Metabolic Syndrome Clinical Trials

31 studies are recruiting for metabolic syndrome in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Study of the Effect of Innate on the Inflammatory Response to Endotoxin

   Background: - Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s re…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

   Run by

   National Institute of Environmental Health Sciences (NIEHS)

   See if you can join NCT01143480 on ClinicalTrials.gov

2. Impact GLP-1 Agonists Following Bariatric

   Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic health of a person. GLP-1 receptor agonists (GLP1-RAs) have been show…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of Missouri Hospital, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06132477 on ClinicalTrials.gov

3. Longevity Metrics AI/ML Development Study

   This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy. Longevity Metrics collects a battery of clinical tests on each participant, in whole or in part, and follows every participant for life. The sit-to-rise tes…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07808619 on ClinicalTrials.gov

4. 100-Year Human Aging Study

   The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07563777 on ClinicalTrials.gov

5. Human Observatory Study

   The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07646782 on ClinicalTrials.gov

6. Health Ahead Comparative Effectiveness Study

   The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening system deployable in any environment, including the most isolated and r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   William Brandenburg, MD

   See if you can join NCT07669168 on ClinicalTrials.gov

7. This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder

   The goal of this observational study is to evaluate cardiorespiratory and muscular fitness in children with obesity, with and without autism spectrum disorder (ASD), and examine how fitness relates to body measurements, body composition, and cardiometabolic health. The main questions it aims to ans…

   Stage

   Not phased

   Ages

   6 to 18

   Site

   UVA Health, Charlottesville, Virginia

   Run by

   University of Virginia

   See if you can join NCT07804680 on ClinicalTrials.gov

8. The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function

   Obesity is associated with increased cardiometabolic disease risk due, in part, to heightened chronic inflammation arising from adipose tissue. There are no current targeted therapies to prevent or reverse the chronic inflammation of obesity, and a better understanding of these inflammatory pathway…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05972564 on ClinicalTrials.gov

9. A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

   TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease …

   Stage

   Not phased

   Ages

   55 and older

   Site

   Chandler Clinical Trials, Chandler, Arizona

   Locations

   125 in total

   Run by

   Cleerly, Inc.

   See if you can join NCT06112418 on ClinicalTrials.gov

10. Circadian Rhythms in Postmenopausal Women

    This is a randomized, parallel two-arm clinical trial design to study the efficacy of time-restricted feeding on metabolic risk in postmenopausal women, who may be particularly vulnerable to disruption of circadian eating rhythms and the associated metabolic dysfunction. It is hypothesized that tim…

    Stage

    Not phased

    Ages

    45 to 65

    Site

    University of Kentucky, Lexington, Kentucky

    Run by

    Julie Pendergast

    See if you can join NCT04893226 on ClinicalTrials.gov

11. Our Voices Matter: Intervention for Depression in Youth

    Over 15 million people participated in racial justice protests nationwide during 2020-2021 spotlighting activism as a collective tool against structural racism and discrimination (SRD). SRD manifests as policies and practices (e.g., redlining, voter suppression, mass incarceration) that produce hos…

    Stage

    Not phased

    Ages

    15 to 20

    Site

    Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

    Run by

    Ann & Robert H Lurie Children's Hospital of Chicago

    See if you can join NCT07216326 on ClinicalTrials.gov

12. Exercise Effects on Adipose Tissue Structure and Function

    Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise …

    Stage

    Not phased

    Ages

    18 to 40

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT04812314 on ClinicalTrials.gov

13. Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI)

    The purpose of this research study is to measure the tolerability and preliminary efficacy of a drug, galantamine, to treat metabolic syndrome (MetS) by reducing circulating inflammation in people with spinal cord injury (SCI). Galantamine is FDA-approved for the treatment of Alzheimer's disease. H…

    Stage

    Phase 2

    Ages

    21 to 75

    Site

    Northwell Health, Manhasset, New York

    Locations

    3 in total

    Run by

    Northwell Health

    See if you can join NCT07625332 on ClinicalTrials.gov

14. Combined Oral Contraceptive Pill and Resistance Starch

    This study will enroll women with PCOS to study the effects of first line therapy, oral contraceptive pills, and then either 12 weeks of resistant starch or 12 weeks of placebo to explore if resistant starch improves cardiometabolic parameters or impacts gut dysbiosis compared to placebo.

