Nicotine Dependence Clinical Trials

21 studies are recruiting for nicotine dependence in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

   Background: - Functional and structural magnetic resonance imaging (MRI) techniques have allowed researchers to map and study how the brain works when at rest and when engaged in specific tasks. MRI scans have provided more information about how drugs affect the brain, and about how drug addiction …

   Stage

   Not phased

   Ages

   18 to 80

   Site

   National Institute on Drug Abuse, Biomedical Research Center (BRC), Baltimore, Maryland

   Run by

   National Institute on Drug Abuse (NIDA)

   See if you can join NCT01036581 on ClinicalTrials.gov

2. Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

   The goal of this clinical trial is to learn if a combination of varenicline and enhanced accelerated Transcranial Magnetic Stimulation (aTMS) works to help adults quit using nicotine products. Researchers will compare varenicline + active aTMS with a single dose of D-Clycloserine to varenicline + s…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07145866 on ClinicalTrials.gov

3. Orexin s Role in the Neurobiology of Substance Use Disorder

   Study Description: Despite the availability of pharmacotherapy for some substance use disorders, relapse vulnerability is still a significant issue. This suggests medications with alternative mechanisms of action should be explored to address this unmet need. Substantial preclinical research indica…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   National Institute on Drug Abuse, Baltimore, Maryland

   Run by

   National Institute on Drug Abuse (NIDA)

   See if you can join NCT05630781 on ClinicalTrials.gov

4. Overcoming Nicotine Dependence to Enable Quitting

   Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers ar…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Rush University Medical Center, Chicago, Illinois

   Run by

   Rush University Medical Center

   See if you can join NCT05513872 on ClinicalTrials.gov

5. A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users

   This clinical trial evaluates a smartphone application (app) called Acceptance and Commitment Therapy (ACT) on Vaping for helping young adults quit using electronic cigarettes (e-cigarettes). E-cigarettes pose numerous risks, particularly to youth and young adults. Addressing the high prevalence of…

   Stage

   Not phased

   Ages

   18 to 30

   Site

   Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington

   Run by

   Fred Hutchinson Cancer Center

   See if you can join NCT06909500 on ClinicalTrials.gov

6. Sex Differences in E-Cigarette Perception

   This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.

   Stage

   Not phased

   Ages

   21 to 44

   Site

   Yale School of Medicine, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT07398976 on ClinicalTrials.gov

7. Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

   Tobacco-free oral nicotine pouches (such as Zyn brand) are a less harmful alternative to cigarette smoking. Pouches, however, contain nicotine, and addictive substance that is not risk-free. The present study is evaluating how well nicotine pouches, at different nicotine levels, help people switch …

   Stage

   Not phased

   Ages

   21 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06678789 on ClinicalTrials.gov

8. Effects of Cannabidiol on Stress and Nicotine Withdrawal

   The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main objectives of the study include examining the effect CBD has on stress, tobacco dependence, tobacco withdrawal, and sex differences between …

   Stage

   Phase 1

   Ages

   21 to 70

   Site

   Behavioral Pharmacology Research Unit, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07001930 on ClinicalTrials.gov

9. Social Media Support Groups for Adolescent Vaping Cessation

   The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program for adolescents and young adults, adapted for use in community settings.

   Stage

   Not phased

   Ages

   13 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT07540780 on ClinicalTrials.gov

10. Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use

    Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their potential as harm-reduction tools for adults who smoke cigarettes. This within-subject, repeated-measures study will evaluate the acute effec…

    Stage

    Not phased

    Ages

    21 to 55

    Site

    University of Southern California - 3641 Watt Way (HNB B22), Los Angeles, California

    Run by

    University of Southern California

    See if you can join NCT07698470 on ClinicalTrials.gov

11. Abuse Liability and Appeal of Oral Nicotine Products

    There has been a recent proliferation of novel oral nicotine products (ONPs) brought to market, including new nicotine gums and pouches. Unlike electronic cigarettes (ECs) ONPs have no impending regulatory barriers with regard to flavoring or nicotine dose, and manufacturers have capitalized on thi…

