Lymphedema Clinical Trials

18 studies are recruiting for lymphedema in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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By city

New York, New York 5 Houston, Texas 4 Harrison, New York 3

Studies now recruiting

  1. Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)

    To learn if pentoxifylline and vitamin E or pravastatin can reduce radiation-induced lymphedema/fibrosis.

    Stage
    Phase 2
    Ages
    18 and older
    Site
    MD Anderson Cancer Center, Houston, Texas
    Run by
    M.D. Anderson Cancer Center

    See if you can join NCT06494111 on ClinicalTrials.gov

  2. A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling Surgeons

    The objective of this study is to evaluate the Symani System's safety and effectiveness for microsurgical anastomosis during free tissue transfer surgery and lymphovenous anastomosis surgery. The primary endpoints are: * Effectiveness- Rate of intraoperative anastomosis patency at first attempt. * …

    Stage
    Not phased
    Ages
    22 and older
    Site
    Cedars Sinai Medical Center, Beverly Hills, California
    Locations
    6 in total
    Run by
    MMI (Medical Microinstruments, Inc.)

    See if you can join NCT06725030 on ClinicalTrials.gov

  3. LYMPHA Procedure for the Prevention of Lymphedema After Axillary Lymphadenectomy

    Lymphedema is a chronic, progressive, and debilitating condition that occurs with disruption or obstruction of the lymphatic system, which commonly occurs a result of breast cancer therapy. The purpose of this study is to determine if the use of a low risk lymphatic reconstruction procedure at the …

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Stanford Cancer Institute, San Francisco, California
    Run by
    Stanford University

    See if you can join NCT05366699 on ClinicalTrials.gov

  4. Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

    To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer. Researchers will compare these drugs to find the most effective therapy for preventing or limiting these side effects.

    Stage
    Phase 2
    Ages
    Any age
    Site
    MD Anderson Cancer Center, Houston, Texas
    Run by
    M.D. Anderson Cancer Center

    See if you can join NCT06912763 on ClinicalTrials.gov

  5. Screening For BCRL In Targeted Therapy For Breast Cancer

    This a prospective, longitudinal study designed to track edema and Breast Cancer Related Lymphedema (BCRL) onset in breast cancer patients taking targeted therapy treatments for early and metastatic breast cancer. A Perometer and Sozo devise will be used to measure volume changes

    Stage
    Not phased
    Ages
    18 to 80
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT05142800 on ClinicalTrials.gov

  6. Lymphedema Surveillance Study

    This study is being done to find out how many women develop lymphedema after an axillary lymph node dissection. The investigators also want to look for reasons why some women get lymphedema and others don't. Specifically, the investigators want to do tests on the breast tissue that is removed at th…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Memorial Sloan Kettering Basking Ridge (Consent only), Basking Ridge, New Jersey
    Locations
    7 in total
    Run by
    Memorial Sloan Kettering Cancer Center

    See if you can join NCT02743858 on ClinicalTrials.gov

  7. Clinical Study to Evaluate the Effectiveness and Health Economics of a Novel Portable Non-Pneumatic Active Compression Device (NPCD) for Lymphedema/Phlebolymphedema

    An open-label, multi-center, prospective VA study to evaluate the effectiveness and health economics of a Novel Portable Non-Pneumatic Active Compression Device (NPCD) for lymphedema/phlebolymphedema

    Stage
    Not phased
    Ages
    18 to 100
    Site
    Glenn Jacobowitz, New York, New York
    Run by
    Koya Medical, Inc.

    See if you can join NCT06418282 on ClinicalTrials.gov

  8. Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.

    To learn if reconstruction of the lymphatic system at the time of axillary lymphadenectomy can reduce the risk of developing lymphedema.

    Stage
    Phase 2
    Ages
    18 and older
    Site
    MD Anderson Cancer Center, Houston, Texas
    Run by
    M.D. Anderson Cancer Center

    See if you can join NCT06989099 on ClinicalTrials.gov

  9. Prospective Screening for Breast Cancer-related Lymphedema

    The primary objectives of this study are twofold: 1) to detect and determine the level of symptoms, functional disability, and changes in quality of life that breast cancer patients experience from changes in their arms during and after treatment for breast cancer by collecting patient reported out…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT01521741 on ClinicalTrials.gov

  10. Vascular Lab Resource (VLR) Biorepository

    This is a study of biomarkers obtained from prospectively collected subject samples and their correlation with cardiovascular and metabolic diseases. The purpose of this initiative is to develop an enduring tool to allow for collaborative research between clinicians at Cleveland Clinic Main Campus …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Cleveland Clinic, Cleveland, Ohio
    Run by
    The Cleveland Clinic

    See if you can join NCT05628948 on ClinicalTrials.gov

  11. A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast Cancer

    The purpose of this study to test whether a comprehensive program may help the lymph fluid to drain out of the arm and prevent lymphedema in participants with breast cancer.

