Neoplasms Clinical Trials

42 studies are recruiting for neoplasms in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells

   This is a prospective study for the long-term follow-up (LTFU) of safety and efficacy for all pediatric and adult participants exposed to Gene-modified (GM) T-cell therapy participating in a previous Celgene sponsored or Celgene alliance partner sponsored study. Participants who received at least o…

   Stage

   Phase 2

   Ages

   Any age

   Site

   University of Alabama Birmingham, Birmingham, Alabama

   Locations

   225 in total

   Run by

   Celgene

   See if you can join NCT03435796 on ClinicalTrials.gov

2. Clinical and Genetic Studies of Li-Fraumeni Syndrome

   Background: - Li-Fraumeni syndrome (LFS) is a genetic condition that increases the risk for some types of cancer. LFS may lead to cancer of the bone or connective tissue, breast, and brain. It may also increase the risk for certain types of leukemia and other cancers. The only known cause of LFS is…

   Stage

   Not phased

   Ages

   Any age

   Site

   National Cancer Institute - Shady Grove, Bethesda, Maryland

   Locations

   2 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT01443468 on ClinicalTrials.gov

3. Cancer Experience Registry (CER) for Cancer Patients and Caregivers

   The Cancer Experience Registry®: An Online Survey Research Study to Understand the Experiences of Those Impacted By a Cancer Diagnosis. The Registry is a web-based platform to distribute cross-sectional and longitudinal surveys. Study surveys are designed based on input from advisor experts, includ…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cancer Support Community Research & Training Institute, Washington D.C., District of Columbia

   Run by

   Cancer Support Community, Research and Training Institute, Philadelphia

   See if you can join NCT02333604 on ClinicalTrials.gov

4. Collection of Tissue Samples for Cancer Research

   Background: -Patients who are being evaluated and/or treated at the NIH Clinical Center and adult patients at participating sites will be entered onto this tissue procurement protocol for collection of tissue specimens. Objectives: * To obtain samples from adult and pediatric patients for research …

   Stage

   Not phased

   Ages

   0 and older

   Site

   Emory University, Atlanta, Georgia

   Locations

   17 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT00900198 on ClinicalTrials.gov

5. A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

   The purpose of this study is to characterize safety and to determine the Recommended Phase 2 Dose (RP2D[s]) and optimal dosing schedule(s) of JNJ-88549968 in part 1 (Dose Escalation); to characterize the safety of JNJ- 88549968 at RP2D(s) in part 2 (Cohort Expansion). For U.S. sites: the purpose of…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   City of Hope, Duarte, California

   Locations

   45 in total

   Run by

   Janssen Research & Development, LLC

   See if you can join NCT06150157 on ClinicalTrials.gov

6. 5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

   Background: Blood, tissue, and tumor cells contain genes. Genes are made up of DNA. DNA is the "instruction book" for each cell. In some people with cancer, the genes that might have slowed the growth of their tumor were "turned off." Researchers want to see if a new drug can turn the genes back on…

   Stage

   Phase 1

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT03366116 on ClinicalTrials.gov

7. Sample Collection and Tracking for the Developmental Therapeutics Clinic

   Background: People who join a study in the Developmental Therapeutics Clinic (DTC) have tests. These include blood draws and biopsies. Researchers collect data from these samples. Some people take part in more than one study at the DTC. At this time, data are connected only with one single study. R…

   Stage

   Not phased

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT03269578 on ClinicalTrials.gov

8. Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel

   Background: People with rare cancers often have limited treatment options. The biology of rare cancers is not well understood. Researchers want to find better treatments for these cancers. They want to test 2 drugs that, taken separately, have helped people with non-rare cancers. They want to see i…

   Stage

   Phase 2

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04449549 on ClinicalTrials.gov

9. Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

   Background: Mesothelioma is an aggressive cancer that grows in the linings of the body; this can include the membranes that line the heart, lungs, and internal organs. Mesothelin (MSLN) is a protein that appears in high numbers in many tumors, including mesothelioma. Researchers are developing a ne…

   Stage

   Phase 1

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT06885697 on ClinicalTrials.gov

10. Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

    This is a multi-site, global, open-label study that includes a phase 1b evaluation of elacestrant in combination with abemaciclib in women and men with brain metastases from estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER-2) negative breast cancer. Phase 1b was design…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Providence Medical Foundation, Fullerton, California

    Locations

    86 in total

    Run by

    Stemline Therapeutics, Inc.

    See if you can join NCT05386108 on ClinicalTrials.gov

11. A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer

    The purpose of this study is to check how well LY35327021 works and how safe it is for controlling nausea and vomiting caused by chemotherapy. Participants who join this study will be in it until all parts are finished, which could take about 2 months.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Marin Cancer Care, Greenbrae, California

    Locations

    67 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07169851 on ClinicalTrials.gov

12. Registry Study for Radiation Therapy Outcomes

    The purpose of this research study is to collect and analyze information from patients being treated with various forms of radiation therapy.

