Insomnia Clinical Trials

58 studies are recruiting for insomnia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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By city

Boston, Massachusetts 9 Baltimore, Maryland 5 Houston, Texas 4 Los Angeles, California 4 Chicago, Illinois 3 Denver, Colorado 3 Kansas City, Kansas 3 Palo Alto, California 3 Providence, Rhode Island 3

Studies, page 2

  1. A Hybrid Effectiveness Implementation Trial Evaluating Behavioral Treatments for Insomnia for Socioeconomically Disadvantaged Adults in Primary Care

    The overall objective of this study is to conduct a randomized effectiveness-implementation trial to test the non-inferiority of tele-Brief Behavioral Treatment for Insomnia vs. tele-Cognitive-Behavioral Therapy for Insomnia among socioeconomically disadvantaged adults with insomnia in the primary …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT05759065 on ClinicalTrials.gov

  2. COMPARATIVE EFFECTIVENESS OF EXERCISE, COGNITIVE BEHAVIOURAL THERAPY, AND THEIR COMBINATION FOR PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN AND POOR SLEEP: SLEEPFIT TRIAL

    This study aims to find out which lifestyle approach works best for people with chronic musculoskeletal pain (such as low back pain or hip/knee osteoarthritis) who also have poor sleep. Participants will be randomly assigned to one of three 12-month home-based programs: exercise, cognitive behavior…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Susan Wakil Health Building, Camperdown, New South Wales
    Locations
    4 in total
    Run by
    University of Sydney

    See if you can join NCT07532070 on ClinicalTrials.gov

  3. Pimavanserin for Insomnia in Veterans With PTSD

    This is a preliminary randomized, double-blind, placebo-controlled trial comparing pimavanserin 34mg at bedtime vs. placebo for the treatment of insomnia associated with post-traumatic stress disorder.

    Stage
    Phase 2
    Ages
    18 to 64
    Site
    Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas
    Run by
    VA Office of Research and Development

    See if you can join NCT05441280 on ClinicalTrials.gov

  4. NiteCAPP: Web-based Interventions for Insomnia in Rural Dementia Caregivers

    The goal of this project evaluate the efficacy of NiteCAPP in improving insomnia in a rural dementia caregiver sample (n of 100 caregiver and PWD dyads). We will measure both the short term (post-treatment) and long term (6 and 12 months) effects of the intervention on CG sleep, arousal, inflammati…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of South Florida, Tampa, Florida
    Run by
    University of South Florida

    See if you can join NCT04896775 on ClinicalTrials.gov

  5. Optimizing the Timing of rTMS to Enhance the Administration of Insomnia Treatment

    Repetitive transcranial magnetic stimulation (rTMS) has shown to be a promising technique for improving insomnia symptoms and sleep quality. However, the impact of circadian rhythmicity on rTMS sessions and its potential influence on insomnia therapy remains unclear. Moreover, the effect of rTMS on…

    Stage
    Not phased
    Ages
    25 to 45
    Site
    1070 Arastradero Road, Palo Alto, California
    Run by
    Stanford University

    See if you can join NCT06656533 on ClinicalTrials.gov

  6. Sleep Mechanisms Of Regulating Emotions

    This project is the second phase of a two-phased project investigating the impact of a proven sleep intervention, Cognitive Behavioral Therapy for Insomnia (CBT-I) on engagement of the emotion regulation brain network as a putative mechanistic target.

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Stanford University, Palo Alto, California
    Run by
    Stanford University

    See if you can join NCT06373718 on ClinicalTrials.gov

  7. Sleep to Reduce Incident Depression Effectively in Peripartum

    Perinatal depression (PND) is the most common complication in pregnancy and postpartum, which increases risk for adverse perinatal outcomes such as preterm birth, maternal suicidal thoughts, and impaired mother-infant bonding. Insomnia often precedes PND cases and may serve as an entry point for in…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Henry Ford Medical Center, Novi, Michigan
    Run by
    Henry Ford Health System

    See if you can join NCT06430333 on ClinicalTrials.gov

  8. Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder

    This pilot pre-post trial will address a gap in knowledge related to addressing modifiable risk factors for cardiometabolic disease through treating residual insomnia, sleep difficulties that remain after successful treatment of another condition, in the context of PTSD in understudied older adults…

    Stage
    Not phased
    Ages
    50 and older
    Site
    VA Greater Los Angeles Healthcare System, North Hills, California
    Run by
    University of California, Los Angeles

