Interstitial Lung Disease Clinical Trials

29 studies are recruiting for interstitial lung disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging

   Background: Injury or diseases of the heart and lung can sometimes cause scar tissue (fibrosis) to build up in those organs. Current imaging scans can see this scar tissue once it has formed, but researchers want to find a way to detect the fibrosis in its earliest stages, while there might still b…

   Stage

   Phase 3

   Ages

   18 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT07613099 on ClinicalTrials.gov

2. Pulmonary Fibrosis Foundation Community Registry

   Pulmonary fibrosis (PF) results from a diverse group of health conditions and affects the lives of patients (including those who are post lung transplant), caregivers and family members. The Pulmonary Fibrosis Foundation Community Registry will offer an online portal where participants can self-enr…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Pulmonary Fibrosis Foundation, Chicago, Illinois

   Run by

   Pulmonary Fibrosis Foundation

   See if you can join NCT05382572 on ClinicalTrials.gov

3. A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease

   The purpose of this study to find out whether giving BIO 300 in combination with thoracic radiation therapy is effective in preventing pneumonitis in people with non-small cell lung cancer (NSCLC) and interstitial lung disease (ILD).

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

   Locations

   7 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT07323732 on ClinicalTrials.gov

4. SUPPORT-T in Patients With Progressive Pulmonary Fibrosis and Their Caregivers

   This pilot randomized controlled trial evaluates the feasibility, acceptability, and accessibility of SUPPORT-T, a digitally delivered palliative care intervention for patients with Progressive Pulmonary Fibrosis (PPF) and their caregivers. The intervention includes a 9-week digital application gui…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT07269262 on ClinicalTrials.gov

5. A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier)

   A Phase 3, Multicenter, Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Inhaled Mosliciguat in Participants with Pulmonary Hypertension Associated with Interstitial Lung Disease

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   Clinical Research Site, Kissimmee, Florida

   Locations

   3 in total

   Run by

   Pulmovant, Inc.

   See if you can join NCT07816185 on ClinicalTrials.gov

6. DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

   This is a prospective, real world, multicenter, registry of patients with pulmonary hypertension associated with interstitial lung disease (PH-ILD) and interstitial lung disease (ILD).

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   71 in total

   Run by

   United Therapeutics

   See if you can join NCT06388421 on ClinicalTrials.gov

7. Emapalumab MDA5 Rapidly Progressive Interstitial Lung Disease (RP-ILD) Study

   This is a proof of concept study to determine if Emapalumab appears effective for the treatment of anti-MDA5 antibody positive rapidly progressive interstitial lung disease (MDA5 RP-ILD). Emapalumab is a medication that is currently used for a severe problem with the immune system, called macrophag…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Miami Hospital and Clinics, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT07486869 on ClinicalTrials.gov

8. PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis

   This is a prospective, observational cohort study. Participants with non-idiopatic pulmonary fibrosis, interstitial lung disease (ILD) will be followed for 24 months to systematically collect clinical, imaging, and biospecimen data. The primary objective is to optimize progressive pulmonary fibrosi…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Massachusetts Chan Medical School, Worcester, Massachusetts

   Locations

   24 in total

   Run by

   University of Massachusetts, Worcester

   See if you can join NCT06855329 on ClinicalTrials.gov

9. Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

   The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, while maintaining a treatment effect.

   Stage

   Phase 2

   Ages

   8 to 60

   Site

   Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

   Locations

   3 in total

   Run by

   Paul Szabolcs

   See if you can join NCT03630211 on ClinicalTrials.gov

10. Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

    The primary objective of this study is to evaluate the effect of 24-weeks of once daily treatment with TPIP versus placebo on exercise capacity in adults with PH-ILD.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    USA001, Santa Barbara, California

    Locations

    145 in total

    Run by

    Insmed Incorporated

    See if you can join NCT07179380 on ClinicalTrials.gov

11. An Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

    The primary objective of this study is to evaluate the safety and tolerability of the long-term use of TPIP in participants with PH-ILD from Study INS1009-311 (NCT07179380).

