Obesity and Overweight Clinical Trials

22 studies are recruiting for obesity and overweight in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder

   The purpose of this study is to assess the efficacy and safety of tirzepatide in adults with obesity and binge-eating disorder, comparing tirzepatide against placebo and lisdexamfetamine dimesylate. All participants will receive guided self-help cognitive behavioral therapy.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Johns Hopkins University, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT06847399 on ClinicalTrials.gov

2. Advancing Biopsychosocial Care Training Initiative

   This project will compare two training approaches for US Preventive Services Task Force recommended obesity care in Federally Qualified Health Centers (FQHC) across four aims. Aim 1 compares patient-level effectiveness [i.e., patient relative weight change and the proportion of patients who achieve…

   Stage

   Not phased

   Ages

   5 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT07049861 on ClinicalTrials.gov

3. Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity

   The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3). The main questions it aims to answer are: * How do the rate of weight loss, body mass index (BMI), body composit…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   University of Kentucky, Lexington, Kentucky

   Run by

   John Bauer

   See if you can join NCT06967389 on ClinicalTrials.gov

4. Time-restricted Eating and Healthy Eating in Patients With Metabolic Liver Disease or Cancer

   This is a feasibility study that will collect data to assess the potential effect of nutritional intervention. This prospective single-site trial will enroll adult patients with liver diseases such as metabolic-dysfunction associated steatotic liver disease (MASLD), metabolic-dysfunction associated…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California San Diego, La Jolla, California

   Run by

   University of California, San Diego

   See if you can join NCT06824974 on ClinicalTrials.gov

5. Study of Patients Being Treated With Anti-obesity Medication

   The goal of this observational study is to learn about the real-world effects of selected obesity medications in adults undergoing medical weight management. The main outcomes of interest are changes in body composition, routine clinical markers, muscular performance, and nutritional intake over th…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Texas Tech University, Lubbock, Texas

   Run by

   Texas Tech University

   See if you can join NCT06790160 on ClinicalTrials.gov

6. Metabolic Health, Bones and Nuts During Weight Loss in Adults

   The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice but are not consumed frequently en…

   Stage

   Not phased

   Ages

   50 to 75

   Site

   Rutgers University - NJ Inst Food Nutrition & Health, New Brunswick, New Jersey

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT06949280 on ClinicalTrials.gov

7. Muscle and Movement With Anti-Obesity Medications

   The goal of this clinical trial is to learn about changes in body composition related to obesity medication use, and whether aerobic or resistance exercise training will impact these body composition changes. It will also provide information about whether aerobic or resistance exercise training has…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Kansas Medical Center, Kansas City, Kansas

   Run by

   University of Kansas Medical Center

   See if you can join NCT06645470 on ClinicalTrials.gov

8. Brain and Behavior Influences on Obesity Development From Infancy Through Childhood

   The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of fami…

   Stage

   Not phased

   Ages

   7 to 12

   Site

   Rhode Island Hospital, Providence, Rhode Island

   Locations

   4 in total

   Run by

   Johns Hopkins University

   See if you can join NCT06861868 on ClinicalTrials.gov

9. Effect of Watermelon on Gut and Cardiometabolic Health

   The goal of this clinical trial is to evaluate the effect of daily fresh watermelon consumption for 6-weeks on gut health, including microbiome diversity, gut barrier and immune function in young adults with overweight and obesity. The main questions it aims to answer are: 1. Will consuming fresh w…

   Stage

   Not phased

   Ages

   18 to 30

   Site

   Florida State University - Gut Biome Lab, Tallahassee, Florida

   Run by

   Florida State University

   See if you can join NCT06588218 on ClinicalTrials.gov

10. CHIME: Comparing Health Interventions for Maternal Equity

    The goal of this comparative effectiveness trial is to compare how three different approaches to overcome barriers to resources and provide nutrition and physical activity counseling improve maternal healthy weight in pregnancy and postpartum. The main question it aims to answer is which of the two…

    Stage

    Not phased

    Ages

    18 and older

    Site

    New York Presbyterian Queens, Flushing, New York

    Locations

    4 in total

    Run by

    Stanford University

    See if you can join NCT06724172 on ClinicalTrials.gov

11. A Mobile Intervention to Reduce Pain and Improve Health-III

    The experience of chronic pain powerfully and negatively affects quality of life and functional independence in aging. Unfortunately, while as many as three in four older adults experience chronic pain, few have access to effective non-pharmacological pain management strategies. Participating in re…

