Neoplasms Clinical Trials

42 studies are recruiting for neoplasms in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells

   This is a prospective study for the long-term follow-up (LTFU) of safety and efficacy for all pediatric and adult participants exposed to Gene-modified (GM) T-cell therapy participating in a previous Celgene sponsored or Celgene alliance partner sponsored study. Participants who received at least o…

   Stage

   Phase 2

   Ages

   Any age

   Site

   University of Alabama Birmingham, Birmingham, Alabama

   Locations

   222 in total

   Run by

   Celgene

   See if you can join NCT03435796 on ClinicalTrials.gov

2. Collection of Tissue Samples for Cancer Research

   Background: -Patients who are being evaluated and/or treated at the NIH Clinical Center and adult patients at participating sites will be entered onto this tissue procurement protocol for collection of tissue specimens. Objectives: * To obtain samples from adult and pediatric patients for research …

   Stage

   Not phased

   Ages

   0 and older

   Site

   Emory University, Atlanta, Georgia

   Locations

   17 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT00900198 on ClinicalTrials.gov

3. Clinical and Genetic Studies of Li-Fraumeni Syndrome

   Background: - Li-Fraumeni syndrome (LFS) is a genetic condition that increases the risk for some types of cancer. LFS may lead to cancer of the bone or connective tissue, breast, and brain. It may also increase the risk for certain types of leukemia and other cancers. The only known cause of LFS is…

   Stage

   Not phased

   Ages

   Any age

   Site

   National Cancer Institute - Shady Grove, Bethesda, Maryland

   Locations

   2 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT01443468 on ClinicalTrials.gov

4. 5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

   Background: Blood, tissue, and tumor cells contain genes. Genes are made up of DNA. DNA is the "instruction book" for each cell. In some people with cancer, the genes that might have slowed the growth of their tumor were "turned off." Researchers want to see if a new drug can turn the genes back on…

   Stage

   Phase 1

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT03366116 on ClinicalTrials.gov

5. A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

   Solid tumours are abnormal lumps of tissue that can occur in different parts of the body. The tumours involved in this study have specific genetic characteristics that can make them more aggressive and challenging to treat. The study will test whether GSK5460025 alone or in combination (potential c…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   GSK Investigational Site, Aurora, Colorado

   Locations

   27 in total

   Run by

   GlaxoSmithKline

   See if you can join NCT07213609 on ClinicalTrials.gov

6. Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel

   Background: People with rare cancers often have limited treatment options. The biology of rare cancers is not well understood. Researchers want to find better treatments for these cancers. They want to test 2 drugs that, taken separately, have helped people with non-rare cancers. They want to see i…

   Stage

   Phase 2

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04449549 on ClinicalTrials.gov

7. A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

   The purpose of this study is to characterize safety and to determine the Recommended Phase 2 Dose (RP2D[s]) and optimal dosing schedule(s) of JNJ-88549968 in part 1 (Dose Escalation); to characterize the safety of JNJ- 88549968 at RP2D(s) in part 2 (Cohort Expansion). For U.S. sites: the purpose of…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   City of Hope, Duarte, California

   Locations

   41 in total

   Run by

   Janssen Research & Development, LLC

   See if you can join NCT06150157 on ClinicalTrials.gov

8. Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

   This is a multi-site, global, open-label study that includes a phase 1b evaluation of elacestrant in combination with abemaciclib in women and men with brain metastases from estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER-2) negative breast cancer. Phase 1b was design…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Providence Medical Foundation, Fullerton, California

   Locations

   86 in total

   Run by

   Stemline Therapeutics, Inc.

   See if you can join NCT05386108 on ClinicalTrials.gov

9. Sample Collection and Tracking for the Developmental Therapeutics Clinic

   Background: People who join a study in the Developmental Therapeutics Clinic (DTC) have tests. These include blood draws and biopsies. Researchers collect data from these samples. Some people take part in more than one study at the DTC. At this time, data are connected only with one single study. R…

   Stage

   Not phased

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT03269578 on ClinicalTrials.gov

10. 100-Year Human Aging Study

    The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07563777 on ClinicalTrials.gov

11. Human Observatory Study

    The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07646782 on ClinicalTrials.gov

12. HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

    This study is a clinical trial to determine the safety of inoculating G207 (an experimental virus therapy) into a recurrent or refractory cerebellar brain tumor. The safety of combining G207 with a single low dose of radiation, designed to enhance virus replication, tumor cell killing, and an anti-…

    Stage

    Phase 1

    Ages

    3 to 22

    Site

    University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

    Locations

    3 in total

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT03911388 on ClinicalTrials.gov

13. A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer

    The purpose of this study is to check how well LY35327021 works and how safe it is for controlling nausea and vomiting caused by chemotherapy. Participants who join this study will be in it until all parts are finished, which could take about 2 months.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Marin Cancer Care, Greenbrae, California

    Locations

    68 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07169851 on ClinicalTrials.gov

14. A Study of JNJ-87890387 for Advanced Solid Tumors

    The purpose of this study is to determine safety and recommended phase 2 dose(s) (RP2Ds) of JNJ-87890387 and to determine the safety of JNJ-87890387 at the RP2D(s).