    Stage

    Phase 2

    Ages

    18 to 40

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06852365 on ClinicalTrials.gov

15. Animal and Plant Proteins and Glucose Metabolism

    The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal,…

    Stage

    Not phased

    Ages

    21 to 70

    Site

    University of Missouri School of Medicine, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT03994367 on ClinicalTrials.gov

16. Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome

    The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and skeletal muscle microvascular blood volume, improves vascular function of the conduit vessels, and enhances insulin's …

    Stage

    Phase 4

    Ages

    21 to 60

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT04575844 on ClinicalTrials.gov

17. Stand up for Your Health With a Sit-stand Desk

    More than 84 million - or 1 out of every 3 U.S. adults - have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years. Average medical expenditures among diabetics are about 2.3 times higher than expenditures for people without diabetes. Physical inactivity and…

    Stage

    Not phased

    Ages

    18 to 79

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT05585190 on ClinicalTrials.gov

18. Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

    The study aims to investigate the relationship between fasting insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across various demographic factors, including age, sex, race/ethnicity, BMI, and polycystic ovary syndrome (PCOS) diagnosis. By analyzing these variables, the stud…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Lilli Health, Houston, Texas

    Run by

    Ali Chappell

    See if you can join NCT05950282 on ClinicalTrials.gov

19. A Study Of Milk Consumption In Metabolic Syndrome

    The primary purpose of this study is to determine the impact of whole-fat dairy consumption on cardiovascular and metabolic risk factors and peripheral vascular function in adults with metabolic syndrome.

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07401888 on ClinicalTrials.gov

20. Metabolic Adaptations to Weight Loss With and Without Exercise

    Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of ad…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT05806801 on ClinicalTrials.gov

21. Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding

    Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans. The capacity of subcutaneous (subQ) adipose tissue to expand and remodel is an important determinant of obesity-related health complications, and impaire…

    Stage

    Not phased

    Ages

    18 to 42

    Site

    Pennington Biomedical Research Center, Baton Rouge, Louisiana

    Run by

    Pennington Biomedical Research Center

    See if you can join NCT04583514 on ClinicalTrials.gov

22. Exercise and Carotid Artery Function in Metabolic Syndrome

    The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely improved with a single bout of exercise. This will be achieved by testi…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT07430839 on ClinicalTrials.gov

23. Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health

    In a randomized controlled trial, the investigators intend to measure the health impact of time restricted eating (TRE) in patients with metabolic syndrome (with elevated blood pressure and at least 2 of the following: increased waist circumference, abnormal cholesterol levels, elevated triglycerid…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Altman Clinical and Translational Research Institute, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT07189234 on ClinicalTrials.gov

24. VR Stimulation of Exercise Response in Sedentary Humans

    Prolonged sedentary conditions contribute to declining health across human populations and cause significant secondary health consequences for many patients whose illnesses or injuries prevent them from exercising. The investigators have demonstrated that in a small animal fruit fly model, genetic …

    Stage

    Not phased

    Ages

    25 to 40

    Site

    Wayne State University, Detroit, Michigan

    Run by

    Wayne State University

    See if you can join NCT07296991 on ClinicalTrials.gov

25. Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.

    DOVE-MET-COME-100 is a single site prescreening survey study designed to identify adults who may be eligible for future industry-sponsored clinical trials. A physician will oversee the informed consent process, after which participants will be surveyed on demographics, medical history, current heal…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Clindove Research LLC, Brooklyn, New York

    Run by

    Clindove Research LLC

    See if you can join NCT07106879 on ClinicalTrials.gov