Meningioma Clinical Trials

19 studies are recruiting for meningioma in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study of Zanzalintinib in Participants With Recurrent or Progressive Meningioma

   The objective of the study is to evaluate efficacy and safety of zanzalintinib in participants with recurrent or progressive meningioma refractory to standard therapies.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Alabama, Birmingham, Alabama

   Locations

   17 in total

   Run by

   Exelixis

   See if you can join NCT07428616 on ClinicalTrials.gov

2. Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)

   This is a multi-arm phase II platform-basket screening study designed to test multiple experimental therapies simultaneously in patients with NF2-related schwannomatosis (NF2-SWN, formerly known as neurofibromatosis type 2) with associated progressive tumors of vestibular schwannomas (VS), non-vest…

   Stage

   Phase 2

   Ages

   12 and older

   Site

   UCLA Medical Center, Los Angeles, California

   Locations

   6 in total

   Run by

   Scott R. Plotkin, MD, PhD

   See if you can join NCT04374305 on ClinicalTrials.gov

3. Adjuvant Hypofractionated Stereotactic Radiosurgery for Intermediate-risk Meningioma

   This clinical trial tests the safety and effectiveness of hypofractionated stereotactic radiosurgery for treating patients who have undergone surgical resection for grade II meningiomas or grade I meningiomas that have come back after a period of improvement (recurrent). Radiation therapy uses high…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06557512 on ClinicalTrials.gov

4. Feasibility of Acquiring Hyperpolarized Imaging in Patients With Meningioma

   This is a Pilot/Phase I clinical study of hyperpolarized 13C (HP 13C) pyruvate injection that includes the acquisition of magnetic resonance (MR) data performed on participants with meningioma to evaluate metabolism and aid in the non-invasive characterization of aggressive tumor behavior

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   Charlie Wang, MD, PhD

   See if you can join NCT06014905 on ClinicalTrials.gov

5. A Study of JZP3507 (ONC206) in Recurrent Grade 2 or 3 Meningioma

   This study will recruit participants with Grade 2 and 3 meningiomas who have failed prior therapy. Participants will receive oral doses of JZP3507. The antitumor activity and safety of JZP3507 will be evaluated.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   NYU- Langone Health, New York, New York

   Locations

   5 in total

   Run by

   Jazz Pharmaceuticals

   See if you can join NCT07533942 on ClinicalTrials.gov

6. Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

   This study will evaluate the safety and efficacy of Lutathera (177Lu-DOTATATE) in patients with progressive or recurrent High-Grade Central Nervous System (CNS) tumors and meningiomas that demonstrate uptake on DOTATATE PET. The drug will be given intravenously once every 8 weeks for a total of up …

   Stage

   Phase 1

   Ages

   4 to 39

   Site

   Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

   Locations

   4 in total

   Run by

   Nationwide Children's Hospital

   See if you can join NCT05278208 on ClinicalTrials.gov

7. Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

   This pilot clinical study evaluates the safety and imaging performance of panitumumab-IRDye800 (pan800), a fluorescent, EGFR-targeted imaging agent - in patients undergoing neurosurgical resection of intracranial lesions.

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Eben Rosenthal

   See if you can join NCT07493447 on ClinicalTrials.gov

8. Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients

   In this proposal, the investigators introduce a novel, translational study to prospectively examine primary brain tumor patients undergoing fractionated radiation therapy to the brain. Quantitative neuroimaging, radiation dose information, and directed neurocognitive testing will be acquired throug…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Moores Cancer Center, San Diego, California

   Run by

   Jona Hattangadi-Gluth

   See if you can join NCT05576103 on ClinicalTrials.gov

9. Cognitive Status After Removal of Skull Base Meningioma

   The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Ohio State University Wexner Medical Center, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT04635657 on ClinicalTrials.gov

10. Tumor Genomics, Individual Risk Factors, and External Drivers of Health on Health Outcomes for Patients With Meningioma

