Long COVID Clinical Trials

27 studies are recruiting for long covid in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Long-Covid-19 Alleviation Through Learning Mindfulness Study

   This research is being done to study a mindfulness intervention among people who have symptoms of Post-Acute Sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID. Mindfulness is defined as paying attention to the present moment with non-judgment and acceptance. Here the investigators a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Columbia University, New York, New York

   Run by

   Columbia University

   See if you can join NCT07140094 on ClinicalTrials.gov

2. PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)

   Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from COVID-19 have long-term symptoms that affect the brain. These include headaches; loss of taste and smell; sleep problems; thinking problems; depression; and anxiety. Researchers want to know if a tracer (a substa…

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT06920628 on ClinicalTrials.gov

3. Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)

   The purpose of this study is to better understand the biological changes associated with Long COVID and to identify laboratory tests (biomarkers) that may help diagnose the condition and measure how it changes over time. Researchers will enroll people with Long COVID as well as people who have full…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Zuckerberg San Francisco General Hospital, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT07770022 on ClinicalTrials.gov

4. Long-term COVID and Rehabilitation

   The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by combating the oxidative stress and inflammation associated with aging and further induced by COVID-1…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City, Utah

   Run by

   VA Office of Research and Development

   See if you can join NCT05373043 on ClinicalTrials.gov

5. Heat thErapy And mobiLity in COVID-19 Survivors

   Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and disabilities. Although exercise intervention is a common strategy to resto…

   Stage

   Not phased

   Ages

   50 to 90

   Site

   University of Nebraska Omaha, Omaha, Nebraska

   Run by

   University of Nebraska

   See if you can join NCT06928116 on ClinicalTrials.gov

6. Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation

   The goal of this clinical trial is to test whether a type of rapid outpatient brain stimulation that uses magnetic fields, called accelerated intermittent theta burst stimulation (iTBS), can treat symptoms such as brain fog, depression, and anxiety in patients with Long COVID. The main questions it…

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   University of New Mexico Health Science Center, Albuquerque, New Mexico

   Run by

   University of New Mexico

   See if you can join NCT06940609 on ClinicalTrials.gov

7. Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

   The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome. The study subjects will receive a single bolus of kisspeptin.

   Stage

   Phase 1

   Ages

   18 to 60

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Stephanie B. Seminara, MD

   See if you can join NCT07224490 on ClinicalTrials.gov

8. Water-based Activity to Enhance Recovery in Long COVID-19

   This two-year study will evaluate the feasibility and safety of an exercise + cognitive training program to improve neurological symptoms of long-COVID. This is a two-phased trial: 1) an exercise phase and 2) a cognitive training phase. The exercise phase will be an aquatic based exercise program. …

   Stage

   Not phased

   Ages

   18 to 89

   Site

   VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California

   Run by

   VA Office of Research and Development

   See if you can join NCT06142253 on ClinicalTrials.gov

9. Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog

   This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic in Arizona, Scottsdale, Arizona

   Run by

   Mayo Clinic

   See if you can join NCT06614309 on ClinicalTrials.gov

10. A Study to Examine Anktiva for the Treatment of COVID-19.

    This study will examine the safety and effectiveness of Anktiva in treating patients with Long COVID-19 which is defined as persistent symptoms of a COVID-19 infection that remain after the infection is over.

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    Chan Soon-Schiong Institute for Medicine (CSSIFM), El Segundo, California

    Run by

    ImmunityBio, Inc.

    See if you can join NCT07123727 on ClinicalTrials.gov

11. Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

    The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of breathlessness on daily activities, post-COVID-19 symptom burden, and biomar…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    University of Arizona, Tucson, Arizona

    Locations

    17 in total

    Run by

    Wes Ely

    See if you can join NCT06631287 on ClinicalTrials.gov

12. A Study to Assess Anktiva in Patients With Long Covid-19.

    This study will test the safety and tolerability of Anktiva in patients with Long Covid. Eligible patients will receive up to 2 doses of Anktiva and have follow-up exams and tests.

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    University of California - San Francisco, San Francisco, California

    Run by

    ImmunityBio, Inc.

