Inflammatory Bowel Diseases Clinical Trials

26 studies are recruiting for inflammatory bowel diseases in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Observational Pharmaco-Epidemiology Research & Analysis

   Greater advances are needed in two separate but related areas in healthcare: 1) the Clinical Decision Support Systems that complement the EHR use in support of routine patient care, population management and disease management; and 2) the use of the point-of-care observational data from the provide…

   Stage

   Not phased

   Ages

   0 and older

   Site

   Epividian, Durham, North Carolina

   Run by

   Epividian

   See if you can join NCT03813862 on ClinicalTrials.gov

2. A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

   This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of 3 active dose regimens of MORF-057 in adult study participants with moderately to severely active Crohn's disease (CD).

   Stage

   Phase 2

   Ages

   18 to 85

   Site

   Gastro Care Institute, Lancaster, California

   Locations

   225 in total

   Run by

   Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)

   See if you can join NCT06226883 on ClinicalTrials.gov

3. A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

   This is a Phase 2, multicenter, proof-of-concept platform study in adult participants with moderately to severely active ulcerative colitis (UC). The primary goal of the study is to assess the efficacy and safety of multiple interventions following intravenous (IV) induction and subcutaneous (SC) m…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Site 024, Canoga Park, California

   Locations

   267 in total

   Run by

   Spyre Therapeutics, Inc.

   See if you can join NCT07012395 on ClinicalTrials.gov

4. A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

   The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD). The study will last about 172 weeks and may include up to 44 visits. Additional treatment may be available to participants via a Contin…

   Stage

   Phase 3

   Ages

   2 to 19

   Site

   UCSF Medical Center at Mission Bay, San Francisco, California

   Locations

   68 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT04844606 on ClinicalTrials.gov

5. Testing the Role of Anti-fungal Therapy in Improving the Response to Therapies for Crohn's Disease

   The goal of this clinical trial is to learn about the effects of fluconazole in patients who plan to start or are currently undergoing standard of care treatment and plan to dose-escalate an IL-23 therapy for their Crohn's disease. The main question it aims to assess is whether or not patient respo…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT06274554 on ClinicalTrials.gov

6. BOOM-IBD2 Pivotal Clinical Trial

   Ulcerative colitis is a long-lasting condition that causes swelling and sores in the large intestine. This study tests whether a small device placed under the skin can help reduce bowel urgency in people with ulcerative colitis. The investigational device sends mild signals to a nerve near the tail…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Gastroenterology Medical Clinic (Objective Health), Folsom, California

   Locations

   19 in total

   Run by

   Boomerang Medical

   See if you can join NCT06571669 on ClinicalTrials.gov

7. Social Determinants of Health, Medication Use, and Quality of Life in Inflammatory Bowel Disease

   Optimizing health related-quality of life (HRQoL) for patients with inflammatory bowel disease (IBD), who often experience a relapsing disease course, is an essential component of care. Improving IBD disease control is linked to increased health-related quality of life. Even as many effective pharm…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Icahn School of Medicine at Mount Sinai, New York, New York

   Locations

   2 in total

   Run by

   Montefiore Medical Center

   See if you can join NCT06266663 on ClinicalTrials.gov

8. Virtual Reality (VR) -Directed Brain Gut Behavioral Treatment (BGBT) for Inflammatory Bowel Disease (IBD) Inpatients

   The research is studying virtual reality (VR)-directed brain-gut behavioral therapy (BGBT) as a pain treatment option for hospitalized patients with inflammatory bowel disease (IBD). This study is being done to learn if VR-directed BGBT is feasible and acceptable for patients with IBD in addressing…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT06188793 on ClinicalTrials.gov

9. Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease

   This research is studying whether changing an individual's behaviors may have an impact as a treatment or outcome for inflammatory bowel disease. This research will increase the understanding of the role of a self-management program in improving health and health-related quality of life for patient…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Micigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07456566 on ClinicalTrials.gov

10. Duloxetine in Inflammatory Bowel Diseases

    This open-label, prospective, single-arm pilot study investigates the use of duloxetine, a central neuromodulator, for improving psychological distress and functional impairment in adults with inflammatory bowel disease (IBD). The study focuses on patient-reported outcomes related to anxiety, depre…

    Stage

    Phase 2

    Ages

    24 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT07431606 on ClinicalTrials.gov

11. Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE)

    This is a prospective observational study collecting long-term clinical data and samples for research in pediatric inflammatory bowel disease (IBD) patients with gut inflammation and a control cohort of pediatric patients with disorders of the brain-gut interactions (DBGI) with no detectable gut in…

    Stage

    Not phased

    Ages

    6 to 21

    Site

    Seattle Children's Hospital, Seattle, Washington

    Run by

    Seattle Children's Hospital

    See if you can join NCT06315179 on ClinicalTrials.gov

12. COMPARE - Pediatric Inflammatory Bowel Disease (PIBD)

    The purpose of the study is to compare the clinical effectiveness and safety of newer inflammatory bowel disease (IBD) medications in anti-tumor necrosis factor (TNF) refractory patients with pediatric IBD (PIBD). Refractory means that there was no clinical response to anti-tumor necrosis factor (T…

