Malignant Neoplasm Clinical Trials

22 studies are recruiting for malignant neoplasm in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

   Researchers are looking for new ways to treat children with hepatoblastoma or rhabdomyosarcoma (RMS) that has relapsed or is refractory: * Hepatoblastoma is a common liver cancer in babies and very young children * RMS is a cancer that starts in muscle cells, often in a child's head and neck, bladd…

   Stage

   Phase 1

   Ages

   0 to 17

   Site

   Childrens Hospital Los Angeles ( Site 3006), Los Angeles, California

   Locations

   63 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT06941272 on ClinicalTrials.gov

2. A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

   Researchers are looking for new ways to treat children with relapsed or refractory solid tumors: * Relapsed means the cancer came back after treatment * Refractory means the cancer did not respond (get smaller or go away) to treatment * Solid tumors are cancers mostly in body organs and tissues, no…

   Stage

   Phase 1

   Ages

   0 to 17

   Site

   Children's Hospital Los Angeles ( Site 4006), Los Angeles, California

   Locations

   26 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT07630974 on ClinicalTrials.gov

3. A Clinical Study of MK-4716 in People With Certain Solid Tumors (MK-4716-001)

   Researchers are looking for new ways to treat certain advanced or metastatic solid tumors. The goal of this study is to learn about the safety of MK-4716 and if people tolerate it when taken alone or with other treatments.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Rutgers Cancer Institute of New Jersey ( Site 0052), New Brunswick, New Jersey

   Locations

   21 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT07247110 on ClinicalTrials.gov

4. A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)

   Researchers are looking for new ways to treat people with certain advanced solid tumors. Advanced means the cancer has spread to other parts of the body and cannot be removed with surgery. Solid tumors are cancers mostly in body organs and tissues, not in the blood or other body liquids. The main g…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   The University of Alabama at Birmingham ( Site 1005), Birmingham, Alabama

   Locations

   49 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT06818643 on ClinicalTrials.gov

5. Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus

   This phase II trial studies how well donor cytotoxic T lymphocytes work in treating patients with malignancies with BK and/or JC virus. Cytotoxic T lymphocytes are made from donated blood cells that are grown in the laboratory and are designed to kill viruses that can cause infections in transplant…

   Stage

   Phase 2

   Ages

   Any age

   Site

   M D Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT02479698 on ClinicalTrials.gov

6. Clinical Study of MK-4884 in Participants With Advanced or Metastatic Solid Tumors (MK-4884-001)

   Researchers are looking for new ways to treat certain types of advanced and/or metastatic solid tumors. The main goal of this study is to learn about the safety of different doses of MK-4884 and if participants tolerate them.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   NEXT Oncology ( Site 0151), San Antonio, Texas

   Locations

   8 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT07600749 on ClinicalTrials.gov

7. KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

   Researchers want to learn if using a study medicine called MK-1084 can help treat Non-Small Cell Lung Cancer (NSCLC). MK-1084 is a type of treatment called targeted therapy for the Kirsten rat sarcoma viral oncogene homolog (KRAS) G12C gene change. The goal of this study is to learn about the safet…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Clermont Oncology Center ( Site 0041), Clermont, Florida

   Locations

   39 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT07252739 on ClinicalTrials.gov

8. A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)

   Researchers want to learn if MK-5684 (the study medicine) can treat breast cancer, ovarian cancer, and endometrial cancer. MK-5684, the study medicine, is designed to treat cancer by blocking the body from making steroid hormones. Researchers will compare MK-5684 to the standard treatments for each…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Alaska Womens Cancer Care ( Site 0037), Anchorage, Alaska

   Locations

   59 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT06979596 on ClinicalTrials.gov

9. Project: Every Child for Younger Patients With Cancer

   This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.

   Stage

   Not phased

   Ages

   Up to 25

   Site

   Children's Hospital of Alabama, Birmingham, Alabama

   Locations

   279 in total

   Run by

   Children's Oncology Group

   See if you can join NCT02402244 on ClinicalTrials.gov

10. Patient-Derived Xenografts to Reduce Cancer Health Disparities

    This trial establishes patient-derived cancer xenografts in addressing cancer health and treatment disparities that disproportionately affect racial/ethnic minorities. Understanding the genetic and response differences among racial/ethnic minorities may help researchers enhance the precision of the…

    Stage

    Not phased

    Ages

    21 to 100

    Site

    UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California

    Locations

    2 in total

    Run by

    University of California, Davis

    See if you can join NCT04410302 on ClinicalTrials.gov

11. New Assessment System in Measuring Symptom Distress in Cancer Patients

    This trial studies how well a new assessment system (MDASI or other MD Anderson-developed PRO instrument) works in measuring symptoms and the impact on quality of life in cancer patients. Development of a new assessment system may provide more information about the common symptoms that may occur in…

    Stage

    Not phased

    Ages

    18 and older

    Site

    M D Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT00505245 on ClinicalTrials.gov

12. Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"

    The main goal of this phase of the study is to determine if objectively assessed Physical Activity (PA) levels in advanced-cancer patients are associated with health care provider (HCP)-assessed ECOG performance status and overall survival. The purpose is to advance the evidence-base for incorporat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    M D Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT01365169 on ClinicalTrials.gov

13. Molecular Genetics Studies of Cancer Patients and Their Relatives

    This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.

