Mild Cognitive Impairment (MCI) Clinical Trials

26 studies are recruiting for mild cognitive impairment (mci) in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Percepta for Cognitive Optimization

   This Phase 1, randomized, double-blind, placebo-controlled trial evaluates the cognitive and neurophysiological effects of a dietary supplement containing cat's claw (Uncaria tomentosa) bark extract and oolong tea extract, in adults aged 40-85 with self-reported mild cognitive impairment (MCI). The…

   Stage

   Not phased

   Ages

   40 to 85

   Site

   Reputable Health, Wilmington, Delaware

   Run by

   Cerebrum DAO Association

   See if you can join NCT07612449 on ClinicalTrials.gov

2. Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

   The goal of this one-arm clinical trial is to determine whether participants with mild cognitive impairment (MCI) can successfully navigate a virtual reality (VR) maze. The VR maze is designed as a training tool aimed at improving participants' spatial navigation abilities. Main Aims: 1. To determi…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Columbia University Irving Medical Center, Manhattan, New York

   Locations

   2 in total

   Run by

   Albert Einstein College of Medicine

   See if you can join NCT07225400 on ClinicalTrials.gov

3. LpD3.5 Intervention Study in Older Adults- LISA-I Trial

   This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological intervention to reduce gut permeability and inflammation in older adults…

   Stage

   EARLY_Phase 1

   Ages

   60 and older

   Site

   Department of Neurosurgery and Brain and Spine and Faculty of USF Center for Microbiome Re-search, Microbiomes Institute, Tampa, Florida

   Run by

   University of South Florida

   See if you can join NCT07794956 on ClinicalTrials.gov

4. Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease

   Alzheimer's Disease (AD) is associated with impairments in both gait and cognition, significantly increasing fall risk. Falls are a leading cause of injury-related disability in older adults, and individuals with AD experience a nearly threefold higher rate of falls compared to neurotypical older a…

   Stage

   Not phased

   Ages

   50 to 90

   Site

   Boston University Neuromotor Recovery Laboratory, Boston, Massachusetts

   Run by

   Boston University Charles River Campus

   See if you can join NCT07659964 on ClinicalTrials.gov

5. Safety And Tolerability Of Gamma Glutamylcysteine (GGC) Oral Supplementation In MCI Patients

   The goal of this study is to evaluate the safety and tolerability of Gamma Glutamylcysteine (GGC) supplement at different doses (400mg/day or 800mg/day or 1200mg/day) when administered orally to patients with MCI over 3 months. This study is designed to generate preliminary clinical safety data to …

   Stage

   Phase 1

   Ages

   55 to 80

   Site

   UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania

   Run by

   Pravat Mandal

   See if you can join NCT07583251 on ClinicalTrials.gov

6. Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial

   Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia. Cognitive training represents an important therapeutic strategy. In a previous study, crossword puzzles were found to be supe…

   Stage

   Phase 2

   Ages

   55 to 89

   Site

   University of Miami Miller School of Medicine, Miami, Florida

   Locations

   4 in total

   Run by

   Columbia University

   See if you can join NCT06601933 on ClinicalTrials.gov

7. Enhancing Attention in Elderly Using a Brain-Computer-Interface

   Cognitive reserve refers to the brain's ability to maintain cognitive performance despite age-related changes or neuropathology. Enhancing cognitive reserve is thought to delay cognitive decline and improve functional outcomes in aging and neurodegenerative conditions. Attention and memory-related …

   Stage

   Not phased

   Ages

   18 to 90

   Site

   The University of Texas at Austin, Austin, Texas

   Locations

   2 in total

   Run by

   University of Texas at Austin

   See if you can join NCT07441122 on ClinicalTrials.gov

8. e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

   The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in depresc…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Johns Hopkins Community Physicians, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07454824 on ClinicalTrials.gov

9. Using Light Therapy for Mild Cognitive Impairment

   The goal of this clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and cognitive function in people with mild cognitive impairment (MCI). Th…

   Stage

   Not phased

   Ages

   55 to 95

   Site

   University of Oklahoma Health Campus, Oklahoma City, Oklahoma

   Run by

   University of Oklahoma

   See if you can join NCT07651787 on ClinicalTrials.gov

10. Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

    This early phase, open label, single arm clinical trial will determine the intraindividual safety, tolerability and effects of NPC1 (parthenolide and ipriflavone) on blood-based biomarkers of Alzheimer's disease (AD) pathology among adults with subjective cognitive decline, mild cognitive impairmen…

    Stage

    Phase 2

    Ages

    55 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07236190 on ClinicalTrials.gov

11. Crownlands Observing Progression With Neurons Study

    The CROWN-I Study is an observational study to learn about molecular features of Alzheimer's disease (AD) and mild cognitive impairment (MCI). The primary objective is to identify the molecular and genetic modules that differentiate patient subtypes and predict progression of AD. Participants will …

    Stage

    Not phased

    Ages

    55 and older

    Site

    Capital Neurology, Germantown, Maryland

    Run by

    Crownlands

    See if you can join NCT07611396 on ClinicalTrials.gov

12. Telehealth-Adapted Compensatory Training and Intervention for Cognition

    The goal of this clinical trial is to develop a five-week virtual cognitive training intervention for people with Mild Cognitive Impairment (MCI) based off an existing eight-week intervention. The main question it aims to answer is: • Is five weeks of training as good as eight weeks in improving co…

    Stage

    Not phased

    Ages

    65 to 84

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT07366346 on ClinicalTrials.gov

13. Brain Stimulation and Cognitive Training for MCI

    This is a randomized clinical trial of a treatment that combines non-invasive brain stimulation with computerized cognitive training (CCT) for people with mild cognitive impairment (MCI). The form of brain stimulation used in this study is accelerated intermittent theta burst stimulation (iTBS). Al…

    Stage

    Not phased

    Ages

    60 to 85

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07526740 on ClinicalTrials.gov

14. Genetic Studies of Early-onset Dementia

    The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.

