Irritable Bowel Syndrome Clinical Trials

17 studies are recruiting for irritable bowel syndrome in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)

   The purpose of this study is to evaluate how well brenipatide (LY3537031) is tolerated, what side effects may occur, and the safety and efficacy in participants with Irritable Bowel Syndrome-Diarrhea (IBS-D). The study drug will be administered subcutaneously (SC) (under the skin) when compared wit…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Del Sol Research Management - Mesa, Mesa, Arizona

   Locations

   89 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07545759 on ClinicalTrials.gov

2. A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)

   The purpose of this study is to evaluate how well brenipatide (LY3537031) is tolerated what side effects may occur, and the safety and efficacy in participants with Irritable Bowel Syndrome-Constipation (IBS-C). The study drug will be administered subcutaneously (SC) (under the skin) when compared …

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Del Sol Research Management - Mesa, Mesa, Arizona

   Locations

   70 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07545772 on ClinicalTrials.gov

3. Mechanisms of Gulf War Illness

   Many veterans with Gulf War Illness developed chronic gastrointestinal symptoms during their deployment to the Persian Gulf. The pathophysiologic mechanisms of these chronic gastrointestinal symptoms are not well understood but cause significant morbidity in veterans. Our proposed studies will prov…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Memphis VA Medical Center, Memphis, TN, Memphis, Tennessee

   Run by

   VA Office of Research and Development

   See if you can join NCT05972291 on ClinicalTrials.gov

4. Mucosal and Microbiota Changes During Acute Campylobacteriosis

   Gastrointestinal (GI) infection with Campylobacter causes inflammation in the bowel and can change bacteria in the gut. Certain individuals with Campylobacter infection are also known to develop chronic bowel problems such as Irritable Bowel Syndrome (IBS). The researchers are doing this study to u…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT03223077 on ClinicalTrials.gov

5. A Study to Investigate Abdominal Symptoms With Camlipixant Compared With Placebo in Adults With Irritable Bowel Syndrome - Diarrhea (IBS-D) and Irritable Bowel Syndrome - Mixed (IBS-M)

   This study is designed to evaluate the efficacy and safety of camlipixant in adults with IBS-D and IBS-M. The study has two parts. After the first part, some participants will be randomly chosen again to either get a higher dose or stop the drug.

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   GSK Investigational Site, Anniston, Alabama

   Locations

   110 in total

   Run by

   GlaxoSmithKline

   See if you can join NCT07519395 on ClinicalTrials.gov

6. Well-being in IBS: Strengths and Happiness (WISH) 2.0

   The purpose of this study is to examine the feasibility, acceptability, preliminary effects, and candidate gut-brain mechanisms of an optimized positive psychology (PP) intervention for patients with irritable bowel syndrome (IBS), entitled "WISH," compared to an educational control intervention.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06866106 on ClinicalTrials.gov

7. Defining Objective Markers of Compliance for Dietary Therapies in IBS

   This research will investigate if a specific marker in your stool or urine can be used to track changes in your carbohydrate intake including fructo-oligosaccharide and mannitol intake

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07494968 on ClinicalTrials.gov

8. Psyllium in Pediatric IBS

   The goal of this clinical trial is to learn if a fiber (psyllium) can change the way bacteria use fructans (a type of sugar) and whether psyllium can help decrease childhood irritable bowel syndrome (IBS) symptoms when eating fructans. The main questions it aims to answer are: Aim 1: The effect of …

   Stage

   Phase 2

   Ages

   12 to 17

   Site

   Duke University, Durham, North Carolina

   Run by

   Dr Bruno Chumpitazi, M.D.

