Heart Diseases Clinical Trials

30 studies are recruiting for heart diseases in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

   The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart failure.

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Alabama at Birmingham Hospital, Birmingham, Alabama

   Locations

   47 in total

   Run by

   BrioHealth Solutions, Inc.

   See if you can join NCT06310031 on ClinicalTrials.gov

2. A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

   The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) will improve procedural efficiency and effectiveness compared with the current standard of care (IVUS-…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Minneapolis Heart Institute, Minneapolis, Minnesota

   Locations

   14 in total

   Run by

   Fundación EPIC

   See if you can join NCT07286578 on ClinicalTrials.gov

3. Abbott Structural Heart Device Registry

   The Abbott Structural Heart (SH) Registry is being conducted to confirm the safety and performance of Abbott's SH devices in a post-market, real-world setting. The Registry primarily involves gathering data from routine hospital practices and standard-of-care (SOC) procedures administered to patien…

   Stage

   Not phased

   Ages

   Any age

   Site

   Robert Wood Johnson University Hospital, New Brunswick, New Jersey

   Locations

   36 in total

   Run by

   Abbott Medical Devices

   See if you can join NCT06590467 on ClinicalTrials.gov

4. Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions

   The objective of this study is to assess the safety and efficacy of the Freesolve resorbable magnesium scaffold (RMS) in the treatment of subjects with up to two de novo lesions in native coronary arteries compared to the Xience coronary drug-eluting stent (DES) system

   Stage

   Not phased

   Ages

   18 to 80

   Site

   MedStar Washington Hospital Center, Washington D.C., District of Columbia

   Locations

   3 in total

   Run by

   Teleflex

   See if you can join NCT07258290 on ClinicalTrials.gov

5. A Preliminary Study for INFORMED

   Investigators will determine whether N-of-1 trials, as a pragmatic, participant-centered approach to medication optimization that can overcome key barriers of deprescribing, can lead to increased participant confidence regarding their preference to continue or discontinue beta-blockers in older adu…

   Stage

   Phase 4

   Ages

   65 and older

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05585125 on ClinicalTrials.gov

6. Randomization of Single vs Multiple Arterial Grafts

   The primary hypothesis of ROMA is that in patients undergoing primary isolated non-emergent coronary artery bypass surgery (CABG), the use of two or more arterial grafts compared to a single arterial graft is associated with a reduction in the composite outcome of death from any cause, any stroke, …

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of Colorado, Boulder, Colorado

   Locations

   59 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT03217006 on ClinicalTrials.gov

7. Transition to KPL-387 Monotherapy Dosing & Administration Study

   The primary objective of this study is to characterize the efficacy and safety of dosing regimens used to transition from prior pericarditis therapies to KPL-387 monotherapy in participants with well-controlled recurrent pericarditis on standard therapies.

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   Investigational Site 031, Phoenix, Arizona

   Locations

   41 in total

   Run by

   Kiniksa Pharmaceuticals International, plc

   See if you can join NCT07288216 on ClinicalTrials.gov

8. Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

   Transthyretin amyloidosis (ATTR) is a disease where the normally occurring transthyretin (TTR) protein falls apart and forms amyloid, a sticky plaque-like substance that accumulates in different organs in the body and can cause damage to the organ. There are two ways that the TTR protein can fall a…

   Stage

   Phase 3

   Ages

   18 to 75

   Site

   University of California, San Diego (UCSD) - Medical Center, La Jolla, California

   Locations

   104 in total

   Run by

   Eidos Therapeutics, a BridgeBio company

   See if you can join NCT06563895 on ClinicalTrials.gov

9. Gauging Outcomes of Total Milk Ingestion on Lipid and gControl

   Atherosclerotic cardiovascular disease remains the leading cause of death for adults in the United States. The cardiovascular impact of milk consumption remains a matter of long-standing scientific debate. Current guidelines for Americans recommend three daily servings of fat-free or low-fat (1%) d…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UCSF Medical Center at Parnassus, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT07087184 on ClinicalTrials.gov

10. Smart Walk: A Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women

    The purpose of this study is to test a culturally tailored, smartphone-delivered intervention designed to increase physical activity and reduce risk for heart disease and type 2 diabetes among African American women.

    Stage

    Phase 2

    Ages

    24 to 65

    Site

    Arizona State University, Phoenix, Arizona

    Run by

    Arizona State University

    See if you can join NCT06337708 on ClinicalTrials.gov

11. Self Expanding Coronary Sinus Reducer for Treatment of Symptomatic Coronary Microvascular Dysfunction (CMD)

    VahatiCor's Coronary Sinus Reducer (A-FLUX) has been designed to improve angina or angina-like symptoms in patients with CMD. SERRA-I is an early feasibility study that evaluates the safety and clinical performance of the A-FLUX Reducer in this population.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale University, New Haven, Connecticut

    Locations

    3 in total

    Run by

    VahatiCor, Inc.