    Stage

    Not phased

    Ages

    35 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT04906863 on ClinicalTrials.gov

15. Predicting Pre-dementia

    The goal of this observational study is to learn how well a multimodal "Progression and Risk" (PR) model can predict and stage early mild cognitive impairment (MCI) due to Alzheimer's disease in cognitively normal or very mildly impaired ApoE4-positive adults aged 55 and older. The main questions i…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Foster Carr MD, San Diego, California

    Run by

    Prevention Research Consortium Corp.

    See if you can join NCT07516119 on ClinicalTrials.gov

16. BID WM Digital Intervention in Aging

    The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are: 1. Does engagement in with a digital intervention improve working memory? 2. Does engagement in with a digital intervention improve inhibito…

    Stage

    Not phased

    Ages

    60 to 85

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06918704 on ClinicalTrials.gov

17. Early-Stage Partner in Care Living Alone Plus

    EPICLA+ (Early-Stage Partners in Care Living Alone Plus) is a research project designed to assist people with early-stage memory loss who live alone in the community by providing early-stage related education and skill-training sessions, held via Zoom, designed to reduce stress, enhance well-being,…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Arizona State University, Phoenix, Arizona

    Run by

    Arizona State University

    See if you can join NCT06962111 on ClinicalTrials.gov

18. Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

    This study plans to learn more about how stimulating the vagus nerve through gentle electrical stimulation applied to the ear can affect decision-making, problem-solving, and other thinking abilities. This process, called transcutaneous auricular vagus nerve stimulation (taVNS), could help improve …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Clinical Translational Research Center at CU Anschutz, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT07424365 on ClinicalTrials.gov

19. Memory Support System for Older Chinese Americans With Mild Cognitive Impairment

    The Memory Support System (MSS) from the Healthy Action to Benefit Independence \& Thinking® (HABIT) Program is an evidence-based, non-pharmacological intervention for mild cognitive impairment (MCI). Despite the clinical benefits and feasibility, the MSS was primarily developed and used with non-H…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Li Lab, Icahn School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07142499 on ClinicalTrials.gov

20. Treating Insomnia in Mild Cognitive Impairment

    The goal of this study is to test a new way to improve sleep quality in persons living with mild cognitive impairment. The treatment combines a safe and gentle way to stimulate the brain, called transcranial magnetic stimulation, with a psychological treatment, called cognitive behavioral therapy f…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06687161 on ClinicalTrials.gov

21. Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study

    Many individuals develop dementia, and dementia has multiple causes, yet we currently have limited treatment options. A critical observation of the effectiveness of the available dementia treatments is that they tend to be more effective when started early. Previous studies have shown that multimod…

    Stage

    Not phased

    Ages

    65 to 75

    Site

    Smith Family Clinic for Genomic Medicine, Huntsville, Alabama

    Run by

    HudsonAlpha Institute for Biotechnology

    See if you can join NCT07146412 on ClinicalTrials.gov

22. Remote Sensing for ADRD-Specific Activities Identification in Older Adults

    The investigators aim to use smart-home sensors and artificial intelligence (AI) to monitor and detect Alzheimer's Disease and Related Dementias (ADRD)-specific daily activities among older adults, with the goal of early symptom detection and personalized support. Dementia, which impacts memory and…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of Missouri, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT07120347 on ClinicalTrials.gov

23. Time Restricted Eating in Alzheimer's Disease

    This pilot and feasibility study will enable the research team to determine the feasibility of implementing a time-restricted eating regimen among adults with mild cognitive impairment (MCI) and the impact of time-restricted eating on cognitive performance and biomarkers of metabolic health in this…

    Stage

    Not phased

    Ages

    55 to 89

    Site

    Arizona State University, College of Health Solutions, Phoenix, Arizona

    Locations

    2 in total

    Run by

    St. Joseph's Hospital and Medical Center, Phoenix

    See if you can join NCT06429124 on ClinicalTrials.gov

24. Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment

    Mild Cognitive Impairment (MCI) in older adults is linked to muscle loss (sarcopenia) and can lead to dementia, with pain further impacting cognitive and physical performance. Tai Chi, a mind-body exercise, is recommended for managing MCI as it supports cognitive function, mood, and physical health…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Ohio University, Athens, Ohio

    Run by

    Ohio University

    See if you can join NCT06828926 on ClinicalTrials.gov

25. Mindfulness for Cognition in Early-stage Alzheimer's Disease

    The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1. How does mindfulness impact thinking and memory? 2. How does mindfulness influence brain function and struct…

    Stage

    Not phased

    Ages

    50 to 100

    Site

    VA Boston Healthcare System - Jamaica Plain Campus, Boston, Massachusetts

    Run by

    VA Boston Healthcare System

    See if you can join NCT06792877 on ClinicalTrials.gov