    Stage

    Phase 3

    Ages

    18 and older

    Site

    USA006, Naples, Florida

    Locations

    9 in total

    Run by

    Insmed Incorporated

    See if you can join NCT07234032 on ClinicalTrials.gov

12. H01 in Adults With Interstitial Lung Disease (The SOLIS Study)

    Background: Interstitial lung disease affects the tissues that aid the transfer of oxygen and carbon dioxide between the air and the bloodstream. The disease can cause fibrosis, a thickening and scarring of lung tissue. Fibrosis often continues getting worse, and most people with this disease die i…

    Stage

    Phase 2

    Ages

    18 to 100

    Site

    NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

    Run by

    National Institute of Environmental Health Sciences (NIEHS)

    See if you can join NCT06325696 on ClinicalTrials.gov

13. The Benefits of Home Exercise in Pulmonary Hypertension Interstitial Lung Disease

    This study evaluates the effects of a structured home exercise program in participants with pulmonary hypertension associated with interstitial lung disease. Participants will complete a defined exercise regimen over a 16-week period, and functional capacity and patient reported outcomes will be as…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester Medical Center, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT07561034 on ClinicalTrials.gov

14. Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

    There is no standard of care therapy for patients with granulomatous-lymphocytic interstitial lung disease (GLILD) seen in common variable immunodeficiency (CVID). Abatacept has recently looked promising for the treatment of patients with complex CVID. This study is a multi-site, phase II, randomiz…

    Stage

    Phase 2

    Ages

    4 and older

    Site

    University of California, San Francisco, San Francisco, California

    Locations

    6 in total

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT04925375 on ClinicalTrials.gov

15. Advanced Imaging to Assess the Effect of Immunosuppression on Progressive Fibrosis

    The purpose of this study is to investigate how immunosuppression treatment affects measurements of active collagen deposition using [68Ga]CBP8 positron emission tomography (PET) and tissue injury using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in individuals with non-idiopathi…

    Stage

    Phase 2

    Ages

    18 to 80

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Peter Caravan

    See if you can join NCT07572383 on ClinicalTrials.gov

16. Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

    Study RIN-PF-305 is designed to evaluate the safety and efficacy of inhaled treprostinil in subjects with progressive pulmonary fibrosis (PPF) over a 52-week period.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    UAB Lung Health Center, Birmingham, Alabama

    Locations

    165 in total

    Run by

    United Therapeutics

    See if you can join NCT05943535 on ClinicalTrials.gov

17. Interstitial Lung Disease Research Unit Biobank

    Establish a interstitial lung disease (ILD) registry and biorepository to lead towards a further understanding of the disease.

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT05392881 on ClinicalTrials.gov

18. An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH

    Study LTI-401 is an open-label, multicenter study which will evaluate the safety and tolerability of LIQ861 in subjects who have WHO Group 1 \& 3 PH.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Arizona Pulmonary Specialists, Phoenix, Arizona

    Locations

    23 in total

    Run by

    Liquidia Technologies, Inc.

    See if you can join NCT06129240 on ClinicalTrials.gov

19. Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

    The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

    Stage

    Phase 1

    Ages

    3 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    Mario Castro, MD, MPH

    See if you can join NCT04624490 on ClinicalTrials.gov

20. Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease

    The overall goal of this study is to define the phenotype of Interstitial Lung Disease (ILD), and identify factors that predict radiologic progression in those with subclinical RA-ILD, in patients with rheumatoid arthritis (RA). The investigators hypothesize that there are common core elements (e.g…

    Stage

    Not phased

    Ages

    45 to 90

    Site

    University of Colorado - Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT03297775 on ClinicalTrials.gov

21. Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD)

    To develop a repository of blood samples from patients with ILD to support future studies into the development of such biomarkers. Patients with pneumonia and healthy patients will also be recruited as a control group.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT03478826 on ClinicalTrials.gov

22. Feasibility of Semaglutide in Advanced Lung Disease

    The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question[s] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide …

    Stage

    Phase 1

    Ages

    18 to 80

    Site

    University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT05746039 on ClinicalTrials.gov

23. Collagen-targeted PET Imaging for Early Interstitial Lung Disease

    The goal of this study is to investigate the ability of [68Ga]CBP8 to detect collagen deposition in early interstitial lung disease.

    Stage

    Phase 2

    Ages

    40 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05417776 on ClinicalTrials.gov

24. Pulmonary Hypertension SOLAR

    The main goal of this study is to develop a noninvasive signature for pulmonary vascular remodeling in Group 3 PH patients, using hyperpolarized 129Xe magnetic resonance imaging (129Xe MRI). Such a signature may identify Group 3 PH responders to PAH-specific therapies. PAH's unique 129Xe MRI signat…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Bastiaan Driehuys

    See if you can join NCT04778046 on ClinicalTrials.gov

25. 129Xe MRI Cardiopulmonary

    The goal of this NIH-sponsored study is to characterize three biomarkers derived from 129Xe gas exchange MRI and to understand how they change in response to interventions.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Bastiaan Driehuys

    See if you can join NCT06038630 on ClinicalTrials.gov