SilverSneakers Benefits for Seniors With Osteoarthritis

    The aim of this pragmatic randomized controlled trial is to test the effects of a brief proactive care intervention involving mailed material and two phone calls on: (1) increasing participation in SilverSneakers exercise programs among older adults with osteoarthritis; (2) improving physical, soci…

    Stage
    Not phased
    Ages
    65 and older
    Site
    Penn State College of Medicine, Hershey, Pennsylvania
    Run by
    Milton S. Hershey Medical Center

    See if you can join NCT06782347 on ClinicalTrials.gov

  17. Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain

    The primary objective of this study is to study how low-impact group exercise classes affect pain scores in patients with knee, hip, and ankle pain when paired with concurrent standard of care dietitian and behavioral health consults.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Missouri Orthopaedic Institute, Columbia, Missouri
    Run by
    University of Missouri-Columbia

    See if you can join NCT03711773 on ClinicalTrials.gov

  18. The Beat Pain Better Trial

    The Beat Pain Better study examines strategies to increase the reach of evidence-based interventions for persons with osteoarthritis (OA) in communities that experience disparities. The study is a hybrid type 3 effectiveness-imple-mentation trial using sequential, multiple assignment, ran¬domi¬zati…

    Stage
    Phase 3
    Ages
    45 and older
    Site
    Association for Utah Community Health, Salt Lake City, Utah
    Locations
    3 in total
    Run by
    University of Utah

    See if you can join NCT06932887 on ClinicalTrials.gov

  19. Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Shoulder

    This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the shoulder. Follow-up will consist of a larger sample including 4,000 patients.

    Stage
    Phase 2
    Ages
    18 to 90
    Site
    VivaTech International, Inc., Grove City, Pennsylvania
    Run by
    VivaTech International, Inc.

    See if you can join NCT02844738 on ClinicalTrials.gov

  20. Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee

    This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the knee. Follow-up will consist of a larger sample including 4,000 patients.

    Stage
    Phase 2
    Ages
    18 to 90
    Site
    VivaTech International, Inc., Grove City, Pennsylvania
    Run by
    VivaTech International, Inc.

    See if you can join NCT02844751 on ClinicalTrials.gov

  21. Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Hip

    This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the hip. Follow-up will consist of a larger sample including 4,000 patients.

    Stage
    Phase 2
    Ages
    18 to 90
    Site
    VivaTech International, Inc., Grove City, Pennsylvania
    Run by
    VivaTech International, Inc.

    See if you can join NCT02844764 on ClinicalTrials.gov

  22. An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint

    This study is being conducted to evaluate the safety and tolerability of OA-SYS in patients with moderate to severe OA of the knee joint.

    Stage
    Phase 2
    Ages
    35 to 75
    Site
    Orthopedic & Sports Medicine Institute of Las Vegas, Las Vegas, Nevada
    Run by
    Ageless Biotech, Inc.

    See if you can join NCT06485843 on ClinicalTrials.gov

  23. Oral Nutritional Optimization in Total Joint Arthroplasty

    The purpose of this study is to determine the effect on hematological markers of nutritional intervention on nutritionally deficient patients following total joint replacement surgery.

    Stage
    Not phased
    Ages
    55 and older
    Site
    NYU Langone Health, New York, New York
    Locations
    2 in total
    Run by
    NYU Langone Health

    See if you can join NCT04210284 on ClinicalTrials.gov

  24. Sustained Acoustic Medicine for Osteoarthritis Pain

    The purpose of this study is to compare Sustained Acoustic Medicine treatment to topical pain relief gel for the symptomatic management of osteoarthritis. The study will measure pain and function scores for patients undergoing treatment.

    Stage
    Phase 1
    Ages
    35 to 85
    Site
    James A Haley Veterans Hospital, Tampa, Florida
    Run by
    ZetrOZ, Inc.

    See if you can join NCT05254574 on ClinicalTrials.gov

  25. Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis

    Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to relieve OA and its associated issues. Traditional surgical interventio…

    Stage
    Not phased
    Ages
    18 to 90
    Site
    Hemwall Center for Orthopedic Regenerative Medicine, Valencia, California
    Locations
    2 in total
    Run by
    Healeon Medical Inc

    See if you can join NCT04238143 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.