    Stage

    Not phased

    Ages

    Any age

    Site

    Valleywise Comprehensive Health Center - Phoenix, Phoenix, Arizona

    Locations

    42 in total

    Run by

    City of Hope Medical Center

    See if you can join NCT04185935 on ClinicalTrials.gov

14. A Study to See if an iPhone Weight Management App Can Help Promote Weight Loss in Adolescents and Young Adults After a Stem Cell Transplant

    This early phase I trial studies how well a behavioral weight loss intervention consisting of a smartphone application and coaching works for the promotion of weight loss in adolescents and young adults after a stem cell transplant. This study may help researchers learn more about how adolescents a…

    Stage

    Not phased

    Ages

    13 to 30

    Site

    UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California

    Run by

    Jonsson Comprehensive Cancer Center

    See if you can join NCT04453072 on ClinicalTrials.gov

15. Norris ORIEN Total Cancer Care

    This research trial collects biological samples and clinical information to create a repository of data from patients with cancer or a predisposition for cancer. Combining genetic information from biological samples and clinical data may lead to more knowledge about why certain cancers respond to t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    USC / Norris Comprehensive Cancer Center, Los Angeles, California

    Run by

    University of Southern California

    See if you can join NCT02970045 on ClinicalTrials.gov

16. Intraoperative Tumor Margin Identification With ICG Dye Imaging

    In this research study we want to learn more about the use of indocyanine green (ICG) during bone or soft tissue mass resections. Indocyanine green (ICG) is a type of dye that is used in medical diagnostics. We want to determine if ICG-guided tumor resection is more effective in obtaining negative …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04752137 on ClinicalTrials.gov

17. A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation

    The study is a first-in-human (FIH), open-label, multi-center phase 1/2 study of TSN1611 in subjects with KRAS G12D mutant advanced solid tumors. This study will consist of a phase 1 dose escalation part and phase 2 dose expansion part. This study will evaluate the efficacy of TSN1611 at RP2D(s) th…

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    MD Anderson Cancer Center, Houston, Texas

    Locations

    19 in total

    Run by

    Tyligand Pharmaceuticals (Suzhou) Limited

    See if you can join NCT06385925 on ClinicalTrials.gov

18. Targeted Genomic Analysis of Blood and Tissue Samples From Patients With Cancer

    This research trial studies the use of targeted genomic analysis of blood and tissue samples from patients with cancer. Genomic sequencing is a laboratory method that is used to determine the entire genetic makeup of a specific organism or cell type. Genomic sequencing can be used to find changes i…

    Stage

    Not phased

    Ages

    1 and older

    Site

    RWJBarnabas Health - Jersey City Medical Center, Jersey City, Jersey City, New Jersey

    Locations

    11 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT02688517 on ClinicalTrials.gov

19. Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers

    This research trial collects and stores blood, tissue, and bone marrow specimens from patients with cancer or blood disorders, and healthy volunteers to study the immune system in a variety of different types of experiments, as well as associated clinical data as appropriate, focused on understandi…

    Stage

    Not phased

    Ages

    19 and older

    Site

    USC / Norris Comprehensive Cancer Center, Los Angeles, California

    Run by

    University of Southern California

    See if you can join NCT03207854 on ClinicalTrials.gov

20. Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing

    This clinical trial studies engagement strategies for recruiting American Indians (AI) of Southwestern Tribal Nations for cancer genome sequencing. American Indians in the Southwest have higher rates of some types of cancer, such as cancers that arise in the liver, kidney, breast, and colon. Americ…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico

    Run by

    New Mexico Cancer Research Alliance

    See if you can join NCT06207864 on ClinicalTrials.gov

21. Germ-Line Mutations in Blood and Saliva Samples From Patients With Cancer

    This research trial studies germ-line mutations in blood and saliva samples from patients with cancer. Studying samples of blood and saliva from patients with cancer in the laboratory may help doctors learn more about how inherited genetic mutations can affect cancer predisposition (an inherited in…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Jonsson Comprehensive Cancer Center, Los Angeles, California

    Run by

    Jonsson Comprehensive Cancer Center

    See if you can join NCT02280161 on ClinicalTrials.gov

22. A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

    This is an open-label, multicenter, first-in-human dose-escalation and expansion Phase 1-2 study designed to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of OR502 administered as a monotherapy and in combination with cemiplimab in subje…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    NEXT Austin, Austin, Texas

    Locations

    4 in total

    Run by

    OncoResponse, Inc.

    See if you can join NCT06090266 on ClinicalTrials.gov