Menopause Clinical Trials

29 studies are recruiting for menopause in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Satavari and Ashoka for Menopause (SAM) Study

   This 12-week randomized, placebo-controlled clinical trial will evaluate the efficacy and safety of a daily oral supplement containing Ashoka Bark and Shatavari in women experiencing menopausal symptoms. Up to 50 participants will be randomized to receive either the active supplement or placebo, wi…

   Stage

   Not phased

   Ages

   40 to 65

   Site

   MusB Research LLC, New Port Richey, Florida

   Run by

   Vidya USA Corporation

   See if you can join NCT07861295 on ClinicalTrials.gov

2. Role of Menopause in Thermoregulation

   The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group a…

   Stage

   Phase 4

   Ages

   42 to 64

   Site

   Noll Laboratory, University Park, Pennsylvania

   Run by

   Penn State University

   See if you can join NCT06798571 on ClinicalTrials.gov

3. Sex Hormones and Aging

   This study investigates the influence of sex hormones and exercise on age-related neuromuscular decline in females. Specifically, the research aims to evaluate how hormonal variations impact both age-associated neuromuscular decline and the subsequent adaptations to exercise and resistance training…

   Stage

   Not phased

   Ages

   50 to 70

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07848438 on ClinicalTrials.gov

4. MenoZen VR for Menopause Symptom Management

   The purpose of this research is to evaluate the feasibility, acceptability, tolerability, and clinical efficacy of MenoZen VR (virtual reality) for managing menopause symptoms in women.

   Stage

   Not phased

   Ages

   45 to 60

   Site

   Mayo Clinic, Jacksonville, Florida

   Run by

   Mayo Clinic

   See if you can join NCT07633743 on ClinicalTrials.gov

5. Randomized Evaluation of Natural Extract for Menopausal Wellness (RENEW)

   This study will evaluate whether an 8-week course of a standardized herbal extract containing Shatavari and natural bio-enhancer ingredients can reduce menopausal symptoms in post-menopausal women. The study will compare the herbal extract with a matching placebo. Approximately 100 women aged 45 to…

   Stage

   Not phased

   Ages

   45 to 60

   Site

   MusB Research LLC, New Port Richey, Florida

   Run by

   India Glycols Ltd

   See if you can join NCT07834463 on ClinicalTrials.gov

6. VEDA Study (DHEA vs Estradiol)

   This study is being done to compare two vaginal treatments, vaginal estrogen and vaginal DHEA, that are used to treat vaginal and urinary symptoms related to menopause. These symptoms may include vaginal dryness, discomfort, painful intercourse, or urinary problems and can affect quality of life an…

   Stage

   Not phased

   Ages

   40 to 90

   Site

   Banner University Medical Center Phoenix, Phoenix, Arizona

   Run by

   University of Arizona

   See if you can join NCT07574216 on ClinicalTrials.gov

7. Cyclic vs. Constant Estradiol: Regimens' Effects on Brain Health

   The purpose of this study is to learn more about how estradiol patch treatment affects brain processes, health, and wellbeing.

   Stage

   Phase 4

   Ages

   38 to 60

   Site

   University of Colorado Anschutz, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07831499 on ClinicalTrials.gov

8. Haelan 951 for Menopause Symptoms in Peri- and Postmenopausal Women

   This proof-of-concept, open-label, single-arm study is designed to evaluate the effects of daily consumption of Haelan 951, a fermented soy conventional food product, on self-reported menopausal vasomotor symptoms, sleep quality, and health-related quality of life in peri- and postmenopausal women.…

   Stage

   Not phased

   Ages

   45 to 65

   Site

   Spectrum Clinical Research, Kansas City, Missouri

   Run by

   Spectrum Clinical Research, LLC

   See if you can join NCT07751029 on ClinicalTrials.gov

9. Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

   The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.

   Stage

   EARLY_Phase 1

   Ages

   18 to 70

   Site

   University of Missouri-Columbia, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06417177 on ClinicalTrials.gov

10. Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

    To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.

    Stage

    EARLY_Phase 1

    Ages

    18 to 70

    Site

    University of Missouri, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT07674680 on ClinicalTrials.gov

11. A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects

    The two products used in this study are transdermal patches that contain selegiline. The test drug is the Estradiol/Levonorgestrel Transdermal Delivery System (TDS). The comparator drug is the Climara Pro® TDS. The purpose of this research study is to compare how the skin tolerates the test TDS and…

    Stage

    Phase 1

    Ages

    40 to 75

    Site

    Novum Pharmaceutical Research Services, Las Vegas, Nevada

    Locations

    2 in total

    Run by

    Corium Innovations, Inc.

