Menopause Clinical Trials

24 studies are recruiting for menopause in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Haelan 951 for Menopause Symptoms in Peri- and Postmenopausal Women

   This proof-of-concept, open-label, single-arm study is designed to evaluate the effects of daily consumption of Haelan 951, a fermented soy conventional food product, on self-reported menopausal vasomotor symptoms, sleep quality, and health-related quality of life in peri- and postmenopausal women.…

   Stage

   Not phased

   Ages

   45 to 65

   Site

   Spectrum Clinical Research, Kansas City, Missouri

   Run by

   Spectrum Clinical Research, LLC

   See if you can join NCT07751029 on ClinicalTrials.gov

2. Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

   The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.

   Stage

   EARLY_Phase 1

   Ages

   18 to 70

   Site

   University of Missouri-Columbia, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06417177 on ClinicalTrials.gov

3. Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

   To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.

   Stage

   EARLY_Phase 1

   Ages

   18 to 70

   Site

   University of Missouri, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT07674680 on ClinicalTrials.gov

4. A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects

   The two products used in this study are transdermal patches that contain selegiline. The test drug is the Estradiol/Levonorgestrel Transdermal Delivery System (TDS). The comparator drug is the Climara Pro® TDS. The purpose of this research study is to compare how the skin tolerates the test TDS and…

   Stage

   Phase 1

   Ages

   40 to 75

   Site

   Novum Pharmaceutical Research Services, Las Vegas, Nevada

   Locations

   2 in total

   Run by

   Corium Innovations, Inc.

   See if you can join NCT07794150 on ClinicalTrials.gov

5. Menopausal Hormone Therapy And Left Ventricular Function

   The purpose of this study is to compare left ventricular stroke volume and heart rate responses to bursts of SNA between PMF using, and not using, MHT.

   Stage

   Not phased

   Ages

   45 to 60

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT07242391 on ClinicalTrials.gov

6. Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females

   The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.

   Stage

   Phase 1

   Ages

   45 to 70

   Site

   University of Connecticut, Department of Nutritional Sciences, Storrs, Connecticut

   Run by

   University of Connecticut

   See if you can join NCT07365514 on ClinicalTrials.gov

7. Focusing on the Menopausal Transition to Improve Mid-Life Women's Health

   What if midlife women, who are inherently at an increased risk for future cardiometabolic disease due to transitioning into menopause, had access to a suite of evidence-based health interventions? Could these interventions reduce menopause-related inflammation, restore a healthier cardiometabolic p…

   Stage

   Phase 2

   Ages

   45 to 55

   Site

   University of Colorado-School of Medicine, Aurora, Colorado

   Locations

   3 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT06975111 on ClinicalTrials.gov

8. Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females

   Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD …

   Stage

   Not phased

   Ages

   45 to 75

   Site

   Student Health and Wellness Building - Department of Kinesiology, Charlottesville, Virginia

   Run by

   University of Virginia

   See if you can join NCT06480695 on ClinicalTrials.gov

9. Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women

   The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.

   Stage

   Not phased

   Ages

   45 to 60

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06743269 on ClinicalTrials.gov

10. CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life

    This study evaluates the feasibility and efficacy of the Samphire Guided Care (SGC) program * a 12-week structured digital health program combining clinician-led onboarding, at-home neuromodulation using the Lutea tDCS device, neuromodulation coach support, and app-based symptom tracking - on work …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Alethios Digital Research Platform (Decentralized), San Francisco, California

    Run by

    Samphire Group, Inc.

    See if you can join NCT07679074 on ClinicalTrials.gov

11. Role of Menopause in Thermoregulation

    The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group a…

    Stage

    Phase 4

    Ages

    42 to 64

    Site

    Noll Laboratory, University Park, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT06798571 on ClinicalTrials.gov

12. Hot Flashes and Neurovascular Function in Women

    Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship. As such, these studies are designed to provide a major step forward in understanding the link between h…

    Stage

    Not phased

    Ages

    40 to 60

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT05193968 on ClinicalTrials.gov

13. Menopausal HT for Women Living With HIV (HoT)

    Women living with HIV have been shown to experience more frequent and severe hot flashes and night sweats (collectively known as vasomotor symptoms) as compared to women living without HIV. This correlates with disturbed sleep, increased depressive symptoms, increased anxiety, worse mental function…

