Non-muscle Invasive Bladder Cancer Clinical Trials

15 studies are recruiting for non-muscle invasive bladder cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

   The purpose of this research is to determine whether bladder cancer monitoring can be improved by replacing some cystoscopy procedures with urine testing. Specifically, this study examines whether there are any differences in urinary symptoms, discomfort, number of invasive procedures, anxiety, com…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   West Haven VA Medical Center, West Haven, Connecticut

   Locations

   10 in total

   Run by

   White River Junction Veterans Affairs Medical Center

   See if you can join NCT05796375 on ClinicalTrials.gov

2. A Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancer

   This is a phase 2 open-label two cohort study of durvalumab plus monalizumab in patients with BCG-unresponsive or BCG-exposed CIS NMIBC. Arm A will enroll 43 participants who have cancer in situ (CIS) with or without high grade papillary urothelial cancer. Arm B will enroll 17 participants who do n…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of California San Francisco, San Francisco, California

   Locations

   5 in total

   Run by

   John Sfakianos

   See if you can join NCT06503614 on ClinicalTrials.gov

3. A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer

   The purpose of this study is to learn how a new medicine called PF-08052667 works when used by itself or together with another medicine called Bacillus Calmette Guerin (BCG), and/or a medicine called sasanlimab. This study is for adults who have a type of bladder cancer that hasn't spread into the …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   The Kirklin Clinic of UAB Hospital, Birmingham, Alabama

   Locations

   68 in total

   Run by

   Pfizer

   See if you can join NCT07206225 on ClinicalTrials.gov

4. Exploration of Novel AI-enabled Blue Light Enhanced Cystoscopy

   Blue light cystoscopy (BLC) is a diagnostic procedure in bladder cancer where the inside of the bladder is observed with a camera to detect bladder lesions. Unlike regular white light cystoscopy, blue light cystoscopy makes use of a drug that induces fluorescence under blue light preferentially in …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Moffitt Cancer Center, Tampa, Florida

   Locations

   8 in total

   Run by

   Photocure

   See if you can join NCT07144319 on ClinicalTrials.gov

5. A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)

   The goal of the study is to learn about the safety of Sacituzumab Tirumotecan and if people can tolerate it when given in the bladder and find the highest dose that people can take without having certain problems. Researchers will then choose a dose level of Sacituzumab Tirumotecan to use in future…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Michael G Oefelein Clinical Trials ( Site 0053), Bakersfield, California

   Locations

   13 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT06637423 on ClinicalTrials.gov

6. Artificial Intelligence Prediction Tool in Non-muscle Invasive Bladder Cancer (NMIBC)

   This is a multi-center study and the aim is to develop and validate an Artificial Intelligence (AI) -based histologic analysis tool to predict responsiveness to intravesical Bacillus Calmette-Guérin (BCG) and intravesical chemotherapy in intermediate and high-risk non-muscle invasive bladder cancer…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   University of Texas Southwestern Medical Center, Dallas, Texas

   Locations

   2 in total

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT05825950 on ClinicalTrials.gov

7. Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

   TARA-002-101-Ph2 is an open-label study to investigate the safety and efficacy of intravesical instillation of TARA-002 in adults 18 years of age or older with high-grade CIS NMIBC (± Ta/T1). The purpose of this Phase 2 study (TARA-002-101-Ph2) is to further assess the safety and efficacy of TARA-0…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Urology Centers of Alabama, Homewood, Alabama

   Locations

   78 in total

   Run by

   Protara Therapeutics

   See if you can join NCT05951179 on ClinicalTrials.gov

8. A Study Comparing Standard Treatments in People With Non-Muscle Invasive Bladder Cancer (NMIBC)

   The purpose of this study is to compare the effectiveness of different FDA-approved/NCCN-recommended drug treatments for NMIBC. In particular, the FDA-approved drug nadofaragene firadenovec will be compared to usual care with other NCCN-recommended standard treatments for NMIBC (gemcitabine with or…

   Stage

   Phase 3

   Ages

   21 and older

   Site

   Memorial Sloan Kettering Basking Ridge (Consent Only), Basking Ridge, New Jersey

   Locations

   9 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT06929286 on ClinicalTrials.gov

9. A Phase I Intravesical PPM Therapy for NMIBC

   This clinical trial is to determine the safety and effectiveness of an investigational bladder cancer drug named "PLZ4-coated paclitaxel-loaded nanoscale micelle (PPM)." PPM is tiny particles that contain the chemotherapy drug paclitaxel. PLZ4 is a molecule that can possibly guide PPM to specifical…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts

   Run by

   VA Office of Research and Development

   See if you can join NCT05519241 on ClinicalTrials.gov

10. Study of 2141-V11 in People With Non-muscle Invasive Bladder Cancer That Did Not Respond to Standard Treatment

    The purpose of this study is to test the safety of the study drug 2141-V11 in people whose NMIBC did not respond to standard treatment, and who will not have the standard surgical procedure to remove the bladder. The researchers will test different doses of 2141-V11 to see which dose is safest in p…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT05126472 on ClinicalTrials.gov

11. Sample Collection for Ongoing Research and Product Evaluation Study - Non-muscle Invasive Bladder Cancer (SCORE-NMIBC)

    The SCORE-NMIBC study is a prospective, multi-center, study designed to collect data and biological samples from participants diagnosed with non-muscle Invasive Bladder Cancer (NMIBC). Study participants will undergo research blood and urine collections, as well as tumor tissue collected as part of…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Natera, Inc., Austin, Texas

    Run by

    Natera, Inc.

    See if you can join NCT07763197 on ClinicalTrials.gov

12. LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

    This study will evaluate the safety and efficacy of intravesical administration of detalimogene (EG-70) in the bladder and its effect on bladder tumors in patients with NMIBC. This study study consists of two phases; a Phase 1 dose-escalation to establish safety and recommended the phase 2 dose, fo…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    The University of Alabama at Birmingham Clinical Research Unit (CRU), Birmingham, Alabama

    Locations

    102 in total

    Run by

    enGene, Inc.

    See if you can join NCT04752722 on ClinicalTrials.gov

13. A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer

    This is a first-in-human (FIH), Phase 1/2a, multi center, open-label, single treatment, dose escalation and expansion study designed to determine the safety and tolerability of STM-416 in patients with bladder cancer.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    East Valley Urology Center of Arizona, Mesa, Arizona

    Locations

    20 in total

    Run by

    SURGE Therapeutics

    See if you can join NCT05710848 on ClinicalTrials.gov

14. Mood Alterations in the Patients With Non-Muscle Invasive Bladder Cancer Treated With BCG

    The purpose of this study is to evaluate mood changes in patients with Non-Muscle Invasive Bladder Cancer who are receiving intravesical Bacillus Calmete-Guerin (BCG). Patients with Non-Muscle Invasive Bladder Cancer receiving intravesical treatments are eligible to participate in this study. Parti…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Sibley Memorial Hospital, Washington D.C., District of Columbia

    Run by

    Johns Hopkins University

    See if you can join NCT05672615 on ClinicalTrials.gov

15. Pre-Habilitation with Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

    The PRIMER (Pre-Habilitation With Mindfulness and Exercise for Patients Undergoing Radical Cystectomy) trial is a pilot designed to estimate the feasibility of integrating a home-based pre-operative exercise and mindfulness program (pre-habilitation program) for patients scheduled to undergo radica…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT05790850 on ClinicalTrials.gov