Obsessive-Compulsive Disorder Clinical Trials

32 studies are recruiting for obsessive-compulsive disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Stanford, California 5 Boston, Massachusetts 4 Belmont, Massachusetts 3 San Francisco, California 3

Studies now recruiting

  1. Developing Brain, Impulsivity and Compulsivity

    Background: Impulsivity is acting 'without thinking.' Compulsivity is being overly inflexible. People vary in how impulsive or compulsive they are. Extreme versions of these behaviors play a role in mental disorders. Researchers want to study changes in the brain to learn more about these behaviors…

    Stage
    Not phased
    Ages
    6 to 80
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Mental Health (NIMH)

    See if you can join NCT04631042 on ClinicalTrials.gov

  2. Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation

    This is a pilot study to examine the tolerability, safety and early efficacy of two forms of transcranial magnetic stimulation (TMS) for treating adolescents with Obsessive Compulsive Disorder (OCD) who have experienced limited improvements with usual treatments for OCD in adolescents. The project'…

    Stage
    Not phased
    Ages
    13 to 17
    Site
    University of California, San Francisco, San Francisco, California
    Run by
    University of California, San Francisco

    See if you can join NCT07065669 on ClinicalTrials.gov

  3. Physiological Brain Atlas Development

    The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essentia…

    Stage
    Not phased
    Ages
    6 to 90
    Site
    Vanderbilt Univeristy, Nashville, Tennessee
    Run by
    Vanderbilt University Medical Center

    See if you can join NCT00575081 on ClinicalTrials.gov

  4. TMS + Exposure Therapy for Pediatric OCD

    The goal of this clinical trial is to compare different forms of transcranial magnetic stimulation (TMS) for improving the outcomes of Exposure with Response Prevention (ERP) in youth and young adults with Obsessive-Compulsive Disorder (OCD). Researchers will compare three groups: ERP with one of t…

    Stage
    Not phased
    Ages
    12 to 21
    Site
    University of Minnesota, Minneapolis, Minnesota
    Locations
    2 in total
    Run by
    Bradley Hospital

    See if you can join NCT05931913 on ClinicalTrials.gov

  5. Anxiety Skills Study

    The purposes of this study are: (1) to identify baseline predictors of relative success in cognitive, behavioral, and mindfulness-based treatments for anxiety, (2) explore who benefits from a brief, video-based skill training compared to receiving 4 sessions of therapy, and (3) to evaluate how dura…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Psychology Building at Ohio State University, Columbus, Ohio
    Run by
    Ohio State University

    See if you can join NCT07774481 on ClinicalTrials.gov

  6. Pilot Study of RR-HNK in OCD

    The purpose of this study is to understand how RR-HNK works in the brain to bring about a reduction in OCD symptoms.

    Stage
    Phase 1
    Ages
    18 to 65
    Site
    Stanford University School of Medicine, Palo Alto, California
    Run by
    Carolyn Rodriguez

    See if you can join NCT06575075 on ClinicalTrials.gov

  7. Neural Mechanisms of Response Inhibition Training for OCRD

    The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. T…

    Stage
    Not phased
    Ages
    18 to 60
    Site
    UWM Anxiety Disorders Laboratory, Milwaukee, Wisconsin
    Run by
    University of Wisconsin, Milwaukee

    See if you can join NCT05377125 on ClinicalTrials.gov

  8. CBT Augmentation to Promote Medication Discontinuation in Pediatric OCD

    The purpose of this study is to examine whether youth with OCD who benefit from CBT augmentation to SRI can discontinue their medication without relapse over 24 weeks.

    Stage
    Not phased
    Ages
    7 to 17
    Site
    Baylor College of Medicine, Houston, Texas
    Run by
    Baylor College of Medicine

    See if you can join NCT05609916 on ClinicalTrials.gov

  9. SONATA LIFU for OCD

    The study tests ATTN201, an investigational non-invasive headband that delivers low-intensity focused ultrasound (LIFU) to the subthalamic nucleus (STN) as a treatment for obsessive-compulsive disorder (OCD). It's a randomized, double-blind, 1:1 (active: sham) study with 40 total participants spann…

    Stage
    Phase 2
    Ages
    22 to 80
    Site
    Attune Neurosciences, San Francisco, California
    Run by
    University of Pennsylvania

    See if you can join NCT07728994 on ClinicalTrials.gov

  10. Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.

    The study tries to improve our treatments for people who have obsessive-compulsive disorder (OCD) by testing psilocybin, a mind altering drug that changes activity in brain areas involved in OCD. 30 patients with moderate or more severe OCD who are not taking mind altering medications or street dru…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    The Clinical and Translational Sciences Research Center, Tucson, Arizona
    Run by
    Francisco A Moreno

    See if you can join NCT07347405 on ClinicalTrials.gov

  11. Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

    Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    Acacia Clinics, Sunnyvale, California
    Locations
    2 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT06376734 on ClinicalTrials.gov

  12. Mechanisms of Exposure Therapy for OCD

    Exposure therapy is the most effective treatment available for obsessive compulsive disorder, yet up to 50% of patients do not recover because the mechanisms underlying successful response are poorly understood, leading to significant variability in how clinicians conduct exposure therapy. The main…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Center for Understanding and Treating Anxiety, San Diego, California
    Locations
    2 in total
    Run by
    Mclean Hospital

