Metastatic Malignant Solid Neoplasm Clinical Trials in Orange, California

5 studies are recruiting for metastatic malignant solid neoplasm in Orange, California right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

   This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or have spread to other places in the body (advanced) …

   Stage

   Phase 2

   Ages

   Any age

   Site

   Children's Hospital of Orange County, Orange, California

   Locations

   482 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05564377 on ClinicalTrials.gov

2. Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

   This phase I trial tests the safety, side effects, and best dose of neratinib in combination with trastuzumab deruxtecan in treating patients with solid tumors that have spread from where it first started (primary site) to other places in the body (metastatic) or that cannot be removed by surgery (…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California

   Locations

   18 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05372614 on ClinicalTrials.gov

3. Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

   This phase I trial tests the safety, side effects, and best dose of ZEN003694 in combination with the usual treatment with capecitabine in treating patients with cancer that has spread from where it first started (primary site) to other places in the body (metastatic) or cannot be removed by surger…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California

   Locations

   22 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05803382 on ClinicalTrials.gov

4. Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

   This phase I trial tests the safety, side effects, and best dose of novobiocin in treating cancer patients with alterations in deoxyribonucleic acid (DNA) repair genes. Novobiocin is an antibiotic that blocks the activity of a protein called DNA polymerase theta, which helps repair DNA that has bec…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California

   Locations

   23 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05687110 on ClinicalTrials.gov

5. Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

   This phase I/II trial studies the side effects and best dose of temozolomide and M1774 and how well they works in treating patients with cancer that has spread from where it first started (primary site) to other places in the body (metastatic) and may have spread to nearby tissue, lymph nodes, or d…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California

   Locations

   23 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05691491 on ClinicalTrials.gov