    See if you can join NCT05516277 on ClinicalTrials.gov

  9. The Effect of Sleep Loss on Emotion Regulation

    The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control. The investigators will address and attempt to answer two questions. (i) How do three nights …

    Stage
    Not phased
    Ages
    18 to 40
    Site
    Beth Israel Deaconess Medical Center, Boston, Massachusetts
    Run by
    Beth Israel Deaconess Medical Center

    See if you can join NCT05393830 on ClinicalTrials.gov

  10. Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)

    This study is designed to evaluate an integrated intervention to reduce alcohol and marijuana use and consequences and improve sleep among young adults with comorbid heavy episodic drinking, marijuana use, and sleep impairment.

    Stage
    Not phased
    Ages
    18 to 29
    Site
    University of Washington, Seattle, Washington
    Run by
    University of Washington

    See if you can join NCT06736444 on ClinicalTrials.gov

  11. mPATH for Low-income Older Adults

    Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in low-income older adults. The study aims to test the immediate and sustaining efficacy of an mHealth-facilita…

    Stage
    Not phased
    Ages
    65 and older
    Site
    The Johns Hopkins University, School of Nursing, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT05935241 on ClinicalTrials.gov

  12. Move and Snooze: Adding Insomnia Treatment to an Exercise Program to Improve Pain Outcomes in Older Adults With Knee Osteoarthritis

    This research will compare the effectiveness of a remotely delivered personalized exercise coaching plus an evidence-based sleep improvement intervention to remotely delivered personalized exercise coaching alone for knee osteoarthritis pain. The study team hypothesize that the combined interventio…

    Stage
    Not phased
    Ages
    50 and older
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT06580561 on ClinicalTrials.gov

  13. Noradrenergic Dysregulation, Sleep and Cognition in Older Adults With Insomnia

    This study investigates the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia - a population at elevated risk for Alzheimer's disease-related dementias (ADRD) - compared to age and sex matched controls with normal sleep. The stud…

    Stage
    Not phased
    Ages
    55 and older
    Site
    Northwestern University Feinberg School of Medicine, Center for Circadian and Sleep Medicine, Chicago, Illinois
    Run by
    Northwestern University

    See if you can join NCT06694441 on ClinicalTrials.gov

  14. The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer

    The investigators propose a randomized controlled clinical trial in 250 women with a history of early stage breast cancer who are overweight or obese with insomnia to test whether a brief, cognitive-behavioral intervention for insomnia (CBT-I) prior to behavioral weight loss (CBT-I+BWL) is superior…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Sibley Memorial Hospital, Washington D.C., District of Columbia
    Locations
    4 in total
    Run by
    Johns Hopkins University

    See if you can join NCT05780814 on ClinicalTrials.gov

  15. University of Colorado - Restoring Efficient Sleep After TBI

    Sleep disturbance is a common condition following traumatic brain injury (TBI) and impairs recovery and quality of life. While efficacious interventions exist many are not accessible to all patients due to a variety of factors (e.g., rurality, access to providers). Further, many of the available tr…

    Stage
    Not phased
    Ages
    18 to 60
    Site
    Rocky Mountain Regional VAMC, Aurora, Colorado
    Run by
    VA Eastern Colorado Health Care System

    See if you can join NCT05683145 on ClinicalTrials.gov

  16. CF Wellness Program

    This study is a pilot randomized control trial (RCT; N=80) comparing the Cystic Fibrosis Wellness Program (CFWP) to usual care (UC) to evaluate (1) Intervention Adherence (completion of the CFWP Coaching Sessions) (2) Study Retention (completion of the Week 15 assessment) and (3) Data Quality (vali…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Johns Hopkins University, Baltimore, Maryland
    Locations
    3 in total
    Run by
    Johns Hopkins University

    See if you can join NCT07071324 on ClinicalTrials.gov

  17. Targeting Adolescent Insomnia to Lessen Overall Risk of Suicidal Behavior

    This study will test the effectiveness of a sleep-related primary suicide prevention program entitled TAILOR (Targeting Adolescent Insomnia to Lessen Overall Risk of Suicidal Behavior), which includes specific behavior-change strategies for adolescents at risk of suicidal behavior who suffer from d…

    Stage
    Not phased
    Ages
    11 to 18
    Site
    Nationwide Children's Hospital, Columbus, Ohio
    Run by
    Jeff Bridge

