Osteoarthritis, Knee Clinical Trials

26 studies are recruiting for osteoarthritis, knee in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

New York, New York 4 Omaha, Nebraska 4 Bellevue, Washington 3 Birmingham, Alabama 3 Boston, Massachusetts 3 Chapel Hill, North Carolina 3 Chicago, Illinois 3 Columbus, Ohio 3 Palm Springs, California 3 San Diego, California 3 Springfield, Missouri 3

Studies now recruiting

  1. A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

    The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for c…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Central Research Associates, Birmingham, Alabama
    Locations
    64 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT05986292 on ClinicalTrials.gov

  2. Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee

    This clinical trial is being done to better understand how daily treatment with Tetrahydrocannabinol (THC), Cannabidiol (CBD), or the combination of CBD plus THC affects knee osteoarthritis pain and other related symptoms. Consented participants will have a screening period and visit (up to 30 days…

    Stage
    Phase 2
    Ages
    21 to 75
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    Steven E Harte, PhD

    See if you can join NCT04992624 on ClinicalTrials.gov

  3. A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

    The main purpose of this study is to test the safety and efficacy of study drug for the treatment of knee pain due to osteoarthritis (OA). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chroni…

    Stage
    Phase 2
    Ages
    40 and older
    Site
    Central Research Associates, Birmingham, Alabama
    Locations
    37 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT07641517 on ClinicalTrials.gov

  4. Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

    The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis. A secondary aim is to determine whether patients experience any more measurable side effects than those receiving sham treatments.

    Stage
    Not phased
    Ages
    50 to 100
    Site
    Mayo Clinic, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT06887829 on ClinicalTrials.gov

  5. AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

    This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the tr…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Neighborhood Healthcare, Escondido, California
    Locations
    81 in total
    Run by
    Novo Nordisk A/S

    See if you can join NCT07509307 on ClinicalTrials.gov

  6. The Osteoarthritis Prevention Study

    The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a d…

    Stage
    Not phased
    Ages
    50 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    4 in total
    Run by
    Wake Forest University

    See if you can join NCT05946044 on ClinicalTrials.gov

  7. MOTION Clinical Trial

    Prospective, multicenter, two-arm, 2:1 randomized controlled trial (RCT) comparing the benefits in subjects with medial knee osteoarthritis who are treated with either the MISHA Knee System or with non-surgical treatment. This is the first randomized head-to-head study comparing outcomes from subje…

    Stage
    Not phased
    Ages
    Any age
    Site
    Scripps Clinic Jefferson, Oceanside, California
    Locations
    9 in total
    Run by
    Moximed

    See if you can join NCT06843980 on ClinicalTrials.gov

  8. Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis

    This study investigates how well individuals with knee osteoarthritis can learn to alter their calf muscle activation using haptic biofeedback while walking and evaluates how these changes affect knee loading. Prior research has utilized musculoskeletal simulations to determine that reducing the ac…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Stanford Human Performance Lab, Stanford, California
    Run by
    Stanford University

    See if you can join NCT06208631 on ClinicalTrials.gov

  9. Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes

    A Phase 2 Randomized Study to Evaluate the Effects of triamcinolone acetonide extended-release (TA-ER; Zilretta) vs. triamcinolone acetonide immediate-release (TA-IR; Kenalog) on Blood Glucose Levels in Diabetic Subjects with Knee Osteoarthritis. Subjects should have Type 2 Diabetes Mellitus (T2DM)…

    Stage
    Phase 4
    Ages
    40 and older
    Site
    University of Kansas Medical Center, Kansas City, Kansas
    Run by
    University of Kansas Medical Center

    See if you can join NCT06478186 on ClinicalTrials.gov

  10. Mobile Technology to Measure Knee Health in Osteoarthritis

    Veterans face a high prevalence of knee osteoarthritis (OA), but current diagnostic methods often miss early stages when interventions are more effective. This project will evaluate smartphone-based motion capture via OpenCap to measure joint mechanics in knee OA patients during functional activiti…

    Stage
    Not phased
    Ages
    30 and older
    Site
    VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California
    Run by
    VA Office of Research and Development

    See if you can join NCT07580222 on ClinicalTrials.gov

  11. Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty

    The goal of this study is to better understand how daily treatment with cannabidiol (CBD) affects the need for opioid pain medication, as well as pain, inflammation and other related symptoms, after knee replacement surgery. The information collected in this study is necessary to help understand wh…

    Stage
    Phase 2
    Ages
    18 to 80
    Site
    University of Michigan, Ann Arbor, Michigan
    Locations
    2 in total
    Run by
    Chad Brummett

    See if you can join NCT06234631 on ClinicalTrials.gov

  12. Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain

    The primary objective of this study is to study how low-impact group exercise classes affect pain scores in patients with knee, hip, and ankle pain when paired with concurrent standard of care dietitian and behavioral health consults.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Missouri Orthopaedic Institute, Columbia, Missouri
    Run by
    University of Missouri-Columbia

    See if you can join NCT03711773 on ClinicalTrials.gov

  13. Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans

    The aims are to determine whether 1) an incentive based on behaviorally-enhanced gamification and social incentives and 2) health coaching can promote adherence to exercise and physical activity after physical therapy for osteoarthritis of the knee (KOA). The research design is a randomized clinica…