    See if you can join NCT06173752 on ClinicalTrials.gov

  13. CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy

    Anxiety-, obsessive-compulsive and trauma- and stressor-related disorders reflect a significant public health problem. This study is designed to evaluate the predictive power of a novel biomarker based on a CO2 challenge, thus addressing the central question "can this easy-to-administer assay aid c…

    Stage
    Not phased
    Ages
    18 to 70
    Site
    Boston University, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Jasper A. Smits

    See if you can join NCT05467683 on ClinicalTrials.gov

  14. Project EMPOWER-OCD

    This research study aims to adapt and evaluate the acceptability and effectiveness of Project EMPOWER-OCD for socioeconomically diverse caregivers of patients with OCD. Designed to reduce obstacles (e.g. months long time commitment, high cost, transportation) to treatment that caregivers may be par…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Boston University, Boston, Massachusetts
    Run by
    Boston University Charles River Campus

    See if you can join NCT07158801 on ClinicalTrials.gov

  15. Study of Dextromethorphan in OCD and Related Disorders

    The purpose of the study is to assess the tolerability and efficacy of dextromethorphan in combination with fluoxetine for symptom relief in OCD and related disorders.

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    Stanford University, Stanford, California
    Run by
    Stanford University

    See if you can join NCT04899687 on ClinicalTrials.gov

  16. Interpretation Bias as a Mechanism of Treatment Response in OCD

    This study will conduct a randomized controlled trial of Cognitive Bias Modification for Interpretation (CBM-I) as an augmentation to treatment as usual for obsessive compulsive disorder (OCD). CBM-I is a digital intervention designed to directly manipulate interpretation bias through repeated prac…

    Stage
    Not phased
    Ages
    18 and older
    Site
    McLean Hospital, Belmont, Massachusetts
    Run by
    Mclean Hospital

    See if you can join NCT05224414 on ClinicalTrials.gov

  17. SEEG-Guided DBS for OCD

    This is a multi-site, double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open-label stimulation for an additional 6 months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain mapping and optimization of st…

    Stage
    Not phased
    Ages
    22 to 75
    Site
    University of Pennsylvania, Philadelphia, Pennsylvania
    Locations
    2 in total
    Run by
    Casey H. Halpern, M.D.

    See if you can join NCT05623306 on ClinicalTrials.gov

  18. A Precision Medicine Approach to Target Engagement for Emotion Regulation

    The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, the investigators will prospectively assign an independent sample of…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Ohio State University, Columbus, Ohio
    Run by
    Matthew Southward, PhD

    See if you can join NCT05651295 on ClinicalTrials.gov

  19. Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder

    The goal of this clinical trial is to learn if deep brain stimulation (DBS) works to treat refractory obsessive-compulsive disorder (OCD). The main questions it aims to answer are: * Assess the effects of the anteromedial sub-thalamic nucleus (amSTN)stimulation on obsessive/compulsive symptoms. * M…

    Stage
    Not phased
    Ages
    22 to 75
    Site
    University of Texas Southwestern Medical Center, Dallas, Texas
    Run by
    Nader Pouratian

    See if you can join NCT06660225 on ClinicalTrials.gov

  20. Cortical Stimulation to Treat Obsessive Compulsive Disorder

    The purpose of this study is to identify abnormal brain signals associated with Obsessive Compulsive Disorder (OCD) and psychiatric symptoms and to investigate novel therapeutic stimulation sites. While treating OCD with standard deep brain stimulation (DBS) therapy, the investigators will also mon…

    Stage
    Not phased
    Ages
    22 to 75
    Site
    UCSF Nancy Friend Pritzker Psychiatry Building, San Francisco, California
    Run by
    Andrew Moses Lee, MD, PhD

    See if you can join NCT04958096 on ClinicalTrials.gov

  21. Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)

    The purpose of this study is to understand how ketamine works in the brain to bring about a reduction in OCD symptoms.

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    Department of Psychiatry & Behavioral Sciences, Stanford, California
    Run by
    Stanford University

    See if you can join NCT05940324 on ClinicalTrials.gov

  22. Retrospective Analyses of TrakStar Database

    In this study, real-world data will be used to better understand the effects patient characteristics, symptoms and TMS protocol parameters have on clinical outcomes with NeuroStar TMS.

    Stage
    Not phased
    Ages
    5 to 120
    Site
    Neuronetics, Malvern, Pennsylvania
    Run by
    Neuronetics

    See if you can join NCT06917339 on ClinicalTrials.gov

  23. A Multicenter Pediatric Deep Brain Stimulation Registry

    There is limited data on outcomes for children who have undergone deep brain stimulation (DBS) for movement disorders, and individual centers performing this surgery often lack sufficient cases to power research studies adequately. This study aims to develop a multicenter pediatric DBS registry tha…

    Stage
    Not phased
    Ages
    0 to 18
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT06585618 on ClinicalTrials.gov

  24. MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)

    The study assesses the safety and preliminary effectiveness of MDMA-assisted cognitive behavioral therapy in participants diagnosed with obsessive-compulsive disorder (OCD).

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Stanford University Medical Center, Palo Alto, California
    Run by
    Carolyn Rodriguez

    See if you can join NCT05783817 on ClinicalTrials.gov

  25. Neurostimulation Versus Therapy for Problems With Emotions

    The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC). The secondary …

    Stage
    Not phased
    Ages
    18 to 55
    Site
    Duke University Medical Center, Durham, North Carolina
    Run by
    Duke University

    See if you can join NCT05712057 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.