    See if you can join NCT05390918 on ClinicalTrials.gov

  18. Enhancing Hypnotic Medication Discontinuation in Primary Care

    Many individuals with insomnia seek treatment in primary care settings, where they often receive prescription hypnotic medications as their first and sometimes only treatment. However, extended use of these medications can lead to reliance and increased health risks, such as falls and cognitive imp…

    Stage
    Phase 4
    Ages
    21 and older
    Site
    National Jewish Health, Denver, Colorado
    Run by
    National Jewish Health

    See if you can join NCT06435520 on ClinicalTrials.gov

  19. CBTi for the Treatment of Insomnia in Type 1 Diabetes

    The goal of this study is to learn if treating insomnia with a therapy intervention in people with type 1 diabetes will help to better control sugar levels, sleep, and quality of life. The questions this study aims to answer include: Will this intervention help the insomnia symptoms? Will obtaining…

    Stage
    EARLY_Phase 1
    Ages
    18 to 65
    Site
    University of Illinois Chicago, Chicago, Illinois
    Run by
    University of Illinois at Chicago

    See if you can join NCT07091318 on ClinicalTrials.gov

  20. Behavioral Insomnia Treatment in Mild Traumatic Brain Injury

    This is a single site, two-armed random controlled trials (RCT) comparing six sessions of Cognitive Behavioral Therapy for Insomnia (CBT-I) with four sessions of Brief Behavioral Therapy for Insomnia (BBT-I) in service members with comorbid insomnia and prolonged postconcussive symptoms present for…

    Stage
    Not phased
    Ages
    18 to 45
    Site
    Carl R. Darnall Army Medical Center, Fort Cavazos, Texas
    Run by
    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06551987 on ClinicalTrials.gov

  21. Resilience Enhancement Following Sleep Treatment

    The primary objective of this study is to evaluate the efficacy of an adaptive intervention targeting both insomnia and positive affect in improving pain outcomes for adults with chronic low back pain (cLBP) and comorbid insomnia. Specifically, the study tests whether augmenting a cognitive behavio…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    University of Virginia, Charlottesville, Virginia
    Run by
    University of Virginia

    See if you can join NCT07298941 on ClinicalTrials.gov

  22. Assessing the Feasibility of Web-based Insomnia Treatment Among Prostate Cancer Survivors

    This pilot study will recruit Black/African American prostate cancer survivors into a clinical trial and will randomize each person to 1 of 2 possible treatments - an internet-based treatment for insomnia called Sleep Healthy Using the Internet (SHUTi) or an educational website. SHUTi provides the …

    Stage
    Not phased
    Ages
    21 and older
    Site
    Georgetown Lombardi Comprehensive Cancer Center, Washington D.C., District of Columbia
    Run by
    Georgetown University

    See if you can join NCT07128927 on ClinicalTrials.gov

  23. Accelerated Treatment for Co-occurring Insomnia, Nightmares, and PTSD

    This study is a two-arm individually randomized group treatment clinical trial evaluating behavioral therapies for insomnia, nightmares, and PTSD. The study will compare cognitive-behavioral therapy for insomnia and nightmares to sleep hygiene (Control), both integrated with Written Exposure Therap…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Fort Hood, Kileen, Texas
    Run by
    Palo Alto Veterans Institute for Research

    See if you can join NCT07069517 on ClinicalTrials.gov

  24. Registry to Collect Information on Pregnancy, Neonatal, and Infant Outcomes in Pregnant Women Exposed to QUVIVIQ®

    This study will investigate pregnancy, neonatal, and infant outcomes in women exposed to QUVIVIQ during pregnancy compared to women unexposed to QUVIVIQ during pregnancy.

    Stage
    Not phased
    Ages
    15 to 50
    Site
    IQVIA US Office, Durham, North Carolina
    Locations
    7 in total
    Run by
    Idorsia Pharmaceuticals Ltd.

    See if you can join NCT06498128 on ClinicalTrials.gov

  25. Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia

    Individuals who have insomnia with short sleep duration (ISS) differ from individuals who have insomnia with normal sleep duration (INS) in terms of health risks (i.e., hypertension) and treatment response. This study will examine whether patients with ISS and INS demonstrate a differential respons…

    Stage
    EARLY_Phase 1
    Ages
    18 and older
    Site
    National Jewish Health, Denver, Colorado
    Locations
    4 in total
    Run by
    Milton S. Hershey Medical Center

    See if you can join NCT06281756 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.