    See if you can join NCT07794150 on ClinicalTrials.gov

12. Menopausal Hormone Therapy And Left Ventricular Function

    The purpose of this study is to compare left ventricular stroke volume and heart rate responses to bursts of SNA between PMF using, and not using, MHT.

    Stage

    Not phased

    Ages

    45 to 60

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07242391 on ClinicalTrials.gov

13. Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females

    The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.

    Stage

    Phase 1

    Ages

    45 to 70

    Site

    University of Connecticut, Department of Nutritional Sciences, Storrs, Connecticut

    Run by

    University of Connecticut

    See if you can join NCT07365514 on ClinicalTrials.gov

14. Focusing on the Menopausal Transition to Improve Mid-Life Women's Health

    What if midlife women, who are inherently at an increased risk for future cardiometabolic disease due to transitioning into menopause, had access to a suite of evidence-based health interventions? Could these interventions reduce menopause-related inflammation, restore a healthier cardiometabolic p…

    Stage

    Phase 2

    Ages

    45 to 55

    Site

    University of Colorado-School of Medicine, Aurora, Colorado

    Locations

    3 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT06975111 on ClinicalTrials.gov

15. Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females

    Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD …

    Stage

    Not phased

    Ages

    45 to 75

    Site

    Student Health and Wellness Building - Department of Kinesiology, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT06480695 on ClinicalTrials.gov

16. Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women

    The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.

    Stage

    Not phased

    Ages

    45 to 60

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06743269 on ClinicalTrials.gov

17. CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life

    This study evaluates the feasibility and efficacy of the Samphire Guided Care (SGC) program * a 12-week structured digital health program combining clinician-led onboarding, at-home neuromodulation using the Lutea tDCS device, neuromodulation coach support, and app-based symptom tracking - on work …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Alethios Digital Research Platform (Decentralized), San Francisco, California

    Run by

    Samphire Group, Inc.

    See if you can join NCT07679074 on ClinicalTrials.gov

18. Hot Flashes and Neurovascular Function in Women

    Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship. As such, these studies are designed to provide a major step forward in understanding the link between h…

    Stage

    Not phased

    Ages

    40 to 60

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT05193968 on ClinicalTrials.gov

19. Menopausal HT for Women Living With HIV (HoT)

    Women living with HIV have been shown to experience more frequent and severe hot flashes and night sweats (collectively known as vasomotor symptoms) as compared to women living without HIV. This correlates with disturbed sleep, increased depressive symptoms, increased anxiety, worse mental function…

    Stage

    Phase 4

    Ages

    40 to 60

    Site

    31788 Alabama CRS, Birmingham, Alabama

    Locations

    23 in total

    Run by

    Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

    See if you can join NCT06856174 on ClinicalTrials.gov

20. Menopause Transition, Sex Hormone Deficiency and Autonomic and Vascular Function

    This is a longitudinal study to determine the influence of the menopause transition on autonomic and vascular function. PI Keller-Ross has published data demonstrating that postmenopausal females have greater sympathetic neural reactivity during a stressor compared with age-matched males and younge…

    Stage

    Not phased

    Ages

    45 to 55

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06490146 on ClinicalTrials.gov

21. The Cardiovascular Impact of Hot Flushes

    The overall objective of this study is to examine the physiological responses that occur during a hot flush in postmenopausal women. The following specific aims will be executed to reach the overall objective of this study. Aim 1: To determine if hot flushes can be reliably induced with a temperatu…

    Stage

    Not phased

    Ages

    40 to 70

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05251324 on ClinicalTrials.gov

22. The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women

    Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap. The goal of this observational study is to address this knowledge gap by looking at the role of meno…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07284082 on ClinicalTrials.gov

23. Effects of Hemp-Derived Cannabinoids on Menopause Symptoms

    The purpose of the study is to examine the impact of hemp-derived minor cannabinoids on symptoms of menopause/perimenopause.

    Stage

    Phase 2

    Ages

    40 to 60

    Site

    Washington State University, Dept of Psychology, Pullman, Washington

    Run by

    Washington State University

    See if you can join NCT07393672 on ClinicalTrials.gov

24. Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

    This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in pre…

    Stage

    Not phased

    Ages

    35 to 70

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT04439370 on ClinicalTrials.gov

25. Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

    The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.

    Stage

    EARLY_Phase 1

    Ages

    18 to 70

    Site

    University of Missouri, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT06787066 on ClinicalTrials.gov