Infections Clinical Trials

17 studies are recruiting for infections in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Exactech Shoulder Post Market Clinical Follow-up Study

   The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restri…

   Stage

   Not phased

   Ages

   21 and older

   Site

   South County Orthopedic Specialists, Laguna Woods, California

   Locations

   40 in total

   Run by

   Exactech

   See if you can join NCT05603728 on ClinicalTrials.gov

2. PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

   This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics. The study population will be 250 patients, 18 years or older, being treated for infected nonunion after internal fixation of a fracture with a…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Indiana University, Indianapolis, Indiana

   Locations

   13 in total

   Run by

   Major Extremity Trauma Research Consortium

   See if you can join NCT05699174 on ClinicalTrials.gov

3. Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

   BTI-203 is a randomized, double-blind, placebo-controlled, multicenter, Phase 2 proof-of-concept (POC) study to evaluate the efficacy and safety of rhu-pGSN plus standard of care (SOC) in subjects with moderate-to-severe ARDS (P/F ratio ≤150) due to pneumonia or other infections. Potential subjects…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Cedars-Sinai Medical Center, Los Angeles, California

   Locations

   70 in total

   Run by

   BioAegis Therapeutics Inc.

   See if you can join NCT05947955 on ClinicalTrials.gov

4. Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)

   The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIIES; Job's syndrome) is caused by STAT3 mutations, and is a multi-system disorder with skeletal, vascular, and connective tissue mani…

   Stage

   Not phased

   Ages

   0 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT00006150 on ClinicalTrials.gov

5. Remote Sputum Collection in Cystic Fibrosis

   Elexacaftor/Tezacaftor/Ivacaftor or Trikafta improves lung health in people with cystic fibrosis (CF), including decreased cough and mucous production. Diagnosing lung infections has become more challenging due to the decrease in sputum and rise of telehealth services. While the option of collectin…

   Stage

   Not phased

   Ages

   18 and older

   Site

   National Jewish Health, Denver, Colorado

   Locations

   4 in total

   Run by

   University of Pennsylvania

   See if you can join NCT06950892 on ClinicalTrials.gov

6. Supporting Weak Immune System During Autoimmune Therapy: Testing Panzyga to Prevent Infections

   A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Panzyga for Prevention of Major Infection in Patients with Hypogammaglobulinemia and Autoimmune or Rheumatic Conditions Receiving Treatment with B-cell Depletion Therapy

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Perseverance Research Center, Phoenix Neurological Associates, Scottsdale, Arizona

   Locations

   6 in total

   Run by

   Octapharma

   See if you can join NCT07220915 on ClinicalTrials.gov

7. Large Algorithm Setting and Validation Study

   In this pilot study, prospectively acquired clinician-collected and participant-collected vaginal swab specimens will be obtained from up to 1000 individuals with signs and symptoms of vaginitis to develop and validate a bacterial vaginosis diagnostic algorithm and evaluate the performance of the N…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Segal Trials, North Miami, Florida

   Locations

   2 in total

   Run by

   Nanopath, Inc

   See if you can join NCT07607470 on ClinicalTrials.gov

8. CIED Infection Quality Initiative Demonstration Project

   The aim of this Quality Initiative (QI) demonstration project is to develop a model to increase guideline-driven care for patients with cardiovascular implantable electronic devices (CIED) infection. Multidisciplinary teams will be established to carry out the multifaceted intervention. This progra…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Northwestern, Chicago, Illinois

   Locations

   3 in total

   Run by

   Duke University

   See if you can join NCT05471973 on ClinicalTrials.gov

9. Effect of Drain Care on Infection Rate and Quality of Life in Implant-Based Breast Reconstruction.

   The goal of this clinical trial is to learn whether showering with surgical drain tubes in place after first stage breast reconstruction causes increased risk of infection. The main questions it aims to answer are: * Is there an increased risk of infection/complications with showering 48 hours afte…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Missouri, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT05846438 on ClinicalTrials.gov

10. EnCoRe MoMS: Engaging Communities to Reduce Morbidity From Maternal Sepsis (Aim 1)

    Sepsis is the second leading cause of maternal death in the U.S. Labor and postpartum are particularly vulnerable risk periods. The goal of this multi-center, multidisciplinary study is to evaluate a maternal sepsis safety bundle.

    Stage

    Not phased

    Ages

    Any age

    Site

    Columbia Unviersity Irving Medical Center, New York, New York

    Locations

    4 in total

    Run by

    Columbia University

    See if you can join NCT06145724 on ClinicalTrials.gov

11. Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

    The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing homes randomized to use a multicomponent intervention to optimize susp…

    Stage

    Not phased

    Ages

    60 to 106

    Site

    Hebrew SeniorLife, Boston, Massachusetts

    Run by

    Hebrew SeniorLife

    See if you can join NCT05950607 on ClinicalTrials.gov

12. Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

    Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to transplantation strategy, but also for those individuals who suffer from…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    UCSF, San Francisco, California

    Locations

    7 in total

    Run by

    International Consortium of Circulatory Assist Clinicians

    See if you can join NCT06039176 on ClinicalTrials.gov

13. Azithromycin Before Induction

    This is a double blinded randomized control trial involving administration of 2 grams prophylactic azithromycin in third trimester patients undergoing induction of labor at our institution to demonstrate reduction in maternal and neonatal infection.

    Stage

    Phase 1

    Ages

    18 to 45

    Site

    Arrowhead Regional Medical Center, Colton, California

    Run by

    Arrowhead Regional Medical Center

    See if you can join NCT06543290 on ClinicalTrials.gov

14. Augmented Reality For MRI-Guided Interventions

    The purpose of this study is to determine feasibility and safety of using an augmented reality system in patients undergoing MRI-Guided needle procedures.

    Stage

    Not phased

    Ages

    3 to 21

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Run by

    Children's National Research Institute

    See if you can join NCT06224933 on ClinicalTrials.gov

15. X-linked Moesin Associated Immunodeficiency

    Moesin deficiency was initially described in 7 male participants aged 4 to 69 years and is characterized by lymphopenia of the 3 lineages and moderate neutropenia. Genetically, 6 out of 7 participants had the same missense mutation in the moesin gene located on the X chromosome. The 7th patient has…

    Stage

    Not phased

    Ages

    4 to 80

    Site

    Hôpital Necker, Paris, PARIS

    Locations

    10 in total

    Run by

    Institut National de la Santé Et de la Recherche Médicale, France

    See if you can join NCT06278337 on ClinicalTrials.gov

16. Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty

    The purpose of this study is to compare two different antibiotic regimens and techniques during total ankle arthroplasty (TAA). Primary Objective: Comparable levels of vancomycin will be found in bone, soft tissue, and systemic samples between patient groups. Secondary Objective: Compare 30 day and…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Houston Methodist Hospital, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT06384651 on ClinicalTrials.gov

17. TriVerity™ for Improved Management of Emergency Department (ED) Patients With Suspected Infections

    A pre/post interventional use trial, with ED patients who are initially triaged to locations other than a dedicated patient room in the main ED (e.g., waiting room, hallway bed, and/or the staging area/fast track area) with suspected infection and tachycardia or fever will be enrolled. Study conduc…

    Stage

    Not phased

    Ages

    18 and older

    Site

    OSF HealthCare Saint Francis Medical Center, Peoria, Illinois

    Locations

    2 in total

    Run by

    Inflammatix

    See if you can join NCT06637904 on ClinicalTrials.gov