    Stage

    Phase 4

    Ages

    40 to 60

    Site

    31788 Alabama CRS, Birmingham, Alabama

    Locations

    23 in total

    Run by

    Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

    See if you can join NCT06856174 on ClinicalTrials.gov

14. Menopause Transition, Sex Hormone Deficiency and Autonomic and Vascular Function

    This is a longitudinal study to determine the influence of the menopause transition on autonomic and vascular function. PI Keller-Ross has published data demonstrating that postmenopausal females have greater sympathetic neural reactivity during a stressor compared with age-matched males and younge…

    Stage

    Not phased

    Ages

    45 to 55

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06490146 on ClinicalTrials.gov

15. The Cardiovascular Impact of Hot Flushes

    The overall objective of this study is to examine the physiological responses that occur during a hot flush in postmenopausal women. The following specific aims will be executed to reach the overall objective of this study. Aim 1: To determine if hot flushes can be reliably induced with a temperatu…

    Stage

    Not phased

    Ages

    40 to 70

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05251324 on ClinicalTrials.gov

16. The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women

    Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap. The goal of this observational study is to address this knowledge gap by looking at the role of meno…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07284082 on ClinicalTrials.gov

17. Effects of Hemp-Derived Cannabinoids on Menopause Symptoms

    The purpose of the study is to examine the impact of hemp-derived minor cannabinoids on symptoms of menopause/perimenopause.

    Stage

    Phase 2

    Ages

    40 to 60

    Site

    Washington State University, Dept of Psychology, Pullman, Washington

    Run by

    Washington State University

    See if you can join NCT07393672 on ClinicalTrials.gov

18. Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

    This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in pre…

    Stage

    Not phased

    Ages

    35 to 70

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT04439370 on ClinicalTrials.gov

19. Depression, Aging, Stress and Heart Health Study

    Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women. The menopausal transition or perimenopause is a period of vulnerability for both depression and CVD, making it a key time to study this critica…

    Stage

    Not phased

    Ages

    44 to 55

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT05570721 on ClinicalTrials.gov

20. Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

    The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.

    Stage

    EARLY_Phase 1

    Ages

    18 to 70

    Site

    University of Missouri, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT06787066 on ClinicalTrials.gov

21. Efficacy and Safety of Shatavari for Treatment of Menopausal Symptoms in Women: A Randomized, Double-blind, Three-arm, Parallel, Placebo-controlled Study

    This is a Multi-center, Multi-national, Prospective, Randomized, Double-Blind, Placebo- Controlled three arm study to evaluate the efficacy and safety of Shatavari for the treatment of Menopausal symptoms in Women. Participants will be randomized to either one of the three treatment arms.Participan…

    Stage

    Not phased

    Ages

    45 to 55

    Site

    SF Research Institute, Inc., San Francisco, California

    Run by

    SF Research Institute, Inc.

    See if you can join NCT06716554 on ClinicalTrials.gov

22. Apple Women's Health Study

    This is an observational longitudinal study to advance the understanding of menstrual cycle and gynecologic health conditions including PCOS, infertility and breast cancer.The study will be hosted within the Research app(available on App Store), which allows a user to find, enroll, and participate …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Harvard T.H. Chan School of Public Health, Boston, Massachusetts

    Run by

    Apple Inc.

    See if you can join NCT04196595 on ClinicalTrials.gov

23. Cardiometabolic Consequences of the Loss of Ovarian Function

    The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease. The purpose of this research is to study how the decrease in estrogen at menopause changes artery health an…

    Stage

    Phase 4

    Ages

    20 to 45

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06264882 on ClinicalTrials.gov

24. Bioenergetic Effects of Aging and Menopause (BEAM)

    The menopause transition is associated with increased risk for weight gain and a shift toward storing fat in the belly region, which may increase risk for cardiovascular disease and diabetes. The study will determine whether the stress hormone cortisol contributes to this shift.

    Stage

    Phase 4

    Ages

    40 to 65

    Site

    University of Colorado - Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT04043520 on ClinicalTrials.gov