    Stage
    Phase 3
    Ages
    40 to 90
    Site
    Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia, Pennsylvania
    Locations
    5 in total
    Run by
    VA Office of Research and Development

    See if you can join NCT06488144 on ClinicalTrials.gov

  14. Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

    This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent antioxidant intervention (glycine + N-acetyl-cysteine(GlyNAC)) reduces oxid…

    Stage
    Phase 4
    Ages
    50 and older
    Site
    Vanderbilt University Medical Center, Nashville, Tennessee
    Run by
    Vanderbilt University Medical Center

    See if you can join NCT06083480 on ClinicalTrials.gov

  15. CBD for Knee Osteoarthritis

    Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population. Many physically active Americans have reported pain-relieving effects of cannabidiol (CBD) that can reduce or eliminate use of nonsteroid…

    Stage
    Phase 1
    Ages
    40 to 75
    Site
    Sports Medicine Research Laboratory, Gainesville, Florida
    Run by
    University of Florida

    See if you can join NCT06414473 on ClinicalTrials.gov

  16. Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee

    In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee. Veterans with as history of chronic shoulder, hip or knee pain and mild/moderate joint degenerative changes will be potential s…

    Stage
    Not phased
    Ages
    25 to 80
    Site
    VA Palo Alto Healthcare System, Palo Alto, California
    Run by
    Palo Alto Veterans Institute for Research

    See if you can join NCT05700682 on ClinicalTrials.gov

  17. Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

    The goal of this randomized clinical trial is to evaluate the effects of vibration on factors related to the risks of post-traumatic knee osteoarthritis and secondary anterior cruciate ligament (ACL) injury in individuals who have undergone anterior cruciate ligament reconstruction surgery (ACLR). …

    Stage
    Not phased
    Ages
    16 to 35
    Site
    MOTION Science Institute, Chapel Hill, North Carolina
    Locations
    2 in total
    Run by
    University of North Carolina, Chapel Hill

    See if you can join NCT04875052 on ClinicalTrials.gov

  18. Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement

    Osteoarthritis (OA), the most common type of arthritis, affects more than 32.5 million adults in the United States. It is also among the most expensive condition to treat when joint replacement surgery is required. Although biomechanics plays an important role in OA disease, the non-surgical treatm…

    Stage
    Not phased
    Ages
    45 to 80
    Site
    Geisinger Medical Center, Danville, Pennsylvania
    Locations
    2 in total
    Run by
    Geisinger Clinic

    See if you can join NCT04732962 on ClinicalTrials.gov

  19. Preventing Injured Knees From osteoArthritis: Severity Outcomes

    This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction. This research study will compare metformin to placebo. The placebo tablet looks exactly like metformin…

    Stage
    Phase 2
    Ages
    18 to 45
    Site
    Emory University, Atlanta, Georgia
    Locations
    9 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT06096259 on ClinicalTrials.gov

  20. Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty

    Patients with degenerative joint disease can effectively be treated with a primary total knee replacement to reduce pain and improve function in their daily lives. Theoretically, achievement of normal knee motion using a medial pivot design in total knee replacements can be recreated in comparison …

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Sinai Hospital of Baltimore, Baltimore, Maryland
    Run by
    LifeBridge Health

    See if you can join NCT04814082 on ClinicalTrials.gov

  21. Effect of Anti-inflammatory Diet in Osteoarthritis

    In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet impr…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of California, San Diego, California
    Run by
    University of California, San Diego

    See if you can join NCT06080347 on ClinicalTrials.gov

  22. Embo Registry; National Registry for Artery Embolization

    Embo Registry is a retrospective and prospective observational study to evaluate real world effectiveness and the use of Artery Embolization as a treatment for chronic pain with patients that have osteoarthritis and localized pain to provide symptomatic relief. This study is to determine the effica…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Vascular Solutions of North Carolina, Cary, North Carolina
    Locations
    2 in total
    Run by
    Vascular Solutions of North Carolina

    See if you can join NCT06477965 on ClinicalTrials.gov

  23. Non-invasive Evaluation of Upper and Lower Body Function With Showmotion

    It is very important to understand joint and body kinematics and muscles activity in clinical settings, which is relevant to identify issues related to the spine, the upper and lower limbs due to injury. In this study, the investigators will use an innovative platform, Showmotion to establish basel…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    University of Colorado Anschutz Medical Campus, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT04137835 on ClinicalTrials.gov

  24. Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Knee Osteoarthritis

    This is a Pilot Study which is randomized, prospective, open label, dose escalation, non-controlled evaluating safety and feasibility of intra-articular Wharton's Jelly (WJ) allograft will be evaluated in patients suffering with knee osteoarthritis. The participants will be randomized to one of thr…

    Stage
    EARLY_Phase 1
    Ages
    30 and older
    Site
    R3 Anti Aging Scottsdale, Scottsdale, Arizona
    Locations
    5 in total
    Run by
    R3 Medical Research

    See if you can join NCT06608134 on ClinicalTrials.gov

  25. Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis

    To study the effect of anti-inflammatory diet on clinical and biological outcomes in patients with knee osteoarthritis

    Stage
    Not phased
    Ages
    18 and older
    Site
    UCSD, La Jolla, California
    Run by
    University of California, San Diego

    See if you can join NCT05559463 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.