    Stage
    Phase 3
    Ages
    18 to 75
    Site
    Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey
    Locations
    7 in total
    Run by
    Memorial Sloan Kettering Cancer Center

    See if you can join NCT06144164 on ClinicalTrials.gov

  12. A Study Comparing Quality of Life in Patients With Lymphedema Who Undergo Surgical Treatment Versus Non-Surgical Management

    This study is being done to see the long-term results for patients who choose to have surgery for lymphedema (with the vascularized lymph node transfer), compared to patients who choose not to have surgery.

    Stage
    Not phased
    Ages
    18 to 80
    Site
    Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison, New York
    Locations
    3 in total
    Run by
    Memorial Sloan Kettering Cancer Center

    See if you can join NCT03248310 on ClinicalTrials.gov

  13. A Real-World Registry of Chronic Wounds and Ulcers

    WOUNDJOURNEY is a longitudinal, real-world, observational registry designed to capture the full clinical course and patient journey associated with chronic wounds and ulcers. Data are collected during routine care from over 1,400 clinicians across the USA and Puerto Rico using a highly structured c…

    Stage
    Not phased
    Ages
    Any age
    Site
    US Wound Registry, The Woodlands, Texas
    Run by
    U.S. Wound Registry

    See if you can join NCT02280733 on ClinicalTrials.gov

  14. Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema

    Lymphedema affects millions and currently lacks effective drug treatments, relying mainly on compression therapy. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown potential in managing obesity and diabetes, which can worsen lymphedema. Although anecdotal evidence suggests benefits o…

    Stage
    EARLY_Phase 1
    Ages
    18 and older
    Site
    River Center, Red Bank, New Jersey
    Locations
    2 in total
    Run by
    Advanced Reconstructive Surgery Alliance

    See if you can join NCT07012642 on ClinicalTrials.gov

  15. LymphBridge: Surgical Evaluation for Breast Cancer-Associated Lymphedema (BioBridge)

    To investigate whether the addition of Fibralign's BioBridge® Collagen Matrix (BioBridge) devices to the standard surgery for vascularized lymph node transfer will improve the outcome of surgical treatment in lymphedema of the upper arm.

    Stage
    Not phased
    Ages
    18 to 75
    Site
    The University of Chicago Biological Sciences Division/University of Chicago Medical Center, Chicago, Illinois
    Locations
    2 in total
    Run by
    Fibralign Corporation

    See if you can join NCT04606030 on ClinicalTrials.gov

  16. Surgical Evaluation for Upper Extremity Lymphedema (BioBridge)

    To investigate whether the addition of Fibralign's BioBridge® Collagen Matrix (BioBridge) devices to the standard surgery for vascularized lymph node transfer will improve the outcome of surgical treatment in lymphedema of the upper arm.

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Stanford University, Stanford, California
    Run by
    Fibralign Corporation

    See if you can join NCT05695924 on ClinicalTrials.gov

  17. Pedal Pump and Leg Lymphedema

    Chronic lymphedema in the lower extremities is a common problem found in older adults that can result in cellulitis, poor wound healing, venous stasis ulcers, and other comorbidities. Compressive therapies are the present gold standard for the manual treatment of lymphedema in the lower extremities…

    Stage
    Not phased
    Ages
    55 to 100
    Site
    Rowan University School of Osteopathic Medicine, Stratford, New Jersey
    Run by
    Rowan University

    See if you can join NCT06235463 on ClinicalTrials.gov

  18. A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery

    To evaluate the Dayspring Active Wearable Compression Technology in enhancing lymph movement and its safety and effectiveness after lymphatic surgery

    Stage
    Not phased
    Ages
    18 and older
    Site
    Dung Nguyen, MD, PharmD, Palo Alto, California
    Run by
    Koya Medical, Inc.

    See if you can join NCT04888975 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.