    Stage

    Not phased

    Ages

    21 to 25

    Site

    University of Southern California, Los Angeles, California

    Locations

    2 in total

    Run by

    University of Southern California

    See if you can join NCT06506162 on ClinicalTrials.gov

12. Smart Olfaction App to Reduce Relapse

    The proposed project aims to refine and test a novel biobehavioral smoking cessation intervention that integrates the strategic application of olfactory stimulation to reduce cigarette craving with an established smartphone-based smoking cessation application. The specific aims of this study are: (…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    RESTORE Laboratory: Research on Emotion, Substance Use Treatment Outcomes, Rehabilitation, and Empowerment, Houston, Texas

    Run by

    University of Houston

    See if you can join NCT07007195 on ClinicalTrials.gov

13. Behavioral Intervention for Youth to Promote Vaping Cessation

    This study will test the hypothesis that the QuitVaping (QV) intervention and additional texting support will improve nicotine abstinence rates in adolescents as compared to Enhanced Usual Care (EUC: education about nicotine, vaping and addiction, advice to quit vaping, referral to TIQ texting supp…

    Stage

    Not phased

    Ages

    14 to 19

    Site

    Massachusetts General Hospital, Center for Addiction Medicine, 101 Merrimac Street, Suite 320, Boston, MA 02114, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06765291 on ClinicalTrials.gov

14. Young Adult Tobacco/Nicotine and Cannabis Co-use

    The goal of this project is to better understand the relationship between tobacco/nicotine and cannabis using behavioral economics during a tobacco/nicotine quit attempt. All participants will receive tobacco/nicotine cessation treatment (smoking and/or vaping treatment) for 12 weeks. To qualify, p…

    Stage

    Not phased

    Ages

    18 to 25

    Site

    Medical University of South Carolina - Charleston, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06239350 on ClinicalTrials.gov

15. E-cigarette Cessation in Adults Who Co-use Cannabis

    The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Inv…

    Stage

    Phase 4

    Ages

    18 to 40

    Site

    MUSC Charleston, Charleston, South Carolina

    Locations

    3 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT06688539 on ClinicalTrials.gov

16. Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity.

    Anxiety sensitivity, reflecting the fear of bodily sensations, is a risk factor for the maintenance and relapse of smoking. This study is designed to address the question - is a smoking cessation intervention personalized to high anxiety sensitive smokers and adapted for implementation by the YMCA …

    Stage

    Phase 3

    Ages

    18 and older

    Site

    University of Texas at Austin, Austin, Texas

    Run by

    Jasper A. Smits

    See if you can join NCT06053567 on ClinicalTrials.gov

17. Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

    In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administrat…

    Stage

    Phase 1

    Ages

    21 to 65

    Site

    Zuckerberg San Francisco General Hospital (ZSFG), San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT05962229 on ClinicalTrials.gov

18. Beta-Adrenergic Modulation of Drug Cue Reactivity

    This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking cues in ongoing cigarette smokers. This is a basic experimental study in …

    Stage

    Phase 4

    Ages

    21 to 60

    Site

    Hardesty Center for Clinical Research and Neuroscience, Tulsa, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT05587361 on ClinicalTrials.gov

19. Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

    The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products. Participants will be randomized to receive either e-cigarettes or nicotine pouches for a duration of 4 weeks and to 1 of 4 possible reg…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06077240 on ClinicalTrials.gov

20. A Trial of Varenicline for E-cigarette Cessation

    This is randomized, placebo-controlled clinical trial in treatment-seeking adults who report regular e-cigarette use to test the hypothesis that varenicline is efficacious for quitting e-cigarettes.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Yale Cancer Center/Smilow Cancer Hospital at Yale-New Haven, New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT07040566 on ClinicalTrials.gov

21. NeuroControl of Nicotine Dependence

    The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may help smokers reduce or quit smoking. Participation in the study will t…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Health Neuroscience Center, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT06347055 on ClinicalTrials.gov