Mild Cognitive Impairment (MCI) Clinical Trials

29 studies are recruiting for mild cognitive impairment (mci) in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Rural Veteran and Care Partner Walking Program

   The purpose of this study is to determine the practicality/feasibility of a virtual physical activity intervention to improve daily steps for Veterans with mild cognitive impairment and their care partners living in rural areas. Participation includes: * Complete a 6-week walking program * Complete…

   Stage

   Not phased

   Ages

   19 to 90

   Site

   Creighton University, Omaha, Nebraska

   Run by

   Creighton University

   See if you can join NCT07914218 on ClinicalTrials.gov

2. Combating Alzheimer's Through Sleep and Exercise

   The Combating Alzheimer's through Sleep and Exercise (CASE) study is an exploratory, hypothesis-generating trial designed to: (1) assess whether improvements in sleep are associated with improvements in cognitive performance and cardiovascular and metabolic health; (2) evaluate the effects of struc…

   Stage

   Not phased

   Ages

   55 to 80

   Site

   University of Miami Hospitals, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT04855630 on ClinicalTrials.gov

3. CMN LIFU for Enhanced Glymphatic Clearance in Amyloid-Positive MCI

   The goal of this clinical trial is to learn if a wearable ultrasound device, called ATTN201, is safe and easy to use. The study is for adults ages 65 and older who have mild cognitive impairment (MCI) and a buildup of a protein called amyloid in the brain. Amyloid buildup is an early sign of Alzhei…

   Stage

   Not phased

   Ages

   65 and older

   Site

   University of California San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT07866768 on ClinicalTrials.gov

4. Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

   This early phase, open label, single arm clinical trial will determine the intraindividual safety, tolerability and effects of NPC1 (parthenolide and ipriflavone) on blood-based biomarkers of Alzheimer's disease (AD) pathology among adults with subjective cognitive decline, mild cognitive impairmen…

   Stage

   Phase 2

   Ages

   55 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07236190 on ClinicalTrials.gov

5. Digital STEADI Efficacy

   The aging of the U.S. population, combined with health care workforce shortages and insufficient access to effective fall prevention and exercise programs, has contributed to a high burden of fall-related injuries in older adults, especially in those with Mild Cognitive Impairment (MCI), a precurso…

   Stage

   Phase 1

   Ages

   50 and older

   Site

   Emory University School of Medicine, Atlanta, Georgia

   Run by

   Friendi.fi Corporation

   See if you can join NCT07852650 on ClinicalTrials.gov

6. Predicting Pre-dementia

   The goal of this observational study is to learn how well a multimodal "Progression and Risk" (PR) model can predict and stage early mild cognitive impairment (MCI) due to Alzheimer's disease in cognitively normal or very mildly impaired ApoE4-positive adults aged 55 and older. The main questions i…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Foster Carr MD, San Diego, California

   Run by

   Prevention Research Consortium Corp.

   See if you can join NCT07516119 on ClinicalTrials.gov

7. Percepta for Cognitive Optimization

   This Phase 1, randomized, double-blind, placebo-controlled trial evaluates the cognitive and neurophysiological effects of a dietary supplement containing cat's claw (Uncaria tomentosa) bark extract and oolong tea extract, in adults aged 40-85 with self-reported mild cognitive impairment (MCI). The…

   Stage

   Not phased

   Ages

   40 to 85

   Site

   Reputable Health, Wilmington, Delaware

   Run by

   Cerebrum DAO Association

   See if you can join NCT07612449 on ClinicalTrials.gov

8. Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

   The goal of this one-arm clinical trial is to determine whether participants with mild cognitive impairment (MCI) can successfully navigate a virtual reality (VR) maze. The VR maze is designed as a training tool aimed at improving participants' spatial navigation abilities. Main Aims: 1. To determi…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Columbia University Irving Medical Center, Manhattan, New York

   Locations

   2 in total

   Run by

   Albert Einstein College of Medicine

   See if you can join NCT07225400 on ClinicalTrials.gov

9. LpD3.5 Intervention Study in Older Adults- LISA-I Trial

   This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological intervention to reduce gut permeability and inflammation in older adults…

   Stage

   EARLY_Phase 1

   Ages

   60 and older

   Site

   Department of Neurosurgery and Brain and Spine and Faculty of USF Center for Microbiome Re-search, Microbiomes Institute, Tampa, Florida

   Run by

   University of South Florida

   See if you can join NCT07794956 on ClinicalTrials.gov

10. Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease

    Alzheimer's Disease (AD) is associated with impairments in both gait and cognition, significantly increasing fall risk. Falls are a leading cause of injury-related disability in older adults, and individuals with AD experience a nearly threefold higher rate of falls compared to neurotypical older a…

    Stage

    Not phased

    Ages

    50 to 90

    Site

    Boston University Neuromotor Recovery Laboratory, Boston, Massachusetts

    Run by

    Boston University Charles River Campus

    See if you can join NCT07659964 on ClinicalTrials.gov

11. Safety And Tolerability Of Gamma Glutamylcysteine (GGC) Oral Supplementation In MCI Patients

    The goal of this study is to evaluate the safety and tolerability of Gamma Glutamylcysteine (GGC) supplement at different doses (400mg/day or 800mg/day or 1200mg/day) when administered orally to patients with MCI over 3 months. This study is designed to generate preliminary clinical safety data to …

