HIV Prevention Clinical Trials

20 studies are recruiting for hiv prevention in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Using PrEP, Doing It for Ourselves

   The goal of this clinical trial is to test a new online program called UPDOs Protective Styles to help people in the southeastern United States learn about and start using PrEP (pre-exposure prophylaxis), a medicine that helps prevent HIV. The study focuses on people who may be at higher risk for H…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Duke University School of Nursing, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT06638892 on ClinicalTrials.gov

2. Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP

   The purpose of this project is to test a culturally-tailored, community-delivered long-acting injectable PrEP (lenacapavir) program for Latine gay and bisexual men (GBM) and transgender women (TGW). The objective is to evaluate whether this intervention demonstrates greater persistence on lenacapav…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   El Centro Hispano, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT07218211 on ClinicalTrials.gov

3. PEP/PrEP Via Pharmacist-Prescribing Implementation (PEPPI)

   The goal of this clinical trial is to learn if use of the PEPPI software can improve pharmacist-provided HIV prevention (PEP/PrEP) services. The main questions it aims to answer are: 1. Does the PEPPI software make it easier for pharmacists to provide PEP/PrEP services in their pharmacy? 2. Does th…

   Stage

   Not phased

   Ages

   18 and older

   Site

   EmpoweRx, Inc, Del Mar, California

   Run by

   EMPOWERX INC

   See if you can join NCT07683117 on ClinicalTrials.gov

4. Evaluating an Interactive Digital Toolkit for Women's PrEP Implementation

   The goal of this study is to test if a Digital PrEP Toolkit helps cisgender women learn about and access PrEP in Alabama and Mississippi. PrEP is a medication that prevents HIV infection. The main questions it aims to answer are: Can participants complete the Digital PrEP Toolkit in under 10 minute…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   4 in total

   Run by

   University of Alabama at Birmingham

   See if you can join NCT07292584 on ClinicalTrials.gov

5. RESTORE Study R61 Phase: Recovery and Engagement for Stimulant Users on Re-entry

   Justice-involved individuals face disproportionately high rates of stimulant use disorder and HIV, along with disrupted access to HIV treatment and prevention services like ART and PrEP. Contingency management (CM) is the most effective intervention for stimulant use, but its use in justice-involve…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Yale University, New Haven, Connecticut

   Locations

   2 in total

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT07136363 on ClinicalTrials.gov

6. Feasibility of Internet-based HIV Prevention Research

   The study will use social media to recruit a diverse sample of people who self-report injecting drugs, assessing the feasibility of online assessments and participants' ability to perform at-home self-administered HIV testing. Participants will complete online questionnaires at baseline and will be…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Montefiore Medical Center, The Bronx, New York

   Run by

   Montefiore Medical Center

   See if you can join NCT07625917 on ClinicalTrials.gov

7. Mobile Vehicle-Based Delivery of Lenacapavir Pre-Exposure Prophylaxis in Los Angeles County

   This project evaluates the implementation strategy of the delivery of lenacapavir pre-exposure prophylaxis (LEN PrEP) - a newly available long-acting, injectable medication for human immunodeficiency virus (HIV) prevention - via a mobile health van model for people who are unstably housed in Los An…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UCLA Health Homeless Healthcare Collaborative, Santa Monica, California

   Run by

   University of California, Los Angeles

   See if you can join NCT07467018 on ClinicalTrials.gov

8. California MEPS Hub

   The California Hub for HIV/SUD Prevention Research with Reentry Populations addresses the question: "Can the evidence-based MEPS intervention be adapted and implemented at a range of organizations to effectively serve a wider range of clients?" The Mobile Enhanced Prevention Support (MEPS) interven…

   Stage

   Not phased

   Ages

   18 to 59

   Site

   CAL-PEP, Oakland, California

   Locations

   3 in total

   Run by

   University of California, Los Angeles

   See if you can join NCT07433985 on ClinicalTrials.gov

9. A Multi-Level Trauma-Informed Approach to Increase HIV Pre-exposure Prophylaxis Initiation Among Black Women

   U.S. epidemiological data indicates that Black women are a high-risk HIV disparity group, yet initiation of novel prevention strategies like pre-exposure prophylaxis (PrEP) among this group is stagnant. Socio-structural challenges like intimate partner violence and gendered racism can constrain PrE…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

   Run by

   Johns Hopkins Bloomberg School of Public Health

   See if you can join NCT06703060 on ClinicalTrials.gov

10. HIV Outpatient Monitoring Evaluation Through Self-collection of Dried Blood Spots

    The goal of this observational study is to establish an operational framework for home self-collections of blood samples to be used for antiviral drug concentration measurements. Participants will continue on their prescribed antiviral(s) for HIV treatment or prevention and followed for up to appro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Colorado Hospital (UCHealth), Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT04979728 on ClinicalTrials.gov