    Stage

    Not phased

    Ages

    1 to 18

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Locations

    4 in total

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT07198113 on ClinicalTrials.gov

13. Therapeutic Endpoint in Pediatric IBD Conditions

    The purpose of this clinical study is the development of physiologic endpoint of inflammation in pediatric patients diagnosed with inflammatory bowel disease (IBD), specifically subtypes Crohn's disease (CD) and ulcerative colitis (UC). The novel medical device evaluates the patient's sensory respo…

    Stage

    Not phased

    Ages

    6 to 21

    Site

    Children's National Health System, Washington D.C., District of Columbia

    Run by

    Children's National Research Institute

    See if you can join NCT06065228 on ClinicalTrials.gov

14. Heart Rate Variability and Inflammatory Bowel Disease

    The goals of this study are to test the effectiveness of a virtually delivered, group-based coping skills treatment program incorporating heart rate variability biofeedback to target autonomic dysfunction in youth diagnosed with inflammatory bowel disease (IBD). The investigators will enroll partic…

    Stage

    Not phased

    Ages

    13 to 18

    Site

    Atlanta Metropolitan Area, Atlanta, Georgia

    Locations

    3 in total

    Run by

    Emory University

    See if you can join NCT06537258 on ClinicalTrials.gov

15. Pre-operative Nutrition for Elective Resection Surgery in Inflammatory Bowel Disease

    This study aims to determine if improved risk stratification tools and interventions to mitigate malnutrition reduce postoperative risk in patients undergoing elective or emergent resection surgery for inflammatory bowel disease (IBD), and if adding immune modulation nutrition improves surgical out…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06309017 on ClinicalTrials.gov

16. The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing

    The purpose of this study is to collect DNA samples from patients undergoing routine care at the University of Chicago. These samples will be tested for differences in genes that may suggest greater risk of side effects or chance of increased benefit from certain medications. The results will be ma…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago Medical Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT01280825 on ClinicalTrials.gov

17. Fermented Food-Supplemented Diet in Ulcerative Colitis

    The purpose of this study is to see how a diet that supplements fermented foods effects inflammation and quality of life in patients with mild to moderate Ulcerative Colitis (UC). There is a paucity of research and an enormous need for better understanding of diet and intestinal inflammation. Ferme…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stanford University, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT04401605 on ClinicalTrials.gov

18. Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study

    PSC is a liver disease that has no medical cure. Patients with PSC are at a greatly increased risk of cancer and infection. Additionally, many patients require a liver transplant. Progress towards a cure has been severely limited by an incomplete understanding of why patients develop PSC. The inves…

    Stage

    EARLY_Phase 1

    Ages

    18 to 80

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT05912387 on ClinicalTrials.gov

19. Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

    The aim of this study is to develop and assess the feasibility and effect of a web-based, personalized risk-estimation for Crohn's disease (PRE-Crohn's) tool on behaviors and biomarkers associated with risk for Crohn's disease in unaffected first-degree relatives of patients with inflammatory bowel…

    Stage

    Not phased

    Ages

    14 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05332639 on ClinicalTrials.gov

20. A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

    The investigators have developed an inexpensive tool to take pictures in the lower GI tract without sedation and to look for signs of disease. The tool is a capsule, about the size of a fish oil or multi-vitamin supplement, attached to a string. The capsule and string are connected to a motor to al…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07219537 on ClinicalTrials.gov

21. Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance

    The goal of this research is to learn how a new device called the wireless thermal capsule (WTC) can collect thermal data to help see diseases that happen in the gastrointestinal (GI) tract, such as Crohn's Disease.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07033208 on ClinicalTrials.gov

22. Regulation of Mucosal Healing in Inflammatory Bowel Disease

    The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid or psoriatic arthritis. Patients will be biopsied at baseline and agai…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    University of Kentucky, Lexington, Kentucky

    Run by

    Terrence A Barrett

    See if you can join NCT04504136 on ClinicalTrials.gov

23. Feasibility Test of Action Planning in Pediatric IBD

    The goal of this interventional study is to test the feasibility of a new communication tool, call MyIBD, in youth ages 13 to 19 years with inflammatory bowel disease. The main question[s] it aims to answer are: * Is the MyIBD communication tool feasible to use in everyday clinical practice? * Does…

    Stage

    Not phased

    Ages

    13 to 19

    Site

    University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06186752 on ClinicalTrials.gov

24. VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems

    Vagal nerve stimulation is a neurosurgical procedure consisting of implantation of an impulse generator battery with leads placed into the vagus nerve in the neck. This procedure was FDA approved for epilepsy in the 1990s and is commonly performed as an outpatient surgery. The mechanism of action i…

    Stage

    Not phased

    Ages

    0 to 60

    Site

    University of Louisville, Louisville, Kentucky

    Locations

    4 in total

    Run by

    University of Louisville

    See if you can join NCT03953768 on ClinicalTrials.gov

25. Beta-Hydroxybutyrate Feasibility Treating IBD

    This clinical trial aims to understand the feasibility of patients taking ketone body supplement beta-hydroxybutyrate (BHB) for 4 weeks with a confirmed diagnosis of Crohn's disease and starting new therapy for active disease. The main questions it aims to answer are: * BHB supplementation will be …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT06351124 on ClinicalTrials.gov