    Meningiomas are the most common primary brain tumor, and some groups are diagnosed with higher-grade tumors and have clinically worse outcomes. This study investigates social determinants of health and individual risk factors that may be associated with meningioma.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07418775 on ClinicalTrials.gov

11. Cabozantinib for Patients With Recurrent or Progressive Meningioma

    A Phase II Study of Cabozantinib for Patients with Recurrent or Progressive Meningioma

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Miami Cancer Institute at Baptist Health, Inc., Miami, Florida

    Locations

    3 in total

    Run by

    Baptist Health South Florida

    See if you can join NCT05425004 on ClinicalTrials.gov

12. Targeted Alpha-Particle Therapy for Advanced Somatostatin Receptor Type 2 (SSTR2) Positive Tumors

    This study is Phase I/IIa First-in-Human Study of [212Pb]VMT-α-NET Targeted Alpha-Particle Therapy for Advanced SSTR2 Positive Tumors

    Stage

    Phase 1

    Ages

    18 to 90

    Site

    Mayo Clinic, Jacksonville, Florida

    Locations

    19 in total

    Run by

    Perspective Therapeutics

    See if you can join NCT05636618 on ClinicalTrials.gov

13. Abemaciclib in Newly Diagnosed Meningioma Patients

    This study is being done to learn about how an investigational drug called abemaciclib works in treating patients with a newly-diagnosed grade 3 meningioma. Abemaciclib is a drug that is approved by the FDA, but not for brain tumors. Participants who consent to the trial will have surgical tissue c…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    St. Joseph's Hospital and Medical Center, Phoenix, Arizona

    Run by

    Nader Sanai

    See if you can join NCT05940493 on ClinicalTrials.gov

14. Feasibility of Intraoperative Tracing of Meningioma Using [Cu64]DOTATATE

    The study team hypothesizes that it is feasible to intraoperatively detect tumor following [CU64]DOTATATE injection using the gamma probe device.

    Stage

    Phase 4

    Ages

    18 to 99

    Site

    New York-Presbyterian/Weill Cornell Medical Center, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT06377371 on ClinicalTrials.gov

15. Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial

    This phase II trial tests the effect of decreasing (tapering) doses of dexamethasone on steroid side effects in patients after surgery to remove (craniotomy) a brain tumor. Steroids are the gold standard post-surgery treatment to reduce swelling (edema) at the surgical site to reduce neurological s…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06132685 on ClinicalTrials.gov

16. Evaluation of the CONVIVO System

    The primary objective of this study is to evaluate the diagnostic performance of the CONVIVO confocal endomicroscope in discriminating between normal and abnormal tissue in vivo during brain tumor surgery. The interpretation of intraoperative images obtained in situ will be tested against conventio…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT05139277 on ClinicalTrials.gov

17. Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

    This phase I trial studies how well zirconium (Zr)-89 crefmirlimab berdoxam and immuno-positron emission tomography (PET) identifies areas of immune cell activity in patients with brain tumors that can be removed by surgery (resectable). One important predictor of the immune response is the presenc…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California

    Run by

    Jonsson Comprehensive Cancer Center

    See if you can join NCT06650163 on ClinicalTrials.gov

18. 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.

    The study population consists of patients who undergo resection for somatostatin receptor-positive (SSTR-positive) CNS tumors, focusing on meningioma, and including esthesioneuroblastoma, hemangioblastoma, medulloblastoma, paraganglioma, pituitary adenoma, and SSTR-positive systemic cancers metasta…

    Stage

    Phase 4

    Ages

    18 to 100

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT04081701 on ClinicalTrials.gov

19. HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

    The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-CA, to improve the quality of life and cognitive function in Service Members, Veterans and civilians who are survivors of brain cancer or a brain tumor (CA participants). This study will also assess the abi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth-Health Lebanon, Lebanon, New Hampshire

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT06930846 on ClinicalTrials.gov