Metastatic Malignant Solid Neoplasm Clinical Trials in Bethesda, Maryland

9 studies are recruiting for metastatic malignant solid neoplasm in Bethesda, Maryland right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

   This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or have spread to other places in the body (advanced) …

   Stage

   Phase 2

   Ages

   Any age

   Site

   Walter Reed National Military Medical Center, Bethesda, Maryland

   Locations

   482 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05564377 on ClinicalTrials.gov

2. Testing How the Body Responds to the Drug CX-5461 (Pidnarulex) in Patients With Metastatic Solid Cancers

   This phase I trial tests the safety, side effects, and best dose of pidnarulex (CX-5461) in treating patients with solid tumors that have spread from where it first started (primary site) to other places in the body (metastatic). Pidnarulex is an oral inhibitor of ribonucleic acid polymerase I, wit…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   National Cancer Institute Developmental Therapeutics Clinic, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT06606990 on ClinicalTrials.gov

3. Durvalumab in Combination With Chemotherapy in Treating Patients With Advanced Solid Tumors, DURVA+ Trial

   This phase II trial studies the side effects of durvalumab when given together with chemotherapy in treating patients with solid tumors that have spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   National Cancer Institute Developmental Therapeutics Clinic, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT03907475 on ClinicalTrials.gov

4. Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and Tuvusertib (M1774) for Advanced Solid Tumors

   This phase I trial tests the safety, side effects and best dose of peposertib (M3814) in combination with tuvusertib (M1774) in treating patients with solid tumors that have spread to other places in the body (advanced). Peposertib and tuvusertib stop the growth of tumor cells by blocking some of t…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   National Cancer Institute Developmental Therapeutics Clinic, Bethesda, Maryland

   Locations

   7 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05687136 on ClinicalTrials.gov

5. Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

   This phase II trial tests whether ZEN003694 (ZEN-3694) in combination with talazoparib works to shrink tumors in patients with solid tumors that are unlikely to be cured or controlled with treatment and that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   National Cancer Institute Developmental Therapeutics Clinic, Bethesda, Maryland

   Locations

   36 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05327010 on ClinicalTrials.gov

6. Testing How the Body Responds to the Drug CBX-12 in Patients With Advanced Solid Cancers

   This phase I trial studies how well CBX-12 works in treating patients with solid tumors that have spread from where they first started (primary site) to started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or other places in the body (metastatic). CBX-12 works by binding t…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   National Cancer Institute Developmental Therapeutics Clinic, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05691517 on ClinicalTrials.gov

7. Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

   This phase I trial tests the safety, side effects, and best dose of novobiocin in treating cancer patients with alterations in deoxyribonucleic acid (DNA) repair genes. Novobiocin is an antibiotic that blocks the activity of a protein called DNA polymerase theta, which helps repair DNA that has bec…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   National Cancer Institute Developmental Therapeutics Clinic, Bethesda, Maryland

   Locations

   23 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05687110 on ClinicalTrials.gov

8. Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

   This phase I/II trial studies the side effects and best dose of temozolomide and M1774 and how well they works in treating patients with cancer that has spread from where it first started (primary site) to other places in the body (metastatic) and may have spread to nearby tissue, lymph nodes, or d…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   National Cancer Institute Developmental Therapeutics Clinic, Bethesda, Maryland

   Locations

   23 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05691491 on ClinicalTrials.gov

9. Studying TAK-243 in Patients With Advanced Cancer

   This phase I trial studies the side effects and best dose of ubiquitin-activating enzyme (UAE) inhibitor TAK-243 (TAK-243) in treating patients with a solid tumor that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has spre…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   National Cancer Institute Developmental Therapeutics Clinic, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT06223542 on ClinicalTrials.gov