Heart Failure With Reduced Ejection Fraction Clinical Trials

19 studies are recruiting for heart failure with reduced ejection fraction in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction

   The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of HJB647 at two different doses in participants with chronic stable heart failure with reduced or mildly reduced ejection fraction (HFrEF/HFmrEF).

   Stage

   Phase 1

   Ages

   18 to 100

   Site

   Synergy Healthcare, Bradenton, Florida

   Locations

   6 in total

   Run by

   Novartis Pharmaceuticals

   See if you can join NCT07465653 on ClinicalTrials.gov

2. Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score

   The purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics. Participants will have the beta-blocker (BB) polygenic score calculated from genotype data. The score will …

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07490067 on ClinicalTrials.gov

3. Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure

   In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may develop and progress over time. We will evaluate distinct sub-groups of hear…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT03480633 on ClinicalTrials.gov

4. Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

   The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   Advanced Cardiovascular, LLC, Alexander City, Alabama

   Locations

   205 in total

   Run by

   Cytokinetics

   See if you can join NCT06736574 on ClinicalTrials.gov

5. A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

   The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left hear…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Banner - University Medical Center Tucson, Tucson, Arizona

   Locations

   6 in total

   Run by

   Pulnovo Medical, Inc.

   See if you can join NCT07214376 on ClinicalTrials.gov

6. A Study Investigating the Impact of IMT With CR On Exercise Responses In HF

   The purpose of this study is to compare the impact of inspiratory muscle training (IMT) combined with cardiac rehabilitation (CR) on cardiovascular function in patients with heart failure.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT07086131 on ClinicalTrials.gov

7. Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure

   RECOVER HF is a clinical study designed to evaluate the safety and efficacy of Synchronized Diaphragmatic Stimulation delivered using the VisONE System in the treatment of patients with heart failure.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Saint Francis Hospital, Tulsa, Oklahoma

   Locations

   3 in total

   Run by

   VisCardia Inc.

   See if you can join NCT06552637 on ClinicalTrials.gov

8. Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure

   An increasing number of guideline-directed medical therapies (GDMT) have been developed for patients with chronic heart failure with reduced ejection fraction (HFrEF). When used in combination at recommended doses, patients often experience significant improvements in cardiac function, quality of l…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Sutter Health, Walnut Creek, California

   Locations

   5 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT06526988 on ClinicalTrials.gov

9. The CardioClip Study

   The CardioClip study is exploring the use of a wireless sensor to monitor pressure in the pulmonary artery. This sensor is inserted much like the mTEER procedure, a non-surgical method through a vein in the groin. The investigators want to find out if the sensor, by constantly sending information a…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Columbia University Irving Medical Center / NewYork-Presbyterian Hospital, New York, New York

   Run by

   Columbia University

   See if you can join NCT06241430 on ClinicalTrials.gov

10. Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG

    This is a prospective, observational study evaluating whether heart sounds (phonocardiograms) and three-lead electrocardiograms (ECGs) recorded using the Eko CORE 500 digital stethoscope can help detect pulmonary hypertension (PH) and low left ventricular ejection fraction (EF ≤ 40%). PH is a condi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Prairie Cardiovascular, O'Fallon, Illinois

    Locations

    4 in total

    Run by

    Eko Devices, Inc.

    See if you can join NCT07087613 on ClinicalTrials.gov

11. Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System

    The Yale HF Registry is a live EHR based registry that allows for retrospective and real-time monitoring of Heart Failure case across the Yale New Haven Health System.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale New Haven Health System, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT04237701 on ClinicalTrials.gov

12. Ketones, SGLT2, HFrEF

    The study team will examine the effects of elevated plasma ketone levels following initiation of SGLT2 inhibitor therapy in high-risk type 2 diabetes mellitus (T2DM) individuals with heart failure (HF) with reduced ejection fraction (HFrEF) providing an energy-rich fuel that is taken up with great …

    Stage

    EARLY_Phase 1

    Ages

    18 to 70

    Site

    Texas Diabetes Institute - University Health System, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06229678 on ClinicalTrials.gov

13. Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure

    Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best c…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06299436 on ClinicalTrials.gov

14. Left vs Left Randomized Clinical Trial

    The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications an…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mercy Gilbert & Chandler Regional Medical Centers, Gilbert AZ, Gilbert, Arizona

    Locations

    71 in total

    Run by

    Baylor College of Medicine

    See if you can join NCT05650658 on ClinicalTrials.gov

15. Home-Based Cardiac Rehabilitation for Patients With Heart Failure

    The vast majority of individuals with heart failure do not participate in center based cardiac rehabilitation (CBCR). While steps to increase utilization of CBCR are important, many individuals will still not participate for a variety of reasons. This pilot randomized controlled trial is evaluating…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT06479876 on ClinicalTrials.gov

16. PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction

    This study is trying to find out whether performing a hybrid aerobic-resistance exercise training program (titled PRIME: Peripheral Remodeling via Intermittent Muscular Exercise) results in better health outcomes than the traditional exercise training program (called COMBO) that is used in individu…

    Stage

    Not phased

    Ages

    65 and older

    Site

    University of Virginia, Department of Kinesiology, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT05609097 on ClinicalTrials.gov

17. Study Assessing Left Ventricular Administration of a Genetic Medicine Directing Organ Regeneration in Heart Failure

    This clinical trial investigates the safety and preliminary effectiveness of YAP101, a gene therapy designed to improve heart function in adults with ischemic heart failure and reduced ejection fraction (HFrEF). Ischemic heart failure, often resulting from a prior heart attack, leads to poor heart …

    Stage

    Phase 1

    Ages

    18 to 79

    Site

    Texas Heart Institute, Houston, Texas

    Run by

    Medley Therapeutics

    See if you can join NCT06831825 on ClinicalTrials.gov

18. Conduction System Vs Surgical Left Ventricular Epicardial Pacing For Coronary Sinus Lead Failure

    This a single-center, retrospective, observational study of patients that undergo coronary sinus(CS) lead revision, comparing epicardial lead placement to coronary sinus pacing(CSP) in those that had lead failure.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kansas City Heart Rhythm Institute, Overland Park, Kansas

    Run by

    Kansas City Heart Rhythm Research Foundation

    See if you can join NCT06342492 on ClinicalTrials.gov

19. Colchicine in Acutely Decompensated HFREF

    This is a double blind, placebo-controlled pilot trial randomizing patients admitted to the hospital with acutely decompensated heart failure (ADHF) and inflammation to receive either colchicine or matching placebo. Upon enrollment, patients will be randomized 1:1 to receive either the experimental…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    UVA Health, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT06286423 on ClinicalTrials.gov