    See if you can join NCT07108036 on ClinicalTrials.gov

13. Long COVID Brain Fog: Cognitive Rehabilitation Trial

    This study will compare two approaches to cognitive rehabilitation in adults with long COVID with persistent, mild to moderate, cognitive impairment. One approach will feature (A) web-based computer "games" that trains how quickly individuals process information that they receive through their sens…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06095297 on ClinicalTrials.gov

14. Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study

    The Long-Covid (LC)-Revitalize clinical study is testing repurposed drug treatments for Long Covid, involving adult participants from Brazil, Canada, Italy, Uganda, the United States, and Zambia. To qualify, participants must have had Covid-19 and experienced Long Covid symptoms for at least three …

    Stage

    Phase 3

    Ages

    18 to 65

    Site

    Laura Rodriguez Research Institute, San Diego, California

    Locations

    9 in total

    Run by

    Douglas D. Fraser

    See if you can join NCT06928272 on ClinicalTrials.gov

15. Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)

    Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss. This study aims to determine the efficacy of two at-home treatments, smell training and non-invasive trige…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05855369 on ClinicalTrials.gov

16. Immune-mediated Pathogenic Mechanisms of Neuro-PASC in Veterans

    Mental health symptoms, including cognitive impairment ("brain fog"), following COVID-19 are of great concern to Veterans. This research seeks to advance understanding of the long-term effects of COVID-19 on neuropsychiatric and neurological functions, identifying clinically relevant biomarkers and…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    VA Portland Health Care System, Portland, OR, Portland, Oregon

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06932237 on ClinicalTrials.gov

17. Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: * Long Covid (LC) * Post-treatment Lyme disease syndrome (PTLDS) * Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

    Stage

    Phase 1

    Ages

    18 and older

    Site

    The Cohen Center for Recovery from Complex Chronic Illnesses (CoRE), New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06511050 on ClinicalTrials.gov

18. Antiviral Clinical Trial for Long Covid-19

    The trial will test if two repurposed HIV antivirals can reduce symptom burden in adult participants with Long Covid compared to placebo. Viral infection and viral reactivation have been documented in Long Covid. Participants will be randomly allocated to receive antivirals, Truvada (tenofovir diso…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    The Cohen Center for Recovery from Complex Chronic Illnesses (CoRE), New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06511063 on ClinicalTrials.gov

19. Mind Body Intervention for Long COVID-19

    The goal of this study is to determine if a mind-body intervention can help people suffering from symptoms associated with Long COVID. The study is a randomized trial examining the effectiveness of a mind body intervention in reducing somatic symptoms from Long COVID in participants as compared to …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06045338 on ClinicalTrials.gov

20. Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

    The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related neuroinflammatory conditions. Participants in the United States aged 2 years…

    Stage

    Not phased

    Ages

    2 and older

    Site

    Brain Inflammation Collaborative, Delafield, Wisconsin

    Run by

    Brain Inflammation Collaborative

    See if you can join NCT04806620 on ClinicalTrials.gov

21. Acupuncture and Chinese Herbal Medicine for Long COVID

    List of the Hypothesis: Primary hypothesis: A flexible acupuncture and Chinese herbal medicine protocol will be feasible, acceptable, and useful for the treatment of long COVID. Secondary hypothesis: Long COVID patients receiving acupuncture treatment or acupuncture treatment and Chinese herbal sup…

    Stage

    Not phased

    Ages

    18 and older

    Site

    SCUHS, Whittier, California

    Run by

    Southern California University of Health Sciences

    See if you can join NCT07285707 on ClinicalTrials.gov

22. Sauna for Long Covid

    Research suggests that Whole Body Hyperthermia in a sauna-like environment can reduce symptoms related to post-acute sequelae of SARS-CoV-2 (PASC), or Long Covid. The investigators aim to study the feasibility and treatment effect of this procedure for patients experiencing Long Covid symptoms.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Depression Clinical and Research Program, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05931497 on ClinicalTrials.gov

23. LIFT: Life Improvement Trial

    The LIFT will be conducted at Brigham and Women's Hospital (BWH) of Harvard Medical School, focusing on the effect of Pyridostigmine (Mestinon) and Low-Dose Naltrexone (LDN) in subjects aged 18-70 meeting the Canadian consensus criteria (CCC) for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (…

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06366724 on ClinicalTrials.gov

24. The Long COVID-19 Wearable Device Study

    To further characterize Long COVID-19 by collecting data from individuals who already own wearable devices or are provided with a wearable device along with basic and enhanced educational materials to determine if both can improve Long COVID-19 symptom management and post-exertional malaise.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Scripps Research, La Jolla, California

    Run by

    Scripps Translational Science Institute

    See if you can join NCT05741112 on ClinicalTrials.gov

25. Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID

    This study is investigating the effects of using an Osteopathic Manipulative Therapy (OMT) treatment protocol that was shown to statistically improve smell in individuals suffering from Long-COVID olfactory (smell) dysfunction in a small single-blinded pilot trial conducted during 2021. The questio…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Louisville Outpatient Care Center, Louisville, Kentucky

    Run by

    University of Louisville

    See if you can join NCT06883513 on ClinicalTrials.gov