Influenza Clinical Trials

26 studies are recruiting for influenza in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. pH1N1 Blinded Challenge Study

   This protocol describes a clinical trial to develop and validate a Controlled Human Infection Model (CHIM) for influenza A/Arkansas/08/2020 (pH1N1). The study is designed to determine the optimal infectious dose of the pH1N1 challenge strain for use in future clinical trials evaluating influenza co…

   Stage

   Phase 1

   Ages

   18 to 55

   Site

   University of Maryland, School of Medicine, Center for Vaccine Development and Global Health, Baltimore, Maryland

   Locations

   2 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT07110532 on ClinicalTrials.gov

2. BPL-1357 Against H1N1 Influenza Virus Challenge

   Background: Influenza (flu) infections are a serious global health threat. Each year, between 3 and 5 million people get the flu, and up to 500,000 die from it. Current vaccines protect against seasonal flus, but broader vaccines are needed to protect against potential flu pandemics. Objective: To …

   Stage

   Phase 2

   Ages

   18 to 55

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Locations

   2 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT07215858 on ClinicalTrials.gov

3. Screening for LID Clinical Studies Unit Healthy Volunteer Protocols

   Background: * The Laboratory of Infectious Diseases (LID) Clinical Studies Unit (CSU) enrolls healthy volunteers into clinical studies to study infectious diseases. * Viruses can be highly infectious and contagious. They cause considerable illness in the United States each year and a good example o…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT01386424 on ClinicalTrials.gov

4. Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.

   The study aims to evaluate an egg-based H5N8 influenza vaccine up to 3 dose levels (low, medium, and high dose) given with or without adjuvant to see if the adjuvant improves vaccine effectiveness. The study will enroll healthy adults aged 18 years and over. Participants will receive 2 injections i…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   AMR Clinical Phoenix, Arizona- Site Number : 8400004, Tempe, Arizona

   Locations

   16 in total

   Run by

   Sanofi

   See if you can join NCT07779408 on ClinicalTrials.gov

5. Observational Digital Biomarker Discovery in Respiratory Virus Challenge Studies

   Background: Respiratory viruses circulate throughout the year and around the globe. Wearable and sensor devices, like smartwatches, may be able to help monitor infectious diseases. Researchers want to use them to learn how respiratory viruses affect people in different ways. Objective: To use digit…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT04772170 on ClinicalTrials.gov

6. Clinical Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)

   The purpose of this study is to comprehensively describe the temporal and geographic utilization of COVID-19 therapies used for mild to moderate disease during different periods of SARS-CoV-2 variant circulation as well as to compare demographic and clinical characteristics of Veterans who are trea…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Portland Health Care System, Portland, OR, Portland, Oregon

   Run by

   VA Office of Research and Development

   See if you can join NCT06160128 on ClinicalTrials.gov

7. Dime La VerDAD: Verify, Debunk, and Disseminate

   Dime la Verdad (Tell me the truth) will evaluate the use of storytelling by community health workers as a communication strategy to disseminate reliable health information on social media and encourage informed decision-making in favor of recommended immunizations in communities with high morbidity…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   University of Chicago, Chicago, Illinois

   Locations

   4 in total

   Run by

   University of Chicago

   See if you can join NCT06417762 on ClinicalTrials.gov

8. Respiratory Virus Sampling and Repository

   Background: Respiratory viruses, like the flu or COVID-19, cause significant illness and death worldwide. Researchers want to collect samples from people with respiratory virus infections. The samples in this natural history study will be used in future research. Objective: To obtain samples from p…

   Stage

   Not phased

   Ages

   3 and older

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Locations

   2 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT05266222 on ClinicalTrials.gov

9. Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years

   This study will evaluate the relative vaccine effectiveness of quadrivalent adjuvanted inactivated influenza vaccine (aIIV4) versus quadrivalent high-dose inactivated influenza vaccine (HD-IIV4) in preventing polymerase chain reaction (PCR)-confirmed influenza and influenza-related outcomes in adul…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Kaiser Permanente Northern California (entire region), Oakland, California