   See if you can join NCT06639984 on ClinicalTrials.gov

9. Fecal Microbiota Transplantation for IBS

   The purpose of this study is to learn the efficacy and safety of fecal microbiota transplantation (FMT) using stool from a donor with low proteolytic activity and containing the bacteria Alistipes putredinis in patients with irritable bowel syndrome (IBS) and high proteolytic activity. Proteolytic …

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   Mayo Clinic in Minnesota, Rochester, Minnesota

   Run by

   Madhusudan (Madhu) Grover, MBBS

   See if you can join NCT05776914 on ClinicalTrials.gov

10. Home-based Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for IBS Pain

    The goal of this clinical trial is to learn the feasibility and safety of using home-based taVNS in young adults with IBS to manage their IBS-related pain and symptoms. It will also learn about participants' experience in using the home-based taVNS intervention. The main questions it aims to answer…

    Stage

    Not phased

    Ages

    18 to 29

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06847360 on ClinicalTrials.gov

11. Online Social Learning Program for Parents With Irritable Bowel Syndrome: Raising Resilient Children

    The goal of this clinical trial is to test efficacy of the REACH program in parents with irritable bowel syndrome (IBS) and their young children. The main question it aims to answer is: -How can parents with IBS help their young kids develop healthy habits? Participants will be asked to complete on…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Seattle Children's Hospital, Seattle, Washington

    Run by

    Seattle Children's Hospital

    See if you can join NCT05730491 on ClinicalTrials.gov

12. Drug Interaction Potential of Pro-Inflammatory Conditions

    Pro-inflammatory cytokines, which are elevated in pro-inflammatory disease states (e.g., type II diabetes mellitus [T2DM], irritable bowel diseases [IBD], and end stage renal disease [ESRD]) have been shown to inhibit hepatic drug-metabolizing enzymes, including members of the cytochrome P450 (CYP)…

    Stage

    Not phased

    Ages

    12 to 99

    Site

    Indiana University Hospital, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT07360938 on ClinicalTrials.gov

13. IBS Skin Patch Test Food Allergy Study

    Participants with IBS are skin patch tested (no needles) to 80 different foods and food additives, compounded for patch testing, in search of food allergies. The testing requires 3 office visits within a 4 or 5 day period. The patches are taped to the back at Visit #. At Visit #2 48 hours later, th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    North Wales Dermatology, PLLC, North Wales, Pennsylvania

    Locations

    2 in total

    Run by

    IBS-80, LLC

    See if you can join NCT06288672 on ClinicalTrials.gov

14. Visible Abdominal Distension

    Background. Abdominal distention is produced by an abnormal somatic postural tone. The authors developed an original biofeedback technique. In a randomized, placebo-controlled trial the authors demonstrated the superiority of biofeedback over placebo for the treatment of abdominal distention. Howev…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California

    Locations

    7 in total

    Run by

    Hospital Universitari Vall d'Hebron Research Institute

    See if you can join NCT06369753 on ClinicalTrials.gov

15. Study to Explore the Therapeutic Effect of Eluxadoline in Treating Irritable Bowel Syndrome With Diarrhea in Children

    The primary objectives of this study are to explore the therapeutic effect of eluxadoline in treating irritable bowel syndrome with diarrhea (IBS-D) in pediatric participants 6-17 years of age, to evaluate the pharmacokinetics of eluxadoline in pediatric participants with IBS-D, and to evaluate the…

    Stage

    Phase 2

    Ages

    6 to 17

    Site

    HealthStar Research of Hot Springs PLLC /ID# 234609, Hot Springs, Arkansas

    Locations

    46 in total

    Run by

    AbbVie

    See if you can join NCT03339128 on ClinicalTrials.gov

16. Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

    This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary goal of the study is to use fluctuations in daily self-reported symptoms…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brown University, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT05754190 on ClinicalTrials.gov

17. Standardized Yoga & Meditation Program for Stress Reduction for Adolescents With Irritable Bowel Syndrome

    Irritable Bowel Syndrome (IBS) is the most common cause of recurrent abdominal pain in children. IBS is a functional gastrointestinal disorder that is linked to motor and sensory physiology, as well as the central nervous system, that presents as abdominal pain with abnormal defecation patterns. Th…

    Stage

    Not phased

    Ages

    12 to 21

    Site

    Cooper University Hospital, Camden, New Jersey

    Run by

    The Cooper Health System

    See if you can join NCT05719246 on ClinicalTrials.gov