    Stage

    Phase 2

    Ages

    65 and older

    Site

    Wake Forest University, Winston-Salem, North Carolina

    Run by

    Wake Forest University

    See if you can join NCT06623669 on ClinicalTrials.gov

12. New Mechanisms of Obesity

    Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in y…

    Stage

    Not phased

    Ages

    15 to 22

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06768827 on ClinicalTrials.gov

13. Comparision of Aerobic Exercise to Aerobic Plus Yoga Exercise for Weight Loss in Adults With Overweight or Obesity.

    The goal of this clinical trial is to learn whether adding yoga exercise to a behavioral weight loss intervention improves weight loss in adults with overweight or obesity. It will also provide information about whether this approach to weight loss has additional benefits on other health and fitnes…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT06636773 on ClinicalTrials.gov

14. Metabotyping of Broccoli Microgreen in Obese Breast Cancer Survivors

    Obesity can pose significant challenges to maintaining long-term health in cancer survivors by increasing their risk of cancer coming back. Eating a healthy diet is an important way to help manage weight and improve overall health. Broccoli microgreens (BMG) are young broccoli plants packed with nu…

    Stage

    Not phased

    Ages

    Any age

    Site

    Breast Evaluation and Treatment Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT07032545 on ClinicalTrials.gov

15. BrainWeighve App Feasibility Study

    Childhood obesity within the United States has been a growing concern over the past number of years, and if not addressed, leads to detrimental health outcomes for youth as they move into adulthood. The literature suggests that over-eating, especially when framed in terms of food addiction, plays a…

    Stage

    Not phased

    Ages

    14 to 21

    Site

    UCLA Marion Davies Children's Center, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05530538 on ClinicalTrials.gov

16. Tirzepatide for Alcohol Use Disorder

    The objective of this Phase 2 randomized controlled trial is to evaluate the effects of weekly tirzepatide (vs. placebo) on alcohol consumption and cardiometabolic outcomes in adults with alcohol use disorder and overweight or obesity.

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    Keck School of Medicine, University of Southern California, Los Angeles, California

    Run by

    University of Southern California

    See if you can join NCT06994338 on ClinicalTrials.gov

17. Effects of Ultra Processed Food on Intestinal Energy Harvest

    Ultra processed food is everywhere in modern society and may contain multiple ingredients that affect the way participants' bodies store energy. Some studies have shown that eating a diet high in ultra processed foods leads to weight gain, but these foods have not been studied enough to understand …

    Stage

    Not phased

    Ages

    25 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT06853288 on ClinicalTrials.gov

18. Weight Management Intervention in College: A Pilot

    This pilot randomized controlled trial will examine a behavioral weight loss intervention that uses a "small change" approach fro emerging adult college students with overweight/obesity. The primary aim is to assess student acceptability and clinically-meaningful weight changes.

    Stage

    Not phased

    Ages

    18 to 29

    Site

    The Miriam Hospital, Providence, Rhode Island

    Run by

    The Miriam Hospital

    See if you can join NCT06994923 on ClinicalTrials.gov

19. FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)

    The goal of this clinical trial is to learn the best combination of family components that yields optimal weight loss among Black adults. The main question it aims to answer is: What combination of four family components in combination with a standard behavioral weight loss program yields optimal w…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06724406 on ClinicalTrials.gov

20. FRESH-EATS Project

    The goal of this randomized controlled trial is to determine the feasibility of the FRESH-EATS project in children ages 8-12 and their parents/caregivers residing in low-income, predominantly minority neighborhoods. The main questions it aims to answer are: Is the FRESH-EATS intervention feasible t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of South Florida, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT07053644 on ClinicalTrials.gov

21. MAINTAIN (Mucosal AblatIoN Therapy After INcretins)

    The purpose of this study is to assess the effect of gastric fundal mucosal ablation (GFMA) on weight trajectory following discontinuation of once-weekly semaglutide or tirzepatide in adults with obesity. In this study, GFMA will be performed on patients who have experienced > 10% weight loss with …

    Stage

    Not phased

    Ages

    21 to 65

    Site

    True You Weight Loss, Cary, North Carolina

    Locations

    2 in total

    Run by

    Dr. Christopher McGowan

    See if you can join NCT06734312 on ClinicalTrials.gov

22. REvision of VSG with Ablation of the Mucosa Procedure

    The purpose of this study is to evaluate the feasibility, safety, and tolerability of endoscopic selective gastric mucosal ablation (GMA) using argon plasma coagulation after sleeve gastrectomy. In this study, GMA will be performed on patients who have experienced weight regain following an initial…

    Stage

    Not phased

    Ages

    22 to 60

    Site

    True You Weight Loss, Cary, North Carolina

    Run by

    Dr. Christopher McGowan

    See if you can join NCT06671119 on ClinicalTrials.gov