Metabolic Disease Clinical Trials

27 studies are recruiting for metabolic disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

   This is a single-arm, open-label, multicenter, ascending dose Phase 1 trial that will enroll participants 18 to 75 years of age with dyslipidemias that are refractory to available treatments.

   Stage

   Phase 1

   Ages

   18 to 75

   Site

   Integrity Clinical Research, Hialeah, Florida

   Locations

   17 in total

   Run by

   CRISPR Therapeutics AG

   See if you can join NCT07491172 on ClinicalTrials.gov

2. Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

   Background: - Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels. Depending on the condition being studied, both affected and nonaffected in…

   Stage

   Not phased

   Ages

   1 to 100

   Site

   Hope Center, Washington D.C., District of Columbia

   Locations

   3 in total

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT01143454 on ClinicalTrials.gov

3. Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency

   Background: Creatine transporter deficiency (CTD) is a genetic disorder that mainly affects the brain in males. CTD causes intellectual disability that can be mild to severe. People with CTD may have seizures and behavioral issues. They may have slow growth and tire easily. CTD may sometimes be con…

   Stage

   Not phased

   Ages

   2 to 40

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

   See if you can join NCT05600946 on ClinicalTrials.gov

4. Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

   Background: People s bodies need to break down food into the chemicals. These chemicals are used for energy and growth. Some people cannot process all chemicals very well. Too much of some chemicals can cause diseases. One of these diseases is called propionic acidemia (PA). People with PA can have…

   Stage

   Not phased

   Ages

   0 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Locations

   2 in total

   Run by

   National Human Genome Research Institute (NHGRI)

   See if you can join NCT02890342 on ClinicalTrials.gov

5. Improving Coronary Vascular Health in Women

   Women with HIV have an increased risk of having a myocardial infarction (heart attack) as compared to women without HIV. One of the mechanisms underlying the increased risk of myocardial infarction among women with HIV may involve reduced ability to increase blood flow through large and small coron…

   Stage

   Phase 2

   Ages

   45 to 75

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06843902 on ClinicalTrials.gov

6. Natural History of the Human Biological Response to Environmental Exposure and Injury

   Background: Environmental exposures like pollution, diet, and stress can help cause human diseases, or make them worse. Researchers want to better understand how injury and inflammation are caused by these exposures. They want to collect biological and environmental samples and other data. They may…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

   Run by

   National Institute of Environmental Health Sciences (NIEHS)

   See if you can join NCT04888923 on ClinicalTrials.gov

7. A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

   This study is First In Human study for Encapsulated Porcine Islet Cells for Xenotransplantation (OPF-310). The purpose of this study to assess the safety, tolerability, and efficacy of OPF-310 transplantation and to define the recommended Phase 2 dose (RP2D) in adult subjects with unstable Type 1 D…

   Stage

   Phase 1

   Ages

   35 to 70

   Site

   University of Illinois Hospital & Health Sciences System, Chicago, Illinois

   Run by

   Otsuka Pharmaceutical Factory, Inc.

   See if you can join NCT06575426 on ClinicalTrials.gov

8. A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

   Background: Pyrimidine and purine metabolism disorders (DPPMs) affect how the body metabolizes chemicals called pyrimidines and purines. DPPMs can cause dysfunctions throughout the body, especially in the brain, blood, kidneys, and immune system. People with DPPMs might have no symptoms, mild sympt…

   Stage

   Not phased

   Ages

   0 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Human Genome Research Institute (NHGRI)

   See if you can join NCT06092346 on ClinicalTrials.gov

9. Evaluation of Children With Endocrine and Metabolic-Related Conditions

   Background: Endocrine glands give off hormones. Researchers want to learn more about the disorders that affect these glands in children. These disorders might be caused by changes in genes. Genes contain DNA, which is the blueprint of how a cell works. Researchers want to identify the genes involve…

   Stage

   Not phased

   Ages

   0 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

   See if you can join NCT02769975 on ClinicalTrials.gov

10. NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

    Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood. Natriuretic peptides (NPs) are hormones produced by the heart that play a role in regulating the met…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04055428 on ClinicalTrials.gov

11. Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

    This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced …

    Stage

    Not phased

    Ages

    14 to 18

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06007404 on ClinicalTrials.gov

12. TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Primary Immunodeficiency and Inherited Metabolic Disorders in Children