11. PrOTECT AL: PrEP Optimization Through Enhanced Continuum Tracking

    The purpose of this study is to enhance and evaluate the implementation of a PrEP Care Continuum data dashboard across seven distinct clinical sites in Alabama. By leveraging real-time data and fostering collaborative partnerships, this project aims to accurately visualize care disparities, allocat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT07231640 on ClinicalTrials.gov

12. Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers

    The goal of this study is to evaluate the pharmacokinetics of a one-time dosing of two F/TAF tablets over a 14-day period.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Johns Hopkins University School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07349758 on ClinicalTrials.gov

13. The Unlocking PrEP Study: Integration of Peer Health Navigation Into Comprehensive Re-entry Services

    This 18-month study, "Integration of peer health navigation into comprehensive re-entry services: improving PrEP implementation for justice-involved individuals," aims to increase PrEP awareness and uptake among people with a history of justice involvement in Dallas, primarily clients of Unlocking …

    Stage

    Not phased

    Ages

    18 to 99

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT07292792 on ClinicalTrials.gov

14. Testing a Gender-inclusive HIV Prevention Program

    If, over time, data suggest the intervention impacts HIV preventive behavior at the population level, it will be unique in that it can be quickly and cost effectively scaled up to impact thousands of trans girls and nonbinary youth assigned male at birth.

    Stage

    Not phased

    Ages

    14 to 18

    Site

    Center for Innovative Public Health Research, San Clemente, California

    Run by

    Center for Innovative Public Health Research

    See if you can join NCT06586151 on ClinicalTrials.gov

15. Suubi4PrEP: Improving PrEP Access and Adherence Among Adolescent Girls and Young Women in Uganda

    The study will employ a multilevel combination intervention focused on PrEP initiation and adherence among adolescent girls and young women (AGYW) (aged 15-24) living in HIV hotpots in Uganda. Specifically, the study will combine: 1) HIV risk reduction (HIVRR) that incorporates sessions on PrEP, 2)…

    Stage

    Not phased

    Ages

    15 to 24

    Site

    International Center for Child Health and Development (ICHAD), Masaka,

    Locations

    2 in total

    Run by

    Washington University School of Medicine

    See if you can join NCT07002866 on ClinicalTrials.gov

16. Stick2PrEP Cisgender Women and Trans Individuals

    Taking a daily anti-HIV pill can protect people from HIV infection. This is called preexposure prophylaxis [PrEP]. Many cisgender women and trans individuals do not know this medication is available; others struggle to take the pill every day. It is important to understand attitudes and preferences…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT05165745 on ClinicalTrials.gov

17. Behavioral Economic Intervention to Improve HIV Behaviors in Sexual Minority Individuals

    This research study is testing a new behavioral therapy called Episodic Future Thinking or EFT can help people reduce drug use and risky sexual behaviors while helping them adhere to their HIV prevention medication (PrEP). Participants will be randomly assigned to one of two groups. One group will …

    Stage

    Not phased

    Ages

    18 to 34

    Site

    University of Texas Health Science Center at San Antonio, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06745947 on ClinicalTrials.gov

18. Prepping for The Talk: Helping Trusted Adults and Youth Talk About Sexual Health

    The goal of this study is to help young people talk to trusted adults (including their parents, but also other adults) about sexual health more openly and honestly- including how to prevent sexually transmitted diseases like HIV - while also respecting a young person's right to privacy. If youth do…

    Stage

    Not phased

    Ages

    14 to 17

    Site

    Rhode Island Hospital, Providence, Rhode Island

    Run by

    Rhode Island Hospital

    See if you can join NCT07011563 on ClinicalTrials.gov

19. Intervention to Enhance PrEP Persistence

    The investigators will conduct a fully powered randomized controlled trial (RCT) to test the effect of a patient navigation intervention for Black/African American (B/AA) men who have sex with men (MSM) on PrEP initiation, adherence and retention in care. B/AA men who have sex with men (MSM) are di…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Whitman Walker Health, Washington D.C., District of Columbia

    Locations

    3 in total

    Run by

    Brown University

    See if you can join NCT06872307 on ClinicalTrials.gov

20. WePrEP: Developing a PrEP Shared Decision-making Tool for Transgender Women

    HIV prevalence among transgender women (TW) in the United States is high (~14%). The best way to reduce HIV incidence in this population is to link TW to HIV pre-exposure prophylaxis (PrEP), which can reduce HIV transmission by up to 86%, with optimal adherence. The FDA approved the first long-acti…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Transgender Center of the Rockies, Sheridan, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06656676 on ClinicalTrials.gov