   Run by

   Kaiser Permanente

   See if you can join NCT06029933 on ClinicalTrials.gov

10. Baloxavir and Oseltamivir for the Treatment of Severe Influenza Infection in Immunocompromised Patients

    This phase II trial studies the effect of baloxavir in combination with oseltamivir in treating severe influenza infection in patients who have previously received a hematopoietic (blood) stem cell transplant or have a hematological malignancy. Baloxavir is an antiviral drug that inhibits the growt…

    Stage

    Phase 2

    Ages

    12 and older

    Site

    M D Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT04712539 on ClinicalTrials.gov

11. The Effects of Endotracheal Suctioning on Pain and Serum Markers

    The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Loma Linda University Medical Center Troesh Medical Campus, Loma Linda, California

    Run by

    Loma Linda University

    See if you can join NCT06692400 on ClinicalTrials.gov

12. First-in-Human Study of VNT-101: Safety, Tolerability, and Pharmacokinetics

    A randomized, double-blind, placebo-controlled Phase 1 study conducted at a single center with approximately 78 healthy adults aged 18-59 years. Part 1 Single Ascending Dose (SAD) will enroll 48 participants into six cohorts (S1-S6) to receive single oral doses of VNT-101 (100-1500 mg) or placebo u…

    Stage

    Phase 1

    Ages

    18 to 59

    Site

    Altasciences Inc - Kansas City, Overland Park, Kansas

    Run by

    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT07169318 on ClinicalTrials.gov

13. A Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants With Influenza and Transmission of Influenza to Household Contacts

    This study consists of two parts: Part A Surveillance and Part B Transmission. The main purpose of Part A is to evaluate the prevalence of pre-dose and treatment-emergent amino acid substitutions in pediatric participants' <12 years with influenza treated with baloxavir marboxil. Part B will includ…

    Stage

    Phase 3

    Ages

    0 to 11

    Site

    Central Alabama Research, Birmingham, Alabama

    Locations

    51 in total

    Run by

    Hoffmann-La Roche

    See if you can join NCT06094010 on ClinicalTrials.gov

14. Woodsmoke Exposure, Influenza Infection, and Nasal Immunity

    This study will investigate the effects of woodsmoke (WS) exposure on human nasal mucosal immune responses to viral infection. The study tests the hypotheses that WS exposure modifies biomarkers of nasal mucosal immune function, increases in Live Attenuated Influenza Virus (LAIV) -induced nasal sym…

    Stage

    Phase 4

    Ages

    18 to 49

    Site

    Mary Ellen Jones, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06841913 on ClinicalTrials.gov

15. High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients

    Influenza virus is a significant pathogen in pediatric solid organ transplant (SOT) recipients. However, these individuals respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV). Recent studies have investigated two strategies to overcome poor immune responses in SOT recipients: (…

    Stage

    Phase 2

    Ages

    3 to 17

    Site

    Stanford University, Stanford, California

    Locations

    8 in total

    Run by

    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT05947071 on ClinicalTrials.gov

16. H5N1 Milk Detection Study

    The purpose of this study is to determine whether drinking pasteurized milk (milk heated to kill harmful germs) that contains inactive particles of a flu virus called A(H5) could lead to the detection of the virus in the nose or throat. Inactive particles are not capable of causing disease. The res…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    Hope Clinic, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06850298 on ClinicalTrials.gov

17. The INFLUENTIAL Trial- Evaluation of National Inpatient Influenza Vaccination Program

    This study plans to learn more about whether a stakeholder-informed, standardized inpatient vaccination program will increase influenza vaccination rates of hospitalized children across US pediatric health systems. The first part of the study is to form a multidisciplinary team of stakeholders, inc…

