Obesity & Overweight Clinical Trials

37 studies are recruiting for obesity & overweight in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Feasibility and Acceptability of a Pediatric Referral to Summer Day Camps to Treat Obesity in Children From Low-Income Households

   Children from low-income households have a 25-30% higher prevalence of OWOB compared to their higher-income peers. The lack of feasible and effective treatments to address obesity in children with OWOB and from low-income household's points to a real need for prioritization and urgency. The U.S. Pr…

   Stage

   Not phased

   Ages

   5 to 11

   Site

   University of Central Florida, Orlando, Florida

   Run by

   University of Central Florida

   See if you can join NCT07464015 on ClinicalTrials.gov

2. The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression

   This research study examines how a medication called lumateperone may affect mood symptoms, and inflammation in adults with bipolar disorder over approximately 6 weeks. An MRI scan to calculate biological age of the brain will also be obtained at the start of the study.

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07699445 on ClinicalTrials.gov

3. Effects of Dietary Supplements on Muscle Mass and Function While Using GLP-1 Medication

   This pilot study will examine whether daily protein supplementation with or without a mixture of culinary spices can help preserve muscle mass and function in adults who are using GLP-1 medications for weight management. The study will include 75 adults who recently started a GLP-1 medication and a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UCLA Center for Human Nutrition, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT07806838 on ClinicalTrials.gov

4. Alpelisib Challenge Test (ACT)

   The goal of this study is to test a potentially easier method for measuring how much insulin a person is capable of producing than the current gold-standard method, the "hyperglycemic clamp." Participants will come in for a two-day (overnight) visit in which they will first undergo a "hyperglycemic…

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT07778524 on ClinicalTrials.gov

5. BRIDGE & Friends Trial

   Aim 1. Conduct a 6-month (24-session) RCT comparing MedDiet-WL to MedDiet-SN among 268 older adults with obesity (50-79 years, BMI = 30-50 kg/m²). We hypothesize that 1) Participants in MedDiet-SN will show improvements in bodyweight/BMI and body fat compared to MedDiet-WL at post-intervention (6-m…

   Stage

   Not phased

   Ages

   50 to 79

   Site

   University of Illinois Chicago, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT07798557 on ClinicalTrials.gov

6. Redefining Evaluation of Adiposity and Leanness: Broadening Objective Diagnostics for Obesity

   The purpose of this study is to evaluate body composition across a variety of medical, professional, and commercial devices, including: bioelectrical impedance analysis (BIA) devices, 3-dimensional optical imaging (3DO), manual anthropometry measurements, dual-energy X-ray absorptiometry (DXA), mag…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Exponent Phoenix, Phoenix, Arizona

   Locations

   3 in total

   Run by

   Foundation for the National Institutes of Health

   See if you can join NCT07776678 on ClinicalTrials.gov

7. Comparing the Effects of Front-of-Package Labeling Schemes in Indonesia

   The goal of this study is to examine what type of front-of-package label (FOPL) would be most effective at discouraging consumption of products high in nutrients of concern in Indonesia. The main questions this experiment aims to answer are: 1. Would nutrient warning labels be more effective at dis…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Carolina Population Center, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT07526584 on ClinicalTrials.gov

8. Prebiotic Inulin for Late-Reproductive Individuals

   This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or obesity. The primary questions this study seeks to answer are: 1. Does 2 weeks of inulin supplementation alter the gut and vaginal estrobolome compared with placebo? 2. Does 2 wee…

   Stage

   Not phased

   Ages

   40 to 55

   Site

   Milken Institute School of Public Health, Washington D.C., District of Columbia

   Run by

   George Washington University

   See if you can join NCT07724522 on ClinicalTrials.gov

9. Improving Cervical Cancer Prevention Among Women Living With Chronic Conditions.

   Our overarching goal is to adapt and test the PINPOINT intervention -PatIent Navigation for the Prevention of CervIcal CaNcer inTervention. We will test the PINPOINT intervention among patients with high-risk profiles for cervical cancer who do not meet the recommended screening for cervical cancer.