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Start Midwest, Grand Rapids, Michigan

    Locations

    6 in total

    Run by

    Janssen Research & Development, LLC

    See if you can join NCT06178614 on ClinicalTrials.gov

15. A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors

    The purpose of this study is to determine the safety, feasibility, recommended dose(s) and regimen(s) of JNJ-87704916 as monotherapy and in combination with cetrelimab.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Locations

    10 in total

    Run by

    Johnson & Johnson Enterprise Innovation Inc.

    See if you can join NCT06311578 on ClinicalTrials.gov

16. A Study of JNJ-1761981 in Participants With Solid Tumors

    The purpose of Part 1 of this study is to determine a safe, tolerable, and feasible recommended total dose of intratumorally administered JNJ-1761981. The purpose of Part 2 of this study is to identify the optimal volumetric dose of JNJ-1761981 for the treatment of tumor lesions.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Mayo Clinic in Florida, Jacksonville, Florida

    Locations

    4 in total

    Run by

    Johnson & Johnson Enterprise Innovation Inc.

    See if you can join NCT07525141 on ClinicalTrials.gov

17. Screening Strategies Among High-risk Populations for Anal Cancer

    The goal of the proposed research is to 1) examine the performance of emerging screening methods for anal high-grade squamous intraepithelial lesion (aHSIL), a precancerous condition of anal cancer, among populations at high risk for anal cancer and 2) characterize DNA methylation, immunologic resp…

    Stage

    Not phased

    Ages

    30 to 80

    Site

    University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

    Locations

    4 in total

    Run by

    Lisa Flowers

    See if you can join NCT06628570 on ClinicalTrials.gov

18. Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

    Background: Mesothelioma is an aggressive cancer that grows in the linings of the body; this can include the membranes that line the heart, lungs, and internal organs. Mesothelin (MSLN) is a protein that appears in high numbers in many tumors, including mesothelioma. Researchers are developing a ne…

    Stage

    Phase 1

    Ages

    18 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Cancer Institute (NCI)

    See if you can join NCT06885697 on ClinicalTrials.gov

19. Biennial CEM in Women With a Personal History of Breast Cancer

    This is a prospective clinical trial that will examine if biennial contrast-enhanced mammography added to annual 3D mammography (tomosynthesis) substantially improves breast cancer detection with minimal increase in false-positives, in women with a personal history of breast cancer.

    Stage

    Not phased

    Ages

    30 to 79

    Site

    UPMC Magee-Womens Imaging - Bethel Park, Bethel Park, Pennsylvania

    Locations

    6 in total

    Run by

    Wendie Berg

    See if you can join NCT06105749 on ClinicalTrials.gov

20. Two Part Study of Nenocorilant Combined With Nivolumab in Patients With Advanced Solid Malignancies

    This open-label, dose-finding, and proof of concept study will evaluate the safety, tolerability, maximum-tolerated dose (MTD) and/or optimal dose of nenocorilant when administered in combination with nivolumab in patients with advanced solid malignancies.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Site 03, Los Angeles, California

    Locations

    5 in total

    Run by

    Corcept Therapeutics

    See if you can join NCT07276373 on ClinicalTrials.gov

21. Phase 1 Study of JV-394 Autologous Anti-CD94 CAR T for r/r CD94+ T/NK Cell Neoplasms

    The goal of this clinical research study is to find the highest tolerable dose of JV-394 (a type of autologous CAR-T cell therapy) that can be given to patients who have T/NK cell lymphoma that is relapsed or refractory. The safety and possible side effects of JV-394 will also be studied.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    The University of Texas M. D. Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT07382817 on ClinicalTrials.gov

22. A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

    This is an open label, multicenter, phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent and in combination with chemotherapy administered intravenously in participants with advanced solid tumors that are antigen-rich.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    AdventHealth Celebration, Celebration, Florida

    Locations

    19 in total

    Run by

    Marengo Therapeutics, Inc.

    See if you can join NCT05592626 on ClinicalTrials.gov

23. A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer

    The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common research protocol. Individual clinical trials under this master protocol define drug/disease-specific research goals and activities to test them. New stu…

    Stage

    Phase 2

    Ages

    1 to 39

    Site

    Phoenix Children's Hospital, Phoenix, Arizona

    Locations

    72 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT05999994 on ClinicalTrials.gov

24. A Study of [18F]LY4214835 in Healthy Volunteers and Participants With Cancer

    The purpose of the study is to check how safe and well-tolerated [18F]LY4214835 injection is in healthy participants and participants with cancer. The study drug will be administered intravenously (IV) (into a vein). Participation in the study will last approximately 35 days.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center, New York, New York

    Locations

    6 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07258836 on ClinicalTrials.gov

25. First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid Tumors

    The purpose of this study is to investigate a new drug GSK5533524 in adults with certain advanced cancers to find a safe dose and learn how well people tolerate it, so researchers can choose the best dose for the next stage of testing. The study will also check whether the drug can shrink tumours o…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    GSK Investigational Site, Philadelphia, Pennsylvania

    Locations

    16 in total

    Run by

    GlaxoSmithKline

    See if you can join NCT07438782 on ClinicalTrials.gov