Major Depressive Disorder (MDD) Clinical Trials in Boston, Massachusetts

4 studies are recruiting for major depressive disorder (mdd) in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

  1. A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

    This is a randomized, parallel-group, double-blind, placebo-controlled, monotherapy study to evaluate the efficacy, safety, and tolerability of SPT-300 (GlyphAllo) in adults with major depressive disorder (MDD), with or without anxious distress.

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    Seaport Investigator Site, Boston, Massachusetts
    Locations
    61 in total
    Run by
    Seaport Therapeutics

    See if you can join NCT07065240 on ClinicalTrials.gov

  2. A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

    In this study, researchers will learn more about a study drug called DT-101 in participants with Major Depressive Disorder (MDD), a form of depression. The goal of this clinical trial is to learn if DT-101 can treat depression in adults. The effect of DT-101 will be compared to placebo. A placebo l…

    Stage
    Phase 2
    Ages
    18 to 75
    Site
    Draig Clinical Site, Boston, Massachusetts
    Locations
    23 in total
    Run by
    Draig Therapeutics Ltd

    See if you can join NCT07610473 on ClinicalTrials.gov

  3. Home-Based tDCS Treatment Of Major Depressive Disorder

    The REACH-tDCS study will evaluate the safety and efficacy of a noninvasive, at-home self-administered Sooma tDCS brain stimulation treatment for Major Depressive Disorder. The study uses randomized, blinded, placebo controlled design. The participants are assessed with video interviews and self-re…

    Stage
    Not phased
    Ages
    22 to 70
    Site
    Curavit Clinical Research (virtual study site), Boston, Massachusetts
    Run by
    Sooma Medical Inc

    See if you can join NCT06976697 on ClinicalTrials.gov

  4. Mechanisms Of Orbitofrontal Stimulation in Depression

    The orbitofrontal cortex (OFC), a region involved in emotional regulation, decision making, and reward processing, is a key area linked to antidepressant response. This study tests whether noninvasive stimulation of the OFC using transcranial magnetic stimulation (TMS) can improve depressive sympto…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Beth Israel Deaconess Medical Center, Boston, Massachusetts
    Run by
    Subha Subramanian

    See if you can join NCT07230990 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.