Insulin Sensitivity Clinical Trials

15 studies are recruiting for insulin sensitivity in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Mechanisms of Ultrasound Neuromodulation Effects in Diabetes

   This study aims to evaluate the effect of hepatic ultrasound treatment on changes from baseline in whole-body insulin sensitivity during a hyperinsulinemic, euglycemic clamp (HE Clamp).

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Yale School of Medicine, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06042517 on ClinicalTrials.gov

2. Circadian Intervention to Improve Cardiometabolic Health

   The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD). Participants will undergo a randomized controlled trial, with circadian intervention and control (healthy lifestyle) groups. The circadian interven…

   Stage

   Not phased

   Ages

   18 to 45

   Site

   College of Health Research Complex--University of Utah, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT05943626 on ClinicalTrials.gov

3. Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

   The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (interve…

   Stage

   Not phased

   Ages

   18 to 45

   Site

   College of Health Research Complex--University of Utah, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT06180837 on ClinicalTrials.gov

4. Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

   Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting ultimate improvement in liver disease. On the other end of the spectru…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Pichamol Jirapinyo, MD, MPH

   See if you can join NCT06138821 on ClinicalTrials.gov

5. Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

   The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of Colorado Anschutz, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT06129110 on ClinicalTrials.gov

6. Metabolic Adaptations to Weight Loss With and Without Exercise

   Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of ad…

   Stage

   Not phased

   Ages

   18 to 40

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT05806801 on ClinicalTrials.gov

7. The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)

   This is an 8 to14-week three-arm randomized controlled in children 8 to 12 years old. The main purpose of the study is to evaluate if stevia has benefits for weight control and metabolic function relative to caloric sweeteners, and whether it provides benefits in this regard similar to water.

   Stage

   Not phased

   Ages

   8 to 12

   Site

   Arkansas Children's Nutrition Center, Little Rock, Arkansas

   Locations

   2 in total

   Run by

   Arkansas Children's Hospital Research Institute

   See if you can join NCT05992688 on ClinicalTrials.gov

8. Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers

   People who experience repeated bouts of circadian misalignment, such as shift workers, are at higher risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D) compared to daytime workers. However, the mechanism(s) by which shift work and associated circadian misalignment increase CVD and T2D r…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Colorado State University, Fort Collins, Colorado

   Run by

   Colorado State University

   See if you can join NCT06550115 on ClinicalTrials.gov

9. Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes

   Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged/older adults with prediabetes is unknown, and potential mechanisms by which this could o…

   Stage

   Not phased

   Ages

   40 and older

   Site

   Virginia Tech, Blacksburg, Virginia

   Run by

   Virginia Polytechnic Institute and State University

   See if you can join NCT05337098 on ClinicalTrials.gov

10. Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition

    The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention. The main…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Pennington Biomedical Research Center, Baton Rouge, Louisiana

    Run by

    Pennington Biomedical Research Center

    See if you can join NCT07265323 on ClinicalTrials.gov

11. Countermeasures to Circadian Misalignment

    Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night …

    Stage

    Not phased

    Ages

    18 to 35

    Site

    Colorado State University, Fort Collins, Colorado

    Run by

    Colorado State University

    See if you can join NCT04966351 on ClinicalTrials.gov

12. MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes

    Diabetic kidney disease and cardiovascular disease remain the leading causes of morbidity and mortality in people with type 1 diabetes and are exacerbated with longer duration of diabetes and time outside goal glycemic range. Yet, type 1 diabetes is a complex disease with pathophysiology that exten…

    Stage

    Phase 1

    Ages

    12 to 25

    Site

    Seattle Children's Hospital, Seattle, Washington

    Locations

    2 in total

    Run by

    Kalie Tommerdahl

    See if you can join NCT05065372 on ClinicalTrials.gov

13. Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth

    To evaluate the effect of estradiol with or without a prior gonadotropin releasing hormone analogue on insulin sensitivity and vascular function in transgender females compared to cisgender controls.

    Stage

    Not phased

    Ages

    13 to 16

    Site

    Children's Hospital Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT04596592 on ClinicalTrials.gov

14. The Acute T-Rex (Timing of Resistance Exercise) Study

    The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laborator…

    Stage

    Not phased

    Ages

    50 to 74

    Site

    University of Utah HPER E Buildling, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT06366399 on ClinicalTrials.gov

15. Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

    The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC). This study looks at whether adipose (fat) tissue contributes to PASC by driving chronic inflammation or by serving as a reservoir…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford Health, Palo Alto, California

    Locations

    2 in total

    Run by

    Stanford University

    See if you can join NCT05833217 on ClinicalTrials.gov