    See if you can join NCT07449325 on ClinicalTrials.gov

12. Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

    The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Banner-University Medical Center Phoenix, Phoenix, Arizona

    Locations

    68 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT06526195 on ClinicalTrials.gov

13. American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)

    Despite many advances in our understanding of the natural history and progression of chronic kidney disease (CKD) and cardio vascular disease (CVD) in the parent CRIC study over the past 15 years, important questions about key risk factors for these diseases remain unanswered in the AI population. …

    Stage

    Not phased

    Ages

    21 to 80

    Site

    First Nations Community Health Source, Albuquerque, New Mexico

    Locations

    3 in total

    Run by

    University of New Mexico

    See if you can join NCT04185844 on ClinicalTrials.gov

14. Sternal Plating High Risk

    Participants are being invited to participate in a research study at University Hospitals because they have heart disease and are scheduled for open heart surgery. Currently, UH cardiac surgeons close the sternum (or breastbone) after a sternotomy (procedure that allows a doctor to reach the heart …

    Stage

    Not phased

    Ages

    18 to 89

    Site

    University Hospitals, Cleveland, Ohio

    Run by

    University Hospitals Cleveland Medical Center

    See if you can join NCT06660186 on ClinicalTrials.gov

15. Mayo AVC Registry and Biobank

    Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as the disease pr…

    Stage

    Not phased

    Ages

    Any age

    Site

    Mayo Clinic, Rochester, Minnesota

    Locations

    2 in total

    Run by

    Mayo Clinic

    See if you can join NCT03049254 on ClinicalTrials.gov

16. The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

    The objective of this prospective, randomized, double- blinded (patient and assessors), sham-controlled clinical trial is to assess the safety and efficacy of the CMCS in treating heart failure with functional regurgitation (FMR).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dignity Health Research Institute at Mercy Gilbert and Chandler Regional Medical Centers, Gilbert, Arizona

    Locations

    92 in total

    Run by

    Cardiac Dimensions, Inc.

    See if you can join NCT03142152 on ClinicalTrials.gov

17. Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II

    AliveCor (www.alivecor.com) has developed several electrocardiogram (ECG) devices that interface with iOS and Android smartphones and tablets via various Kardia apps. The current Kardia family of devices can measure single lead and six limb-lead ECGs, depending on the device. KardiaMobile, KardiaMo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Locations

    4 in total

    Run by

    AliveCor

    See if you can join NCT06271577 on ClinicalTrials.gov

18. Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

    The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grafting (SAG). The specific aims of ROMA:Women are: Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and c…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Locations

    146 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT04124120 on ClinicalTrials.gov

19. Lumason® Infusion vs. Bolus Administrations

    A phase III study designed as a randomized, within-patient comparison of continuous infusion of diluted Lumason® versus the bolus administration of undiluted Lumason® for degree of LVO and assessment of LV EBD (co-primary endpoints).

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Interventional Cardiology Medical Group, West Hills, California

    Locations

    6 in total

    Run by

    Bracco Diagnostics, Inc

    See if you can join NCT06400004 on ClinicalTrials.gov

20. Health Electronic Assessment of Risks and Trends Using Biometric Equipment and Technology

    This is a phase 0, non-interventional, longitudinal, electronic data capture (EDC) study to facilitate the HEARTBEAT Study project has set out to explore the potential use of smartwatches in collecting and analyzing biometric data to improve the detection, identification, and understanding of cardi…

    Stage

    Not phased

    Ages

    18 to 120

    Site

    East Jefferson General Hospital, New Orleans, Louisiana

    Locations

    3 in total

    Run by

    Tulane University

    See if you can join NCT06753045 on ClinicalTrials.gov

21. The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing

    The purpose of this study is to collect DNA samples from patients undergoing routine care at the University of Chicago. These samples will be tested for differences in genes that may suggest greater risk of side effects or chance of increased benefit from certain medications. The results will be ma…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago Medical Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT01280825 on ClinicalTrials.gov

22. PKP2-ACM Natural History Study

    The goal of this study is to describe the natural history and clinical events for patients who have Arrhythmogenic Cardiomyopathy with Pathogenic Plakophilin-2 Variants (PKP2-ACM) managed with standard of care.

    Stage

    Not phased

    Ages

    12 and older

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Rocket Pharmaceuticals Inc.

    See if you can join NCT06644742 on ClinicalTrials.gov

23. Use of Bedside Imaging and Community Health Workers for Early Screening and Referral of Pre-symptomatic Stage B Heart Failure in the Emergency Department

    The goal of this clinical trial is to learn if using point-of-care ultrasound (POCUS) can increase participant engagement and changes in behavior among adults with risk factors for pre-symptomatic heart failure presenting to the emergency department. The main questions it aims to answer are: 1. Doe…

    Stage

    Not phased

    Ages

    45 and older

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT06769880 on ClinicalTrials.gov

24. Understanding Decentralized Trial Engagement and Clinical Impediments Through Digital Efforts (UDECIDE) Among Unrepresented Groups With Poor Cardiovascular and Cardiometabolic Health

    The objective of the UDECIDE study is to demonstrate adherence to decentralized clinical trials among underrepresented groups with cardiometabolic conditions .

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06587204 on ClinicalTrials.gov

25. Angiography and Electrogram Guided Bachmann Bundle Pacing

    People eligible for this study are scheduled to have a permanent pacemaker (PPM) or defibrillator device (ICD) implanted as part of their routine care. This device will also have a wire placed in the right atrium (RA) of the heart. As an alternative to the RA, the wire can also be placed in the Bac…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Geisinger Wyoming Valley, Wilkes-Barre, Pennsylvania

    Run by

    Pugazhendhi Vijayaraman

    See if you can join NCT07110922 on ClinicalTrials.gov