    This research is being done to learn if a new type of haploidentical transplantation using TCR alpha beta and CD19 depleted stem cell graft from the donor is safe and effective to treat the patient's underlying condition. This study will use stem cells obtained via peripheral blood or bone marrow f…

    Stage

    Phase 2

    Ages

    Up to 21

    Site

    Johns Hopkins All Children's Hospital, St. Petersburg, Florida

    Run by

    Johns Hopkins All Children's Hospital

    See if you can join NCT04414046 on ClinicalTrials.gov

13. Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

    Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting ultimate improvement in liver disease. On the other end of the spectru…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Pichamol Jirapinyo, MD, MPH

    See if you can join NCT06138821 on ClinicalTrials.gov

14. Cardiovascular and Metabolic Sciences Biorepository

    The purpose of the Cardiovascular and Metabolic Sciences Biorepository is to collect and store information and biospecimens (blood, urine, stool, and heart tissue) from patients with and without cardiovascular and metabolic diseases to create a readily available biorepository of samples and related…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic Main Campus, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06560424 on ClinicalTrials.gov

15. Exercise Effects on Adipose Tissue Structure and Function

    Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise …

    Stage

    Not phased

    Ages

    18 to 40

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT04812314 on ClinicalTrials.gov

16. Alzheimer"s Imaging Biomarkers in Obesity

    High body fat at midlife, as evidenced by overweight or obese body mass index (BMI), is increasingly understood as a risk factor for Alzheimer's disease. However, the underlying processes and mechanisms that may underlie this risk remains unknown. With this project, the Investigator proposes to cre…

    Stage

    Not phased

    Ages

    40 to 60

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Cyrus A Raji

    See if you can join NCT05077579 on ClinicalTrials.gov

17. Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

    The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or a combination of cognitive-behavioral therapy and exercise trainin…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Children's Hospital Colorado, Aurora, Colorado

    Locations

    2 in total

    Run by

    Colorado State University

    See if you can join NCT05543083 on ClinicalTrials.gov

18. Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder

    This pilot pre-post trial will address a gap in knowledge related to addressing modifiable risk factors for cardiometabolic disease through treating residual insomnia, sleep difficulties that remain after successful treatment of another condition, in the context of PTSD in understudied older adults…

    Stage

    Not phased

    Ages

    50 and older

    Site

    VA Greater Los Angeles Healthcare System, North Hills, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05516277 on ClinicalTrials.gov

19. Metabolic Adaptations to Weight Loss With and Without Exercise

    Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of ad…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT05806801 on ClinicalTrials.gov

20. Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure

    Gastric myotomy has been performed for several years as a means of addressing chronic stenosis after sleeve gastrectomy and treating gastroparesis. The Pylorus Sparing Antral Myotomy (PSAM) technique has the opposite effect by leaving the pylorus intact and extending the myotomy proximally to the d…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Christopher C. Thompson, MD, MSc

    See if you can join NCT05711758 on ClinicalTrials.gov

21. Vascular Lab Resource (VLR) Biorepository

    This is a study of biomarkers obtained from prospectively collected subject samples and their correlation with cardiovascular and metabolic diseases. The purpose of this initiative is to develop an enduring tool to allow for collaborative research between clinicians at Cleveland Clinic Main Campus …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT05628948 on ClinicalTrials.gov

22. Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers

    People who experience repeated bouts of circadian misalignment, such as shift workers, are at higher risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D) compared to daytime workers. However, the mechanism(s) by which shift work and associated circadian misalignment increase CVD and T2D r…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Colorado State University, Fort Collins, Colorado

    Run by

    Colorado State University

    See if you can join NCT06550115 on ClinicalTrials.gov

23. Rare and Atypical Diabetes Network

    RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: 1. Identify and enroll indi…

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Colorado- Denver, Aurora, Colorado

    Locations

    13 in total

    Run by

    University of South Florida

    See if you can join NCT05544266 on ClinicalTrials.gov

24. Countermeasures to Circadian Misalignment

    Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night …

    Stage

    Not phased

    Ages

    18 to 35

    Site

    Colorado State University, Fort Collins, Colorado

    Run by

    Colorado State University

    See if you can join NCT04966351 on ClinicalTrials.gov

25. HIIT Effects on Cardiometabolic Health

    The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-res…

    Stage

    Not phased

    Ages

    18 to 25

    Site

    Women's Building, Syracuse, New York

    Run by

    Syracuse University

    See if you can join NCT05838950 on ClinicalTrials.gov