Keratoconus Clinical Trials

15 studies are recruiting for keratoconus in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases

   The overall goal of this study is to develop Brillouin microscope as a novel tool for measuring biomechanical and hydration properties of human tissues in vivo.

   Stage

   Not phased

   Ages

   20 to 79

   Site

   Massachusetts General Brigham, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07780890 on ClinicalTrials.gov

2. Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus

   Clinical trial to evaluate the safety and feasibility of corneal cross-linking in both eyes on the same day in subjects with keratoconus.

   Stage

   Phase 4

   Ages

   13 and older

   Site

   Glaukos Investigative Site, Westerville, Ohio

   Run by

   Glaukos Corporation

   See if you can join NCT07629557 on ClinicalTrials.gov

3. Corneal Elastography and Patient Specific Modeling

   The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors. Patients who either 1) have keratoconus and are being evaluated for corne…

   Stage

   Not phased

   Ages

   16 to 80

   Site

   Cleveland Clinic Foundation Cole Eye Institute, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT03030755 on ClinicalTrials.gov

4. Intacs Prescription Inserts for Keratoconus Patients

   The US food and Drug Administration (FDA) originally approved INTACS prescription inserts in April 1999 for the correction of low levels of nearsightedness (-1.00 to -3.00 diopters). Additional clinical data have shown that INTACS are safe for the treatment of keratoconus, in July 2004, FDA approve…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UTSW Medical Center at Dallas, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT02138669 on ClinicalTrials.gov

5. Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus

   Multi-center, parallel-group, placebo-controlled trial designed to assess the safety and efficacy of twice-daily topically administered GLK-221 Ophthalmic Solution in subjects with keratoconus.

   Stage

   Phase 2

   Ages

   18 to 55

   Site

   Glaukos Clinical Study Site, Westerville, Ohio

   Run by

   Glaukos Corporation

   See if you can join NCT07400952 on ClinicalTrials.gov

6. Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases

   The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively thin, steep, and misshapen, causing vision to be blurred. CXL is performe…

   Stage

   Phase 3

   Ages

   8 and older

   Site

   Woolfson Eye Institute, Atlanta, Georgia

   Locations

   12 in total

   Run by

   Woolfson Eye Institute

   See if you can join NCT07124910 on ClinicalTrials.gov

7. Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome

   The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively thin, steep, and misshapen, causing vision to be blurred. CXL is performe…

   Stage

   Phase 3

   Ages

   8 and older

   Site

   Woolfson Eye Institute, Atlanta, Georgia

   Locations

   12 in total

   Run by

   Woolfson Eye Institute

   See if you can join NCT07135167 on ClinicalTrials.gov

8. fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

   Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).

   Stage

   Not phased

   Ages

   8 to 35

   Site

   Boston Children's Hospital, Boston, Massachusetts

   Run by

   Boston Children's Hospital

   See if you can join NCT04439552 on ClinicalTrials.gov

9. A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia

   We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties of Keratoconus vs. Normal corneas and compare biomechanical properties…

   Stage

   Not phased

   Ages

   20 to 75

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT02118922 on ClinicalTrials.gov

10. Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia

    To evaluate the safety and effectiveness of the PXL Platinum 330 system for performing corneal cross-linking (CXL) for the treatment of ectatic disorders.

    Stage

    Phase 2

    Ages

    10 and older

    Site

    Goodman Eye Center, San Francisco, California

    Run by

    Goodman Eye Center

    See if you can join NCT04094090 on ClinicalTrials.gov

11. OCT in Diagnosis of Irregular Corneas

    This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: 1…

    Stage

    Not phased

    Ages

    14 to 85

    Site

    Humberto Martinez, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT03504800 on ClinicalTrials.gov

12. Collagen Cross-linking in Keratoconus

    Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberra…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT03760432 on ClinicalTrials.gov

13. Scleral Lens Fitting Using Wide-Field OCT

    The purpose of this study is to see if OCT technology can optimize scleral contact lens fittings. Subjects with keratoconus, post-penetrating keratoplasty (PK), post-LASIK ectasia, post-radial keratotomy (RK), or a variety of anterior surface disorders requiring scleral lens fittings will be consid…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Oregon Health & Science University, Casey Eye Institute, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT04570020 on ClinicalTrials.gov

14. The K-Map Study, Global Prevalence of KC

    Keratoconus is a ocular disease classified under ectatic diseases which often results in bilateral and asymmetrical corneal distortion. It usually affects patients at young age and can cause severe visual loss. The overall goal of this study is to assess the prevalence of keratoconus (KC) in childr…

    Stage

    Not phased

    Ages

    6 to 23

    Site

    USC Roski Eye Institute, Los Angeles, California

    Locations

    12 in total

    Run by

    University Hospital, Geneva

    See if you can join NCT03115710 on ClinicalTrials.gov

15. Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea Thinning

    This study study is to determine the effectiveness of cornea cross linking in patients with Keratoconus or other cornea thinning conditions.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Cohen Laser and Vision Center, Boca Raton, Florida

    Run by

    Cohen Laser and Vision Center

    See if you can join NCT05516004 on ClinicalTrials.gov