   Stage

   Not phased

   Ages

   25 and older

   Site

   UF Health Internal Medicine, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT07351110 on ClinicalTrials.gov

10. Gestational Response, Outcomes, and Weight After GLP-1 Use

    The goal of this observational study is to learn if using GLP-1RA medications for weight loss before pregnancy influences gestational weight gain and pregnancy outcomes. The main aims of the study are to: * Compare gestational weight gain between women with preconception GLP-1RA exposure and those …

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT07743567 on ClinicalTrials.gov

11. Tirzepatide Impact Assessment Study

    This study examines how two different weight-loss strategies affect heart and metabolic health, as well as changes at the molecular level in the body. One group includes adults who are starting a GLP-1 receptor agonist medication (i.e., semaglutide or tirzepatide) prescribed by their own doctor for…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Nutrition Metabolic Health Initiative (NMHI), Lubbock, Texas

    Run by

    Texas Tech University

    See if you can join NCT07740291 on ClinicalTrials.gov

12. Fast In-Bed Tracking (FIT) System Lifestyle Intervention is a Clinical Trial of a Bed Scale Device. Overweight Wheelchair Users Will Complete a Weight Loss Program, Half Get Scales at Baseline, Half at Month 6 Those Who Receive the Bed Scales at Baseline Are Expected to Have Increased Weight Loss

    This project will complete the final design and development steps to commercialize the Fast In-Bed Tracking (FIT) Platform, which is an e-Health and wellness Internet of Things (IoT) monitoring system that can be integrated into a user's bed and provide person-centered, real-world outcomes to suppo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pittsburgh, Bakery Square, Department of Rehabilitation Science and Technology, Pittsburgh, Pennsylvania

    Run by

    Jonathan Pearlman

    See if you can join NCT07141342 on ClinicalTrials.gov

13. A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity

    This study investigates the Topical-Lingual (T-L) delivery of semaglutide, a GLP-1 receptor agonist (GLP-1RA), via an oral liquid emulsion formulation as a Proof-of-Concept for the T-L delivery of metabolic hormones in general. GLP-1 is a gut-derived hormone that induces satiation through hypothala…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Clinical Research Institute of Minnesota, Minneapolis, Minnesota

    Run by

    Gila Therapeutics, Inc.

    See if you can join NCT07728383 on ClinicalTrials.gov

14. Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists

    This study examines how adults who take a GLP-1 receptor agonist medication (such as semaglutide [Ozempic, Wegovy, Rybelsus], liraglutide [Saxenda, Victoza], or tirzepatide [Mounjaro, Zepbound]) perform resistance (strength) training before and after starting their medication. GLP-1 medications are…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT07702461 on ClinicalTrials.gov

15. Family-Based Weight Wellness Treatment Through Food is Medicine and Group Medical Visits in Pediatric and Adult Primary Care

    The proposed project aims to implement and evaluate a novel, family-based lifestyle medicine intervention integrating group Shared Medical Appointments (SMAs) for parents and adolescents with a twelve-month medically tailored groceries (MTG) and six-month culinary medicine Food is Medicine program.…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Tufts Medical Center, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Tufts University

    See if you can join NCT07717658 on ClinicalTrials.gov

16. Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food

    This pilot study aims to explore the potential benefits of consuming Greek bottarga (grey mullet fish roe) in individuals with at least one metabolic abnormality (low HDL cholesterol, high LDL cholesterol, high triglycerides, obesity, or HbA1c ≥ 5.7%) or a diagnosis of diabetes. Before initiating t…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Cambridge Health Alliance, Sommerville, Massachusetts