    Stage

    Not phased

    Ages

    0 to 99

    Site

    Ann and Robert Lurie's Children Hospital of Chicago, Chicago, Illinois

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT05832307 on ClinicalTrials.gov

18. Influenza Human Challenge Model

    This study examines how the immune system responds to the flu virus (H3N2) during and after infection and how the flu virus is transmitted in the environment. The study will used a flu virus called the H3N2 influenza challenge virus which was produced specifically for use in clinical research in co…

    Stage

    Phase 1

    Ages

    18 to 49

    Site

    Hope Clinic, Atlanta, Georgia

    Locations

    2 in total

    Run by

    Emory University

    See if you can join NCT05332899 on ClinicalTrials.gov

19. Influenza Immunization in Adults Over Age 75

    The immune system is the part of the body that protects against infection. The immune system often doesn't work as effectively as people get older. This research is being done to find out how the immune systems in older people who are over age 75 respond to influenza vaccine (flu shot). We also wan…

    Stage

    Not phased

    Ages

    75 and older

    Site

    Johns Hopkins University; JHAAC 5501 Hopkins Bayview Circle, 1B84, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT02200276 on ClinicalTrials.gov

20. Dissecting Human Immune Responses to Infection With Influenza or SARS-CoV-2

    The purpose of this study is to evaluate the virus-specific immune response in people who are symptomatic with confirmed influenza or COVID-19. We will study the immune response of people who have and who have not been vaccinated with the seasonal influenza and COVID-19 vaccines within the past yea…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Washington University in Saint Louis Department of Emergency Medicine, Emergency Care Research Core, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06848309 on ClinicalTrials.gov

21. Immune Defense Protein Impact On Respiratory Immune Outcomes

    The primary goal of this study is to observe the impact of the IDP® Supplement on the duration and severity of upper respiratory symptoms in older individuals during the cold and flu season. Secondary aims include observing the product's effect on rescue medication use, quality of life, and overall…

    Stage

    Not phased

    Ages

    60 and older

    Site

    People Science, Inc., Los Angeles, California

    Run by

    Quantec Ltd

    See if you can join NCT07431840 on ClinicalTrials.gov

22. A/Texas Flu Challenge

    This study is designed to help us better understand how the immune system responds to the flu and how flu is transmitted in the environment. The ultimate goal is to develop better vaccines and drugs to protect against or fight the flu. This study will describe how the body's immune system responds …

    Stage

    Phase 1

    Ages

    18 to 49

    Site

    Emory University Hospital Clinical Research Network, Atlanta, Georgia

    Locations

    2 in total

    Run by

    Emory University

    See if you can join NCT06753474 on ClinicalTrials.gov

23. Influenza & COVID-19 Obstetric and Perinatal Epidemiology Study in India

    This study will be conducted as a prospective cohort study, enrolling all eligible women in their first trimester of pregnancy during a baseline visit during week 6-13 of pregnancy at Government Medical College Hospital, Nagpur. The Hospital provides primary, secondary, and tertiary care and the ob…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Boston University School of Public Health, Global Health, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Boston University

    See if you can join NCT06168019 on ClinicalTrials.gov

24. High vs. Standard Dose Influenza Vaccines in Lung Transplant (Repeater)

    This will be a follow-up study to the "Comparison of High Dose vs. Standard Dose Influenza Vaccine in Lung Allograft Recipient" study (DMID Protocol Number 22-0014) at Vanderbilt University Medical Center. Lung transplantation is a life-saving therapy for patients with advanced lung disease, and is…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT07192458 on ClinicalTrials.gov

25. Systems Investigation of Vaccine Responses in Aging and Frailty

    This study will compare the immune response signatures (including immunologic, transcriptomic and metabolomic) of the two influenza vaccines approved for use in adults age 65 and over (Fluad and Fluzone High-Dose).

    Stage

    Phase 2

    Ages

    21 and older

    Site

    Yale School of Medicine, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT05291676 on ClinicalTrials.gov