    Stage

    Phase 1

    Ages

    55 to 80

    Site

    UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania

    Run by

    Pravat Mandal

    See if you can join NCT07583251 on ClinicalTrials.gov

12. Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial

    Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia. Cognitive training represents an important therapeutic strategy. In a previous study, crossword puzzles were found to be supe…

    Stage

    Phase 2

    Ages

    55 to 89

    Site

    University of Miami Miller School of Medicine, Miami, Florida

    Locations

    4 in total

    Run by

    Columbia University

    See if you can join NCT06601933 on ClinicalTrials.gov

13. Enhancing Attention in Elderly Using a Brain-Computer-Interface

    Cognitive reserve refers to the brain's ability to maintain cognitive performance despite age-related changes or neuropathology. Enhancing cognitive reserve is thought to delay cognitive decline and improve functional outcomes in aging and neurodegenerative conditions. Attention and memory-related …

    Stage

    Not phased

    Ages

    18 to 90

    Site

    The University of Texas at Austin, Austin, Texas

    Locations

    2 in total

    Run by

    University of Texas at Austin

    See if you can join NCT07441122 on ClinicalTrials.gov

14. e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

    The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in depresc…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Johns Hopkins Community Physicians, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07454824 on ClinicalTrials.gov

15. Using Light Therapy for Mild Cognitive Impairment

    The goal of this clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and cognitive function in people with mild cognitive impairment (MCI). Th…

    Stage

    Not phased

    Ages

    55 to 95

    Site

    University of Oklahoma Health Campus, Oklahoma City, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT07651787 on ClinicalTrials.gov

16. Crownlands Observing Progression With Neurons Study

    The CROWN-I Study is an observational study to learn about molecular features of Alzheimer's disease (AD) and mild cognitive impairment (MCI). The primary objective is to identify the molecular and genetic modules that differentiate patient subtypes and predict progression of AD. Participants will …

    Stage

    Not phased

    Ages

    55 and older

    Site

    Capital Neurology, Germantown, Maryland

    Run by

    Crownlands

    See if you can join NCT07611396 on ClinicalTrials.gov

17. Telehealth-Adapted Compensatory Training and Intervention for Cognition

    The goal of this clinical trial is to develop a five-week virtual cognitive training intervention for people with Mild Cognitive Impairment (MCI) based off an existing eight-week intervention. The main question it aims to answer is: • Is five weeks of training as good as eight weeks in improving co…

    Stage

    Not phased

    Ages

    65 to 84

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT07366346 on ClinicalTrials.gov

18. Brain Stimulation and Cognitive Training for MCI

    This is a randomized clinical trial of a treatment that combines non-invasive brain stimulation with computerized cognitive training (CCT) for people with mild cognitive impairment (MCI). The form of brain stimulation used in this study is accelerated intermittent theta burst stimulation (iTBS). Al…

    Stage

    Not phased

    Ages

    60 to 85

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07526740 on ClinicalTrials.gov

19. Genetic Studies of Early-onset Dementia

    The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.

    Stage

    Not phased

    Ages

    35 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT04906863 on ClinicalTrials.gov

20. BID WM Digital Intervention in Aging

    The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are: 1. Does engagement in with a digital intervention improve working memory? 2. Does engagement in with a digital intervention improve inhibito…

    Stage

    Not phased

    Ages

    60 to 85

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06918704 on ClinicalTrials.gov

21. Early-Stage Partner in Care Living Alone Plus

    EPICLA+ (Early-Stage Partners in Care Living Alone Plus) is a research project designed to assist people with early-stage memory loss who live alone in the community by providing early-stage related education and skill-training sessions, held via Zoom, designed to reduce stress, enhance well-being,…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Arizona State University, Phoenix, Arizona

    Run by

    Arizona State University

    See if you can join NCT06962111 on ClinicalTrials.gov

22. Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

    This study plans to learn more about how stimulating the vagus nerve through gentle electrical stimulation applied to the ear can affect decision-making, problem-solving, and other thinking abilities. This process, called transcutaneous auricular vagus nerve stimulation (taVNS), could help improve …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Clinical Translational Research Center at CU Anschutz, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT07424365 on ClinicalTrials.gov

23. Memory Support System for Older Chinese Americans With Mild Cognitive Impairment

    The Memory Support System (MSS) from the Healthy Action to Benefit Independence \& Thinking® (HABIT) Program is an evidence-based, non-pharmacological intervention for mild cognitive impairment (MCI). Despite the clinical benefits and feasibility, the MSS was primarily developed and used with non-H…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Li Lab, Icahn School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07142499 on ClinicalTrials.gov

24. Treating Insomnia in Mild Cognitive Impairment

    The goal of this study is to test a new way to improve sleep quality in persons living with mild cognitive impairment. The treatment combines a safe and gentle way to stimulate the brain, called transcranial magnetic stimulation, with a psychological treatment, called cognitive behavioral therapy f…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06687161 on ClinicalTrials.gov

25. Remote Sensing for ADRD-Specific Activities Identification in Older Adults

    The investigators aim to use smart-home sensors and artificial intelligence (AI) to monitor and detect Alzheimer's Disease and Related Dementias (ADRD)-specific daily activities among older adults, with the goal of early symptom detection and personalized support. Dementia, which impacts memory and…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of Missouri, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT07120347 on ClinicalTrials.gov