    Run by

    Cambridge Health Alliance

    See if you can join NCT06988462 on ClinicalTrials.gov

17. Changes in Body Composition Including Muscle With Anti-Obesity Medications, Both With and Without Exercise

    The goal of this clinical trial is to learn whether adding either cardiovascular exercise or resistance exercise to pharmacotherapy treatment for obesity improves the retention of lean mass compared to pharmacotherapy alone in adults with overweight or obesity who are prescribed pharmacotherapy for…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT07698145 on ClinicalTrials.gov

18. FIM+DASH: Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control

    The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leve…

    Stage

    Phase 2

    Ages

    Any age

    Site

    Mile Square Health Center - South Shore, Chicago, Illinois

    Locations

    4 in total

    Run by

    University of Illinois at Chicago

    See if you can join NCT07332741 on ClinicalTrials.gov

19. A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Orally Administered TIX100 in Healthy Subjects

    Randomized, Placebo-controlled Study to determine the safety and tolerability of multiple oral doses of TIX100 administered daily for 28 days to otherwise healthy overweight/obese subjects.

    Stage

    Phase 1

    Ages

    18 to 70

    Site

    ProSciento, INC, Chula Vista, California

    Run by

    TIXiMED, Inc.

    See if you can join NCT07675590 on ClinicalTrials.gov

20. Optimizing Self-Monitoring Feedback Delivery for the Treatment of Overweight and Obesity

    The purpose of this research study is to learn how to best provide weekly feedback on individual progress toward intervention goals during a weight loss program.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Advocate Aurora Research Institute, Milwaukee, Wisconsin

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT07227051 on ClinicalTrials.gov

21. A Phase 2A Clinical Trial to Assess the Safety and Tolerability of ERX1000 in Men and Women for the Treatment of Obesity.

    The primary objective is to assess the safety and tolerability of oral dose ERX1000 in obese subjects.

    Stage

    Phase 2

    Ages

    18 to 60

    Site

    Monroe Biomedical Research, Louisville, Kentucky

    Locations

    3 in total

    Run by

    ERX Pharmaceuticals

    See if you can join NCT07570758 on ClinicalTrials.gov

22. A Study to Evaluate the Safety and Tolerability of Different Doses of CX11 Tablets

    A multi-center, randomized, placebo-controlled, double-blinded (within cohorts), Sponsor-unblinded, Phase 1b study to explore the safety, pharmacokinetics, and pharmacodynamics of CX11 tablets in participants with obesity or overweight with weight-related comorbidities.

    Stage

    Phase 1

    Ages

    18 to 55

    Site

    Corxel Investigational site, Las Vegas, Nevada

    Locations

    2 in total

    Run by

    Corxel Pharmaceuticals

    See if you can join NCT07652047 on ClinicalTrials.gov

23. Efficacy of Center-based Childcare to Mitigate Unhealthy Weight Gain in Preschoolers From Low-income Households During the Summer

    Studies show that preschool-age children are especially vulnerable to accelerated weight gain during the summer, with those from low-income households (≤185% poverty level or Medicaid eligible - the target population for this study) exhibiting the greatest risk of unhealthy weight gain. Despite num…

    Stage

    Not phased

    Ages

    3 to 5

    Site

    University of South Carolina, Columbia, South Carolina

    Run by

    University of South Carolina

    See if you can join NCT07583459 on ClinicalTrials.gov

24. Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy

    This is a 17 - week study consisting of a one - week run - in period and a 16 - week intervention. The 16 - week pilot interventions aims to increase hydration in those beginning GLP - 1 RA therapy. Investigators aim to increase hydration to potentially decrease side effect severity, amount of side…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    State University of New York at Buffalo, South Campus, Buffalo, New York

    Run by

    State University of New York at Buffalo

    See if you can join NCT07641361 on ClinicalTrials.gov

25. Testing a Tailored Approach to Long-Term Weight Loss Success

    The purpose of this study is to develop and test an adaptive, individually tailored intervention to prevent weight regain in people who have intentionally lost weight. The main questions it aims to answer are: * Is an adaptive intervention with tailored re-engagement support feasible for individual…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT07577765 on ClinicalTrials.gov