    Stage

    Not phased

    Ages

    Any age

    Site

    Mayo Clinic, Scottsdale, Arizona

    Locations

    29 in total

    Run by

    Proton Collaborative Group

    See if you can join NCT01255748 on ClinicalTrials.gov

13. A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)

    This study aims to evaluate the safety and tolerability of RO7673396 in participants with advanced solid tumors harboring RAS mutation(s). This study consists of two stages: Stage 1 (Dose Escalation) and Stage 2 (Dose Expansion). Stage 1 will define the recommended dose(s) for expansion (RDEs) of R…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    City of Hope Comprehensive Cancer Center, Duarte, California

    Locations

    25 in total

    Run by

    Hoffmann-La Roche

    See if you can join NCT06884618 on ClinicalTrials.gov

14. A Study of JNJ-87890387 for Advanced Solid Tumors

    The purpose of this study is to determine safety and recommended phase 2 dose(s) (RP2Ds) of JNJ-87890387 and to determine the safety of JNJ-87890387 at the RP2D(s).

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Start Midwest, Grand Rapids, Michigan

    Locations

    6 in total

    Run by

    Janssen Research & Development, LLC

    See if you can join NCT06178614 on ClinicalTrials.gov

15. A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors

    The purpose of this study is to determine the safety, feasibility, recommended dose(s) and regimen(s) of JNJ-87704916 as monotherapy and in combination with cetrelimab.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Locations

    10 in total

    Run by

    Johnson & Johnson Enterprise Innovation Inc.

    See if you can join NCT06311578 on ClinicalTrials.gov

16. A Study of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors

    The goal of this clinical trial is to test a new medicine called GSK5764227, which delivers a toxin directly to cancer cells to destroy them while sparing healthy cells. The study will combine GSK5764227 with standard treatments to evaluate its safety, examine how the body processes it, check if it…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    GSK Investigational Site, Reunion, Florida

    Locations

    22 in total

    Run by

    GlaxoSmithKline

    See if you can join NCT07277270 on ClinicalTrials.gov

17. First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid Tumors

    The purpose of this study is to investigate a new drug GSK5533524 in adults with certain advanced cancers to find a safe dose and learn how well people tolerate it, so researchers can choose the best dose for the next stage of testing. The study will also check whether the drug can shrink tumours o…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    GSK Investigational Site, Philadelphia, Pennsylvania

    Locations

    20 in total

    Run by

    GlaxoSmithKline

    See if you can join NCT07438782 on ClinicalTrials.gov

18. A Study of JNJ-1761981 in Participants With Solid Tumors

    The purpose of Part 1 of this study is to determine a safe, tolerable, and feasible recommended total dose of intratumorally administered JNJ-1761981. The purpose of Part 2 of this study is to identify the optimal volumetric dose of JNJ-1761981 for the treatment of tumor lesions.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Mayo Clinic in Florida, Jacksonville, Florida

    Locations

    4 in total

    Run by

    Johnson & Johnson Enterprise Innovation Inc.

    See if you can join NCT07525141 on ClinicalTrials.gov

19. A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

    Solid tumours are abnormal lumps of tissue that can occur in different parts of the body. The tumours involved in this study have specific genetic characteristics that can make them more aggressive and challenging to treat. The study will test whether GSK5460025 alone or in combination (potential c…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    GSK Investigational Site, Aurora, Colorado

    Locations

    27 in total

    Run by

    GlaxoSmithKline

    See if you can join NCT07213609 on ClinicalTrials.gov

20. 100-Year Human Aging Study

    The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07563777 on ClinicalTrials.gov

21. Human Observatory Study

    The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07646782 on ClinicalTrials.gov

22. HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

    This study is a clinical trial to determine the safety of inoculating G207 (an experimental virus therapy) into a recurrent or refractory cerebellar brain tumor. The safety of combining G207 with a single low dose of radiation, designed to enhance virus replication, tumor cell killing, and an anti-…

    Stage

    Phase 1

    Ages

    3 to 22

    Site

    University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

    Locations

    3 in total

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT03911388 on ClinicalTrials.gov

23. Screening Strategies Among High-risk Populations for Anal Cancer

    The goal of the proposed research is to 1) examine the performance of emerging screening methods for anal high-grade squamous intraepithelial lesion (aHSIL), a precancerous condition of anal cancer, among populations at high risk for anal cancer and 2) characterize DNA methylation, immunologic resp…

    Stage

    Not phased

    Ages

    30 to 80

    Site

    University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

    Locations

    4 in total

    Run by

    Lisa Flowers

    See if you can join NCT06628570 on ClinicalTrials.gov

24. Biennial CEM in Women With a Personal History of Breast Cancer

    This is a prospective clinical trial that will examine if biennial contrast-enhanced mammography added to annual 3D mammography (tomosynthesis) substantially improves breast cancer detection with minimal increase in false-positives, in women with a personal history of breast cancer.

    Stage

    Not phased

    Ages

    30 to 79

    Site

    UPMC Magee-Womens Imaging - Bethel Park, Bethel Park, Pennsylvania

    Locations

    6 in total

    Run by

    Wendie Berg

    See if you can join NCT06105749 on ClinicalTrials.gov

25. Two Part Study of Nenocorilant Combined With Nivolumab in Patients With Advanced Solid Malignancies

    This open-label, dose-finding, and proof of concept study will evaluate the safety, tolerability, maximum-tolerated dose (MTD) and/or optimal dose of nenocorilant when administered in combination with nivolumab in patients with advanced solid malignancies.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Site 03, Los Angeles, California

    Locations

    5 in total

    Run by

    Corcept Therapeutics

    See if you can join NCT07276373 on ClinicalTrials.gov